OVERWEIGHT

This study tests a new drug called IBI362 in people with mild to moderate high blood pressure who are also overweight or obese and not taking blood pressure medication. The goal is to see if the drug can lower blood pressure and help with weight loss compared to a placebo. About …

This study tests whether drinking special hydrogen-rich water every day can help overweight adults lose weight and improve their metabolism. Researchers will compare the hydrogen water to regular water in 120 people over time. The goal is to see if this simple, non-drug approach …

This study tests whether tracking only high-calorie, low-nutrition foods (simplified approach) works as well as tracking all foods and calories for weight loss. About 328 adults with overweight or obesity will use a digital program for 12 months. The goal is to see if the simpler…

This early-stage study tests two versions of the medicine cagrilintide in 234 adults with overweight or obesity (BMI 27-35). Participants receive either version D or version B by chance, and researchers compare how the drug behaves in the body over about 6 months. The goal is to …

This study tests whether two experimental drugs, macupatide and eloralintide, can help people with obesity or overweight lose weight safely. About 400 adults who do not have type 2 diabetes will take the drugs alone, together, or a placebo for around 64 weeks. The main goal is to…

This study tests a once-monthly injection called berobenatide to help adults with overweight or obesity lose weight. About 954 participants will receive either the drug or a placebo for 20 months. The goal is to see if the drug is safe and effective for weight loss, including in …

This study tests two different versions of the drug cagrilintide in 50 adults with overweight or obesity. Participants will receive injections of either version B or D for about 14 weeks to compare how the drug behaves in the body. The goal is to find which version works best for…

This study tests a new medicine, CagriSema, to help people with overweight or obesity lose weight. About 1,400 adults will receive either CagriSema or a placebo injection for one year. The study compares two different injection devices to see if they work the same way.

This study tests a weekly oral medication called ecnoglutide (VRB-101) to see if it can help people with obesity or overweight maintain their body weight. Participants must have already been on weekly injections of similar drugs for at least 6 months. The goal is to find the best…

This early-stage study tests whether a new drug called NNC0113-5840 is safe for people with overweight or obesity. About 48 adults will receive either the drug or a placebo by chance. The main goal is to check for side effects and how the drug moves through the body.

This study tests two experimental drugs, PF-08653945 and PF-08653944, given alone or together, to help adults with overweight or obesity lose weight. About 872 participants will receive either the drugs or a placebo. The main goal is to see how much weight they lose and if the dr…

This study is the first time the experimental drug SA030 is being tested in people. It aims to check the safety and how the body handles a single dose in 40 overweight or obese adults aged 18 to 55. Participants will be randomly assigned to receive either SA030 or a placebo, and …

This study tests a new weekly injection, NNC0487-0111, against the approved drug semaglutide in 1000 adults with overweight or obesity and type 2 diabetes. Participants will receive two weekly shots (one active, one placebo) for about a year. The main goal is to see how much weig…

This study looks at whether a type of talk therapy called Acceptance and Commitment Therapy (ACT), given in group sessions and through a mobile app, can help overweight people who eat in response to emotions like stress or sadness. About 78 adults will be randomly placed into gro…

This study aims to find the best combination of four dietary strategies—limiting high-calorie foods, eating within a set time window, increasing protein, and increasing fiber—for weight loss in adults with overweight or obesity. Over 12 weeks, 208 participants will track their we…

This early-stage study tests a new medicine, NNC0497-0040, given as a weekly shot. It will include healthy people, those who are overweight or obese, and people with type 1 diabetes who are also overweight. The main goal is to check if the drug is safe and tolerable, and how the …

This study looks at whether brief, intense stair-climbing sessions, called 'exercise snacks,' can improve blood vessel function and body composition in overweight adults aged 18-35. Sixty participants will be split into four groups, including a no-exercise control group, for 6-8 …

This study looks at how body fat and muscle affect the way anesthetic drugs work in overweight and obese patients. Researchers will measure body composition and track drug levels and complications during surgery. About 2,100 adults aged 18-65 will take part. No new treatments are…

This early-phase study looks at how a single shot of HDM1005 moves through the body in people with reduced kidney function compared to healthy volunteers. About 30 overweight or obese adults aged 18-75 will take part. The goal is to understand safety and drug levels, not to treat…

This study looks at how to help VA medical centers better serve women Veterans, especially those in midlife. Researchers will test two different strategies to get more women involved in programs for heart health, weight management, and stress. The study involves 18 VA sites and f…

This early-stage study is testing a new medicine for overweight and obesity in 35 adults with and without liver problems. The goal is to see how the drug moves through the body and if it is safe. Results will help guide future use in people with reduced liver function.

This early-stage study looks at how a new drug called HDM1005 affects stomach emptying and interacts with common medications like metformin, atorvastatin, warfarin, and digoxin in 42 overweight or obese Chinese adults aged 18-45. The goal is to understand how the body processes t…