Overweight

This study tests a 6-month program where patients work with a pharmacist and their primary care doctor to make shared decisions about medications and lifestyle. The goal is to see if this team-based approach improves heart and kidney health scores and medication adherence. The st…

This trial tests whether mazdutide, an experimental weekly injection, can reduce fat buildup in the pancreas of adults with overweight or obesity. About 194 participants will receive either mazdutide or a placebo, alongside standard lifestyle advice, for 48 weeks. Researchers wil…

Researchers are studying zenagamtide, an experimental drug for overweight and obesity, to see how food and water affect the tablet version. Participants take zenagamtide as either a tablet or an injection, and the tablet group tries different meal timings and water amounts around…

This early-stage trial tests an experimental drug called LY4329090 in adults with obesity or overweight. The main goal is to see how safe and tolerable the drug is, and how the body processes it. Participants receive either the drug or a placebo by injection, and researchers moni…

This Phase 3 trial tests whether berobenatide, a once-weekly injection, helps Chinese adults with overweight or obesity lose weight. About 300 participants will receive either berobenatide or a placebo for 48 weeks, with researchers tracking changes in body weight and safety. The…

This early trial tests an investigational pill called IBI3042, which activates the GLP-1 receptor, a target used by many weight-loss drugs. Researchers want to see if single and repeated doses are safe and tolerable in healthy, overweight, and obese adults. The study also tracks …

This early-stage trial is testing an investigational drug called BI 3034701 in people with overweight or obesity who also have at least one weight-related health condition. The main goal is to see how safe and tolerable the drug is when given by injection, and to understand how i…

This trial tests whether orforglipron, a once-daily oral medication, helps Chinese adults with obesity or overweight and related health conditions lose weight. Participants take either orforglipron or a placebo for about a year. Researchers measure changes in body weight, waist s…

This Phase 3 trial will test whether a new drug called zenagamtide helps people with obesity lose more weight than the current treatment semaglutide. About 650 adults will receive weekly injections of either zenagamtide, semaglutide, or a placebo. The main goal is to see how much…

This phase 3 trial is testing whether an experimental once-daily oral drug called zenagamtide can safely help people with excess body weight lose weight. Around 950 adults aged 18 and older with overweight or obesity will be randomly assigned to receive either zenagamtide or a pl…

This trial tests whether adding mazdutide, a weekly injection that helps with weight loss, to a hormonal intrauterine device (IUD) can improve treatment for overweight or obese women with atypical endometrial hyperplasia or early-stage endometrioid endometrial cancer who wish to …

This Phase 3 study tests whether a weekly injection called zenagamtide helps Asian adults with overweight or obesity lose weight safely. About 400 participants will receive either the drug or a placebo for several weeks. The main goal is to see how much body weight changes, with …

This trial tests whether adding laser acupuncture to a standard acupuncture technique—thread embedding—can enhance weight loss in adults with obesity. Participants receive the same thread embedding treatment, but half also get active laser acupuncture while the other half gets a …

This early-stage trial is testing whether a new drug called macupatide, given alone or with another drug called eloralintide, is safe and well-tolerated in Japanese adults with obesity or overweight who do not have type 2 diabetes. Participants will receive multiple doses and sta…

This study compares how well women with overweight or obesity stick to a 10-week dance-based exercise program versus a clinical Pilates program. Participants, aged 18-60 with a BMI between 25 and 35, will be randomly assigned to one of the two supervised group programs, held twic…

This study tests whether motivational interviewing—a supportive, goal-oriented counseling style—can help overweight and obese adults improve their eating habits, health literacy, and body measurements. Participants will receive either four structured counseling sessions plus rout…

The Reset trial, led by Stanford University, aims to find the best combination of four dietary strategies for weight loss in a fully digital program. 208 adults with overweight or obesity will receive a 12-week remote intervention that includes daily self-weighing, weekly lessons…

This study investigates whether replacing some wheat flour with legume flours (chickpea, pea, or lentil) in Arabic bread can reduce blood sugar spikes after eating. Overweight or obese adults aged 18–65 will consume different breads and have their blood glucose and appetite measu…

This study tests a web-based program called Confident Moves designed to help adults with obesity increase their physical activity and improve overall health. About 348 adults aged 18-64 with a BMI of 25 or higher will be enrolled. Participants will use an online platform with sel…

This early-stage study tests a single dose of SA030 injection in 40 overweight or obese adults aged 18–55. The main goal is to check safety and how the body handles the drug. It is the first time SA030 is given to humans, so results will guide future research.

This Phase 3 trial tests a new once-weekly injection, NNC0487-0111, against the approved drug semaglutide in 1000 adults with overweight or obesity and type 2 diabetes. Participants receive two weekly shots (active drug plus placebo) to see if the new drug is safe and leads to gr…

This study tests whether drinking hydrogen-rich water every day can help adults who are overweight improve their body composition and metabolism. Researchers will compare hydrogen water to plain water in 120 participants over a period of time. The goal is to see if this simple dr…

This phase 3 trial tests whether orforglipron, a daily oral medication, can help overweight adults reduce their risk of developing obesity-related complications such as type 2 diabetes, high blood pressure, and high cholesterol, as well as progression to class 1 obesity. Particip…

This trial tests whether taking 2 grams of spirulina daily for 8 weeks can improve metabolic health, body composition, sleep quality, and mood in mildly overweight postmenopausal women. Researchers will measure changes in blood sugar, cholesterol, weight, waist size, depression s…

This study tests whether tracking only high-calorie, low-nutrition foods (Red Zone Foods) works as well as tracking all foods and calories for weight loss. About 328 adults with overweight or obesity will use a digital program for 12 months. The goal is to see if a simpler approa…

This study looks at whether brief, intense stair-climbing sessions (called 'exercise snacks') can improve blood vessel function and body composition in overweight adults aged 18-35. Sixty participants will be split into four groups, including a no-exercise control group, for 6-8 …

This study looks at whether a type of talk therapy called Acceptance and Commitment Therapy (ACT), combined with a mobile app, can help overweight people who eat in response to emotions like stress or sadness. About 78 adults will be split into groups: some get group therapy, som…

This phase 1 trial examines whether eloralintide, an experimental drug for obesity, changes how the body processes a common birth control pill containing levonorgestrel and ethinyl estradiol. Researchers will give the pill to women with overweight or obesity, with and without elo…

This phase 1 trial asks whether a single dose of tirzepatide changes how quickly the stomach empties in adults with type 1 diabetes who are overweight or have obesity. Researchers will give participants either tirzepatide or a placebo injection, then measure stomach emptying usin…

This phase 1 trial examines how severe kidney impairment or end-stage kidney disease affects the levels of ribupatide, an experimental drug, after a single injection. Researchers compare drug exposure in 32 participants: some with normal kidney function and others with severe kid…

This early-stage study is testing a new medicine for overweight and obesity. The main goal is to see how the drug behaves in people with different levels of liver function, from normal to severely reduced. About 35 adults aged 18-80 will take a single dose, and researchers will m…

This early study will test a single dose of the experimental drug HDM1005 in 30 overweight or obese adults, some with moderate or severe kidney disease and some with healthy kidneys. The goal is to see how kidney function affects the drug's levels in the body and to check for saf…

This study watches how body fat and muscle affect the way anesthetic drugs work in overweight and obese patients. Researchers will measure body composition and drug levels in 2,100 adults during surgery. The goal is to understand why heavier patients may have more complications, …

This early-stage study will test an experimental drug called HDM1005 in 42 overweight or obese adults. Researchers want to see how HDM1005 affects stomach emptying and whether it changes how the body processes common medications like metformin, atorvastatin, warfarin, and digoxin…

This study looks at ways to help VA medical centers put proven health programs into practice for women Veterans in midlife. The programs focus on heart health, weight management, diabetes, mental health, and menopause care. Researchers will test two support strategies at 18 VA si…