Natural supplement shows promise for shedding body fat
NCT ID NCT02818699
First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tested whether a natural plant compound called EMIQ can safely help overweight and obese adults lose body fat. Over 12 weeks, 65 participants took either EMIQ or a placebo twice daily. Researchers measured changes in body fat, weight, and other health markers to see if EMIQ offers a safe way to manage weight.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- enzymatically modified isoquercitrin (EMIQ), a natural plant product
- What this could lead to
- If it works, this could point toward a safe, natural supplement to help reduce body fat in overweight and obese individuals.
- What could go wrong
- This is a small, early-stage study with only 65 participants, so results may not apply to everyone. The effect on body fat may be modest or no better than placebo.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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65 people
The number who actually took part.
- Started
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Aug 2016
- Finished
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Sep 2018
- Lead sponsor
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Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 to 65 years
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Male or female age 18-65 years. * Premenopausal female with regular menstrual cycle or post-menopausal female with cessation of menstrual cycle for a minimum of 6 months. * BMI in the range of 28.0-35.0 * Beck Depression Inventory Score less than 20. * Fluency in spoken or written English. * Willingness to be randomized to take EMIQ or placebo. * Must weigh at least 164lbs Exclusion Criteria: * Any major illness or condition that may interfere with study outcomes at the discretion of the study physician. * Diabetes Type I \& Type II, or use of any pharmacological treatment for diabetes. * Use of medications that interfere with energy metabolism * Receiving hormone therapy growth hormone, testosterone, or estrogen with the exception of hormone contraceptives. * GI diseases, conditions or medications known to influence GI absorption including active peptic ulcer disease or inflammatory bowel disease such as ulcerative colitis, Crohn's disease, celiac disease, chronic diarrhea or constipation. * Undergone gastric bypass or other bariatric weight loss procedure. * Lipid lowering medications such as: bile acid sequestrants (Cholestyramine, Colestipol, Colesevelam, etc.), cholesterol absorption inhibitors (Ezetimibe-Zetia), and fibrates (Gemfibrozil, Clofibrate, Fenofibrate, Triclor). Exceptions to this exclusion are 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (HMG-CoA reductase or Statins). * On or planning to participate in a weight loss program. * Weight loss or weight gain greater than 10 lbs in the past 6 months. * History of eating disorders, anorexia, bulimia, or binge-eating in the past 5 years. * Participation in any regular endurance exercise: running, biking or aerobics (except walking) greater than 2.5 hours per week, or resistance training greater than once per week. * Regular use of acid lowering medications (greater than 3 times per week) such as antacids, proton pump inhibitors (PPIs), or H2 blockers. * Unstable thyroid disease. * Psychiatric disorders including schizophrenia, bipolar, major depression or psychosis. * Antidepressant medication: selective serotonin reuptake inhibitors (SSRIs), serotonin norepinephrine reuptake inhibitors (SNRIs), monoamine oxidase (MAO) inhibitors, or tricyclic antidepressants (TCAs). * Cancer of any type (except for non-melanoma skin) in the past 5 years. * Use of chemotherapeutic agents. * Pregnancy, planning to become pregnant during the study period, or breastfeeding. * Unwilling to use effective birth control during study. * History of bilateral mastectomy with nodal dissection. * Alcohol use, on average, greater than 3 servings per day, 20 servings per week (Serving size: 12oz beer, 4oz wine, 2oz hard liquor), or self-reported binge drinking. * Uncontrolled hypertension (HTN) determined at the discretion of the study MD or registered nurse (RN). HTN medications allowed in the study: angiotensin converting enzyme (ACE) inhibitors, calcium channel blockers, and diuretics. * Medications for chronic obstructive pulmonary disease (COPD) or kidney disease. * α-adrenergic or β-adrenergic blockers (oral or ocular) and diuretics. * Renal or chronic kidney disease due to any condition, renovascular disease, or dialysis. * Chronic liver disease such as hepatitis B, hepatitis C, or cirrhosis. * Cardiovascular disease including: myocardial infarction, cerebrovascular disease (CVA), coronary artery bypass graft, stenosis greater than 50%, angina, coronary artery disease (CAD), congestive heart failure (CHF),peripheral vascular disease (PVD) or dysautonomia. * History of autoimmune diseases such as rheumatoid arthritis, lupus, multiple sclerosis, vitiligo, or psoriasis. * HIV or AIDS based on self-report. * Steroid use with the exception of over-the-counter topical and nasal steroids such as Flonase. * Allergy medication or regular antihistamine use. * Seizure disorders. Acceptable if managed with medication and free of seizure activity for 5 years. * Smoking or the use of nicotine replacement products in the past 6 months. * Use of dietary supplements containing vitamins (except Calcium and Vitamin D), minerals, herbal or plant-based preparations, fish oil or homeopathic remedies during study participation unless willing to discontinue prior to enrollment. * Current participation in another research study. * Non-English speaking. * No social security number. * Participation in another research study.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Human Nutrition Research Center on Aging at Tufts University
Boston, Massachusetts, 02111, United States
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