Va Office Of Research And Development

This study tests whether spinal cord stimulation can improve arm and hand function in people with tetraplegia (paralysis from the neck down) caused by a cervical spinal cord injury. Researchers will use targeted electrical stimulation combined with motor training to help restore …

This study looks at two common heart medications, metoprolol and carvedilol, in people on dialysis. The goal is to see which one better prevents heart attacks, strokes, heart failure, and death. About 2,540 adults on hemodialysis will be randomly assigned to one of the two drugs …

This study tests a program called Transition to Cardiac Rehabilitation (T2CR) for veterans with heart disease who also have other health problems or frailty. The program provides in-person support to help them start and succeed with home-based cardiac rehab. Researchers will comp…

This study tests whether a telehealth pain management program can help veterans who have surgery outside VA hospitals avoid becoming dependent on opioids long-term. About 400 veterans having orthopedic surgery will either get the program or standard care. The goal is to see if th…

This study tests a program that combines PTSD treatment with weight management for Veterans who have both conditions. The goal is to see if this combined approach helps Veterans lose more weight and reduce PTSD symptoms better than standard VA care. About 182 Veterans will take p…

This study tests whether MDMA-assisted therapy can help veterans who have both PTSD and alcohol use disorder. Participants receive three monthly therapy sessions with either MDMA or a low-dose placebo, plus non-drug therapy. The goal is to see if this treatment reduces PTSD sympt…

This study is for veterans with prostate cancer that has come back or spread to a few places (up to 10 spots). It compares standard hormone therapy alone versus standard therapy plus PET-guided radiation to those spots. The goal is to see if adding radiation delays the cancer fro…

This study looks at two standard treatments for early-stage lung cancer: surgery and a precise type of radiation called stereotactic radiotherapy. About 670 veterans with stage I non-small cell lung cancer will take part. The goal is to see which treatment leads to longer surviva…

This study looks at people with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL) who are already taking a BTKi pill (like ibrutinib). Half will keep taking their current pill alone, while the other half will add a second pill called venetoclax for one year, …

This study tests a computer program called Approach Avoidance Training (AAT) for veterans with alcohol use disorder. The training aims to change unconscious urges to approach alcohol. Researchers will see if adding this to standard care helps 176 veterans reduce heavy drinking an…

This study tests whether taking a drug called capivasertib along with intensified hormone therapy before prostate surgery can shrink or destroy high-risk prostate cancers that have a specific genetic change (PTEN loss). About 30 men with localized but aggressive prostate cancer w…

This study compares two treatments for veterans with PTSD who are at high risk for suicide. One combines Dialectical Behavior Therapy (DBT) with a PTSD-focused exposure therapy; the other is the current standard VA care. Researchers want to see which better reduces suicidal behav…

This study tests a combination of two drugs—tulmimetostat and pembrolizumab—in people with advanced non-small cell lung cancer whose cancer has gotten worse after standard treatments. The goal is to see if the combination can shrink tumors and control the disease. About 66 vetera…

This study looks at whether empagliflozin, a drug used for diabetes and chronic kidney disease, is safe for people who have received a kidney transplant. The goal is to see if it can help protect the transplanted kidney and the heart from future problems. About 264 veterans who h…

This study looks at whether a type of dietary fiber (soluble corn fiber) can help older men absorb more calcium and strengthen their bones. Researchers will enroll 30 male Veterans aged 60 and older. Participants will try the fiber supplement and have their calcium absorption, bo…

This study looks at how well a combined recovery program and home telehealth support help veterans with alcohol or drug problems. About 195 veterans in a VA inpatient unit will take part. The goal is to see if these extra services reduce substance use and improve recovery compare…

This study tests whether metformin, a safe diabetes drug, can improve walking ability and reduce leg pain in 200 veterans with peripheral artery disease (PAD). Participants will take metformin or a placebo for several months. The goal is to see if metformin can reduce inflammatio…

This study tests whether a butyrate supplement (a gut-healthy fatty acid) can improve physical function in 120 veterans with Gulf War Illness. Participants take the supplement for several weeks while researchers measure changes in fatigue, memory, gut symptoms, and inflammation. …

This study is for veterans with stage 3 non-small cell lung cancer that cannot be removed by surgery. It combines chemotherapy, immunotherapy, and radiation to see if this approach helps control the cancer longer and is safe. About 25 participants will receive the treatment, and …

This study tests whether sharing genetic test results with veterans who have high cholesterol and heart disease risk can help them feel more comfortable taking statins. Many veterans avoid statins due to fear of side effects or doubts about benefits. By showing each person their …

This study tests a program called MINDSET for veterans who have chronic conditions like heart disease or diabetes and continue to smoke or drink despite brief advice from their doctor. Participants will receive a mailed packet with personalized information about how their habits …

This study tests whether colchicine, an inexpensive anti-inflammatory drug used for gout, can prevent heart attacks, strokes, and death in heart disease patients undergoing major surgery. Researchers will give the drug to 700 veterans before and after their operation. The goal is…

This study looks at 136 Veterans recently hospitalized for suicide risk. Half will get a longer psychotherapy, half a shorter one, to see which works better at reducing suicidal thoughts and actions. Researchers will also use MRI brain scans to track changes over a year and see i…

This study tests a simple, non-invasive technique called remote ischemic preconditioning in 240 adults with heart failure who are scheduled for heart catheterization. The technique involves briefly inflating a blood pressure cuff on the arm to trigger the body's natural defenses,…

This study tests a new method to remove excess fluid during dialysis by using a patient's recent blood pressure patterns to guide how much fluid is taken out. The goal is to reduce dangerous drops in blood pressure during treatment while still controlling fluid buildup. The study…

This study aims to improve hand hygiene in VA mental health units, where sinks and alcohol-based sanitizers are limited for safety reasons. Researchers will test a tailored hand hygiene bundle, including alcohol-free hand rubs, with about 4 VA staff participants. The goal is to r…

This study tests a surgically implanted device that uses small electrical pulses to activate trunk and hip muscles in people with spinal cord injury. The goal is to improve seated posture, balance, breathing, reaching, and wheelchair mobility. Ten participants with injuries betwe…

This study tests whether empagliflozin, a diabetes medication, can make arteries less stiff in veterans with obesity. Fifty participants will take either the drug or a placebo for 12 weeks. The main goal is to measure changes in arterial stiffness, a key marker of heart health.

This study looks at whether adding digital coaching to home-based cardiac rehabilitation helps veterans with heart disease complete more rehab sessions and improve their health. 150 veterans from two programs will be randomly assigned to standard home rehab or home rehab plus a p…

This study looks at whether adding a smartphone app to standard medication helps Veterans with alcohol use disorder reduce heavy drinking more than medication alone. About 330 Veterans from VA primary care will take part. The app aims to make it easier to get both treatments with…

This study tests a program called Measurement-Based Care (MBC) for veterans with inflammatory bowel disease (IBD). The program involves regular check-ins between clinic visits to track symptoms and adjust treatment early. Researchers want to see if this approach improves quality …

This study tests a smart mat that checks foot temperature at home to help prevent diabetic foot ulcers in 800 Veterans with diabetes who have had a foot ulcer or amputation. The mat sends data to a monitoring team that alerts VA providers if a problem is detected. The goal is to …

This study tests whether adding a drug that blocks a cancer cell survival process called autophagy can make standard TACE therapy more effective for liver cancer. TACE cuts off the tumor's blood supply, but cancer cells often survive by eating their own parts for energy. The tria…

This study tests a special therapy program for veterans who have been involved with the criminal justice system. The program, called DBT-J, combines mental health support, substance use help, and case management. Researchers want to see if it lowers the risk of future criminal be…

This study tests a program for Veterans with advanced liver disease. A nurse counselor will talk with them about their illness, what matters most to them, and options like transplant or comfort care. The goal is to help more Veterans get considered for transplant and have importa…

This study tests if a computer-based brain training program can help people who survived a stay in the Intensive Care Unit (ICU) recover their thinking and memory skills. Many ICU survivors experience long-term cognitive problems similar to dementia. The study will involve 160 ad…

This study looks at how obesity affects recovery from post-COVID conditions in older Veterans. Researchers will test if a weight loss program with diet and exercise can reduce inflammation and improve physical function and quality of life. The study involves 150 Veterans, some wi…

This study tests a new combination of two oral drugs, Stenoparib and Temozolomide, for people whose small cell lung cancer has returned after initial treatment. The trial uses a blood test to see which patients might benefit most from the combo, while others receive standard care…

This early-stage trial tests a new treatment for a type of bladder cancer that hasn't been helped by the usual therapy (BCG). The treatment uses tiny particles called micelles that carry a chemotherapy drug and are designed to target and kill cancer cells directly in the bladder.…

This study tests whether mild intermittent hypoxia (short, controlled periods of low oxygen) can help prevent dangerous blood pressure swings in people with spinal cord injuries. The treatment aims to improve autonomic function, reducing episodes of high or low blood pressure. Th…

This study tests whether adding itraconazole, a common antifungal medication, to standard chemotherapy and radiation can improve outcomes for people with esophageal cancer. About 78 participants will receive itraconazole before surgery to see if it increases the rate of complete …

This study tests whether letting patients with chronic kidney disease manage their own blood pressure medications, with guidance from a clinical pharmacist, works better than standard care. About 160 veterans with kidney disease and high blood pressure will participate. The goal …

This study tests a new type of nerve stimulation to help Veterans with bladder control problems caused by nerve damage. A small wireless sensor is placed in the bladder to detect when it is filling and trigger stimulation to prevent leakage. The goal is to see if this approach wo…

This study tests whether empagliflozin, a drug used for diabetes, can protect the kidneys and heart in people who have received a heart transplant. About 200 veterans will take either the drug or a placebo daily for 12 months. The goal is to see if it improves kidney function and…

This study tests whether a virtual group exercise program combined with health education can lower fall risk and increase physical activity in older veterans who have both obesity and signs of muscle loss (sarcopenia). About 50 veterans aged 55 and older will take part. The goal …

This study tests whether a once-monthly injection of buprenorphine helps veterans with opioid use disorder stay in treatment and avoid opioids better than the standard daily under-the-tongue tablet. About 952 veterans will take part for up to a year. The goal is to find a more ef…

This study tests whether a low dose of thyroid hormone (Synthroid) can help Veterans with NASH, a serious liver condition that can lead to liver failure or cancer. About 128 overweight or obese Veterans with NASH will receive either the hormone or a placebo daily for 52 weeks. Th…

This study tests a new approach for men with a tough-to-treat form of prostate cancer that has spread and stopped responding to standard hormone therapy. Instead of continuing hormone blockers, participants get a precise type of radiation to all visible tumors plus a radioactive …

This study tests if a smartphone app can detect early knee osteoarthritis by measuring how the knee moves during activities like walking. Researchers will compare the app's results to standard motion capture systems and patient symptoms. The goal is to help doctors diagnose knee …

This study tests whether a two-session alcohol counseling program can help veterans reduce drinking and prevent intimate partner violence. 300 veterans who are already in a partner violence program will be randomly assigned to receive either the alcohol counseling, alcohol educat…

This study tests if a faster MRI scan, combined with a blood test, can find liver cancer earlier than the standard ultrasound in people with cirrhosis. The goal is to catch cancer at an early, more treatable stage and reduce deaths from liver cancer. About 4,700 veterans with cir…

This study tests a decision support tool called CAPP-FIT to help prevent pressure injuries (bedsores) in people with spinal cord injury. About 808 veterans from seven VA clinics will use a survey and provider report to identify risks and take action. The goal is to reduce these p…

This study looks at whether metformin, a medicine used for diabetes, can lower the risk of death, heart attacks, or strokes in veterans who have pre-diabetes and already have heart or blood vessel disease. About 7,400 participants will be followed over time. The goal is to see if…

This study looks at whether a special exercise program using flywheel resistance and aerobic training can reduce fatigue and improve muscle function in veterans with early-stage chronic kidney disease. About 30 participants aged 50 and older will be enrolled. The goal is to find …

This study tests if using mild electrical pulses inside the rectum can help people with spinal cord injury empty their bowels faster and easier. Currently, a finger is used to stretch the rectum, but electricity might work just as well. The study will compare the two methods in 1…

This study tests a short therapy program for veterans who hurt themselves without intending suicide. The goal is to reduce these behaviors and improve daily life. About 40 veterans will take part to see if the therapy is practical and helpful.

This study tests a short, 3-session program called MERA (Manage Emotions to Reduce Aggression) for veterans with PTSD who struggle with impulsive aggression. The goal is to help them better manage their emotions and reduce aggressive outbursts, which may also prepare them for mor…

This study tests a mobile app designed to help veterans with PTSD who struggle with anger. 150 veterans will be randomly assigned to use either the anger-reduction app or a health education app. The goal is to see if the anger app helps more veterans get their anger under control…

This study looks at whether treating sleep apnea early can improve long-term outcomes for veterans with both PTSD and substance use disorder. About 194 veterans in a residential treatment program will either receive sleep apnea treatment right away or be placed on a waitlist. The…

This study looks at two different exercise plans for veterans with moderate Parkinson's disease. One group will exercise a lot for one week each month and rest the other three weeks, while the other group exercises every week without breaks. Researchers will measure walking speed…

This study looks at whether a special intermittent fasting diet can help people with advanced lung cancer who are already receiving immunotherapy. Researchers want to see if the diet is safe and doable for patients. The study will enroll 66 participants and track how many can com…

This study tests whether hearing aids can improve daily life for veterans who struggle to hear in noisy places despite having normal hearing on standard tests. About 142 veterans will be randomly assigned to receive hearing aids or not, and researchers will measure changes in hea…

This study tests whether a drug called pimavanserin can improve sleep in veterans with post-traumatic stress disorder (PTSD) who also have insomnia. About 60 veterans will receive either the drug or a placebo for 8 weeks. The goal is to see if it reduces insomnia severity and imp…

This study tests whether a type of talk therapy called exposure and response prevention (ERP) can improve daily functioning and quality of life for veterans with obsessive compulsive disorder (OCD). About 160 veterans with OCD, half of whom also have PTSD, will receive either ERP…

This study tests whether a program combining walking, Tai Chi, and a step tracker can improve physical function in veterans who have both COPD (a lung disease) and long-term muscle or joint pain. About 136 veterans aged 40 and older will take part. The goal is to see if this non-…

This study looks at whether cognitive behavioral therapy (CBT) can help veterans with serious mental illness, like schizophrenia or bipolar disorder, who also have chronic low back pain. About 190 veterans will take part to see if CBT improves their daily functioning, quality of …

This study tests whether a short writing therapy called Written Exposure Therapy (WET) can help veterans who have both posttraumatic stress disorder (PTSD) and a substance use disorder. About 170 veterans will complete five writing sessions about their trauma. The goal is to see …

This study looks at whether walking on an incline is better than walking faster on flat ground for people with COPD. The goal is to find ways to improve exercise programs so patients feel less short of breath. About 54 veterans with COPD will take part, and researchers will measu…

This study tests a new way to help veterans with PTSD stop smoking. It combines counseling, nicotine gum, and a noninvasive brain stimulation called TMS. The goal is to see if this approach is feasible and helps veterans stay smoke-free for at least 3 months. About 50 veterans wi…

This study looks at whether adding aerobic exercise (like walking or cycling) to standard physical therapy can help stroke survivors recover better. The goal is to improve arm movement, thinking, and mood. About 40 people who had a stroke at least 6 months ago will take part. Res…

This study tests a therapy called Targeted Cognitive Training (TCT) for 80 veterans with serious mental illnesses like schizophrenia, bipolar disorder, or PTSD. TCT uses computer exercises to improve how the brain processes sounds and information, aiming to boost thinking, daily …

This study looks at whether using a weighted blanket at night can help veterans with chronic pain and sleep problems. About 160 veterans will use either a light or heavy blanket for 6 weeks at home. Researchers will track changes in pain, sleep quality, and pain medication use.

This study looks at whether adding Whole Health Coaching (WHC) to standard pain management helps veterans with chronic pain feel better and use opioids more safely. About 432 veterans will take part. The goal is to reduce pain-related interference in daily life and improve opioid…

This study looks at whether a new way of setting hearing aids, called speech-based audiometry, can help veterans who were exposed to blasts but have normal hearing tests. These veterans often struggle to hear in noisy places. The study will compare standard and speech-based heari…

This pilot study tests whether breathing air with slightly higher carbon dioxide (hypercapnia) for two weeks can improve breathing and reduce sleep apnea in veterans with spinal cord injury. About 30 participants will be enrolled to see if this approach is feasible and helps with…

This study looks at whether giving L-Citrulline, tetrahydrobiopterin (BH4), and atorvastatin can improve blood vessel function and physical ability in veterans with a type of heart failure called HFpEF. About 90 participants will take these medications and be tested on how well t…

This study tests whether a dietary fiber supplement can improve gut health and quality of life in 52 veterans with Gulf War Illness (GWI). GWI causes pain, fatigue, and digestive issues in many Gulf War veterans. Researchers believe an unhealthy gut microbiome may play a role, so…

This study compares two ways to deliver a home-based walking program for veterans with peripheral artery disease (PAD), a condition that causes leg pain while walking. Participants will either use a website, get telehealth support, or receive usual care. The goal is to see which …

This study tests a mobile app called MIST designed to help veterans reduce suicidal thoughts. The app uses techniques to change negative thinking patterns linked to suicide. About 50 veterans from one VA hospital will try the app alongside their usual care. The goal is to see if …

This study looks at whether giving Veterans who have trouble hearing a small personal amplifier in the emergency room can help them understand their discharge instructions better and lower their chances of coming back to the ER within 3 or 30 days. About 1,050 Veterans from six V…

This study tests a non-invasive device that stimulates the vagus nerve to help veterans with alcohol use disorder. The goal is to reduce withdrawal-related distress and cravings, and improve quality of life. Eighty veterans will receive the stimulation and be monitored for change…

This study tests a home-based exercise program for Veterans with peripheral artery disease (PAD), a condition that causes leg pain and limits walking. Instead of traveling to a facility, participants use a wearable activity monitor and join group coaching sessions through a mobil…

This study tests whether a 6-month online spin cycling program can improve vision and daily function in veterans aged 65-89 with intermediate age-related macular degeneration (AMD). Participants will join group spinning classes from home and have their eyesight, thinking, and phy…

This study compares two programs for veterans with mental health and relationship issues. One is a 3-session couple-based program called the Brief Relationship Checkup, and the other is individual care. The goal is to see which approach better reduces suicide risk factors by impr…

This study tests a home-based virtual reality program to help veterans with traumatic brain injury who have trouble focusing on close objects. The program uses games to improve eye coordination and reading ability. 45 veterans in the Cleveland area will participate to see if the …

This study looks at whether adding morning bright light therapy to cognitive training can improve thinking, daily function, and sleep in 144 veterans who have both mild traumatic brain injury and PTSD. Participants will receive either the light therapy or a placebo light device. …

This study tests a new training program for veterans who have both mild traumatic brain injury (mTBI) and PTSD. The training combines exercises to recognize emotions in faces and voices with attention training, since paying attention is key to understanding emotions in daily life…

This study tests whether adding a memory-enhancing technique to standard PTSD therapy helps older veterans learn and remember therapy content better. About 30 veterans over age 59 with PTSD will take part. The goal is to see if this approach is feasible and reduces PTSD symptoms …

This study looks at how to best offer cognitive behavioral therapy for chronic insomnia to older veterans at 20 VA clinics. About 20 veterans will take part to see if the therapy helps them sleep better and feel better. The goal is to find the best way to bring this effective tre…

This study looks at how to best offer group physical therapy to veterans with knee osteoarthritis. About 20 VA clinics will take part to see if this approach helps more patients start and stick with therapy. The goal is to make it easier for veterans to manage knee pain and stay …

This study tests a new treatment for post-stroke neglect, a condition where people ignore one side of their world. The treatment combines repetitive task practice with mild brain stimulation. Researchers aim to see if this approach improves attention and movement. The study invol…

This study compares a single therapy (Transdiagnostic Behavior Therapy) to separate treatments for social anxiety and PTSD in 264 veterans. The goal is to see if one therapy can effectively reduce symptoms and improve daily life. Participants will be assessed before, during, and …

This study tests whether a natural hormone called pregnenolone can improve daily functioning in veterans with moderate to severe anxiety and depression. About 84 veterans will take pregnenolone or a placebo for several weeks. The goal is to see if it helps with mood, sleep, pain,…

This study tests a new bandage called exciflex that delivers small electrical pulses to help heal chronic wounds in the legs. It is for Veterans with diabetes or spinal cord injury whose wounds are not healing normally. The bandage can stay on for up to seven days and aims to imp…

This study tests a new way for people with Parkinson's disease to do cycling exercises at home while a coach watches and adjusts the workout remotely. The goal is to improve movement and reduce symptoms without needing to travel to a clinic. Researchers will track changes in abno…

This study tests whether adding a topical cream called imipramine to standard photodynamic therapy (PDT) can improve treatment of actinic keratosis (skin pre-cancers) in 48 veterans. PDT uses light to destroy pre-cancer cells, but it can temporarily weaken the skin's immune respo…

This study tests whether small electrical pulses to leg nerves can restore sensation in people who have lost a limb due to diabetes or have severe nerve damage. Fifteen participants will have electrodes implanted to send signals to the brain, mimicking natural feeling. The goal i…

This study tests whether adding a non-invasive brain stimulation technique called rTMS to a short writing therapy helps reduce PTSD symptoms in veterans. About 98 veterans with PTSD will receive either real or fake rTMS along with the therapy. The goal is to see if the combinatio…

This study tests whether methylphenidate, a drug used for ADHD, can improve memory and attention in adults with epilepsy. About 226 participants will be randomly assigned to take either the drug or a placebo for 8 weeks, then all can take the drug for another 2 months. The goal i…

This study tests whether a 12-session home-based talk therapy (Behavioral Activation) can improve social functioning and mood in 132 veterans recently hospitalized for heart disease. Participants receive either the therapy or standard post-discharge care. The goal is to see if th…

This pilot study tests a non-invasive device that stimulates the vagus nerve through the neck, aiming to improve walking and balance in veterans with Parkinson's disease. About 40 participants will use the device at home while researchers measure changes in stride length. The goa…

This study develops and tests a 12-week exercise program designed specifically for women veterans who have experienced sexual violence. The program aims to improve physical and mental health, addressing gaps in current care. Researchers will enroll 40 women to see if the program …

This study is for Veterans who smoke and want to quit. Each Veteran picks a support person (like a friend or family member) to help them through the quitting process. Researchers will track how many Veterans use proven quit-smoking treatments (like medication or counseling) over …

This study tests whether yoga-based exercises can help veterans with schizophrenia, schizoaffective disorder, or bipolar 1 disorder improve their ability to function in daily life—like socializing, working, and managing leisure activities. About 112 veterans will be randomly assi…

This study tests whether a wearable robotic arm device (MyoPro) can help people who had a stroke more than 6 months ago and have severe arm weakness. The device reads muscle signals to assist arm movement during therapy. About 60 adults will be randomly assigned to get therapy wi…

This study is testing a new way to help people with chronic stroke improve their balance. The method uses gentle vibrations on the skin to give the brain extra sensory information about body position. Researchers will enroll 36 participants to see if this approach can reduce fall…

This study explores whether a virtual reality (VR) mindfulness program can help veterans with spinal cord injury and chronic pain. Ten veterans will test the program, which will be adapted to their needs. The goal is to see if VR is a practical and acceptable way to deliver mindf…

This study looks at whether using a positive airway pressure (PAP) machine at night can improve thinking, sleepiness, and quality of life in older veterans (age 60+) who have both COPD and obstructive sleep apnea (called overlap syndrome). About 668 veterans will be followed to s…

This study tests whether a supervised home-based group exercise program can improve heart and lung fitness in high-risk Veterans who had COVID-19. About 80 Veterans with conditions like high blood pressure or diabetes will take part. They will exercise together online, guided by …

This study tests a drug called CORT108297 that blocks the stress hormone cortisol. It aims to reduce PTSD symptoms in 40 veterans and check the drug's safety. Participants must have PTSD symptoms and be willing to use birth control. The results will help design larger future stud…

This early-phase study tests a non-invasive magnetic pulse treatment called iTBS to see if it can safely reduce impulsivity and suicidal thoughts in veterans who have had a mild traumatic brain injury. About 55 veterans will receive the treatment over two weeks. The goal is to ga…

This study compares three group-based psychological treatments—Cognitive-Behavioral Therapy, Emotional Awareness and Expression Therapy, and Mindfulness Meditation—delivered via video to older veterans with chronic musculoskeletal pain. The goal is to see which approach reduces p…

This study tests a home-based program for veterans aged 60 and older who have multiple health conditions and trouble with physical function. The program combines high-intensity exercise, self-management skills, and social support through video calls. Researchers want to see if it…

This study is testing a mobile health app called MyHealtheBladder to help women veterans with urinary incontinence. Researchers want to see how well the app works and how many women use it. About 20 VA clinics will take part, and women who have had bladder leaks for at least 3 mo…

This study tests whether tadalafil, a drug often used for erectile dysfunction, can reduce shortness of breath in 126 veterans who have both COPD and high blood pressure in the lungs. Participants will be randomly assigned to take either tadalafil or a placebo for 6 months, and n…

This study tests a special type of talk therapy for insomnia (trauma-informed CBT-I) in women veterans who also have PTSD. The goal is to see if improving sleep makes them more ready and willing to start PTSD treatment. About 100 women veterans from VA clinics will take part, wit…

This study tests a non-invasive program using a modified rolling walker and sleep position changes to relieve symptoms of lumbar spinal stenosis in 20 older veterans. Participants will be monitored for pain relief and walking improvement over 6 weeks. The goal is to see if this a…

This study looks at whether a smartphone app called PE Coach can help veterans with PTSD do better in a proven type of talk therapy called prolonged exposure. About 124 veterans will be randomly assigned to receive therapy with or without the app. The goal is to see if the app im…

This study tests a prescription wrist device called NightWare in 125 veterans with PTSD who have frequent nightmares. The device is designed to improve sleep quality by interrupting nightmares. Researchers also want to see if better sleep leads to improved cardiovascular health. …

This study tests a home-based rehabilitation program for 40 veterans who finished lung cancer treatment 1-6 months ago. The program uses video calls and a fitness tracker to help reduce shortness of breath, fatigue, and fear of cancer returning. The goal is to improve quality of …

This study tests four different programs to help cancer survivors who have been using opioids for a long time reduce their opioid use while still managing chronic pain. The goal is to find which approach works best to lower opioid doses without making pain worse. About 294 Vetera…

This study tests if a special sound therapy can help Veterans with tinnitus (ringing in the ears). The therapy uses noise that has a gap around the pitch of the ringing. 108 Veterans will wear ear-level devices for 12 weeks. The goal is to see if this reduces the loudness and bot…

This study tests whether a combined attention and thinking skills training program works as well when delivered via telehealth as it does in person. It includes 63 veterans with mild traumatic brain injury and PTSD who have trouble focusing. The goal is to improve their attention…

This study looks at whether a new method of giving rTMS (a non-invasive brain stimulation) can help treat depression in people with spinal cord injury. Standard rTMS dosing relies on thumb movement, which many with spinal cord injury cannot do. The study will enroll 24 veterans a…

This study aims to find the most effective non-surgical treatments for chronic low back pain in Veterans. Over 2,500 participants will first try either continued care, an online pain self-management program, or enhanced physical therapy. Those who don't improve can then choose fr…

This study tests a new wheelchair design that lets users change gears, making it easier to push uphill, over carpet, or from a stop. Researchers will compare the multi-speed chair to a standard manual wheelchair in 30 adults with spinal cord injuries or diseases. The goal is to s…

This study tests whether cannabis compounds (THC, CBD, or both) can reduce chronic nerve pain better than a placebo in 320 Veterans. Participants will take the study drugs for 6 weeks, and researchers will measure pain levels and side effects. The goal is to provide clear evidenc…

This study tests whether brief, mild low-oxygen breathing sessions can improve blood vessel function, lower blood pressure, and reduce tiredness in people with obstructive sleep apnea. Researchers will enroll 60 adults aged 30-60 who are newly diagnosed and not yet using CPAP. Th…

This study tests whether a three-month online nutrition program, including food delivery and virtual cooking classes, can improve diet and social connections for veterans aged 65 and older who have trouble walking. Participants will receive healthy produce and attend group cookin…

This study tests a new type of prosthetic foot that can change shape to fit different shoes, giving women veterans with below-knee amputations more footwear options. Researchers want to see if having more shoe choices improves body image and helps them take part in more social ac…

This study tests a strength training program using blood flow restriction (BFR) in people with advanced multiple sclerosis (MS) who need help walking or use a wheelchair. BFR uses a device that partially blocks blood flow to the exercising limb, allowing low-intensity exercise to…

This study looks at whether high intensity interval training (HIIT) can help older veterans become less frail and bounce back better from stress. Researchers will have 200 veterans aged 65 and older do HIIT exercises at a center or at home. They will measure improvements in fitne…

This study tests whether a single dose of intravenous ketamine can quickly improve depression in 80 veterans with Parkinson's disease who haven't responded well to standard antidepressants. Researchers will also measure changes in brain flexibility and inflammation to understand …

This study tests whether methylphenidate, a medication often used for ADHD, can improve PTSD symptoms and related thinking problems like poor memory and concentration in Veterans. About 70 Veterans will take turns receiving the drug or a placebo every 4-5 weeks over 20 weeks, wit…

This study tests a program called Contingency Management (CM) that gives rewards to Veterans who quit smoking, verified by breath tests. Researchers will first gather feedback from Veterans and staff, then run a small pilot with 20 Veterans over 5 weeks. If successful, a larger t…

This study tests whether a non-invasive magnetic brain stimulation technique called rTMS can reduce fatigue in people who had a stroke more than six months ago. About 60 participants will receive rTMS, and researchers will measure changes in fatigue, mood, and thinking. The goal …

This study tests whether a high-protein nutrition plan combined with light resistance exercises, given before and after surgery, can help older adults with cancer keep their physical strength and recover more quickly. About 188 Veterans over age 55 with certain cancers will take …

This study looks at whether a daily supplement called glutamine can help veterans with Gulf War Illness who have ongoing stomach issues like pain, diarrhea, and bloating. Researchers will give 80 veterans either glutamine or a placebo for 12 weeks to see if it reduces symptoms an…

This study tests a mobile app that guides veterans through mental exercises to reduce phantom limb pain—pain felt where a leg used to be. About 36 veterans with a below-knee amputation will use the app at home with telehealth support. The goal is to see if the app is easy to use …

This study tests two treatments for insomnia in veterans who also have PTSD. One is a brief behavioral therapy focused on sleep habits, and the other is a relaxation technique. Researchers want to see which one improves sleep and daily life more, and if benefits last over time. A…

This study looks at whether daily growth hormone shots for 6 months can improve quality of life in veterans who have both mild traumatic brain injury and adult growth hormone deficiency. About 172 veterans aged 21-55 will receive either the hormone or a placebo. The main goal is …

This study tests a 12-session workshop called STEP-Home-SP for veterans who left the military within the last three years. The workshop teaches skills to manage the transition, provides suicide prevention education, and helps connect veterans to VA healthcare. The goal is to redu…

This study tests a smartphone tool called the Virtual Hope Box Enhanced Facilitation (VHB-EF) to see if it lowers suicide risk in veterans after they leave a psychiatric hospital. About 928 veterans who recently had a suicidal crisis will use the tool, which provides coping resou…

This study tests whether practicing driving skills in a simulator can improve real driving performance for veteran stroke survivors. One hundred participants will each receive both active training (focused on skills like speed control and collision avoidance) and a control sessio…

This early-phase study tests whether stem cells taken from a patient's own bone marrow can reduce the long-term pain caused by chronic pancreatitis. Researchers will also check if the treatment improves pancreas function and quality of life. The trial involves 40 adults with conf…

This study compares two support programs for family and friends caring for Veterans with dementia after a hospital stay. One program, Hospital GamePlan4Care, offers a handbook, online training, and phone coaching tailored to the caregiver. The other provides general education and…

This study looks at whether a group exercise program done over video calls is practical and liked by Veterans with knee or hip arthritis. Fifty Veterans will take part in a 3-month exercise program, followed by a 6-month phase where some get extra support via text or booster sess…

This study tests two approaches to help people with knee osteoarthritis stay active after physical therapy: a game-like reward system with social support, and health coaching. About 254 veterans will use a Fitbit and smartphone app to track their progress. The goal is to see if t…

This study looks at whether a supervised exercise program can improve balance and mobility in older adults with moderate (50-69%) narrowing of the carotid artery who have not had a stroke. About 50 participants will take part in an exercise program focusing on aerobic and balance…

This study is testing a web-based program called Calm Moms for pregnant veterans who have experienced trauma and are feeling anxious, stressed, or down. The program uses proven techniques to help manage these symptoms and is tailored to the unique concerns of pregnancy. About 36 …

This study tests two walking training programs to help veterans with leg amputation walk more evenly. The goal is to reduce pain, improve mobility, and protect the skin of the remaining limb. About 54 veterans who lost a leg due to diabetes or artery disease will take part.

This study is testing a portable, wearable exoskeleton that helps stretch the legs and improve walking in people with spasticity caused by spinal cord injury. Ten veterans will wear the device during stretching, treadmill, and overground walking exercises. The goal is to see if t…

This study tests a short, skills-based program called PST-Concussion for Veterans who have had a mild traumatic brain injury (concussion) and also struggle with mental health symptoms like depression or PTSD. The goal is to see if learning practical problem-solving skills can red…

This study is for Veterans aged 60 and older with mild to moderate sleep apnea. Researchers want to see if three treatments—oxygen, finasteride, and acetazolamide—can help stabilize breathing during sleep. The goal is to find new, effective ways to improve sleep and overall healt…

This study tests a new, non-invasive brain stimulation technique called LIP-tES neurofeedback to help reduce light sensitivity in Veterans who have had a mild traumatic brain injury. The goal is to see if the treatment is practical and well-liked by participants. Researchers will…

This study tests a personalized brain and spinal cord stimulation technique to strengthen hand muscles in people with ALS. Researchers will first tailor the stimulation for each participant, then compare two weeks of paired stimulation with or without hand exercises. The goal is …

This study compares a new adjustable prosthetic socket to a standard one in 40 veterans with below- or above-knee amputations. The goal is to see if the adjustable socket improves walking, comfort, and satisfaction. Participants will try both sockets so researchers can find which…

This study compares a new type of below-knee amputation (Ewing amputation) to the standard surgery in 120 veterans with peripheral artery disease. The goal is to see if the new method improves walking, balance, and pain. Participants are randomly assigned to one of the two surger…

This study tests a 40-minute web-based program designed to teach Veterans coping skills for suicidal thoughts. Researchers will compare the program to standard care in 180 Veterans over one month. The goal is to see if the online tool reduces suicidal thoughts and behaviors more …

This study tests a new tool that helps physical therapists create personalized recovery plans for veterans after knee replacement surgery. Instead of a one-size-fits-all approach, the tool tailors therapy to each person's needs and goals. The goal is to improve how well veterans …

This study tests whether a gentle brain stimulation technique called tDCS can boost the effects of cognitive training to help veterans with obesity become less impulsive and lose weight. About 124 veterans will receive either real or fake tDCS while doing computer-based training.…

This study tests a safe, non-invasive treatment called rTMS (repetitive transcranial magnetic stimulation) to see if it can improve thinking skills in veterans with Parkinson's disease who have mild memory or attention problems. About 56 veterans will receive the treatment, and r…

This study tests whether dronabinol, a drug similar to a compound in marijuana, can help people with obstructive sleep apnea. 120 adults with moderate to severe sleep apnea will take the drug for two weeks. Sleep tests before and after treatment will measure if their breathing im…

This study tests a simple, 3-session expressive writing program to help sexual minority Veterans cope with stress from discrimination and reduce symptoms of depression and anxiety. About 85 Veterans who identify as gay, lesbian, bisexual, or queer and have significant distress wi…

This study looks at whether a 15-week lifestyle program combining weight loss and exercise can improve walking and daily life for obese veterans who had a stroke at least 6 months ago. About 99 veterans will take part. The goal is to see if this approach helps with physical movem…

This study looks at whether interval exercise (short bursts of activity with rest) can improve daily steps, daytime sleepiness, and heart health in veterans who have both COPD and obstructive sleep apnea (called Overlap Syndrome). About 28 veterans will take part for 12 weeks. Th…

This study is testing a new social skills training program for Veterans with serious mental illness (like schizophrenia, bipolar disorder, or PTSD) who are looking for work. The program teaches skills to better understand social cues and handle workplace relationships. Researcher…

This study is testing whether a lightweight, wearable exoskeleton can help people with Parkinson's disease walk better and reduce falls. Thirty veterans with mild to moderate Parkinson's will use the device during supervised walking sessions twice a week for eight weeks. Research…

This study tests whether adding an oxytocin nasal spray to a brief couples therapy can help veterans with PTSD feel better and improve their relationships. About 240 veterans and their partners will take part. Half will get the oxytocin spray before therapy sessions, and the othe…

This study helps Veterans with long-term muscle or joint pain learn ways to manage it without using medications. Participants work with a coach to find non-drug approaches that fit their personal values and goals. The study aims to reduce how much pain interferes with daily life,…

This study tests whether wearing bright light glasses can reduce daytime sleepiness and depressive symptoms in people with obstructive sleep apnea who still feel tired despite using their CPAP machine. About 60 participants will wear active or sham light glasses for 4 weeks each,…

This study tests whether a powered prosthetic knee (the Össur Power Knee) helps people with above-knee amputations walk better and use less energy compared to a standard passive knee. Twenty adults aged 45-75 who have used a prosthetic leg for at least a year will try both knees …

This study is for veterans who have both mild traumatic brain injury (mTBI) and PTSD. Researchers want to see if using a non-invasive vagus nerve stimulator (a device placed on the neck) twice a day can improve memory and reduce PTSD symptoms. The study will compare active stimul…

This study tests whether a device that gently stimulates a nerve in the neck can reduce PTSD symptoms in veterans. Eighty veterans will use the device or a fake version at home twice daily for three months. Researchers will measure changes in brain activity, heart function, and P…

This study is testing whether ketamine infusions, followed by a short behavioral program, can help veterans with long-term low back pain and depression. About 44 veterans will take part. The goal is to see if this approach is safe, acceptable, and helps reduce pain and improve mo…

This study tests a small, FDA-cleared device that gently stimulates nerves in the ear to reduce pain and improve daily function in 240 veterans with fibromyalgia. Half will get the real device, half a sham, and researchers will track pain levels and brain activity over 24 weeks. …

This study tests a brief, two-session program for family members of Veterans with PTSD. The goal is to see if this family support helps Veterans stay in their regular PTSD therapy longer and have fewer symptoms. About 200 Veterans and their family members will take part. If it wo…

This study looks at how different amounts and types of exercise can improve thinking and memory in Veterans aged 65 and older. Researchers will measure changes in cognitive skills and blood markers related to brain health. The goal is to understand which exercise habits work best…

This study uses a special X-ray technique to see exactly how the leg bone and skin move inside a prosthetic socket when people with below-knee amputations walk. Researchers want to compare two types of socket suspension to find which one reduces movement and improves comfort. The…

This study is developing and testing a group therapy called Continuous Identity-Cognitive Therapy (CI-CT) for veterans who have recently experienced a suicidal crisis. The goal is to help them recover, regain hope, and build a positive sense of self and future. About 57 veterans …

This study tests whether a mild electrical current applied to the ear can help the brain learn and control hand movements. Researchers want to understand how this stimulation affects brain chemicals that support learning. The study involves 110 adults, including some who have had…

This study aims to understand what causes substance use and cravings in veterans by creating a personal model for each participant. Researchers will test if showing veterans their personal triggers and giving feedback helps reduce substance use and related problems like anxiety o…

This study looks at a specific kind of tinnitus (ringing in the ears) called somatosensory tinnitus, where the ringing changes when you move your head or neck. Researchers want to better understand this condition and test a possible treatment approach. The study will involve 72 a…

This study looks at how emotions and brain inflammation are connected to pain in veterans with fibromyalgia, a chronic pain condition. Researchers will measure mood, pain sensitivity, and markers of inflammation in 60 veterans. The goal is to use this information to create an exe…

This study looks at whether walking backwards can help Veterans who have had a stroke improve their walking and balance. About 48 participants will try either 18 or 27 sessions of backward walking training. Researchers will also use brain scans to see how the brain changes and to…

This study looks at how different blood pressure treatment goals affect artery stiffness in veterans over 60 with high blood pressure. Researchers will measure stiffness caused by blood pressure itself and by changes in the artery wall, and explore genetic factors. The goal is to…

This study looks at whether a genetic test can better identify which men ages 55-69 are at risk for serious prostate cancer and which are not. Current screening methods often lead to unnecessary biopsies. The goal is to see if using genetic information can help high-risk men get …

This study looks at how sleep issues and sleep apnea might affect thinking, memory, and daily life in people who had COVID-19. Researchers will follow 200 veterans for up to a year, testing their brain function, sleep quality, and exercise ability. The goal is to find out if trea…

This study looks at how a moderate traumatic brain injury (TBI) from early or middle adulthood might speed up physical and mental decline in older age. Researchers will test balance and thinking in 70 Veterans aged 50-75 who had a TBI at least 15 years ago, even if they feel fine…

This study aims to create brain-based tools to identify which veterans with chronic psychosis are most likely to benefit from cognitive rehabilitation. Researchers will use EEG recordings to measure brain activity and see if these signals can predict improvements in thinking skil…

This study looks at how deep brain stimulation (DBS) in the subthalamic region affects the ability to align and focus both eyes on objects at different distances in people with Parkinson's disease. Researchers will use eye-tracking technology and brain models to find the best sti…

This study tests whether goal-oriented cognitive training delivered via video telehealth can help veterans with mild to moderate traumatic brain injury (TBI) improve attention, planning, and daily functioning. About 80 veterans with lasting cognitive difficulties will participate…

This study uses a robotic arm and brain stimulation to learn how different brain areas control reaching movements in people who have had a stroke and those who haven't. Researchers will measure movement paths, speeds, and accuracy. The goal is to understand brain changes after st…

This study looks at whether a brief PTSD therapy called Written Exposure Therapy (WET) works for veterans who also have a serious mental illness like schizophrenia or bipolar disorder. About 48 veterans will try the therapy, and researchers will check if it's practical and liked …

This study looks at whether a brain scan can identify which stroke survivors with spatial neglect—a condition that makes it hard to notice or act on the left side—will benefit most from prism adaptation therapy. About 244 Veterans who had a right-brain stroke will be tested. The …

This study looks at whether mild traumatic brain injuries (mTBIs) in Veterans increase the risk of dementia. Researchers will measure memory, brain waves, brain structure, and certain proteins linked to brain injury and dementia. The goal is to better understand how mTBI may cont…

This study looks at whether a personalized cognitive training program can help veterans with mild traumatic brain injury (TBI) improve their attention and daily functioning. About 65 veterans with ongoing cognitive issues will either receive the training or standard care. The goa…

This study is creating a program and assessment tools to help veterans with mental illness or substance use disorders adjust to life after prison. Researchers will work with 20 veterans who have been out of prison for up to 3 years to test the program's effectiveness. The goal is…

This study will analyze health records from up to 400,000 Veterans to see how COVID-19 treatments like Paxlovid and remdesivir are used and how well they work. Researchers will also look at flu and RSV treatments and vaccines. The goal is to find the best ways to prevent hospital…

This study looks at whether a direct-to-patient teledermatology app can improve access to skin care for veterans. Researchers will track wait times, travel distance, and satisfaction, and use the data to develop an AI system. Over 63,000 new dermatology patients at three VA facil…

This study looks at how two types of exercise—endurance (like walking or cycling) and resistance (like lifting weights)—affect bone health in older veterans. Researchers want to see if either type of exercise causes bone breakdown or helps build bone. The study involves 120 healt…

This study looks at why some veterans experience lasting mental health and memory problems, like brain fog, after COVID-19. Researchers will track 200 veterans over time, using surveys and thinking tests to measure symptoms. They also check blood and saliva for signs of inflammat…

This study tests whether an untrained helper can use a simple digital scanner to capture the shape of a veteran's residual limb, replacing one in-person visit to the prosthetist. 25 veterans with below-knee amputations will be randomly assigned to get a socket made from a helper'…

This study tests a new care pathway to help primary care doctors better diagnose and treat non-alcoholic fatty liver disease (NAFLD) in Veterans. The pathway automatically identifies at-risk patients and educates providers. The goal is to see if it increases diagnosis rates and r…

This study aims to help Veterans and their primary care doctors decide whether an in-person, phone, or video visit is best for each situation. Researchers will survey 600 Veterans and their doctors to understand what they value in each type of visit. Then, they will test a new te…

This study is testing a new group program called Qnnections designed to help LGBTQ+ veterans who are having suicidal thoughts feel more connected to others. The program aims to reduce social isolation, which is a major risk factor for suicide. Researchers will work with 66 vetera…

This study aims to understand why people with Parkinson's disease have balance problems and falls. Researchers will use wearable sensors and brain recordings from deep brain stimulation electrodes in 100 Veterans. The goal is to find brain pathways linked to balance issues so new…

This study compares two different brain injury rehab programs delivered remotely to Veterans who have had a traumatic brain injury (TBI). The goal is to see which approach better helps Veterans improve attention, memory, and the ability to achieve personal goals at work or school…

This study looks at how spinal cord stimulation (SCS) affects brain activity in veterans with long-term nerve pain. Researchers will use safe, non-invasive brain scans (fNIRS and EEG) to compare brain connections in people who already use SCS and those about to try it. The goal i…

This study tests whether giving high-risk veterans a trained peer sponsor plus extra mental health care helps them adjust to civilian life and lowers suicide risk. About 2,700 veterans leaving the Army will be assigned to usual care, a peer sponsor, or a sponsor plus targeted VA …

This study looks at why veterans with a common type of heart failure (HFpEF) have trouble exercising due to poor blood flow in their leg muscles. Researchers will compare 35 veterans with HFpEF to healthy volunteers, then have the veterans do 8 weeks of knee exercises to see if i…

This study looks at whether special rehabilitation therapies can improve blood vessel health in older Veterans (age 50+) who have Long-COVID. The goal is to reduce inflammation and oxidative stress caused by both aging and COVID-19. Researchers will measure changes in blood vesse…

This study looks at whether older adults (75+) who had precancerous polyps removed in the past still benefit from repeat colonoscopies. Researchers will analyze health records from 130,000 Veterans and interview patients and doctors. The goal is to create clear guidelines on who …

This study looks at how to train therapists so they can better help veterans with PTSD. It compares different training methods to see which ones work best. About 240 mental health providers will take part over 9 months. The goal is to create a personalized training program that i…

This study tests whether a computer-based working memory training program can help veterans with PTSD learn to reduce fear responses. About 120 veterans will undergo memory training or a sham version, then have their brain activity and fear reactions measured. The goal is to see …

This study tests whether small electric currents applied to nerves in the arm can give people with upper-limb amputations a sense of where their missing hand is and how it moves. Researchers will try different stimulation placements to see which works best. The goal is to use the…

This study looks at why central sleep apnea (CSA) occurs in people with heart failure or those taking opioid painkillers. Researchers will test combinations of breathing machines and medications to find better treatments. The goal is to understand the body's breathing control sys…

This study looks at how a single dose of nasal testosterone affects nerve and automatic body functions (like heart rate) in male veterans with spinal cord injury. Many men with spinal cord injury have low testosterone, which may worsen nerve problems. The study will test 15 men t…

This study aims to create and test a telehealth program to help veterans with psychogenic nonepileptic seizures (PNES) improve their thinking skills and daily functioning. About 47 veterans with PNES who report cognitive difficulties will give feedback to design a cognitive treat…

This study aims to find ways to predict which stroke survivors will improve their walking speed with high-intensity interval training (HIIT). Researchers will measure blood lactate levels during exercise and use brain scans to look at key chemicals and blood flow. The goal is to …

This study is testing a new type of prosthetic arm that uses an implanted wireless device to help people who have lost an arm or hand. The goal is to see if the device is safe and if it can improve how well the prosthetic works and feels. About 15 adults who have had an amputatio…

This study looks at a program where volunteers act as personal sponsors for veterans leaving the military. The goal is to ease their transition to civilian life, reduce stress, and prevent suicide. Researchers will track 630 veterans in Texas to see if the program helps them feel…

This study looks at older veterans who have both sleep apnea and COPD to see if having both conditions leads to worse memory, attention, and thinking problems than having just one. Researchers will also test whether treating sleep apnea with a breathing machine (PAP) plus extra o…

This study looks at 200 people with rheumatoid arthritis to understand why some have symptoms when lowering their steroid dose while others do not. Researchers will track inflammation, brain processing, and hormone levels to find patterns. The goal is to develop better, personali…

This study tests a new exercise program for people with peripheral artery disease (PAD), where blocked leg arteries cause pain when walking. Instead of standard treadmill walking, the program uses a sensor to measure muscle oxygen levels and guide when to rest. The goal is to see…

This study looks at how Long-COVID (PASC) affects walking and balance in 136 veterans. Researchers will test thinking, vision, muscle strength, and movement to understand why some veterans have trouble with gait and balance. The goal is to create better ways to diagnose and treat…

This study looks at whether a simple wearable device can reliably measure balance in veterans who have lost part of a leg. Better balance is linked to more physical activity and strength. The goal is to give doctors an easy, affordable tool to help improve mobility and quality of…

This study tests a new program that combines counseling and mobile phone tools to help homeless veterans with serious mental illness (like schizophrenia or severe mood disorders) better connect with their community. Fifty veterans will be randomly assigned to either the new progr…

This study looks at whether exercise and monitoring can help older Veterans with chronic kidney disease recover muscle mass and strength after being in the hospital. Researchers will test different ways to measure muscle health and compare home-based versus supervised exercise pr…

This study tests whether smartphone location data can give early warning of mood episodes (mania or depression) and drops in social activity for 200 veterans with bipolar disorder. Participants use an app that tracks their phone's GPS, and researchers will build computer algorith…

This study is developing and testing a program to help older veterans maintain their independence as they age. The program uses behavioral activation, a type of counseling that encourages people to do activities that matter to them. Researchers will first adapt the program for vi…

This study looks at whether a program called VA Brief Intervention and Contact (VA BIC) can lower suicide risk in Veterans after they leave a non-VA mental health facility. About 120 Veterans who recently had suicidal thoughts will take part. Researchers will track their suicidal…

This study tests a training program for VA doctors to improve how they care for Veterans with Long-COVID. The training focuses on listening to patients, building a shared understanding of the condition, and creating a personalized action plan. About 348 Veterans and their doctors…