Va Office Of Research And Development

This study tested a new group program called Project Life Force against standard care for veterans at high risk of suicide. The program helps veterans build and improve their personal safety plans over 10 sessions using skills like emotion regulation and coping. The goal was to s…

This small pilot study tested two ways to stimulate the spinal cord—one with a surgically implanted device and one with surface electrodes—combined with a robotic exoskeleton to help people with spinal cord injury walk. Four men with complete paralysis below the chest took part. …

This study looked at whether testosterone therapy can improve bone health in men who have both type 2 diabetes and low testosterone. About 92 male veterans aged 35 to 70 took part. Researchers measured bone strength using special scans and blood tests over 12 months to see if tes…

This study tested a non-invasive brain stimulation method called rTMS to help veterans with alcohol use disorder stay sober. 49 veterans received either real or fake (sham) rTMS, and researchers tracked their alcohol use for 6 months. The goal was to see if rTMS could reduce rela…

This study tested a special support program for veterans with both bipolar disorder and substance use problems after they left the hospital. Half of the 138 participants received the new program, while the other half got extra safety monitoring. The goal was to see if the program…

This study tested a telehealth program for 30 veterans who misuse alcohol and have high blood pressure or other heart risks. The program combined counseling, text messages, and coaching calls to help reduce drinking and improve heart health. Researchers wanted to see if the progr…

This study tested whether long-term aerobic exercise can slow the progression of Parkinson's disease. Researchers enrolled 57 adults with mild to moderate Parkinson's to see if regular exercise improves movement, thinking, and driving safety. The goal is to find a low-cost, acces…

This study tested a program to help veterans with heart disease or rheumatic conditions take their medications as prescribed. Over 5,000 participants received reminders via text or phone calls, with extra support if needed. The goal was to improve medication adherence and reduce …

This study tested whether a small wearable sensor, combined with a smart computer program, could detect early signs of worsening heart failure and alert doctors to adjust treatment before a hospital stay is needed. Researchers enrolled 176 veterans with heart failure and randomly…

This study looked at whether adding the antibiotic rifampin to usual treatment can prevent amputations in diabetic patients with serious foot bone infections. Over 800 veterans took part. The goal was to see if the combination works better than standard care alone to save limbs.

This study looked at 1,424 veterans with high heart risk who had major surgery. It compared giving blood transfusions when hemoglobin drops below 10 (liberal strategy) versus below 7 (restrictive strategy). The goal was to see which approach better prevents serious problems like …

This study tested whether a 12-week high-intensity exercise program could slow aging and reduce inflammation in 89 older veterans living with HIV. Participants exercised via video conferencing without needing special equipment. The goal was to improve fitness and quality of life,…

This study tested a weight management program designed specifically for veterans with PTSD who are overweight or have obesity. The program added extra support to standard PTSD care to help overcome barriers like stress and low motivation. 174 veterans took part to see if the prog…

This study looked at whether having a spouse, partner, or other adult living with them helps Veterans lose more weight in a VA weight management program. About 300 Veterans with obesity took part, and their weight was tracked for 72 weeks. The goal was to see if social support bo…

This pilot study tested whether combining electrical muscle stimulation with vitamin D pills could improve bone quality in veterans with chronic spinal cord injury. Six participants received the combination therapy for 9 months. The goal was to see if this approach could reverse …

This study tested whether probenecid, a medicine usually used for gout, can help veterans with a type of heart failure called heart failure with reduced ejection fraction (HFrEF). 99 veterans took probenecid twice daily for 180 days. Researchers measured changes in heart function…

This study tested whether a program of diet, aerobic exercise, and balance training could improve nerve function and balance in people with prediabetes or early type 2 diabetes. 61 participants were assigned to either the program or standard care. The goal was to see if these lif…

This study tested two different texting programs to help Veterans with type 2 diabetes manage their blood sugar. 366 Veterans took part. One program sent standard daily tips, while the other let Veterans customize the messages they received. The goal was to see which approach wor…

This study tested a 12-month remote weight loss program for 696 veterans with obstructive sleep apnea and obesity. Participants watched videos, tracked food and activity, and had access to a lifestyle coach. The goal was to improve sleep-related quality of life and reduce weight.…

This study tested a program of diet, exercise, and the drug metformin in 114 older veterans with obesity and frailty. The goal was to see if this combination could improve physical function and reverse age-related muscle loss. Participants were aged 65-85 and followed the program…

This study tested whether ibudilast, a drug that reduces brain inflammation, could help people addicted to methamphetamine. Researchers measured changes in brain function and thinking skills in 176 participants. The goal was to find a medication to support recovery, not to cure t…

This study looked at whether a pharmacist-led medication review done through a video call to the home could improve medication safety for older Veterans. The study included 304 Veterans who take at least 5 daily medications and have 2 or more chronic conditions. The goal was to r…

This study tested whether a nurse-led program could help veterans with HIV lower their blood pressure and reduce their risk of heart disease. 305 veterans with HIV and high blood pressure took part. The program used video visits and care coordination to help manage blood pressure…

This study tested a new approach for Veterans who have both PTSD and a smoking habit. It combined a proven PTSD therapy (Cognitive Processing Therapy) with extra support to help them quit smoking, including counseling, medication, and rewards for staying smoke-free. The goal was …

This study tested a weight loss program called CoachToFit for 257 veterans with serious mental illness (like schizophrenia or bipolar disorder) who were obese. The program used a smartphone app and support from peer specialists to help participants lose weight and walk farther. T…

This study looked at whether repeated sessions of passive heating (like sitting in a warm room or bath) can help reduce inflammation and improve heart and blood vessel health in people with spinal cord injury. Ten adults with stable spinal cord injury for over a year took part. T…

This study tested whether a mental technique called WOOP (Wish, Outcome, Obstacle, Plan) could help veterans with obesity lose more weight when added to the VA's telephone-based MOVE! program. About 405 veterans took part. The goal was to see if this easy-to-learn strategy boosts…

This study tested whether a person with arm and hand paralysis from a spinal cord injury could control hand movements using their own brain signals. The participant had already received a brain implant as part of another study. Small electrodes placed in the arm and hand delivere…

This study tested a combination of testosterone therapy and a special type of electrical stimulation to rebuild leg muscle in 12 people with spinal cord injury. Participants had severe muscle loss because nerves to their legs were damaged. The goal was to see if this approach cou…

This study checked whether 3D-printed nasal swabs work as well as standard swabs for diagnosing COVID-19. About 1,179 people who had COVID-19 symptoms or were recently exposed took part. Researchers compared the new swabs' accuracy and safety, like nosebleed risk, to the usual on…

This study tested whether an electronic self-report screening system (eScreening) helps VA clinics detect depression, PTSD, alcohol problems, and suicide risk more quickly and more often in newly enrolled post-9/11 veterans. Researchers compared screening rates and referral times…

This study looked at whether a heart-healthy, low-salt diet (the DASH diet) could prevent heart failure in older Veterans with high blood pressure, obesity, and metabolic syndrome. 71 participants followed the diet and researchers measured changes in artery stiffness and heart st…

This study tested whether a simple checklist could reduce MRSA infections after joint replacement or heart surgery in over 23,000 veterans. The checklist included steps like testing for MRSA before surgery and using special cleaning methods. The goal was to see if this approach c…

This study tested a program called PEACE for veterans leaving a psychiatric hospital. The program combines a mobile app to boost social connections and brief counseling to encourage follow-up care. 92 veterans took part, and the goal was to see if the program reduces suicidal tho…

This study looked at over 5,000 people with kidney disease who needed an angiogram (a test that uses dye to see blood vessels). The goal was to see if giving sodium bicarbonate (a type of baking soda) or N-acetylcysteine (a common supplement) could prevent serious problems like k…

This study tested a shorter version of Cognitive Processing Therapy (CPT) for Veterans with PTSD. Many Veterans drop out of the standard 12-session program, missing the most helpful parts. The goal was to find which therapy components work best and deliver them in fewer sessions …

This study tested whether personalized health coaching can improve daily life for Veterans suffering from long-term pain and related symptoms. Researchers enrolled 260 Veterans with chronic multisymptom illness (like fibromyalgia) and measured changes in pain and disability. The …

This study tested a new therapy called Impact of Killing (IOK) for 100 veterans with PTSD caused by moral injury—distress from killing or being responsible for a death in war. The therapy aims to improve quality of life and reduce PTSD symptoms, and was compared to a standard tal…

This pilot study tested a brief text-based intervention to help veterans with social anxiety reduce safety behaviors (like avoiding eye contact or rehearsing sentences). 23 veterans enrolled in a work therapy program participated. The goal was to see if this approach is feasible …

This study looked at 53 veterans with PTSD, sleep apnea, and insomnia who were not using their CPAP machines regularly. Researchers compared adding a sleep medication (eszopiclone) to brief behavioral therapy versus therapy alone. The goal was to see if the combination improved s…

This study tested a motorized shoe (exoskeleton footwear) to see if it helps people with peripheral artery disease (PAD) walk more easily. 47 adults over 40, some with PAD and some healthy, tried the shoes at different assistance levels. Researchers measured walking mechanics, mu…

This study tested whether adding a non-invasive brain stimulation technique called tDCS to physical therapy helps stroke survivors walk better. 44 people who had a stroke at least 6 months earlier took part. The goal was to see if the combination improved walking speed and functi…

This study looked at how often diabetic foot ulcer patients wear their prescribed orthotic walking boots and whether it helps ulcers heal faster. Researchers tracked 18 veterans to measure boot wear time, ulcer size, and healing status. The goal is to improve healing, reduce futu…

This study tested whether adding a phone coach to an online insomnia program helps veterans sleep better. 244 veterans with insomnia took part. Some received the online program plus coaching calls, while others got the program alone. The goal was to see if coaching improves sleep…

This study looked at whether a tailored telephone coaching program could reduce diabetes distress and improve self-management in veterans with type 2 diabetes. 34 veterans participated, taking photos of their daily challenges and receiving personalized coaching calls. The goal wa…

This study looked at whether adding a smartphone app that teaches cognitive behavioral therapy (CBT) skills helps veterans with depression recover better than standard CBT alone. Fifteen veterans who served in Iraq or Afghanistan took part. The goal was to see if the app improves…

This study tested a smartphone app designed to help veterans reduce or stop long-term use of benzodiazepines (medications like Ativan or Xanax). Long-term use can lead to dependence, falls, and thinking problems. The app provided self-help tools to help 170 veterans safely cut ba…

This study tested whether morning bright light therapy could improve sleep and reduce pain in 77 veterans with chronic mild traumatic brain injury (mTBI). Participants had ongoing sleep problems and moderate to severe pain. The goal was to see if better sleep leads to less pain a…

This study tested a type of talk therapy called Acceptance and Commitment Therapy (ACT) to help veterans with PTSD improve their social support and relationships. 107 veterans took part, and the therapy focused on helping them feel less isolated and more connected to family and f…

This study tested a short type of talk therapy (cognitive behavioral therapy) for Veterans with anxiety. 225 Veterans from three VA medical centers received the therapy either in person or by video at home. The goal was to see if this brief therapy works better than the usual car…

This study tested a short form of talk therapy (6 sessions, 30 minutes each) for veterans with long-term muscle or joint pain. 184 veterans took part to see if the therapy helped them do daily activities with less pain interference. The goal was to offer a practical pain manageme…

This study tested two sleep medications, trazodone and eszopiclone, in 673 veterans with PTSD-related insomnia. The goal was to see if these drugs could reduce insomnia symptoms over 12 weeks. Participants were adults aged 18-75 with military-related PTSD and insomnia. The study …

This study tested a 10-week, at-home cognitive training program for 9 veterans with major depression and a recent suicide attempt. The program aimed to improve decision-making and reduce depression through problem-solving exercises delivered via video calls. Early results suggest…

This pilot study tested whether a non-invasive device called TENS (transcutaneous electrical nerve stimulation) is safe and practical for treating chronic eye pain. 39 veterans with persistent eye pain for at least 6 months used the device at home for 6 months. The goal was to se…

This study looked at whether a non-invasive brain training method called neurofeedback can help veterans who have had a mild traumatic brain injury and still suffer from chronic headaches, trouble sleeping, and attention problems. 87 veterans were randomly assigned to receive neu…

This study tested whether a combined speech and exercise program delivered via telemedicine can improve speech clarity in people with Parkinson's disease. 104 veterans with speech problems took part. The goal was to see if remote training could help them communicate better in dai…

This study looked at whether a 6-month supervised exercise program could help older veterans with PTSD. About 80 veterans took part, doing regular exercise to see if it would reduce their PTSD symptoms and improve physical health. The goal was to find a safe, drug-free way to hel…

This study looked at two ways to help Veterans with chronic insomnia get brief behavioral treatment in primary care clinics. One approach trained providers to deliver the treatment, and the other added extra support to help them use it more. The goal was to see if more Veterans w…

This study tested a personalized version of cognitive processing therapy (CF-CPT) for veterans with PTSD. 179 veterans participated to see if tailoring therapy to individual needs improves daily functioning, quality of life, and treatment completion compared to standard therapy. …

This study tested a non-drug, non-device treatment called myofunctional therapy for people with mild to moderate sleep apnea. Instead of using a CPAP machine at night, participants did specific tongue and throat exercises during the day. The goal was to see if these exercises cou…

This study looked at whether a type of talk therapy called Cognitive Behavioral Therapy for Chronic Pain (CBT-CP) can help veterans who also have serious mental illnesses like schizophrenia or bipolar disorder. 47 veterans took part to see if the therapy was acceptable and practi…

This study tested two different group exercise programs delivered by video call to help reduce leg spasticity (muscle stiffness) in people with multiple sclerosis. 232 veterans with MS took part. The goal was to see which program better improves daily life and sleep.

This study tested a 12-week program where older veterans with health problems and mobility issues were guided by trained peer leaders to eat better and exercise more. The goal was to see if this approach could improve their diet quality and physical endurance. The program involve…

This study looked at whether mindfulness training can reduce anger and aggression in veterans with PTSD. 61 veterans who struggled with anger took part. The goal was to see if learning mindfulness techniques helps them regulate difficult emotions and lower aggressive behavior.

This study tested a home-based program to help aging veterans with a history of traumatic brain injury (TBI) improve their thinking skills, such as attention and planning. Twenty-nine veterans aged 65 and older used telehealth technology to complete cognitive exercises from home.…

This study tested whether a dietary supplement of branched-chain amino acids (BCAAs) could improve sleep and thinking in 160 veterans with mild traumatic brain injury. Participants took either the supplement or a placebo for several months. The goal was to see if the treatment wa…

This study tested whether neuromuscular electrical stimulation (NMES) can help Veterans with blood cancers maintain physical function and reduce fatigue during stem cell transplant. 46 participants used NMES while in the hospital. The goal was to see if this approach could preven…

This study tested whether veterans with chronic low back pain can reduce pain and improve daily function by learning self-administered acupressure. About 300 veterans participated, with half using a tablet app to guide daily acupressure sessions for 6 weeks. The goal was to see i…

This study tested a therapy called Cognitive Behavioral Therapy for Work Success (CBTw) in 294 veterans with serious mental illness (like depression, bipolar disorder, or PTSD) who were unemployed. The goal was to help them find and keep competitive jobs, which can improve their …

This study tested whether a non-invasive, FDA-approved device that sends mild electrical current through the head (cranial electrical stimulation, or CES) can reduce chronic pain in veterans with fibromyalgia. Fifty veterans participated, with half receiving real stimulation and …

This study tested whether adding oxytocin (a natural hormone) to standard talk therapy helps veterans with PTSD feel better faster and stay in treatment longer. 180 veterans took part. The goal was to see if the combination reduces PTSD symptoms more than therapy alone.

This study tested a program called Whole Health STEPS for 82 Veterans with mental health concerns who were not getting mental health care. The program uses a peer support specialist to help Veterans set and work toward wellness goals, with increasing support as needed. The goal w…

This completed study tested whether repetitive transcranial magnetic stimulation (rTMS) can relieve pain, headaches, depression, and other symptoms in 204 veterans with Gulf War Illness. Participants received rTMS, a non-invasive brain stimulation, and reported changes in pain, m…

This study tested whether prazosin, a drug often used for blood pressure and PTSD nightmares, can reduce the frequency and severity of chronic headaches in veterans and service members who had a mild traumatic brain injury. About 89 participants received either prazosin or a plac…

This study tested whether peer specialists—people with serious mental illness who are trained to support others—can effectively lead cognitive-behavioral social skills training for veterans. 191 veterans took part in either peer-led training, standard social skills training, or u…

This study tested whether specially designed shoes (carbon fiber or spring-loaded) could help people with peripheral artery disease (PAD) walk farther and with less pain. Ten veterans with PAD wore the shoes for three months. Researchers measured changes in walking distance and c…

This study tested a new 8-week group program called Mindful Action for Pain (MAP) that combines mindfulness meditation with other proven techniques to help veterans with chronic pain. The goal was to improve daily functioning and reduce how much pain interferes with life. 126 vet…

This study tested a workshop called STEP-Home for 221 post-9/11 Veterans who had trouble reintegrating into civilian life. The workshop taught skills like emotional control, problem solving, and attention to improve daily function and reduce anger. It was designed as a non-stigma…

This study tested a therapy called ACT-MI for veterans struggling with moral injury—pain from events that went against their values. 74 warzone veterans took part to see if the therapy was acceptable and practical. The goal was to help them live meaningful lives, not to cure a di…

This study tested a problem-solving program delivered by phone and online for 210 Hispanic caregivers of veterans who had a stroke. The goal was to reduce caregiver depression and burden, and improve their quality of life. The program was adapted to be culturally relevant for His…

This study tested whether magnetic stimulation to the front of the brain could help older veterans stick to a home exercise program using Nintendo Wii-Fit. 72 sedentary veterans aged 60+ were asked to exercise 45 minutes daily, five days a week for 12 weeks. Those who struggled w…

This study tested a non-drug approach to help people with phantom limb pain—pain felt in a missing limb. Twenty adults with arm or leg amputations learned to change their brain responses using real-time feedback. The goal was to retrain the brain to reduce pain and improve qualit…

This study tested a therapist-assisted self-management program for veterans who had already completed trauma-focused therapy for PTSD and seen improvement. The goal was to help them maintain or build on their progress, feel more confident managing symptoms, and reduce the number …

This study tested a program called Compensatory Cognitive Training (CCT) in 21 veterans with PTSD who still had memory and attention problems after standard PTSD treatment. The goal was to see if CCT could help improve their thinking skills and daily functioning. The study was sm…

This study tested a phone-based program called Caregiver SOS (Self-Management of Stress) for employed people caring for Veterans with mental health issues like depression, anxiety, PTSD, or brain injury. About 199 caregivers participated to see if the program could reduce their d…

This study looked at a rehabilitation program called Live Long Walk Strong for veterans aged 50 and older. The goal was to see if the program could improve walking speed and leg strength. 151 veterans took part in the study, which focused on exercises to help them move better in …

This study tested two different 2-month training programs to help veterans with psychosis improve their social interactions and quality of life. 113 veterans took part. The goal was to see which training worked better for everyday social situations.

This small study tested whether shining special LED lights on the head could help veterans with mild traumatic brain injury (TBI) and PTSD think more clearly and feel better. Eight veterans received the noninvasive light treatment, and researchers measured changes in memory, atte…

This study looked at whether giving repeated doses of ketamine (compared to a placebo) could help veterans with PTSD feel better faster while they also received a standard talk therapy called Prolonged Exposure. About 75 veterans took part. The goal was to see if ketamine could s…

This study tested whether transcranial magnetic stimulation (TMS) can reduce apathy—a severe lack of motivation—in older veterans with mild cognitive impairment (MCI). About 103 participants received either real or fake TMS over 20 sessions. The goal was to see if TMS could impro…

This study tested a behavioral program to help older veterans with obstructive sleep apnea use their positive airway pressure (PAP) machine more consistently. About 100 veterans who had stopped using their PAP device worked with a sleep coach over several sessions. The goal was t…

This study tested a compassion meditation program for 142 veterans with chronic pain and either depression or PTSD. Participants were split into two groups: one learned compassion meditation, the other received health education. The goal was to see if the meditation could reduce …

This study tested a new approach to help veterans at high risk for suicide. It combined a type of brain stimulation (TMS) with brief cognitive behavioral therapy. 55 veterans took part. The goal was to see if this combination could reduce suicide attempts and thoughts more than c…

This study tested an internet-based sleep program for veterans with COPD and insomnia. 13 veterans were randomly assigned to either an online behavioral treatment for insomnia or online sleep education. The goal was to see if the program could improve sleep and quality of life. R…

This study tested whether a non-invasive treatment called repetitive transcranial magnetic stimulation (rTMS) could improve memory and thinking in 32 older veterans with mild cognitive impairment or dementia. Participants received rTMS sessions, and researchers measured changes i…

This study tested a special type of talk therapy (cognitive-behavioral therapy, or CBT) delivered over telehealth to help veterans who feel lonely and struggle with substance use. The goal was to see if the program was practical and well-liked by participants. Thirty-six veterans…

This study looked at whether two types of talk therapy—Behavioral Therapy and Cognitive Therapy—can help Gulf War Veterans who have trouble sleeping. Fifty veterans took part, and their sleep problems were measured using a standard questionnaire. The goal was to see which therapy…

This study tested a structured cognitive rehabilitation program in 77 veterans and active-duty personnel who had mild traumatic brain injury from blasts. The program aimed to improve thinking skills and quality of life. Participants were aged 21 to 50 and had brief loss of consci…

This study looked at whether a 16-week program of aerobic and resistance exercise could improve heart and muscle health in 33 HIV-infected veterans aged 50 and older. Participants did treadmill tests and heart imaging to measure changes in fitness and inflammation. The goal was t…

This study tested whether placing mild electrical stimulation on the skin over the spine could help raise and stabilize low blood pressure in veterans with spinal cord injury. Ten participants with injuries at or above the T6 level took part. The goal was to find the best electro…

This study tested whether a walking program combined with pain education could help veterans who are being treated for opioid use disorder manage their chronic pain. 60 veterans took part. The program used pedometers and mobile devices to track progress. The goal was to see if th…

This study tested a behavioral sleep treatment in 36 veterans who have PTSD, insomnia, and sleep apnea. The goal was to see if the treatment improves their daily functioning and sleep quality. Researchers measured quality of life and sleep-related functioning before and after the…

This study tested a specially adapted sleep therapy, called Sleep-SMART, for 30 older veterans who have both mild cognitive impairment (MCI) and chronic insomnia. The therapy combines standard insomnia treatment with extra memory and thinking strategies to help veterans learn and…

This study tested whether transcranial magnetic stimulation (TMS) — a non-invasive treatment that uses magnetic fields to stimulate specific brain areas — can improve daily functioning in veterans with PTSD. Researchers compared real TMS to a sham (fake) treatment in 59 veterans.…

This study tested whether adding CBD (a non-psychoactive cannabis compound) to standard talk therapy helps reduce PTSD symptoms in military veterans. 136 veterans participated, receiving either CBD or a placebo alongside therapy. The goal was to see if CBD could improve treatment…

This study looked at whether Tai Chi or a Wellness program could help Gulf War Veterans with long-term pain, fatigue, and mood problems. A total of 114 veterans took part, either in person or later online due to COVID-19. The goal was to see if these mind-body approaches could re…

This study tested a short, non-medication anxiety treatment called VAST for veterans in primary care. About 170 veterans with anxiety symptoms were randomly assigned to receive VAST or usual care. The goal was to see if VAST reduces anxiety and improves daily life better than sta…

This study tested whether virtual peer support groups, co-led by a mental health clinician and a trained peer specialist, could help veterans with serious mental illness (like schizophrenia or bipolar with psychosis) feel more socially connected and less distressed. Twenty-eight …

This study tested whether a supplement called MitoQ can reduce fatigue in people with multiple sclerosis (MS). 45 adults with MS and significant fatigue took either MitoQ or a placebo daily for 12 weeks. Researchers measured changes in fatigue, thinking speed, and overall disabil…

This study looked at whether adding a short writing therapy (Written Exposure Therapy) to a 28-day residential substance use program helps veterans who have both PTSD and substance use disorders. Fifty-six veterans took part, and researchers measured satisfaction, symptoms, and s…

This study looked at whether an 8-week mindfulness program (MBSR) can improve quality of life, thinking, and mood in people with Parkinson's disease. 107 adults with Parkinson's took part. The goal was to see if learning to focus on the present moment can help manage daily challe…

This study developed and tested a mobile website called LIMIT to help veterans safely reduce their opioid use while still managing chronic pain. 44 veterans on long-term opioid therapy participated. The goal was to see if the tool was acceptable and effective in supporting opioid…

This study tested a virtual mindfulness-based program to help Veterans with depression and difficulty adjusting to civilian life. 36 Veterans took part. The program aimed to reduce depressive symptoms and improve community reintegration using online sessions.

This study tested a 10-week group program called START for 45 veterans with PTSD who had not responded to other treatments. The program helped veterans gradually reduce their reliance on safety behaviors (like always carrying a weapon or checking locks) to lower PTSD symptoms. Re…

This study tested whether custom 3D-printed shoe inserts can reduce pressure on the feet of people with diabetes who are at risk for foot ulcers. Thirty adults wore different types of insoles while walking in a lab, and researchers measured foot pressure and movement. The goal wa…

This study tested whether a natural substance called pregnenolone can reduce PTSD symptoms in 96 Iraq/Afghanistan-era veterans. Over 10 weeks, participants took either pregnenolone or a placebo and had regular check-ins and assessments. The goal was to see if this supplement coul…

This study tested a personalized version of Cognitive Rehabilitation and Exposure/Sorting Therapy (CREST) for veterans with hoarding disorder. The therapy was delivered at home via telemedicine and home visits over 24 sessions. The goal was to improve daily functioning, reduce ho…

This study tested a one-day life skills workshop for veterans with mild traumatic brain injury, chronic pain, and mental health conditions like PTSD and depression. The goal was to reduce distress and help them reintegrate into civilian life. 176 veterans participated, and the wo…

This study tested a short talk therapy called behavioral activation for veterans with traumatic brain injury (TBI) and depression. About 46 veterans took part, with some receiving the therapy plus usual care and others only usual care. The goal was to see if the therapy was pract…

This study tested whether a single therapy (Transdiagnostic Behavior Therapy) can treat PTSD, depression, and panic disorder as effectively as using separate, disorder-specific therapies. 304 veterans participated, and their symptoms were measured before, during, and after treatm…

This small study tested whether a special laser treatment can help veterans with leg amputations who have painful scars that make wearing their artificial limb hard. Ten veterans received the laser therapy, and researchers measured changes in pain, scar appearance, walking abilit…

This study tested whether weekly social groups could help older veterans with depression feel less lonely and improve their mood. 18 veterans joined the groups and filled out questionnaires about their symptoms and social connections. The goal was to see if the program works and …

This study tested a special wheelchair that lets people with spinal cord injuries stand up and move around at the same time. The goal was to see if using this chair at home and in the community helps them stand more often and feel more satisfied with their daily activities. Twent…

This study tested whether an internet-based walking program with a pedometer could help veterans with COPD who cannot attend hospital rehab become more active. 146 veterans took part, and the program aimed to increase daily steps over 12 weeks. The goal was to improve physical ac…

This study tested a special type of talk therapy, called Cognitive Behavioral Therapy for Loneliness (CBT-L), delivered by phone or computer to veterans with chronic pain who also feel lonely. The goal was to see if it could reduce loneliness and pain-related problems. About 40 v…

This study tested a program called Recovery Bridge, where trained peer specialists help people leaving a psychiatric hospital adjust to life back in the community. Fifteen veterans took part to see if the program was feasible and acceptable. The goal was to reduce hospital readmi…

This study looked at ways to help VA clinics increase referrals to a suicide prevention telehealth program for veterans who have had suicidal thoughts or behaviors in the past year. Researchers worked with 4 clinic teams using training and quality improvement tools. The goal was …

This study looked at how to help busy doctors at VA clinics adopt better treatments for three common issues: reducing risky medications in older adults, using blood thinners more safely, and offering talk therapy for insomnia instead of sleep pills. Researchers compared two diffe…

This study looked at how veterans with HIV use a website called My HealtheVet to manage their health. Researchers reviewed medical records and interviewed veterans and staff to understand what helps or hinders use of the online tools. They then created and tested a program to enc…

This study looked at whether a gentle, non-invasive brain stimulation technique can help older adults learn and remember new walking skills. Researchers worked with 72 people aged 65 and older who had some walking difficulty. They used MRI scans to see how the brain changes with …

This study tested whether a smartphone app could passively track activity, sociability, and sleep in 87 veterans with serious mental illnesses like schizophrenia and bipolar disorder. The goal was to see if phone data could detect early warning signs of worsening symptoms. The st…

This study tested whether a gentle brain stimulation technique called tDCS could make cognitive training more effective for veterans with alcohol use disorder. Forty-five veterans participated, receiving either real or fake tDCS while doing brain exercises. The goal was to see if…

This study tested different public messages to encourage veterans who recently left the military and are thinking about suicide to seek mental health care. Researchers enrolled 355 veterans who had suicidal thoughts but were not currently in treatment. They measured whether the m…

This study tested a new program to help veterans at risk for suicide by discussing safe storage of firearms and medications. Forty veterans from VA clinics took part. The goal was to see if the program was practical and well-received, not to measure if it directly prevented suici…

This study looked at how often thiamine (vitamin B1) deficiency occurs in hospitalized veterans who do not abuse alcohol. Thiamine deficiency can cause symptoms like fatigue, confusion, and weakness, and may be more common in veterans due to food insecurity and chronic illness. R…

This study looked at whether drinking calcium before exercise helps bones get stronger. During exercise, blood calcium levels drop, and the body pulls calcium from bones to compensate, which might reduce the benefits of exercise for bone health. Researchers tested this idea in 18…

This study looked at whether offering PTSD therapy several times a week (massed format) helps veterans complete their treatment compared to the usual once-a-week schedule. 30 veterans with PTSD took part. The goal was to see if the massed approach is acceptable and improves reten…

This study looked at how to best help emergency room doctors avoid prescribing potentially harmful medications to older veterans. Researchers compared two methods: giving doctors regular reports on their prescribing habits (passive feedback) versus having them actively discuss an…

This study tested a web-based decision support tool designed to help women veterans discuss their reproductive goals—like planning a healthy pregnancy or choosing birth control—with their VA doctors. About 465 women veterans took part, with half receiving a link to the tool befor…

This study tested whether support from a trained peer specialist—a fellow Veteran who has faced similar challenges—can help Veterans at high risk for suicide. 17 Veterans took part, and researchers measured changes in hope, connection, and suicidal thoughts. The goal was to see i…

This study tested a new way to deliver mental health care to rural veterans by combining in-person primary care with telemedicine support. About 318 veterans with depression, alcohol use problems, or PTSD took part. The goal was to see if this blended approach improves mental hea…

This study tested a self-help tool called EMBER to see if it helps veterans with obesity use VA weight management programs more often. About 470 veterans were randomly assigned to receive EMBER or just a list of programs. Researchers checked program use after 2 and 6 months to se…

This study tested a telehealth program (CBT-TS) to help 300 veterans with chronic pain who were taking prescription opioids. The goal was to see if the program could encourage them to start and stick with non-drug pain treatments like physical therapy or counseling. The approach …

This study tested a program called SLAC that helps Veterans who drink heavily and have mental health issues like PTSD or depression get connected to alcohol care. 140 Veterans from VA primary care took part. The goal was to see if the program is practical and liked by Veterans an…

This study tested a new type of pump that creates a vacuum to help hold a prosthetic limb in place. 12 people with amputations walked in a lab to see if the pump worked well. The goal was to improve limb health and make walking easier.

This study looked at whether giving veterans their genetic test results could help them better manage heart disease. Over 100 veterans received their results and were followed for 6 months to see if their cholesterol levels improved. The goal was to learn how to return genetic in…

This study looked at whether balance and walking problems in people with Parkinson's disease are caused by changes in the inner ear (the body's balance center) rather than just a lack of dopamine in the brain. 60 participants with Parkinson's underwent standard balance tests and …

This study looked at whether measuring specific brain waves (gamma oscillations) can help detect and treat brain injury caused by blast exposure in combat veterans. Researchers planned to enroll 50 veterans but only 5 took part. The goal was to understand how close blast distance…

This study looked at a telemedicine program called TOP that helps rural veterans with PTSD get therapy and medication without traveling far. Over 500 veterans took part. The goal was to see which way of rolling out the program worked better and whether it improved PTSD symptoms.

This study looked at whether veterans with traumatic brain injury (TBI) and insomnia can reliably measure their internal body clock at home. Thirty-one veterans wore a wrist device for a week and collected saliva samples to track melatonin levels. The goal was to see if these hom…

This study tested a new program called the Relational Playbook, which gives nurse managers tools and coaching to create a better work environment for heart clinic teams. Ten staff members from six VA cardiac catheterization labs took part. The goal was to see if the program was p…

This study looked at 37 obese adults to understand why the brain's pleasure response to food is weaker in obesity. Researchers tested if insulin resistance in the brain causes this reduced response and if weight loss can improve it. The goal is to learn why weight loss is hard an…

This study tested a new approach called Patient Priorities Care in 420 older veterans with multiple chronic conditions. Instead of following standard care, doctors worked with patients to identify their personal health goals and tailor treatments accordingly. The goal was to see …

This study monitored the sleep of 48 Veterans with PTSD who have frequent trauma nightmares. Using special mattress sensors at home, researchers tracked sleep quality and heart activity before and after a nightmare treatment. The goal was to learn more about what happens in the b…

This study tested a special training platform designed to help older veterans and those with disabilities improve their balance and reduce the risk of falling. Researchers enrolled 62 participants and used reaching tasks at the limits of balance to measure and train stability. Th…

This study looked at whether a 12-week indoor cycling program could improve blood flow and brain health in older veterans aged 65-80 who do not exercise regularly. Researchers measured brain blood vessel function before and after the exercise program. The goal was to learn how ex…

This study looked at whether it's possible and acceptable to screen for hearing loss in the emergency department (ED). Researchers tested 133 veterans with mild hearing problems to see if using a hearing device helped them communicate with doctors and understand their discharge i…

This study looked at how brain signals and thinking skills change during recovery from cocaine addiction in 63 veterans. Researchers used a behavioral treatment called contingency management, which rewards drug-free urine tests. The goal was to find brain-based clues that predict…

This study followed 416 veterans with low back pain to see which physical activities cause short-term pain flares and which help long-term recovery. Participants reported their pain and disability over time. The goal was to identify helpful and harmful activities, not to test a t…

This study tested whether a coaching program called practice facilitation helps VA primary care doctors provide better care for veterans with unhealthy alcohol use. Researchers worked with 42 veterans and their doctors at one VA clinic to see if doctors would offer more counselin…

This study looked at nearly 1,000 transgender veterans to understand what helps or hinders them from getting gender-affirming treatments like hormone therapy and mental health care. Researchers surveyed veterans to find out which treatments they received and where, and how this a…

This completed study looked at how often and in what way word-retrieval therapy should be given to help stroke survivors with aphasia (trouble finding words). Researchers worked with 32 Veterans who had a stroke at least six months earlier. They tested different treatment schedul…

This study looked at brain activity in people with and without Parkinson's disease while they moved their legs. Researchers wanted to see if two types of partnered dance could change brain signals. 87 adults aged 40-70 took part at the Atlanta VA Medical Center and Emory Universi…

This study tested whether gentle reminders sent to doctors could increase the number of veterans with heart failure who receive two types of lifesaving medications. Researchers compared three different reminder strategies against no reminder at all. The goal was to see if these s…

This pilot study tested a group program called Race-Based Stress/Trauma and Empowerment (RBSTE) for Veterans of Color. The goal was to see if the program is acceptable and feasible, and to gather information for a larger future study. 37 Veterans participated, and the focus was o…

This study looked at why some veteran stroke survivors find it easier or harder to do arm exercises at home. Researchers gave surveys about mood, confidence, and sleep, then asked participants to track their home exercise with a smart watch. The goal was to understand what helps …

This study looked at whether a program called MISSION-CJ can help homeless veterans who have both substance use and mental health problems stay out of trouble with the law. 134 veterans took part, and researchers tracked arrests, substance use, housing, and employment. The goal w…

This study created and tested a mobile app called VetEd for student veterans dealing with mental health issues like depression, PTSD, or anxiety. The goal was to help them manage academics, mental health, and find resources. Researchers worked with 13 veterans to see if the app w…

This study looked at how people with ankle arthritis did after surgery. Researchers followed 368 patients for up to 12 years, using surveys and walking tests to measure function. The goal was to see which surgeries worked best and how patients improved over time.

This study followed 227 veterans with swallowing problems (dysphagia) for 8 weeks to see if measuring throat pressure during swallowing can predict who will improve with therapy. Participants did standard strengthening exercises, and researchers compared their pressure readings, …

This study looked at 100 veterans with mental health conditions like schizophrenia, PTSD, or mood disorders. It tested whether a simple brain wave measurement (mismatch negativity) could help choose the best cognitive training for each person. The goal was to improve thinking, da…

This pilot study tested whether health coaching can help veterans who recently left the military adjust to civilian life and reduce suicide risk. Researchers worked with 95 veterans to see if the program was practical and well-received. The goal was to prepare for a larger future…

This study looked at 622 veterans with chronic lung disease who had COVID-19. Researchers tracked their health outcomes, recovery, and need for rehabilitation services. The goal was to understand which factors lead to more severe illness and what support patients need after recov…

This study looked at whether skipping the first in-person clinic visit and going straight to home sleep testing can help Veterans get diagnosed and treated for sleep apnea faster. Over 6,500 Veterans took part. The goal was to see if this direct approach works as well as the trad…

This study looked at different methods to screen male veterans for osteoporosis, a condition that weakens bones and raises fracture risk. Over 3,500 high-risk veterans took part to see which screening approach worked best. The goal was to improve early detection and treatment wit…

This study looked at whether adding family members to cognitive behavioral therapy (CBT) helps veterans with anxiety disorders. 48 veterans and their family members tried a new program called AF-CBT. The goal was to see if the program was acceptable and practical, not yet to prov…

This study looked at why veterans aged 50 and older feel tired after COVID-19 and tested a simple home exercise program. 21 veterans with long-lasting fatigue took part. The goal was to understand what causes their tiredness and see if a minimal-dose resistance exercise program i…

This study tested a simple, portable virtual reality system to measure balance in veterans with cervical spondylotic myelopathy (CSM), a spinal cord condition that affects walking and stability. Eight participants completed balance tasks under different visual and surface conditi…

This study tested a program called Collaborative Decision Skills Training (CDST) to help veterans with serious mental illness, like schizophrenia, work together with their doctors on treatment choices. Thirty-nine veterans took part in a small trial to see if the training was pra…

This study looked at whether diuretics (water pills) can help reduce extra fluid in the body and improve heart health in people with early chronic kidney disease. Researchers measured changes in heart stress markers, fatigue, and depression after 4 weeks of treatment. The goal wa…

This study looked at how complementary health approaches like acupuncture, massage, and yoga affect chronic pain in over 3,600 veterans. Researchers compared the effects of practitioner-delivered therapies alone versus combining them with self-care practices. The goal was to unde…

This small study tested whether real-time neurofeedback—a technique where people learn to control their own brainwaves—could improve memory-related brain activity in older veterans with mild cognitive impairment. Four veterans aged 60 and older participated. The goal was to see i…

This study combined six smaller projects to help more Veterans get treatment for opioid use disorder. Researchers worked with 63 VA sites to find better ways to increase the use of effective medications and pain alternatives. The goal was to improve care and save lives.

This study looked at how negative emotions and stress influence alcohol use in 81 women veterans, including those with and without PTSD. Researchers measured alcohol cravings, heart rate, and drinking patterns during lab sessions. They also examined whether emotion regulation tec…

This study tested a new way to assess and train balance using a reaching task on a screen. Seven people (healthy adults and stroke survivors) participated. The goal was to see if this engineering-based approach could improve dynamic balance and help prevent falls.

This study tested a new way to control a robotic arm mounted on a power wheelchair. The arm uses a camera to help guide itself, making it easier to do everyday tasks like picking up a glass or opening a fridge. 21 adults who use power wheelchairs and have trouble with such tasks …

This study created and tested a career counseling program called Purposeful Pathways for veterans with psychiatric disorders who struggle to find and keep jobs. Researchers worked with 67 veterans to design the program and check if it was helpful and practical. The goal was to im…

This study looked at whether measuring the skin's electrical activity can warn of agitation or aggressive behavior in people with dementia. 21 patients from a dementia unit took part. The goal was to see if a warning signal appears before an outburst, which could help caregivers …

This study looked at whether a program that helps doctors and patients make decisions together can improve outcomes for veterans with rheumatoid arthritis. About 900 veterans took part across multiple VA clinics. The goal was to see if shared decision-making leads to better disea…

This study looked at whether training VA staff with computer simulations (called participatory system dynamics) helps more veterans start and finish effective treatments for PTSD, depression, and opioid use disorder. About 720 staff from 24 VA health systems that were below avera…

This study tested a program where rural hospitals connect with an infectious disease expert through video calls to improve antibiotic use. The goal was to reduce unnecessary antibiotics and fight drug-resistant infections. Eight VA medical centers participated, and the approach h…

This study tested a program to help VA doctors and nurses practice mindfulness—a way to focus and reduce stress—by using hand washing as a reminder. About 343 healthcare workers took part, with some learning mindfulness techniques and using an optional app. The goal was to see if…

This study looked at whether sending caring postcards from fellow Veterans can reduce loneliness and improve mental health in older Veterans. Nearly 1,000 Veterans aged 50 and older who had missed VA appointments took part. They received up to 10 postcards and completed surveys t…

This study looked at whether brain activity during sleep can help doctors diagnose PTSD and measure how severe it is. Researchers studied 26 veterans with PTSD using EEG recordings while they slept. The goal was to find objective brain markers that could improve diagnosis beyond …

This study tested a motorized prosthetic foot that twists side-to-side as you walk, just like a real ankle does. 14 people with a below-knee amputation tried different twist settings while walking straight and in circles. The goal was to find the setting that feels best and puts …

This study looked at how mild traumatic brain injury (mTBI) affects self-regulation—the ability to plan, focus, and manage emotions. Researchers used brain scans (fMRI) to measure brain activity and tested whether the drug tolcapone could improve memory and self-control. 55 veter…

This study tested a new type of therapy for veterans who have suicidal thoughts and their romantic partners. The therapy, called TR&ST, combines suicide prevention techniques with couples counseling to improve communication and reduce suicide risk. 104 veterans and their partners…

This study tested a program called Enhanced Chronic Care to help veterans who were not ready to quit smoking. Over 500 veterans took part. The program offered ongoing support and motivation to help them become ready to quit. Researchers compared this to standard care and measured…

This study looked at how information about what matters to older Veterans with chronic pain—like their home life and daily challenges—can help doctors provide better care. Researchers talked to 230 Veterans aged 65 and older, their caregivers, and clinicians to develop a computer…