University Of Maryland, Baltimore

This early-stage study is testing whether HEPLISAV-B, a vaccine normally used to prevent hepatitis B, is safe for people who already have chronic hepatitis B. Ten adults on antiviral therapy will receive two vaccine shots and be monitored for side effects and immune responses ove…

This study looks at how well the drug Imdusiran works in the liver of people with chronic hepatitis B. Ten adults will receive four injections of Imdusiran, one every 8 weeks, and will have two liver biopsies to measure drug levels and virus changes. The goal is to understand how…

This study tests whether taking a daily zinc supplement for one year can lower blood sugar and HbA1c levels in people with prediabetes. Researchers will compare zinc to a placebo in 200 Amish adults aged 18-80. The goal is to see if zinc can help control blood sugar and prevent t…

This study looks at whether using gentle electrical muscle stimulation and giving extra protein early on can help adults recover muscle strength and metabolism after a type of brain bleed called aneurysmal subarachnoid hemorrhage (SAH). About 30 people who have had this bleed wil…

This study tests whether adding precise, high-dose radiation to cancer spots that have spread (metastases) can improve outcomes for men with prostate cancer that has spread to a few places. About 122 men with up to 5 metastases will receive standard treatment plus either addition…

This study tests two methods for managing severe open tibia fractures: an antibiotic bead pouch or a vacuum-sealed dressing. About 312 adults with these serious breaks will be randomly assigned to one treatment. The goal is to see which approach leads to better healing, fewer inf…

This study looks at whether eating one cup of broccoli microgreens every day for two weeks can improve health in 24 obese breast cancer survivors. The goal is to see if this diet change is practical and if it helps with metabolism and inflammation, which are linked to cancer retu…

This early-phase study tests whether adding a short course of high-dose radiation before standard chemotherapy and immunotherapy can help shrink borderline resectable non-small cell lung cancer before surgery. About 18 adults with stage II to IIIC lung cancer will receive three d…

This study tests whether using smart insulin pens with continuous glucose monitors and telemedicine helps veterans with type 2 diabetes control their blood sugar better than traditional methods. About 50 adults on multiple daily insulin injections will be enrolled. The goal is to…

This study compares two bone graft materials to see which better preserves jawbone after a tooth is pulled, making it easier to place a dental implant later. About 24 adults needing a tooth extraction and implant will be randomly assigned to receive either a mix of human and anim…

This study tests whether lowering body temperature to 34-35°C (therapeutic hypothermia) for 48 hours can help people with severe lung injury (ARDS) breathe better and need less time on a ventilator. About 340 adults on breathing machines will be randomly assigned to cooling or us…

This early-stage study tests whether MRI-guided focused ultrasound can safely treat task-specific focal hand dystonia, a condition that causes hand cramps during activities like writing or playing an instrument. Ten adults who have not improved with standard treatments will recei…

This study tests a two-step treatment for people newly diagnosed with high-grade gliomas, a fast-growing type of brain tumor. First, a laser is used to heat and destroy tumor tissue. Then, a short course of radiation is given to kill remaining cancer cells. The goal is to safely …

This study tests whether trained peer supporters can help Black adults with HIV or at high risk stay on track with long-acting injectable HIV medication (PrEP/ART) and reduce substance use. About 186 participants will receive either peer-delivered coaching or standard care. The g…

This study is testing a new service that assigns navigators to help people aged 13–35 with early psychosis stay connected to their care programs. The goal is to reduce the number of people who drop out of treatment and increase the time they stay in care. The service will be deve…

This study tests a treatment plan for people whose brain tumors (gliomas) have come back after standard care. The approach uses laser heat to destroy tumor tissue, followed by a short course of focused radiation. The goal is to see if this combination is safe and can help control…

This study tests whether fluoxetine (Prozac) and/or DHEA can improve the body's ability to defend against low blood sugar in people with type 1 diabetes. About 60 adults will receive either one or both drugs or a placebo, and their hormone and nervous system responses will be mea…

This study is for people with locally advanced pancreatic cancer that cannot be removed by surgery. It combines a precise type of radiation called proton therapy with two chemotherapy drugs (nab-paclitaxel and gemcitabine). The main goal is to find the highest safe dose of the ch…

This early-phase study tests whether adding hyperthermia (heat therapy) and a special type of radiation to standard chemoimmunotherapy is safe and feasible for people with advanced bile duct cancer that cannot be removed by surgery. About 15 participants will receive the combinat…

This study tests a drug called onvansertib in about 37 adults with small cell lung cancer that came back or didn't respond to chemo. Onvansertib blocks a protein (PLK1) that cancer cells need to repair themselves, aiming to shrink tumors. The main goal is to see how many patients…

This study is for women with early-stage breast cancer. It tests a single, focused dose of radiation using a special machine called GammaPod before the standard lumpectomy surgery. The goal is to find a safe and effective radiation dose that kills the tumor while reducing side ef…

This study tests a new type of MRI that uses a special substance to make brain tumors show up more clearly. The goal is to see if this method can diagnose gliomas (a type of brain tumor) more accurately than standard MRI. Up to 5 adults with suspected or known gliomas will receiv…

This study is testing a new type of MRI that uses a special form of sugar (pyruvate) to see how tumors use energy. Cancer cells consume more sugar than normal cells, and this scan aims to make that visible. About 25 adults with known or suspected tumors will be scanned to see if …

This study tests a personalized training program to help older adults at high risk of falling. About 40 people aged 60 to 85 who have fallen before will get home and hospital exercises based on their unique balance problems. The goal is to reduce falls and improve safety.

This study looks at whether taking methadone once or twice a day is better for managing both chronic pain and opioid use disorder. About 150 adults currently on methadone treatment will participate. Researchers will track pain levels and tolerance over 12 weeks to find the best d…

This study tests whether buspirone, a medication used for anxiety, can reduce withdrawal symptoms and cravings in people with opioid use disorder. About 100 adults will stay in a clinic for 10-12 days while they gradually stop taking opioids. The goal is to see if buspirone makes…

This study tests a new glue for braces that skips the acid step, which can weaken teeth and cause white spots. Twenty people getting braces will have the new glue on one side of their mouth and the standard glue on the other. Researchers will check which side has fewer brackets p…

This study tests whether a virtual reality (VR) program used at home can help cancer survivors manage ongoing symptoms like pain, fatigue, anxiety, and depression. About 30 adults who finished cancer treatment at least 3 months ago will use either VR or an audio program daily for…

This study tests whether a wearable robot can help people who recently had a stroke recover movement, balance, and walking ability. About 140 participants with ankle weakness will use the robot for intensive therapy. The goal is to improve motor and sensory function during the ea…

This study tests whether using virtual reality (VR) alongside standard care can reduce pain for adults with sickle cell disease who are in the emergency department with a painful crisis. About 30 participants will be split into three groups to compare pain scores and comfort. The…

This study is testing a special radiation device called the GammaPod to give a quick, precise boost to the area where breast cancer was removed. The goal is to see if shortening treatment by a few days improves quality of life for women. About 160 women who had a partial mastecto…

This study tests whether following a healthy, anti-inflammatory diet for 16 weeks can reduce fatigue and improve muscle strength in adults aged 50 and older with long COVID. Participants are randomly assigned to either a personalized diet plan or general health sessions. The goal…

This study tests whether low doses of ketamine can reduce cravings and withdrawal symptoms like depression and poor sleep in adults with opioid use disorder who are starting methadone treatment. About 50 participants will receive either a low or very low dose of ketamine four tim…

This study tests whether eating all food within a 10-hour window each day can reduce severe, long-lasting fatigue in blood cancer survivors. About 96 adults who finished cancer treatment at least 2 months ago will either follow this time-restricted eating plan or receive standard…

This study tests whether giving the drug daratumumab as a shot in the upper thigh works as well as the usual shot in the abdomen for people with plasma cell disorders like multiple myeloma. The goal is to find a less painful or more accessible injection spot. About 30 adults will…

This study tests a home-based robotic device combined with mild electrical stimulation to improve leg movement and walking in people who have had a stroke. About 60 adults, at least 6 months post-stroke and able to walk a short distance with help, will use the robot alone or with…

This study tests whether a prebiotic (a type of fiber that feeds good gut bacteria) can reduce inflammation and improve thinking and memory in people with schizophrenia or schizoaffective disorder. Researchers will enroll 60 adults who are stable on antipsychotic medication. The …

This early-phase study tests whether diclofenac, a common anti-inflammatory drug, can increase a brain-protecting chemical and reduce alcohol cravings in people with Alcohol Use Disorder. 24 participants will receive different doses or a placebo across four sessions. The goal is …

This study looks at how immersive virtual reality changes the way the brain processes chronic pain, compared to a placebo effect. Researchers will measure brain activity and pain tolerance in 78 adults with temporomandibular disorder (jaw pain). The goal is to develop new, low-ri…

This study looks at tissue removed during surgery from people with a rare airway scarring condition called tracheal stenosis. Researchers will analyze the genetic activity in this tissue to understand what causes the scarring. The goal is to find better ways to treat or prevent t…

This registry study enrolls up to 8,000 people with severe carotid artery disease (narrowing of the neck arteries) to monitor the safety of a procedure called carotid artery stenting. Participants include those with or without symptoms, and the main goal is to track strokes or de…

This study looks at how opioid withdrawal symptoms vary from person to person. Researchers will monitor 60 adults with opioid use disorder as they slowly stop taking opioids with the help of medication. The goal is to better understand withdrawal patterns, not to test a new treat…

This study looks at whether older adults (55+) receiving methadone for opioid use disorder can use fun, short brain games on a smartphone to track and possibly improve their thinking skills. Thirty participants will play these games for 15 days, and researchers will measure how o…

This study explores whether virtual reality exercise can help older adults (55+) stay physically active and maintain their strength and mental health while in the hospital. Researchers will test the approach with 140 participants to see if it is acceptable and practical. The goal…

This study tests whether a special parenting program (Attachment Biobehavioral Catch-Up) can help low-income Latino children have fewer illnesses, better sleep, and healthier weight. About 260 mothers and their 9-month-old babies will take part. The program focuses on strengtheni…

This study explores whether a 12-week program combining computer-based brain training and aerobic exercise can improve brain function in older adults with mild cognitive impairment (MCI), a condition that sometimes leads to Alzheimer's. Researchers will measure changes in brain s…

This study is for people with HPV-related throat cancer who have surgery to remove their tumor. Researchers want to see if a blood test that looks for leftover cancer DNA can tell who truly needs radiation afterward. If the test is negative after surgery, patients may skip radiat…

This study looks at how doctors treat pelvic fractures in people aged 60 and older. It aims to see if patients and surgeons are willing to participate in a future trial that compares surgery versus non-surgery. The goal is to gather information to design a larger study that could…

This study is a small pilot trial to see if giving older adults a nerve block (a numbing injection) before leg fracture surgery is feasible for a larger study. Researchers want to know if this approach can reduce complications and improve recovery, beyond just pain relief. About …

This study aims to learn how the body's immune system responds to the oral typhoid vaccine. Healthy adults aged 18 and older will receive the FDA-approved Vivotif vaccine and provide blood, saliva, and stool samples over up to eight years. The goal is to better understand immune …

This study looks at how well the eye's blood flow responds to changes, as a possible early sign of glaucoma. Researchers will measure blood flow in the retina of 90 adults with early glaucoma or healthy eyes. The goal is to find a simple, non-invasive way to catch glaucoma sooner…

This study tests whether a type of brain stimulation called repetitive TMS can increase natural brain inhibition in 34 people with schizophrenia. The goal is to see if this change relates to better thinking and memory. Participants will receive five days of treatment and undergo …

This study tests whether a special eye scan (OCT) can detect changes in immune cells in the retina of people with relapsing multiple sclerosis (MS) who start the drug ublituximab (Briumvi). Researchers will compare 15 people starting ublituximab with 15 people on stable MS treatm…

This study follows 250 adults aged 65 and older who have had a mild traumatic brain injury (TBI), often from a fall. Researchers will check their thinking, physical abilities, mood, and sleep at 2 weeks, 3 months, 6 months, and 1 year after the injury. The goal is to understand h…

This study tests a program called PAIN-CPG-EIT, which helps nursing home staff better assess and manage pain in residents with dementia. About 300 residents from 12 nursing homes will take part. Half the homes will use the program, and the other half will receive standard educati…

This study tests a program to help doctors and staff in three psychiatric clinics prescribe more medications for alcohol use disorder to patients who also have serious mental illness. About 40 healthcare workers and their patients will take part. The goal is to see if extra suppo…

This study looks at whether giving less fluid during heart surgery, a technique to reduce blood loss, increases the risk of kidney injury. Researchers will measure kidney injury markers in 100 adults having elective bypass surgery. The goal is to understand if this common practic…

This study uses a special camera (Brillouin microscopy) to measure how stiff the cornea is in people with glaucoma and healthy volunteers. The goal is to see if these measurements can help predict glaucoma risk or track the disease. About 60 adults will take part, and the study d…

This study looks at how different levels of low blood sugar (hypoglycemia) affect blood vessels in healthy adults. Researchers want to understand the body's response to low blood sugar, which could help improve care for people with diabetes. The study involves 32 healthy voluntee…

This study collects information and biological samples from 150 adults who have had cancer therapy and now have eye complications, such as dry eye or graft-versus-host disease. Researchers will track their eye health over time using standard exams and lab tests. The goal is to le…

This study looks at whether it is safe to send people home the same day after hip or knee replacement without a final physical therapy check. Instead, patients learn to walk with a therapist before surgery and are helped by nurses after. The goal is to see if this approach leads …

This study is creating a registry and biobank for 350 adults with autosomal dominant polycystic kidney disease (ADPKD). Researchers will collect medical images, blood, urine, and DNA samples, and track quality of life. The goal is to provide a resource that helps other scientists…

This study looks at whether learning to play a pretend musical instrument can help repair brain wiring in people with schizophrenia. The researchers will use brain scans to measure changes in white matter, which helps different brain regions communicate quickly. The goal is to un…

This study aims to create a complete artificial blood substitute by combining lab-made oxygen carriers, plasma, and platelets. It is designed for use when real blood is not available, such as on battlefields or in remote areas. The research involves 250 healthy adults and uses la…

This study looks at the best way to inform family members about their risk for two inherited conditions: Long QT Syndrome and Familial Hypercholesterolemia. Researchers will compare having the study team directly contact relatives versus asking the patient to contact them. About …

This study tests two new risk scores that predict a patient's chance of developing sepsis or having a serious decline (like cardiac arrest) within the next four hours. The scores alert hospital staff so they can check vital signs sooner. About 150,000 adult patients at University…

This study looks at eye changes in 150 adult cancer patients to understand why some develop severe dry eye after stem cell transplants (graft-versus-host disease). Researchers will collect eye samples and medical data to identify risk factors, markers, and possible treatment targ…