University Of Maryland, Baltimore

This study tests a typhoid vaccine (Vi-TCV) in 30,000 children aged 9 months to 12 years in Malawi. Half get the typhoid vaccine, half get a meningitis vaccine for comparison. Researchers track who gets typhoid to see if the vaccine works and is safe.

This study looks at three different ways to treat deep cavities in children's baby molars without pulling the tooth. The treatments are two types of pulpotomy (removing part of the tooth nerve and placing a material on it) and an indirect pulp cap (leaving some decay and sealing …

This early-phase study tests a new type of CAR T-cell therapy that targets three different markers on cancer cells (CD19, CD20, and CD22) for people with B-cell lymphomas that have come back or not responded to standard treatments. About 15 adults will receive the therapy to see …

This early-phase study tests a new drug called CRD3874-SI that activates the STING protein to help the immune system fight cancer cells. It is for adults with acute myeloid leukemia that has returned or not responded to standard treatments. The main goals are to check the drug's …

This early-stage study tests whether suvorexant, a sleep medication, can reduce how much people with opioid use disorder want and use drugs. Researchers will measure drug demand and sleep in 75 adults. The goal is to see if this approach can help control opioid dependence.

This study tests whether adding bavituximab to pembrolizumab can help the immune system fight advanced head and neck cancer that has stopped responding to standard immunotherapy. About 7 adults whose cancer worsened after prior treatment will receive the combination. The main goa…

This study looks at men whose prostate cancer has come back in a few spots (oligometastatic) and who have certain gene mutations. It compares standard care (hormone therapy plus radiation) against the same treatment plus a 6-month course of two drugs (niraparib and abiraterone wi…

This early-stage trial tests the safety of combining precise radiation (SBRT) with immunotherapy (durvalumab) and two chemotherapy drugs (platinum and etoposide) for people with extensive-stage small cell lung cancer that has stopped responding to platinum chemo. The study aims t…

This study tests a program to help 750 people with HIV in Botswana stop smoking. The program combines counseling, a medication called varenicline, and a referral system. Quitting smoking can improve health and reduce deaths in people living with HIV.

This study tests a remote monitoring system (smartphone app and medication support) to help people with inflammatory bowel disease (IBD) take their medications as prescribed and track symptoms. About 123 adults starting a new oral or injectable IBD treatment will use the system o…

This study tests whether having obstetric providers manage care for a full year after childbirth can improve blood pressure and blood sugar control in mothers with high blood pressure or diabetes. About 100 pregnant women with these conditions and Medicaid insurance will receive …

This early-phase study tests whether giving higher doses of radiation to the prostate in fewer sessions, while also treating the pelvic lymph nodes, is safe for men with intermediate- or high-risk prostate cancer. The goal is to find the shortest treatment schedule that does not …

This study tests a telehealth program for 300 adults with serious mental illness who live in community settings. The program uses a medication management platform and extra care coordination services to help people stay on track with their health. Researchers will measure if it r…

This study tests a personalized support program (C4) to help Black men who have sex with men take their HIV prevention medication (PrEP) consistently. About 350 men will either get the program or standard care. The program addresses personal needs like mental health and housing t…

This study tests a smartphone-based program called HMP to help young men (ages 15-24) who have sex with men start and stick with HIV prevention (PrEP) or treatment. About 1500 participants will either get the app right away or after a delay. The goal is to see if the app improves…

This large study in Mali tests whether giving the antibiotic azithromycin to pregnant women and their newborns can prevent stillbirths and infant deaths. Over 99,000 participants are involved, comparing the antibiotic to a placebo during routine care. The goal is to find a simple…

This study tests whether a ketogenic (low-carb, high-fat) diet can reduce symptoms of schizophrenia or schizoaffective disorder. Fifty adults aged 18-64 with these conditions will be randomly assigned to either a ketogenic diet or a control diet for about 4 weeks. Researchers wil…

This early-phase study tests whether MRI-guided focused ultrasound can safely reduce severe facial pain in people with trigeminal neuralgia that hasn't responded to medication. Ten adults aged 21-75 with chronic pain for over 6 months will receive a precise ultrasound treatment t…

This study looks at how immersive virtual reality affects chronic pain, specifically in people with temporomandibular disorder (TMD). Researchers will compare VR to a placebo to see if it can increase pain endurance. About 259 adults aged 18-88 with TMD for at least 3 months are …

This study looks at whether a moderate exercise program focusing on strength, balance, speed, and agility can help children with sickle cell disease. Twenty kids aged 6 to 17 will take part. The goal is to see if the program is doable and if it improves muscle strength, walking a…

This study tests if chewing sugar-free gum during colonoscopy bowel preparation helps reduce nausea, bloating, and discomfort. About 100 adults scheduled for a colonoscopy will either chew gum or not while taking their prep drink. The goal is to see if this simple trick makes the…

This study looks at how being physically active during pregnancy changes the placenta and helps the baby grow. Researchers will collect samples from 40 pregnant women to measure how well the placenta produces energy. The goal is to understand the link between exercise and a healt…

This study was designed to see if a natural hormone called GLP-1 could protect blood vessels during repeated low blood sugar episodes in people with type 1 diabetes. It planned to enroll 40 adults aged 18-50. However, the study was withdrawn before any participants were enrolled,…

This study looks at how common undiagnosed atrial fibrillation (Afib) is in women aged 70 and older. Afib can raise the risk of stroke, and women often have worse outcomes. Researchers will use a wearable device to check heart rhythm for two weeks and track how many women are fou…

This study looks at whether modern medicines (like statins and newer blood thinners) can keep the one-year stroke rate below 5% in people with narrowed neck arteries who have already had a minor stroke or warning signs. About 114 participants are being followed to see how well th…

This study looks at whether a drug can improve how red blood cells handle stress from cold temperatures and low oxygen, like at high altitudes. Researchers will test the drug on blood samples from 50 healthy adults in a lab. The goal is to find ways to help soldiers perform bette…

This study looks at how the typhoid vaccine changes immune cells and bacteria in the gut. About 87 adults scheduled for routine colonoscopies will either get the vaccine before or after the procedure, or not at all. Researchers will collect tissue, blood, saliva, and stool sample…

This study looks at whether starting to walk immediately after surgery for broken leg, pelvis, or hip bones is safe and helpful compared to waiting 6-12 weeks. About 100 adults who had surgery within a week of their injury will be randomly assigned to one of two groups. The goal …

This study looks at how precisely small tooth-colored bumps used with Invisalign aligners match their planned shapes and sizes. Researchers will compare two attachment designs—optimized and conventional—in 30 adults starting Invisalign treatment. Digital scans taken right after p…

This study looks at whether a person's genes can predict how their body responds to canagliflozin, a drug used for type 2 diabetes. About 700 healthy Amish adults will take the drug for five days, and researchers will measure changes in urine sugar and other markers. The goal is …

This study teaches healthcare workers and researchers how to start and follow a medical ketogenic diet for mental health. Participants attend a class and can try the diet themselves for 4 weeks with group support. The goal is to help professionals feel confident using this diet i…

This study looks at how low blood sugar (hypoglycemia) affects blood vessel function in people with type 2 diabetes and healthy adults. Researchers want to see if a natural gut hormone called GLP-1 can change those effects. The goal is to better understand the link between low bl…

This study aimed to compare two devices—ultrasound and a near-infrared device called Vein Viewer—to see which helps emergency room staff start IVs faster in patients with difficult veins. The goal was to reduce delays in care. However, the study was withdrawn before enrolling any…

This study looks at two common surgeries for a certain type of hip fracture in people aged 60 and older: hip replacement or using screws/pins to hold the bone together. The main goal is to see if a larger study is possible by checking how many people join, how well the treatments…

This study was designed to see if a new method for fitting breast pump flanges (the part that goes over the breast) helps parents in the NICU produce more milk and feel more satisfied with pumping. Researchers planned to compare the new fitting method to standard instructions. Ho…

This study looks at whether eating only during certain hours of the day (time-restricted eating) can help older adults on hormone therapy for prostate or breast cancer stay stronger and more resilient. Researchers will track 30 people over 55 to see if this eating pattern is prac…

This study looks at whether a single dose of diclofenac, a common pain reliever, can change a specific brain chemical in people with alcohol use disorder. Twelve adults with mild to severe alcohol use disorder will receive either diclofenac or a placebo in a double-blind fashion.…

This study aimed to find the best length of time for patients to take antibiotics after surgery for an infected joint replacement. It planned to compare different antibiotic durations to see which works best to prevent the infection from coming back and to avoid antibiotic resist…