University Of Maryland, Baltimore

This early-stage trial is testing the safety of combining adaptive radiation with immunotherapy (durvalumab) and standard chemotherapy for people with extensive-stage small cell lung cancer that has stopped responding to platinum chemotherapy. The study aims to see how many patie…

This study looks at three different ways to treat deep cavities in children's baby molars without pulling the tooth. The treatments are two types of pulpotomy (removing part of the tooth nerve) and an indirect pulp cap (leaving some decay and sealing it). The goal is to see which…

This study tests a program to help 750 people with HIV in Botswana stop smoking. The program combines counseling and a medication called varenicline. Quitting smoking can reduce the harmful effects of HIV and prevent early death. The study also looks at how to make this help avai…

This study looks at whether chewing sugar-free gum during colonoscopy bowel preparation can help people feel less nausea, bloating, and discomfort. About 100 adults aged 45-75 scheduled for a colonoscopy will either chew gum or not during their prep. The goal is to see if this si…

This study looks at how immersive virtual reality affects chronic pain, especially in people with temporomandibular disorder (TMD). Researchers want to see if VR works differently than a placebo to reduce pain. About 259 adults aged 18-88 with TMD for at least 3 months will take …

This study tests whether a ketogenic diet (low-carb, high-fat) can reduce symptoms of schizophrenia or schizoaffective disorder. Fifty adults aged 18-64 with stable antipsychotic medication will be randomly assigned to either the ketogenic diet or a control diet for several weeks…

This study looks at whether eating only during certain hours of the day (time-restricted eating) can help older adults on hormone therapy for prostate or breast cancer stay stronger and more resilient. Researchers will measure frailty and how well the body handles stress. The goa…

This pilot study looks at two common surgeries for a certain type of hip fracture in people 60 and older: hip replacement or using screws/pins to hold the bone in place. The main goal is not to decide which is better, but to see if a larger study is possible by checking how many …

This study teaches healthcare workers and researchers how to use a medical ketogenic diet to improve mental health. Participants first attend an education class, then have the option to follow the diet themselves for 4 weeks with group support. The goal is to help professionals f…

This study checks for atrial fibrillation (an irregular heartbeat) in women aged 70 and older who have never been diagnosed with it. Researchers want to see how common it is and whether finding it leads to more use of blood thinners to prevent strokes. Participants wear a heart m…

This study looks at how a person's genes might influence their body's response to canagliflozin, a drug used for type 2 diabetes. Healthy volunteers of Amish descent will take the drug for five days, and researchers will measure how much sugar is passed in urine and check other h…