New drug combo aims to reboot immune attack on head and neck cancer
NCT ID NCT04150900
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase 2 trial tests whether adding bavituximab to pembrolizumab can help people with advanced head and neck cancer whose tumors have stopped responding to standard immunotherapy. The study enrolled 7 participants and measures how many tumors shrink or disappear. The goal is to see if this combination can re-energize the immune system to fight the cancer.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- pembrolizumab and bavituximab (two drugs that help the immune system fight cancer)
- What this could lead to
- If it works, this combination could offer a new treatment option for people with advanced head and neck cancer that has stopped responding to standard immunotherapy.
- What could go wrong
- This is a very small, early-phase trial with only 7 participants, so results may not apply to everyone. The drugs may cause immune-related side effects, and the combination might not work better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
University of Maryland Medical Center
Baltimore, Maryland, 21201, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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