University Of Maryland, Baltimore

This study tests a combination of high-protein supplements, mobility-based physical therapy, and neuromuscular electric stimulation in older adults (60+) who have been in the ICU for at least two weeks and now have muscle weakness. The goal is to see if this approach can improve …

This study looks at whether using a continuous glucose monitor (CGM) after leaving the hospital helps people with diabetes control their blood sugar better than traditional finger-stick testing. About 120 adults with poorly controlled diabetes will be randomly assigned to use eit…

This study tests a special membrane made from donated placental tissue to see if it helps preserve the jawbone after a tooth is pulled. Twelve adults needing a single back tooth extracted and later replaced with a dental implant will take part. The goal is to compare this new mem…

This study aims to develop and validate a blood test that detects DNA changes (epigenetic signatures) to diagnose pancreatic cancer. Researchers will collect blood samples from 450 adults with or at high risk for pancreatic cancer and follow them for up to 5 years. The goal is to…

This study is testing a new blood test that looks for specific DNA changes (called epigenetic changes) to help diagnose breast cancer. Researchers will collect blood samples and medical information from 450 participants, including people with breast cancer, healthy volunteers, an…

This early-stage study tests whether wearable biosensors (like a wristband or earphones) can detect malaria infection before symptoms appear. 32 healthy adults will be exposed to the malaria parasite or a placebo in a controlled setting. Researchers will compare biosensor reading…

This study tests whether giving oral vancomycin alongside other antibiotics can prevent Clostridioides difficile infection (C. diff) in older adults at high risk. About 200 participants aged 65+ who have recently been hospitalized or on antibiotics will be randomly assigned to re…

This study compares two doses of the antibiotic ceftriaxone for adults hospitalized with pneumonia. The goal is to see if a 1-gram daily dose works just as well as a 2-gram daily dose but causes fewer side effects. About 430 participants who are not in the intensive care unit wil…

This study tests a special robot-aided elliptical machine that trains the knee in side-to-side and twisting motions, not just forward-and-back. The goal is to improve knee control, reduce joint stress, and ease pain for people with knee osteoarthritis. The study will include 36 a…

This study tests a program called FPCI-AL to improve how staff and residents with dementia interact during daily care. About 100 residents aged 55+ with Alzheimer's or related dementias will take part. The goal is to reduce distress and resistance to care, and make care tasks mor…

This study tests whether a ketone supplement drink can reduce cravings and withdrawal symptoms in adults with opioid use disorder who are undergoing detox in a treatment center. Fifty participants will receive either the ketone drink or a placebo three times daily for seven days.…

This study looks at whether using a small electrical stimulation device at home can help reduce pain and improve movement in people with frozen shoulder (adhesive capsulitis). Ten adults will use the device alongside their usual clinic therapy. The goal is to see if the device is…

This early study tests whether a diabetes drug called glibenclamide (glyburide) is safe and can help reduce nerve pain in people with multiple sclerosis. Ten adults with MS and significant neuropathic pain will take the drug and be monitored for side effects and pain changes. The…

This study tests two simple activities—volunteering inside the assisted living community or joining a current events discussion group—to see if they can reduce apathy in residents with mild to moderate memory problems. About 200 people aged 55 and older will take part for 6 month…

This study compares two standard radiation methods—proton therapy and photon therapy—for women with newly diagnosed cervical or endometrial cancer. The goal is to see which approach causes fewer stomach and bowel side effects. About 116 participants will be randomly assigned to o…

This study tests whether mirikizumab, a drug that blocks IL-23 (a protein involved in inflammation), can improve negative symptoms like lack of motivation and social withdrawal in people with schizophrenia. The trial enrolls 40 adults who have a specific immune marker (AGA IgG an…

This study tests a wearable robot that helps people with traumatic brain injury (TBI) relearn leg movements while still in the hospital bed. The robot guides the leg through exercises, even if the person cannot move on their own. The goal is to improve leg function and range of m…

This study tests a drug called lebrikizumab in 15 adults with moderate-to-severe Prurigo Nodularis, a condition causing intense itching and hard skin bumps. The goal is to see if the drug can reduce itch and clear the bumps over 24 weeks. Participants receive the drug and are mon…

This study is for people with HPV-related oropharyngeal (throat) cancer, which often responds well to treatment. The goal is to see if lowering the radiation dose to certain areas can reduce side effects like dry mouth without hurting the chance of curing the cancer. About 132 pa…

This study tests whether a gradual exercise program, starting at a center and then moving to home, can help people aged 50 and older with a recently healed diabetic foot ulcer walk farther and improve strength without causing the ulcer to come back. The goal is to reduce the high…

This study aims to understand why some people develop a narrowing of the windpipe (tracheal stenosis) and how the tissue heals after laser treatment. About 40 adults with this condition will have small tissue samples taken during their routine procedure. By analyzing these sample…

This study will test whether a personalized exercise app (Gingko Active) helps middle-aged and older adults improve their strength, endurance, and balance more than following a standard exercise booklet. About 60 healthy adults aged 45 and older, some with controlled high blood p…

This study looks at whether a decision aid pamphlet can help people with low-risk thyroid cancer feel less anxious and more prepared when choosing a treatment. About 34 people will get the pamphlet after diagnosis but before seeing a surgeon. The pamphlet explains treatment optio…

This study looks at whether using a special fluid management system (ACUMEN) during heart surgery can help prevent kidney damage. About 100 adults having bypass or valve surgery will be enrolled. Researchers will measure kidney injury markers and track how much fluid is given, ai…

This study looks at how healthy people without diabetes respond to sitagliptin, an FDA-approved diabetes medication. Researchers want to understand why some people's bodies process sugar differently after taking the drug. About 400 healthy Amish adults will take part in two clini…

This study aims to understand how the nasal spray flu vaccine works by looking at immune cells in the tonsils and adenoids. Researchers will give the vaccine to 25 children and adults who are already scheduled to have their tonsils or adenoids removed for sleep apnea. By studying…

This study tests whether combining 4D MRI scans with X-ray videos taken during treatment can track lung tumors and nearby organs more accurately than current methods. About 44 adults with stage II-III lung cancer will participate. The goal is to improve radiation precision by acc…