University Hospital, Basel, Switzerland

This study looks at whether a low dose of the steroid prednisolone can effectively treat liver inflammation (hepatitis) caused by immune checkpoint inhibitors in cancer patients. About 63 adults with grade 2-3 liver inflammation will receive 0.5-1 mg per kg of prednisolone. The g…

This study tests a peer-led program called PEGISUS for young people aged 16-24 in vocational training in Zambia, Zimbabwe, and South Africa who use alcohol or drugs weekly. Participants join nine group sessions focused on reducing substance use and promoting fair gender beliefs. …

This study tests whether adding the antibiotic linezolid to standard treatment helps people with serious staph bloodstream infections. About 606 hospitalized adults will be randomly assigned to get either standard antibiotics alone or standard antibiotics plus linezolid. The goal…

This study tests whether empagliflozin, a diabetes drug, can safely raise low sodium levels in patients with certain conditions like liver or kidney failure. About 172 adults with chronic low sodium will receive either the drug or a placebo for a short period. The goal is to see …

This study looks at whether a special retreat program called 'Via Shalva' is helpful and practical for people who have finished treatment for breast or gynecologic cancer. About 30 survivors will take part to see if the retreat improves their quality of life, stress, and overall …

This study looks at whether it is safe to temporarily stop taking beta-blockers (a heart medication) before a procedure called transcatheter aortic valve replacement (TAVR) for people with severe aortic stenosis. About 498 adults who are scheduled for TAVR and have been on beta-b…

This study follows 1000 men with enlarged prostate symptoms who receive Rezum water vapor therapy. The goal is to see how well the treatment relieves urinary symptoms and improves quality of life over 5 years. Participants are real-life patients treated at multiple centers, and t…

This study tests whether a nasal spray containing oxytocin can help reduce anxiety and improve how people with central diabetes insipidus recognize emotions in others. About 112 adults with the condition and high anxiety levels will receive either oxytocin or a placebo spray for …

This study is for 500 adults having elective heart surgery with a heart-lung machine. Researchers will monitor each patient's personal blood pressure limits using special brain sensors. The goal is to see if keeping blood pressure within those limits reduces the risk of brain pro…

This study looks at whether trained community health workers can effectively screen and manage chronic diseases like high blood pressure and diabetes in rural Lesotho. About 17,500 adults will take part, with health workers using simple tools and eHealth apps to monitor and refer…

This study aims to find out whether the antidepressant effects of DMT come from the psychedelic experience itself or from biological changes in the brain. Researchers will give DMT to 112 adults with major depression, but some will receive a sedative (propofol) to block the psych…

This study explores whether taking oral estradiol can trigger the release of oxytocin, a key hormone. Researchers aim to develop a safe diagnostic test for oxytocin deficiency in people with AVP deficiency (diabetes insipidus). The study involves 28 healthy adults and patients, m…

This study uses whole genome sequencing to track how ESBL-producing bacteria (a type of drug-resistant germ) spread among hospital patients and staff. Researchers will analyze samples from 2,000 people to find out whether infections come from other patients, the environment, or e…

This worldwide study looks at a rare but serious complication—a torn blood vessel—that can happen during a stroke treatment called thrombectomy. Researchers will study 1000 patients to find out what makes this tear more likely and how doctors can best manage it. The goal is to ma…

This study follows nearly 20,000 adults who had major non-cardiac surgery to learn how often heart injury occurs, who is at risk, and what happens over the next year. Researchers will track deaths and major heart problems to find better ways to prevent and treat this condition.

This study looks at how energy use inside cancer and immune cells influences treatment success in blood cancers like leukemia and lymphoma. Researchers will analyze samples from 350 adults to understand why some cancers resist therapy. The goal is to find new ways to improve outc…

This study tests whether an artificial intelligence (AI) system can measure hydration status using ultrasound images of a large vein in the belly, compared to experienced and beginner human operators. Fifty healthy adults will have their vein scanned before and after a fluid chal…