University Hospital, Basel, Switzerland

This study tests a drug called nintedanib in 20 people who developed bronchiolitis obliterans syndrome (a lung condition) after a stem cell transplant. Participants take the drug daily for 12 months on top of their usual anti-rejection medicines. The goal is to see if the drug is…

This study looks at how two different ways of using dopamine agonists (medicines that shrink prolactinomas) affect the body's ability to handle sugar. About 60 adults with prolactinoma will be randomly assigned to one of two treatment strategies. The main goal is to see which app…

This study involves 600 people with HER2+ or triple-negative breast cancer who still have cancer in their armpit lymph nodes after chemotherapy. Researchers want to see if it is safe to skip removing those lymph nodes (axillary lymph node dissection) without increasing the risk o…

This study tests whether adding a blood pressure drug (nicardipine) to a standard liver cancer treatment (TACE) can improve outcomes. About 152 adults with liver cancer will receive either TACE plus nicardipine or TACE alone. The goal is to see if the combination shrinks tumors m…

This study tests a new treatment for knee osteoarthritis (patellofemoral type) using a cartilage graft made from the patient's own nasal cells. 150 adults aged 18-70 will receive either this experimental implant or standard care (a cartilage repair procedure or partial knee repla…

This study compares two ways to stop long-term steroid treatment in people with inflammatory or autoimmune conditions. One group stops steroids right away, while the other slowly reduces the dose over 4 weeks. The goal is to see if stopping quickly is as safe and causes fewer sid…

This study tests whether a lab-grown cartilage implant made from a patient's own nasal cells can reduce knee pain from patellofemoral osteoarthritis better than standard platelet-rich plasma injections. About 75 adults aged 18–65 with moderate knee damage will receive either the …

This study tests whether gently stretching the pylorus (the valve between stomach and small intestine) with a balloon during minimally invasive esophageal cancer surgery can prevent a common complication where the stomach empties too slowly. About 116 adults with esophageal cance…

This study tests whether offering a choice of nicotine replacement products (like e-cigarettes, nicotine pouches, or patches) helps people with HIV quit smoking. About 972 smokers from the Swiss HIV Cohort Study will be randomly assigned to receive either the usual care or a menu…

This study looks at whether adding a drug called Wilate (a von Willebrand factor concentrate) to standard platelet transfusions can reduce bleeding and the need for more blood products in intensive care patients. About 120 adults who need platelets during or after surgery will be…

This study tests whether using telemedicine (video or phone check-ins) can help doctors better adjust heart failure medications after patients leave the hospital. About 140 adults with heart failure and reduced pumping ability will be split into two groups: one gets usual care, t…

This study tests whether the diabetes drug empagliflozin (Jardiance) can safely raise low sodium levels in people with certain conditions like SIADH, liver failure, or kidney failure. About 172 adults with chronic low sodium will receive either the drug or a placebo for up to 30 …

This study tests whether adding the antibiotic linezolid to standard treatment helps people with serious staph infections in the blood. About 606 hospitalized adults will be randomly assigned to get either standard antibiotics alone or standard antibiotics plus linezolid. The goa…

This study tests a treatment that uses immune cells taken from a patient's own lung tumor. These cells are grown in large numbers and given back to the patient to attack the cancer. The trial includes 30 adults with advanced non-small cell lung cancer that has worsened after stan…

This study looks at whether a low dose of the steroid prednisolone can effectively treat moderate to severe liver inflammation (hepatitis) that some cancer patients get from immunotherapy drugs. About 63 adults with cancer who develop this side effect will receive a low steroid d…

This study is for adults with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS) who have had a stem cell transplant from a half-matched donor. After the transplant, participants receive extra immune cells called natural killer (NK) cells from the same donor to try t…

This study tests if placing a small tube (stent) in a hardened brain artery during a stroke helps patients recover better than standard clot removal methods. About 500 adults with severe stroke from a blocked large artery will be randomly assigned to one of the two treatments. Th…

This study tests two new measurements (aSID and ChU) to help doctors quickly identify why hospitalized patients on thiazide diuretics have low sodium levels. About 136 adults will be randomly assigned to receive treatment guided by these new tests or standard care. The goal is to…

This study explores whether taking a specific estrogen pill can safely trigger the release of oxytocin, a hormone important for social bonding and childbirth. Researchers will measure oxytocin levels in 28 healthy volunteers and people with AVP deficiency (a condition affecting w…

This study tests whether giving ICU patients 0.5 liters of wheat beer each evening for 6 days can lower their risk of developing delirium, compared to patients who receive water. Delirium is a sudden confused state common in intensive care. The trial will include 380 adults who h…

This study tests two simple methods—drinking less water or taking protein supplements—to prevent low sodium levels after pituitary surgery. Low sodium is a common complication that can cause confusion and other issues. About 282 adults having pituitary surgery will be randomly as…

This study tests whether an intensive follow-up program can improve bowel control and quality of life for people who have had rectal cancer surgery. About 140 adults who had surgery and a temporary colostomy will be split into two groups: one gets the intensive program with extra…

This study looks at whether it is safe to temporarily stop taking beta-blockers (a heart medication) in patients scheduled for a procedure called transcatheter aortic valve replacement (TAVR) to treat a narrowed heart valve. About 498 adults with severe aortic stenosis will be ra…

This study tests whether using a smaller chest drain (16F) instead of the standard larger one (24F) can reduce pain after minimally invasive lung surgery for cancer. About 124 adults having lung lobe or segment removal will be randomly assigned to one drain size. The main goal is…

This study compares two treatments for breast cancer that has spread to lymph nodes: radiotherapy (ART) or surgery (ALND). The goal is to see which approach causes less arm swelling and better quality of life two years after treatment. About 1,060 adults with node-positive breast…

This study compares lymphatic surgery to standard conservative therapy (like compression and massage) for people with chronic arm swelling after breast cancer treatment. About 280 participants will be randomly assigned to one of the two approaches. The main goal is to see if surg…

This study tests whether moderate to high doses of LSD can reduce anxiety, depression, and pain in people with advanced, life-limiting illnesses. Sixty participants with a life expectancy of 12 weeks to 2 years will receive either two moderate-to-high LSD doses or two very low (a…

This study tests whether a nasal spray containing oxytocin (the 'love hormone') can improve sexual well-being in people with central diabetes insipidus, a condition that causes extreme thirst and frequent urination. About 42 participants (patients and healthy volunteers) will rec…

This early-stage study explores whether MDMA (the active ingredient in ecstasy) can reduce pain. Twenty healthy volunteers will receive either MDMA or a placebo, while mild pain is created using small electrical pulses under the skin. Researchers will compare pain ratings between…

This study follows 1000 men with an enlarged prostate who are receiving Rezum water vapor therapy, a minimally invasive steam treatment. The goal is to see how well it relieves urinary symptoms and improves quality of life over 5 years. Researchers will track symptom scores, urin…

This study tests whether a nasal spray containing oxytocin, a natural hormone, can reduce anxiety and improve emotional recognition in adults with central diabetes insipidus (a condition where the body can't balance water properly). About 112 participants with high anxiety or tro…

This study looks at whether a special retreat program called 'Via Shalva' is helpful and practical for people who have finished treatment for breast or gynecologic cancer. About 30 survivors will take part to see if the program improves quality of life, stress, and other health m…

This study looks at whether trained community health workers can effectively screen and manage chronic diseases like high blood pressure and diabetes in rural Lesotho. About 17,500 adults will take part, with health workers using simple tools and eHealth apps to monitor and refer…

This study tests whether an artificial intelligence (AI) system can measure hydration status using ultrasound as well as experienced and beginner human operators. Fifty healthy adults will have their main vein (inferior vena cava) scanned before and after a fluid challenge. The g…

This study looks at whether taking 200mg of caffeine (about two cups of coffee) changes how active your brown fat is when you're mildly cold. Brown fat is a type of body fat that burns energy to generate heat. Researchers will scan 12 healthy adults to measure brown fat activity …

This study looks at whether slowly increasing the dose of the sleep medicine propofol based on each person's needs can keep blood pressure more stable than a standard starting dose. It involves 320 adults aged 55 and older having planned non-heart surgery. The goal is to find a s…

This study gives healthy adults a single intravenous dose of 5-MeO-DMT, a psychedelic substance, or a placebo. Researchers monitor how participants feel, their heart rate and blood pressure, and drug levels in the blood. The goal is to understand the drug's short-term effects and…

This study looks at how the immune system helps the body accept a pregnancy during the first three months. Researchers will analyze blood samples from 100 women undergoing IVF to understand which immune cells and genes are linked to healthy pregnancies or miscarriages. The goal i…

This study aims to find out if the antidepressant effects of DMT come from the psychedelic experience itself or from biological changes in the brain. Researchers will give DMT to 112 adults with major depression, but some will also receive propofol to block the psychedelic experi…

This study looks at whether fluid buildup in veins (congestion) affects blood flow in the smallest blood vessels after planned heart surgery. Researchers will monitor 40 adults in the ICU using ultrasound and other tools. The goal is to better understand these connections, not to…

This study tests a new MRI method called AMIRA to better detect spinal cord lesions in people with multiple sclerosis (MS). Ten adults with MS will get both standard and new MRI scans. The goal is to see if the new method finds more lesions and helps doctors agree on what they se…

This study looks at people who have had repeated, mild episodes of diverticulitis (inflammation of pouches in the colon). It compares those who have surgery to remove the affected part of the colon with those who manage the condition without surgery. The goal is to see which appr…

This study is testing a tool called the International Early Warning Score (IEWS) to see if it can better predict which emergency room patients are at risk of dying within 30 days. Researchers will track about 6,500 adults who come to the ER over several weeks, looking at their sy…

This study uses whole genome sequencing to track how ESBL-producing bacteria (a type of drug-resistant germ) spread among hospital patients and staff. Researchers will analyze samples from 2,000 people to find out where infections come from and how they move. The goal is to bette…

This study looks at how physical activity, fitness, stress, and sleep impact pregnancy rates in women receiving fertility treatments like IVF or IUI. Researchers will track 115 women's exercise habits and health factors to see if they relate to treatment success. The goal is to b…

This study looks at 500 adults having heart surgery to see if keeping blood pressure within a personalized range for each patient's brain can lower the risk of confusion, stroke, or memory loss after surgery. Researchers will use special monitors to track brain blood flow and adj…

This study reviews medical records of 1,000 patients who came to the hospital with sudden neurological symptoms like weakness, speech problems, or seizures. The goal is to find out how many are diagnosed with Functional Neurological Disorder (FND), a condition where the brain doe…

This study aims to create a new tool to measure pain during cesarean delivery (C-section) while the mother is awake. Researchers will review existing studies, ask experts for their opinions, and interview 15 women who recently had a C-section to make sure the tool focuses on what…

This study is a registry that will collect health information from 5,000 adults (18 and older) with congenital heart disease who are treated at specialized Swiss centers. The goal is to better understand long-term complications and improve treatment strategies. No new treatments …

This study aims to better understand multiple sclerosis (MS) by using artificial intelligence and digital health tools. Researchers will follow 100 adults with MS, collecting medical images, blood samples, and smartphone data to find patterns that predict disease progression. No …

This study explores whether music enhanced by sonic augmentation technology can raise oxytocin levels with few side effects. Researchers will compare the effects of modified music versus regular music in 22 healthy adults and patients with AVP-deficiency. The goal is to understan…

This study is looking at whether tiny bits of tumor DNA (ctDNA) found in blood or urine can help doctors better understand and predict the course of a high-risk type of bladder cancer called T1G3. About 35 adults with this cancer will provide samples before, during, and after tre…

This study follows 600 transgender and gender-diverse people in Switzerland to learn what affects their health and happiness during gender-affirming treatments. Participants fill out surveys, give blood and other samples, and have routine check-ups. The goal is to find out which …

This study looks at how different breathing pressures and body positions (on your back vs. on your stomach) change blood flow in the veins of 40 healthy adults. Researchers use ultrasound to measure vein congestion. The goal is to better understand these effects, not to treat any…

This large international study is investigating a rare but serious complication that can happen during a procedure to remove blood clots in stroke patients: a tear in a blood vessel. Researchers will study 1000 patients to understand what causes these tears and how to best manage…

This study looks at whether giving protein in small, frequent doses (like a bolus) is better than continuous feeding for preventing muscle wasting in critically ill patients. Researchers will measure how quickly patients reach their daily protein goal and track muscle changes wit…

This study looks at a new compound called DDH-LSD, which is similar to LSD but is expected to wear off faster. Researchers will give 24 healthy adults DDH-LSD, LSD, or a placebo in random order to compare how long each lasts, how the body processes them, and what effects people f…

This study tests a peer-led program called PEGISUS that aims to reduce substance use and promote fair gender attitudes among young adults aged 16-24 in vocational training programs in Zambia, Zimbabwe, and South Africa. Participants will either join the PEGISUS peer group session…

This study looks at how energy use inside cancer and immune cells changes the bone marrow and may make treatments stop working. Researchers will collect samples from 350 adults with certain blood cancers and from healthy volunteers. The goal is to find new clues that could lead t…

This study is tracking how breast surgery affects patients' quality of life and satisfaction. Researchers will survey 1000 adults who had any type of breast surgery at the University Hospital of Basel. The goal is to better understand the surgery's impact, not to test a new treat…

This early-phase study looks at whether a natural smell can be detected in the spinal fluid of 32 adults (some obese, some lean) after they inhale it. Participants already scheduled for a spinal tap will also give blood samples and breathe in either the odor or a placebo. The goa…