University Hospital, Basel, Switzerland

This study tests whether trained village health workers, supported by an eHealth app, can effectively manage high blood pressure in rural Lesotho. About 1,350 adults with either uncontrolled or controlled hypertension will receive either community-based care from these workers or…

This early-phase trial tests a new treatment for advanced melanoma that uses a patient's own immune cells (tumor-infiltrating lymphocytes) combined with a drug called ANV419 to help those cells grow. The main goal is to check safety in 10 adults with stage III or IV melanoma that…

This pilot study tests whether a 6-month low-carbohydrate diet can improve blood sugar control and body composition in 40 obese adults with or without prediabetes or diabetes. Participants follow a low-carb eating plan, and researchers measure changes in blood sugar, body fat, an…

This study tests whether trained village health workers can safely manage type 2 diabetes in rural Lesotho using eHealth tools. About 252 adults with diabetes will either receive care from village workers or standard clinic care. The goal is to see if community-based care can con…

This early-phase study tests a radioactive drug (177Lu-PP-F11N) that seeks out and attaches to cancer cells in people with advanced medullary thyroid cancer and certain other neuroendocrine tumors. The goal is to see if the drug can help image tumors and deliver targeted radiatio…

This study tests whether a less extensive surgery that removes only the cancer-affected lymph nodes, followed by radiation, works as well as removing all lymph nodes in the armpit for breast cancer patients whose cancer has spread to the nodes. The goal is to reduce side effects …

This study compares two blood test methods for diagnosing heart attacks in people with chest pain. The standard method measures a heart damage marker at arrival and again 3 hours later. The newer method does the second measurement just 1 hour later. Researchers want to see if the…

This study compares a new, non-invasive PET-MRI scan to the current standard invasive test (IPSS) for finding pituitary tumors in people with Cushing's disease. The goal is to see if the scan can accurately tell Cushing's disease from other similar conditions. About 43 adults wit…

This study looks at whether a simple blood test (liquid biopsy) can be used during routine care for people with advanced solid tumors. Researchers will check how often the test finds cancer DNA and whether it helps doctors choose better treatments. About 159 patients will partici…

This study planned to test whether two drugs, empagliflozin and anakinra, could help people with prediabetes who experience low blood sugar after meals. The trial was withdrawn before enrolling any participants, so no results are available. It was designed for adults with prediab…

This study looks at why some people have Long COVID symptoms like fatigue and brain fog. It also tests if a 12-week smartphone app with breathing exercises, relaxation, and energy management can help. About 120 adults with Long COVID are taking part to share health data and try t…

This study looks at whether low blood pressure during major non-cardiac surgery can harm organs like the heart and kidneys. Researchers used a special brain monitor to find each patient's safe blood pressure range. The goal is to see if staying within that range can reduce compli…

This study surveys 530 prolactinoma patients and their doctors to understand real-world treatment experiences, side effects, and preferences. The goal is to identify gaps in care and guide future research for better, more personalized treatment strategies. No new treatments are t…

This study follows nearly 20,000 patients who had major non-cardiac surgery to learn about heart injuries that can happen during or after the procedure. Researchers track how common these injuries are, what patient factors are involved, and how they affect survival and heart heal…

This study looks at how changing the length of the small intestine during gastric bypass surgery affects metabolism and inflammation in people with severe obesity. Researchers will compare 50 patients who had the surgery with 15 healthy volunteers. The goal is to understand the b…

This study looks at how three common sugars—sucrose, glucose, and fructose—affect the body in healthy, normal-weight adults. Researchers will measure changes in gut hormones, blood sugar, blood clotting, and how fast the stomach empties. The goal is to better understand the body'…

This study looks at whether a new screening system can help doctors find heart complications early in patients who are at high risk after noncardiac surgery. About 900 adults aged 40-85 will be monitored using blood tests and checkups. The goal is to see if this approach is pract…

This study tests whether a new monitoring method can track brain blood flow in real time during major noncardiac surgery. Researchers will enroll 256 adults to see if the Medtronic Cotrending algorithm works reliably. The goal is to learn if this tool can help doctors keep the br…

This pilot study looks at how daily consumption of erythritol (a sugar substitute) compares to regular sugar over 5 weeks in healthy adolescents aged 14-18. Researchers are measuring insulin resistance, blood clotting, and how well the body handles glucose. The goal is to gather …