National Cancer Institute (nci)

This study tested whether combining two immunotherapy drugs (ipilimumab and nivolumab) with radiation therapy works better than the standard chemotherapy (temozolomide) plus radiation for a type of aggressive brain cancer called glioblastoma that lacks a specific marker (MGMT unm…

This early-stage trial tested a combination of two drugs, lenalidomide and blinatumomab, in 35 adults with non-Hodgkin lymphoma that had come back or stopped responding to treatment. The main goal was to find the safest dose and understand side effects. Researchers also looked at…

This study tested whether adding the drug veliparib to standard chemotherapy (cisplatin) helps people with advanced triple-negative or BRCA-related breast cancer, including those with brain tumors. About 344 participants received either cisplatin plus veliparib or cisplatin plus …

This large phase III trial tested whether adding bortezomib and sorafenib to standard chemotherapy helps people with newly diagnosed acute myeloid leukemia (AML) live longer without the cancer returning. Over 1,600 participants took part. The study focused on patients with a spec…

This early-phase trial tested a new drug called TdCyd in 27 adults with advanced solid tumors that had stopped responding to standard treatments. The drug is designed to turn back on genes that may slow tumor growth. The main goal was to find a safe dose and check for side effect…

This early-phase study tested a combination of two chemotherapy drugs (gemcitabine and carboplatin) plus lenalidomide, which blocks blood vessel growth in tumors, for people with advanced solid tumors, especially urothelial (bladder) cancer. The main goal was to find the safest d…

This study tested whether adding a drug called oblimersen to standard chemotherapy (daunorubicin and cytarabine) helps older adults (60+) with untreated acute myeloid leukemia live longer or achieve remission. About 500 participants were randomly assigned to receive chemo with or…

This study tested whether adding two immunotherapy drugs (dinutuximab and GM-CSF) to standard chemotherapy is safe and doable for children newly diagnosed with high-risk neuroblastoma. Forty-two children took part. The goal was to see if the extra drugs cause too many side effect…

This study tested different combinations of immunotherapy drugs in 59 adults with advanced prostate cancer that no longer responds to hormone therapy. The goal was to see if these combinations are safe and can help shrink tumors or lower PSA levels. Participants received up to fo…

This study tested a combination of three hormone-blocking drugs (abiraterone, enzalutamide, and standard hormone therapy) given before surgery in 12 men with newly diagnosed prostate cancer that hadn't spread. Researchers also used special MRI and PET/CT scans with a new tracer t…

This study tested whether the drug palifermin could make stem cell transplants from unrelated donors safer and more effective for people with blood cancers like leukemia or lymphoma. 34 adults received palifermin before transplant to see if it would reduce severe graft-versus-hos…

This study tested a special pump placed under the skin that sends chemotherapy directly to the liver through the hepatic artery. It was for people with colorectal cancer that had spread to the liver and who had already tried other chemotherapies. The goal was to see if this direc…

This study tested a combination of three drugs (carfilzomib, lenalidomide, and dexamethasone) in 55 people with high-risk smoldering multiple myeloma, a condition that often leads to active myeloma. The goal was to see if early treatment could reduce or eliminate cancer cells in …

This study tested a combination of two drugs—nilotinib pills and paclitaxel given through a vein and directly into the abdomen—in 21 adults with cancers that had spread to the lining of the belly and could not be surgically removed. The goal was to shrink the tumors enough to all…

This early-phase study tested a combination of two drugs, dasatinib and bevacizumab, in 50 adults with advanced solid tumors that no longer responded to standard treatments. The goal was to find the safest dose and see how the drugs affect the cancer and the body. Participants to…

This study tested two different drug combinations in 135 people with untreated follicular lymphoma, a slow-growing blood cancer. One group received ofatumumab and bendamustine, while the other got those two drugs plus bortezomib. The goal was to see which combination led to more …

This study looked at 196 people with advanced head and neck cancer who could not take the standard drug cisplatin. Researchers compared radiation therapy combined with either durvalumab (an immunotherapy) or cetuximab (a targeted drug) to see which worked better. The goal was to …

This early-phase study tested a combination of four drugs (romidepsin, CC-486, dexamethasone, and lenalidomide) in 26 adults with T-cell cancers that had returned or stopped responding to standard treatments. The main goal was to find a safe dose and see how well patients tolerat…

This study tested two oral medications, sunitinib and cediranib, in 34 people with a rare and hard-to-treat cancer called alveolar soft part sarcoma (ASPS) that had spread. Participants were randomly assigned to one drug, and if their cancer worsened, they could switch to the oth…

This study tested a new treatment for children and young adults (ages 1-39) with B-cell leukemia or lymphoma that did not respond to standard therapy. The treatment involved taking a patient's own white blood cells, modifying them in a lab to target the CD22 protein on cancer cel…

This study tested a drug called pomalidomide in 34 adults with chronic graft-versus-host disease (GvHD) that didn't improve with standard treatments. GvHD can happen after a stem cell transplant when the donor cells attack the recipient's body. Participants took pomalidomide caps…

This study tested whether adding the drug veliparib to standard chemotherapy (FOLFIRI) helps people with metastatic pancreatic cancer that has come back after initial treatment. 123 adults took part. The goal was to see if the combination improves overall survival compared to che…

This study tested the safety and highest tolerable dose of a second round of radiation for people whose glioblastoma (a type of brain tumor) came back after initial treatment. Seventeen adults aged 18 to 50 with good overall health took part. The goal was to find a dose that cont…

This early-phase trial tested whether combining two drugs—durvalumab and vicineum—is safe and effective for people with a high-grade bladder cancer that hasn't spread to the muscle but came back after standard treatment. Fifteen adults took part, receiving the drugs for up to two…

This early-phase study tested whether adding nilotinib (a pill) to paclitaxel (a standard chemo drug) could safely treat advanced solid tumors that had stopped responding to other therapies. 47 adults and children aged 12 and older took part. The goal was to find the safest dose …

This early-phase study tested a three-drug combination (IL-15, nivolumab, and ipilimumab) in 31 adults with cancers that no longer responded to standard treatments. The goal was to find the safest dose and see if the drugs could work together to help the immune system attack tumo…

This study looked at whether giving a special antibody (edrecolomab) after surgery helps people with stage II colon cancer live longer. About 2,100 patients took part, some getting the antibody and some just being watched. The goal was to see if the antibody could kill any leftov…

This study tested whether adding a precise type of radiation (SBRT) to the immunotherapy drug pembrolizumab helps control advanced Merkel cell carcinoma better than the drug alone. Nine adults with cancer that had spread took part. The goal was to see if the combination slowed tu…

This study tested a drug called trametinib in 260 people with low-grade ovarian or peritoneal cancer that returned or worsened. Trametinib works by blocking certain enzymes that help cancer cells grow. The goal was to see if it works better than standard treatments like hormone t…

This study tested whether adding trastuzumab (a targeted antibody) to standard chemoradiation helps people with HER2-positive esophageal cancer. About 200 patients participated. The goal was to see if the combination delays cancer return or spread. Results showed improved disease…

This early-phase study tested a highly targeted type of radiation (SBRT) in 17 men whose prostate cancer returned after prior radiation. The goal was to find the highest safe dose and see how well the body tolerated it. Participants received five focused treatments over two weeks…

This study tested a new combination of treatments for people with advanced gastric or head and neck cancer that had not responded to standard therapy. Participants received specially engineered natural killer (NK) cells along with two immunotherapy drugs to help the immune system…

This study tested the drug palbociclib in 23 children and young adults (ages 1-21) with advanced cancers that had come back or weren't responding to treatment. Only patients whose tumors had specific gene changes (cell cycle mutations) and a protein called Rb were included. The g…

This study looked at 55 people with advanced head and neck cancer that had come back or spread. It compared the drug cetuximab alone versus cetuximab plus sorafenib to see which worked better at slowing the cancer. The goal was to find a more effective treatment option for this h…

This study tested a high-dose internal radiation therapy (brachytherapy) in 43 adults with cervical, endometrial, esophageal, prostate, or biliary cancer. The goal was to see if the radiation implants could be placed accurately to deliver the right dose. Participants received the…

This early-phase study tested whether adding the immunotherapy drug atezolizumab before and during standard chemoradiation could help the immune system fight advanced cervical cancer that has spread to lymph nodes. Forty participants with stage IB2 to IVA cervical cancer received…

This early-phase trial tested two experimental drugs, FdCyd and THU, taken by mouth to treat advanced solid tumors that no longer respond to standard therapies. The study involved 59 adults and aimed to find a safe dose and schedule. The drugs work by changing how cancer cells us…

This study tested the drug cabozantinib in 102 people with endometrial cancer that returned or spread. The goal was to see if the drug could shrink tumors or slow cancer growth by blocking certain enzymes and blood flow to tumors. The trial focused on how many patients responded …

This early-phase study tested a combination of two cancer drugs, bortezomib and clofarabine, in 28 adults with advanced solid tumors, lymphomas, or myelodysplastic syndromes that had stopped responding to standard treatments. The main goal was to find the safest dose and check fo…

This early-phase trial tested an experimental drug called Z-Endoxifen in 40 adults with hormone receptor-positive cancers (like breast, ovarian, or desmoid tumors) that had stopped responding to standard treatments. The drug works by blocking estrogen from fueling cancer growth, …

This study tested whether adding a prostate cancer vaccine (PROSTVAC) and chemotherapy (docetaxel) to standard hormone therapy could help men whose prostate cancer had spread. 74 men with metastatic castrate-sensitive prostate cancer took part. The goal was to see if the combinat…

This early-phase study tested a combination of two drugs—veliparib and temozolomide—in 66 adults with acute leukemias that had come back or not responded to standard treatment. The goal was to find the safest dose and see how well the combination worked. Veliparib blocks a repair…

This study tested a drug called tazemetostat in 20 children and teens whose cancers had come back or didn't respond to treatment. Only those with specific gene changes (EZH2, SMARCB1, or SMARCA4) in their tumors were included. The goal was to see if the drug could shrink tumors o…

This early-phase study tested a combination of two drugs, sapanisertib and ziv-aflibercept, in 83 people with advanced solid tumors that had spread or could not be removed. The goal was to find the safest dose and check for side effects. The drugs work by blocking cancer cell gro…

This early-stage trial tested whether adding immunotherapy drugs (durvalumab, monalizumab, or oleclumab) to radiation therapy is safe for people with locally advanced non-small cell lung cancer that cannot be removed by surgery. Twenty-six participants received different combinat…

This study tested whether adding immunotherapy (dinutuximab plus immune-stimulating drugs) to standard treatment after a stem cell transplant helps children with high-risk neuroblastoma live longer without the cancer coming back. About 1,400 children took part. The results showed…

This early-phase study tested a new drug (AZD8186) combined with chemotherapy (docetaxel) in 23 people with advanced solid tumors that have certain gene mutations (PTEN or PIK3CB). The main goal was to find the safest dose and understand side effects. The study is complete, and r…

This study tested a drug called samotolisib in 18 children whose cancers had come back or didn't respond to treatment. The children had specific gene changes in their tumors. The goal was to see if the drug could shrink or stop the cancer. The study was completed, but results are…

This study tested a treatment for advanced melanoma that uses a patient's own immune cells, grown in a lab, to attack tumors. Before getting the cells back, patients received chemotherapy to lower their immune system. Some patients also got total body radiation to see if it helpe…

This study tested a new three-drug combination (VIP152, venetoclax, and prednisone) in 8 adults with aggressive lymphomas that had stopped responding to treatment or come back. The goal was to check safety and find the best dose, while also measuring how many patients had their t…

This study tested the drug ibrutinib as a first treatment for people newly diagnosed with moderate to severe chronic graft-versus-host disease (cGVHD), a condition where donor cells attack the recipient's body after a stem cell transplant. Ten adults took ibrutinib daily for up t…

This large study tested whether giving chemotherapy directly into the abdomen (intraperitoneal) works better than standard IV chemo when both are combined with the drug bevacizumab. It included over 1,500 people with stage II–IV ovarian, fallopian tube, or primary peritoneal canc…

This study looked at 546 people who had surgery for pancreatic cancer. It tested whether adding a targeted drug (erlotinib) or radiation therapy to standard chemotherapy could help them live longer. The goal was to see if these extra treatments could kill any remaining cancer cel…

This study tested whether adding bevacizumab to the immunotherapy drug ipilimumab helps people with advanced melanoma that cannot be surgically removed. A total of 169 participants received either ipilimumab alone or with bevacizumab. The goal was to see if the combination improv…

This early-phase trial tested a new combination of drugs for people with extensive-stage small cell lung cancer that had not been treated before. The goal was to find the best dose and see if adding entinostat to standard treatments (atezolizumab, carboplatin, and etoposide) is s…

This early-stage trial tested whether adding the drug navtemadlin to standard radiation therapy before surgery is safe for people with soft tissue sarcoma. The goal was to find the best dose and see if the combination could shrink tumors, making surgery less extensive. 39 partici…

This study tested whether using PET/CT scans during treatment to adjust radiation doses can improve outcomes for people with stage III non-small cell lung cancer. 138 participants received either standard radiation or a personalized, adaptive approach. The goal was to see if the …

This study tested two drugs, olaparib and ramucirumab, together in people with advanced stomach or gastroesophageal junction cancer that had spread or come back. The goal was to find the safest dose and see if the combination could shrink tumors. 51 participants took part in this…

This study tested a new treatment for cancers caused by HPV-16, such as cervical, throat, and anal cancers. Researchers took patients' white blood cells, added genes to help them recognize and attack cancer cells with the E7 protein, and infused them back. The goal was to find a …

This study tested whether adding either veliparib or pembrolizumab to standard chemotherapy and radiation could improve outcomes for people with locally advanced rectal cancer. 363 participants received one of these combinations before surgery. The goal was to shrink tumors and r…

This large phase 3 trial studied nearly 6,000 children and young adults with newly diagnosed, high-risk B-cell acute lymphoblastic leukemia (B-ALL), including those with a specific genetic mutation (Ph-like). The goal was to see if different combinations and doses of chemotherapy…

This early-stage trial tested a combination of two drugs, magrolimab and dinutuximab, in 12 children and young adults with neuroblastoma or osteosarcoma that had come back or stopped responding to treatment. The main goal was to find the safest dose and see if the combination cou…

This early-phase study tested whether immune cells called natural killer (NK) cells could be safely given to children and young adults with solid tumors that did not respond to standard treatments. Sixteen participants received their own activated NK cells, with or without an imm…

This early-phase study tested whether giving specially engineered immune cells from the original stem cell donor could help control B-cell cancers (like some leukemias and lymphomas) that returned after a transplant. 85 adults aged 18-75 who had a prior donor stem cell transplant…

This study tested a shorter course of a chemotherapy combination called EPOCH-R in 68 people with HIV and a type of lymphoma. The goal was to see if less chemotherapy could still control the cancer while reducing damage to the immune system. Participants received 3 to 6 cycles of…

This study tested an oral drug called Minnelide in 16 adults with a rare, aggressive form of pancreatic cancer (ASCP) that had not responded to prior treatments. The goal was to see if the drug could shrink tumors or stop them from growing for at least 16 weeks. Participants took…

This study tested whether adding carboplatin and/or bevacizumab to standard chemotherapy before surgery helps shrink tumors more effectively in people with a hard-to-treat type of breast cancer (hormone receptor-poor, HER2-negative). About 454 participants received weekly paclita…

This study looked at two ways to manage ovarian cancer risk in 40 women with BRCA gene mutations or strong family history. One group had preventive surgery to remove ovaries and fallopian tubes, while the other group had regular CA-125 blood tests to catch cancer early. Researche…

This study tested whether using a virtual reality (VR) headset at home could help reduce anxiety and distress in adults with primary brain tumors. Sixty-one participants used VR to view calming, computer-generated environments. The goal was to see if this approach was practical a…

This study tested a shorter course of radiation (2–4 weeks instead of 6–7) for men whose prostate cancer came back after prostate removal. The goal was to find the shortest schedule that is safe and tolerable. 30 men participated, and the researchers focused on giving a higher do…

This study looked at whether a 12-week physical activity program could improve memory and attention in children ages 8-17 who had radiation for a brain tumor at least 2 years ago. 36 children were split into two groups: one started the exercise program right away, the other conti…

This study tested whether PET-CT scans can find leukemia hiding outside the bone marrow in people with relapsed or hard-to-treat B-cell acute lymphoblastic leukemia (ALL). Ten participants received a PET scan before CAR T-cell therapy to look for these hidden spots. The goal was …

This study looked at people with three rare genetic diseases that affect the body's ability to repair DNA: xeroderma pigmentosum (XP), Cockayne syndrome (CS), and trichothiodystrophy (TTD). Researchers examined 709 participants, including patients and their family members, to und…

This study looked at 200 women aged 25-55 who have a high genetic risk of breast cancer due to BRCA1 or BRCA2 gene mutations. Researchers tested new screening methods like breast MRI and duct lavage alongside standard mammograms to see if they could detect cancer earlier. The goa…

This study created a large collection of biological samples (like sputum, blood, and urine) from over 9,700 tin miners in China who are at very high risk for lung cancer due to exposure to radon, arsenic, and tobacco. The goal was to find early markers that could help detect lung…

This study gathered health history, symptoms, and genetic information from 326 adults with rare central nervous system tumors. Participants completed surveys and provided saliva samples. The goal is to learn what factors are linked to these tumors, which may help with earlier det…

This study aims to understand why testicular cancer sometimes runs in families. Researchers will collect DNA samples and medical information from about 750 people in families with multiple cases of testicular cancer. No treatment is given; the goal is to find genes that increase …

This study follows over 32,000 people from Linxian, China, who previously took part in a nutritional trial testing vitamins and minerals to prevent esophageal and stomach cancer. The original trial found that certain supplements reduced cancer risk and deaths. Now, researchers ar…

This study looks at genes to find out why some people with neurofibromatosis type 1 (NF1) have more medical problems than others. Researchers will examine patients, their family members, and people with rare NF1 features. The goal is to identify genes that affect disease severity…

This study aimed to create a blood test that could predict if ovarian, peritoneal, or fallopian tube cancer would come back after remission. Researchers looked for specific protein patterns, called a 'fingerprint,' in the blood of 119 women with stage III or IV cancer who were in…

This study tested a document called Voicing My CHOiCES to help young adults (ages 18-39) with cancer or other chronic illnesses plan their future medical care. Participants filled out surveys about anxiety, support, and communication, then used the document to record their care p…

This completed study enrolled 377 individuals and families with a high risk of breast or ovarian cancer due to known or suspected genetic factors. Researchers collected medical records, questionnaires, and biological samples to better understand the disease's natural history and …

This study enrolled 1,214 people with brain or spinal cord tumors to collect medical history, blood, urine, spinal fluid, and tumor tissue samples. The goal was to better understand these tumors and identify new areas for research. Participants also received guidance on managing …

This study looked at how radiation therapy changes the brains and bodies of children with central nervous system tumors. Researchers measured things like memory, quality of life, and blood markers in 76 kids over 5 years. The goal was to learn more about side effects, not to test…

This study looked at the genes of over 1,300 people with blood cancers like leukemia, lymphoma, and multiple myeloma. The goal was to find genetic differences that explain why some patients respond well to treatment while others do not. By analyzing stored tumor samples, research…

This study looked at nearly 1,900 male farmers over age 50 to see if pesticides are linked to early signs of blood cancers like multiple myeloma. Researchers collected blood and urine samples and asked about pesticide use. No treatment was given—the goal was simply to understand …

This study tested whether iPhones and Apple Watches can reliably collect health data from people with cancer. 49 adults undergoing cancer treatment wore an Apple Watch and used an iPhone for 4 months to track activity, fatigue, and thinking skills. The goal was to see if these de…

This study collected information from 733 people with a personal or family history of hereditary stomach cancer. The goal was to better understand how these cancers develop and what genes are involved. Participants provided medical history, blood samples, and genetic testing. The…

This study looked at how common BRCA1 and BRCA2 gene mutations are in Hispanic/Latino women with breast cancer. Researchers collected saliva samples and medical history from 266 participants to better understand these mutations in this group. No treatment was given; the goal was …

This completed Phase 2 trial studied 47 adults with newly diagnosed glioblastoma or gliosarcoma. Researchers gave patients a combination of immunotherapy drugs (ipilimumab and nivolumab) plus standard chemotherapy (temozolomide) after surgery and initial radiation. The goal was t…

This study looked at whether newer imaging techniques can better detect when a person with early blood conditions (MGUS or smoldering myeloma) is developing active multiple myeloma. Thirty-one adults with these conditions received three types of scans: a standard PET/CT, an exper…

This study collected tumor tissue and blood samples from 64 people with advanced or treatment-resistant cancers. The goal was to store these samples for future research on how genes affect cancer and response to treatment. No direct treatment was given; the focus was on building …

This study looked at the DNA of over 7,700 people to find genes that increase the risk of esophageal and stomach cancers. Researchers collected blood and tissue samples from patients and healthy volunteers in high- and low-risk areas of China. The goal is to better understand who…

This study looked at whether simple thinking and memory tests can detect changes in people with cancer that has spread to the brain after they receive radiation therapy. 35 adults took tests before and after treatment to measure memory, attention, and daily skills. The goal was t…

This study looked at leftover tissue samples from 130 people with lymphoma or related conditions. Researchers measured proteins and chemical modifications on chromosomes to find patterns linked to different lymphoma types. The goal was to better understand the biology of these ca…

This study looked at 10 people with neurofibromatosis type 1 (NF1) to understand how benign tumors (plexiform neurofibromas) turn into a rare cancer called MPNST. Researchers used advanced scans and genetic testing of tumor samples to find better ways to detect cancer early. The …

This study looked at over 50,000 adults in Iran to understand why esophageal cancer is so common there. Researchers collected lifestyle information and samples like blood and hair to find possible causes such as diet, hot tea, and environmental exposures. The goal was to gather k…

This study looked at whether a mindful self-compassion program can be helpful for young adults (ages 18-29) with Li-Fraumeni syndrome, a genetic condition that greatly raises cancer risk. Seven participants attended a one-day workshop and gave feedback on how to make the program …

This study tested whether machine learning can analyze facial expressions and voice recordings to measure pain in people with cancer. 83 participants, aged 12 and older, recorded short videos at clinic visits and at home over about 3 months. The goal was to see if this technology…

This study looked at whether pesticides in homes or farms increase the risk of childhood leukemia. Researchers collected dust samples from carpets and mapped nearby farm fields to measure chemical exposure. The goal was to find links between these chemicals and leukemia in childr…

This study followed 17 adults with neurofibromatosis type 1 (NF1) for up to 2 years to learn how their skin tumors grow and change. Researchers took detailed photos, skin samples, and blood tests to measure tumor growth and look for genes that might affect tumor behavior. The goa…

This study looked at why some women have dense breasts on mammograms and why that increases their risk of breast cancer. Researchers collected tissue samples, medical records, and health updates from 466 women aged 40-65 who were having a breast biopsy. The goal was to understand…

This study reviewed medical records of 730 people who had a bone marrow transplant between 2010 and 2015. The goal was to find out how often viral infections happen after transplant and what makes some people more likely to get them. No new treatments were tested; instead, resear…