New immunotherapy combo shows promise for tough childhood cancer
NCT ID NCT03786783
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tested whether adding two immunotherapy drugs (dinutuximab and GM-CSF) to standard chemotherapy is safe and doable for children newly diagnosed with high-risk neuroblastoma. Forty-two children took part. The goal was to see if the extra drugs cause too many side effects or prevent patients from getting enough doses. The approach aims to help the immune system fight the cancer better while shrinking tumors before a stem cell transplant.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Children's Hospital Los Angeles
Los Angeles, California, 90027, United States
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Children's Hospital of Pittsburgh of UPMC
Pittsburgh, Pennsylvania, 15224, United States
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Children's National Medical Center
Washington D.C., District of Columbia, 20010, United States
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Dana-Farber Cancer Institute
Boston, Massachusetts, 02215, United States
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NYP/Columbia University Medical Center/Herbert Irving Comprehensive Cancer Center
New York, New York, 10032, United States
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Primary Children's Hospital
Salt Lake City, Utah, 84113, United States
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Royal Children's Hospital
Parkville, Victoria, 3052, Australia
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Saint Jude Children's Research Hospital
Memphis, Tennessee, 38105, United States
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Starship Children's Hospital
Grafton, Auckland, 1145, New Zealand
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The Children's Hospital at Westmead
Westmead, New South Wales, 2145, Australia
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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