National Cancer Institute (nci)

This study tests a vaccine called SurVaxM in 80 current or former smokers at high risk for lung cancer. The vaccine trains the immune system to attack cells that produce a protein called survivin, which is common in early lung cancers. If successful, this approach could help prev…

This study looks at whether giving the drug venetoclax for a shorter time, along with the combination drug ASTX727, is as effective as the usual longer course for adults aged 60 and older with newly diagnosed acute myeloid leukemia (AML) who cannot tolerate intensive chemotherapy…

This study tests whether two immunotherapy drugs, botensilimab and balstilimab, can clear tiny amounts of cancer DNA from the blood of people with stage II or III colorectal cancer after standard treatment. About 20 adults whose blood still shows signs of cancer will receive the …

This study tests whether adding the drug venetoclax to standard chemotherapy and a stem cell transplant can help keep acute myeloid leukemia (AML) from coming back. About 244 adults with AML in first remission will receive either venetoclax or a placebo before and after their tra…

This early-phase study tests a new treatment for people with extensive-stage small cell lung cancer or similar neuroendocrine cancers that did not respond to or came back after standard therapy. The treatment uses the patient's own immune cells (T cells) that are modified in a la…

This study tests whether the immunotherapy drug atezolizumab can prevent stage I non-small cell lung cancer from returning after it has been completely removed by surgery. About 336 people who have had surgery for early-stage lung cancer will either receive atezolizumab or be wat…

This early-stage trial tests a drug called teclistamab in 30 adults with plasmablastic lymphoma that has returned or not responded to prior therapy. Teclistamab is a special antibody that helps the immune system recognize and attack cancer cells. The study aims to find the safest…

This early-phase study tests a new drug called glofitamab combined with standard chemotherapy for people with untreated mantle cell lymphoma, a type of blood cancer. The goal is to find the safest dose and see how well the body tolerates the treatment. About 16 adults aged 18 to …

This study tests whether adding the antifungal drug itraconazole to standard heat ablation therapy can better prevent esophageal cancer in people with high-risk Barrett's esophagus. About 64 participants will receive either itraconazole or a placebo alongside their usual endoscop…

This study tests a wearable patch called TempTraq that continuously monitors body temperature in cancer patients receiving immunotherapy. The goal is to see if catching fevers early can reduce the risk of severe cytokine release syndrome (CRS), a serious immune reaction. About 13…