HIV INFECTIONS

This early-stage study tests whether new mRNA-based vaccines for HIV are safe and can trigger an immune response. About 96 healthy adults without HIV in South Africa will receive either the vaccine or a placebo. The goal is to see if the vaccines can train the body to make specia…

This early-stage study tests a new HIV vaccine booster called VRIPRO in 40 healthy adults aged 18–60 who previously received an HIV vaccine in the HVTN 706 trial. Participants will get three shots over 24 weeks. The main goals are to check safety and measure the immune response, …

This study in Botswana tests whether a combination of three lab-made antibodies can safely control HIV in children who started treatment early. About 41 kids will either receive the antibodies or pause their regular HIV medication under close monitoring. The goal is to see if the…

This study tests whether a mobile app called Positive Peers can help young people (ages 13-34) with HIV keep the virus under control. About 250 participants who are racial, ethnic, sexual, or gender minorities will use the app and complete surveys over 12 months. The main goal is…

This study tests if a monthly or every-other-month injection can control HIV in people who still have detectable virus despite taking daily oral medication. About 332 participants will be randomly assigned to either the injectable treatment or continue standard oral therapy. The …

This study tests whether providing medically tailored meals along with intensive lifestyle coaching can help adults with HIV and type 2 diabetes or prediabetes manage their weight and blood sugar. About 200 participants will be randomly assigned to receive either the meals plus c…

This study is testing a mobile app called WiseApp along with a smart pill dispenser to help Spanish-speaking people with HIV take their medication as prescribed. The study involves 248 participants in New York City and the Dominican Republic and will track medication adherence, C…

This study looks at whether giving young women (ages 15-24) living with HIV a long-acting injectable HIV treatment along with their birth control is safe and effective. Researchers will compare this approach to standard daily pills. The goal is to see if combining these long-acti…

This study tests whether a peer-led program combining acceptance and commitment therapy, exercise, and social support can help women living with HIV improve their medication adherence. The program also addresses substance use, trauma, and violence. Researchers will enroll 300 wom…

This study tests whether a team-based program (ARTAS) can help people with HIV get linked to care after leaving the hospital and reduce the chance of being readmitted. About 250 adults with HIV who are not currently on treatment or seeing a specialist will take part. Researchers …

This study tests whether a combination of lab-made antibodies and a special vaccine can help people with HIV control the virus without daily antiretroviral therapy. It involves 48 adults who started HIV treatment very early after infection. The goal is to see if this approach is …

This study tests whether smartphone tools can help 1000 people with HIV who struggle to keep the virus under control. It focuses on those facing extra challenges like drug use, mental health issues, or living in rural areas. The goal is to improve medication adherence and viral s…

This study tests a new treatment for HIV that uses a person's own immune cells, modified to better recognize and attack the virus. About 18 adults with well-controlled HIV will receive these special cells, and then temporarily stop their regular HIV medications to see if the trea…

This study tests a program called Kisoboka for men living with HIV who drink heavily in fishing communities. The goal is to help them drink less, take their HIV medication as prescribed, and reach undetectable viral loads. About 716 men will take part and be followed for 12 month…

This study tests a new oral drug, VH4524184, taken with two standard HIV medicines (emtricitabine and tenofovir alafenamide) in 150 adults with HIV-1 who have never received treatment. The goal is to see if the new combination can suppress the virus as well as a current standard …

This study looks at people in Uganda and South Africa whose HIV medication (TLD) is no longer working well. Researchers will test different strategies to get the virus under control again. The goal is to find the best way to help these patients achieve undetectable viral levels.

This study tests whether bempedoic acid, a cholesterol-lowering drug, can reduce artery inflammation and improve heart health in people with HIV who are on effective treatment. About 121 adults aged 40 and older with controlled HIV and at least one heart risk factor will receive …

This study tests a new long-acting injectable drug called VH4524184 in healthy adults to see if it is safe and well-tolerated. The goal is to find a dose that could be used as a future HIV treatment, given as a shot instead of daily pills. About 268 healthy volunteers aged 18 to …

This study tests whether trained peer supporters can help Black adults with HIV or at high risk stay on track with long-acting injectable HIV medication (PrEP/ART) and cut down on substance use. About 186 participants will receive either peer-led coaching or standard care. The go…

This study tests a new way to support people with HIV in rural Uganda. Traditional healers will be trained to offer HIV testing, counseling, and help with starting and staying on medication. The goal is to see if this extra support helps more people achieve an undetectable viral …

This study is checking the long-term safety and effectiveness of a long-acting injectable drug (CAB LA) for preventing HIV. About 3,500 people who were already in earlier HIV prevention studies will continue getting the shots and be monitored for new HIV infections and side effec…

This study tests whether taking the antibiotic doxycycline shortly after sex (called doxy-PEP) can prevent bacterial STIs like syphilis, gonorrhea, and chlamydia. It involves 200 sexual and gender minorities in Rio de Janeiro who are living with HIV or taking PrEP. Participants c…

This study is testing a program called TENDAI4PrEP to help pregnant women in Zimbabwe take PrEP, a daily pill that prevents HIV. The program combines problem-solving support to address barriers like depression and anxiety. About 132 pregnant women at risk for HIV will participate…

This study tests a six-session program called SER Familia for Latino immigrant families with a parent and a child aged 12–17. The program, led by community health workers, aims to reduce stress from adapting to a new culture and build resilience to prevent substance abuse, intima…

This study tests a family-based program that includes Black male caregivers to help protect Black girls aged 14-18 from HIV, other sexually transmitted infections, and sexual violence. Researchers will enroll 612 participants to see if involving male caregivers reduces infection …

This study tests if a text messaging program can reduce new HIV infections in teen boys and young men (ages 13-22) who have sex with men. About 5,000 participants across the US will receive either HIV prevention texts or general healthy lifestyle texts. The goal is to see if simp…

This study follows 3,000 people in the US who choose lenacapavir (a long-acting injection) to prevent HIV. Researchers want to see how well participants stick with the treatment over a year. The goal is to understand how this new PrEP option works in everyday clinics, not just in…

This study is testing a virtual reality tool to help young people who have experienced trauma reduce their risk of substance use and HIV. The study includes 50 participants aged 15-30 who are men who have sex with men or have substance use disorder. Researchers will use interview…

This study compares two ways of offering HIV prevention medication, hepatitis C treatment, and substance use disorder care through telehealth to 350 people who inject drugs. Participants must be HIV-negative and willing to stay in the area for 12 months. The goal is to see which …

This study aims to help people who use drugs stay safe from both HIV and overdose. It offers drug-checking services to understand what's in the drug supply, along with HIV prevention medication (PrEP) for those who are HIV-negative. The goal is to see if this combined approach in…

This study tests a smartphone app called MY-RIDE designed to help homeless youth reduce substance use and adopt HIV prevention strategies like condom use and PrEP medication. Researchers will enroll 450 young people experiencing homelessness who use alcohol or drugs and are sexua…

This study tests two strategies—direct distribution and referral—to see which better gets HIV self-test kits and PrEP information to people in the social networks of current PrEP users. About 320 participants will take part. The goal is to increase HIV testing and connect more pe…

This early-stage study tests a new long-acting injectable drug, VH4011499, for safety and how the body processes it. About 168 healthy adults without HIV will receive one or more doses. The goal is to see if the drug is safe and stays in the body long enough to potentially preven…

This study tests a new way to prevent HIV among people who inject drugs and their friends or partners. Researchers will train some participants to become peer educators, teaching their social network about HIV testing, PrEP (a daily pill that prevents HIV), and treatment for opio…

This study is testing a new program called QUIT-AD to help people living with HIV or tuberculosis (TB) in Cape Town, South Africa, quit smoking. The program combines existing methods to support smoking cessation and improve HIV/TB treatment outcomes. Researchers will enroll 86 da…

This study tests a culturally adapted cognitive behavioral therapy (CBT) for depression and anxiety in 50 adults living with HIV in Pakistan. Participants will either receive six therapy sessions from trained health workers or standard care. The goal is to see if this approach is…

This study aims to find out how common chronic kidney disease (CKD) is in semi-rural Sub-Saharan Africa and what factors increase the risk. Researchers will follow 1,200 adults for one year, measuring kidney function and checking for conditions like diabetes, high blood pressure,…

This study follows 300 young men who have sex with men (ages 18-24) living with HIV in Ho Chi Minh City, Vietnam, for 12 months. Researchers will track how well they are doing on their HIV medication, their viral suppression, mental health, and quality of life. The goal is to und…

This study looks at how HIV affects a natural cell process called autophagy, which helps clean up damaged parts of cells. Researchers will compare blood samples from 180 HIV-positive people (on therapy or untreated) and healthy volunteers. The goal is to understand why immune cel…

This study looks at 400 women living with HIV to understand how the bacteria in their gut and vagina may influence HPV infection and cervical cell changes. Researchers will collect samples to see if an imbalance in vaginal bacteria makes these women more likely to get HPV and dev…

This study looks at whether fungi moving from the gut into the blood can cause inflammation and worsen lung function in people with HIV. Researchers will measure a fungal marker called BDG in blood and urine, and track lung health over three years. The goal is to better understan…

This study tests a new approach to help syringe service programs offer routine HIV and Hepatitis C testing to people who inject drugs. Researchers will work with 40 programs to see if funding and support can increase testing and connect more people to care. The goal is to make te…

This study looks at how exercise affects blood pressure and heart rate in people with HIV. Researchers will compare a group that exercises for 12 weeks with a group that does not. The goal is to see if regular exercise can improve how the body controls blood flow and heart functi…

This study looks at the gut bacteria of people with HIV who are over 55 and have had the virus under control for at least 5 years. Researchers want to see if changes in gut bacteria over time are linked to signs of frailty and other health problems. The goal is to better understa…

This study tracks 20 adults with chronic hepatitis delta (a serious liver infection) who are starting a new drug called bulevirtide. Researchers want to see how the drug changes the gut's bacteria and bile acids over 48 weeks, and how those changes relate to inflammation and live…

This study looks at whether high-intensity exercise can improve thinking and memory in older adults living with HIV. Researchers will also explore what helps people stick with an exercise routine. The goal is to find better ways to prevent dementia in this group.

This early-stage study is testing a long-acting HIV drug called cabotegravir in 214 healthy adults. The goal is to see how the drug moves through the body and if it is safe when given as a shot. Participants do not have HIV and will not receive any direct treatment benefit, but t…

This study is testing whether an AI-powered chatbot on a smartphone can encourage more men in Malaysia to get tested for HIV. The study will include 296 men who have sex with men and who have not been tested recently or don't know their status. Researchers will track how many par…

This study tests a faster way to screen and treat cervical cancer in women living with HIV in the Dominican Republic. It compares same-day HPV testing and treatment to the usual care. The goal is to see if more women complete the full screening process, which could save lives.

This study looks at how well leg muscles produce energy in people aged 60 and older, both with and without HIV. Researchers want to see if muscle metabolism problems are linked to difficulty exercising. Participants will undergo muscle tests and walking assessments. The goal is t…

This study looks at whether switching from daily oral HIV pills to a long-acting injectable treatment can reduce the hidden virus in the body, lower inflammation, and improve gut health. Researchers will follow 120 people with HIV who have well-controlled virus levels. The goal i…

This study looks back at medical records of 50 adults recently diagnosed with HIV to see if doctors missed warning signs during earlier visits. The goal is to understand why HIV testing wasn't done sooner and how to improve early detection. No new treatments or tests are given—ju…

This study compares two ways to offer cervical cancer screening to women living with HIV: standard clinic-based screening versus also providing HPV self-collection kits through community health workers. About 2,900 women will take part to see if the community approach increases s…