HIV INFECTIONS

This study is testing the safety and immune response of a new HIV vaccine candidate called VRIPRO. It will enroll 40 healthy adults, aged 18-60, who previously participated in a specific earlier HIV vaccine trial (HVTN 706). Participants will receive three injections over 24 week…

This is an early-stage study testing three different experimental mRNA vaccines designed to prevent HIV infection. It will enroll 96 healthy, HIV-negative adults in South Africa to check if the vaccines are safe and if they trigger a helpful immune response. The study will test t…

This study is testing a smartphone app designed to help people living with HIV stay on their medication and keep their appointments. Researchers will follow 1,000 participants for up to four years to see if the app helps them achieve and maintain an undetectable viral load. The f…

This study aims to see if switching from daily oral HIV pills to a monthly long-acting injectable treatment has different effects on the body. Researchers will compare the two approaches in 120 people living with well-controlled HIV to see if the injectable treatment better reduc…

This study is testing a Spanish-language mobile app called WiseApp, paired with a smart pill box, to help Spanish-speaking people living with HIV remember to take their daily medication. Researchers will enroll 248 participants in New York City and the Dominican Republic to see i…

This study is testing three different approaches to help people in Uganda and South Africa whose HIV is no longer controlled by their standard medication. It will compare standard care, personalized treatment based on test results, and an immediate switch to a different type of m…

This study is testing whether a free smartphone app called Positive Peers can help young adults (ages 13-34) with HIV keep their virus at undetectable levels and stay connected to their medical care. Researchers will see if using the app leads to better health outcomes compared t…

This early-stage study is testing a two-part strategy to help the body control HIV without needing daily antiretroviral therapy (ART). It combines lab-made antibodies with a therapeutic vaccine in people who started treatment very early after infection. The main goals are to see …

This study is testing whether a program where trained peers provide support can help people stick to their schedule of long-acting injectable HIV medications (for treatment or prevention) and reduce substance use. It will involve 186 adults, primarily from Black communities, who …

This study is testing a new oral medication, VH4524184, for adults who have never taken HIV treatment before. Researchers want to see if taking VH4524184 with two other standard HIV drugs works as well as or better than a current standard treatment combination. The main goal is t…

This early-stage study is testing an experimental drug, VH3810109, to see if it can reduce the hidden, inactive HIV that persists in the body even with standard treatment. It will involve 100 adults living with HIV, including some just starting treatment and others who have been …

This study is testing a faster, one-visit approach to prevent cervical cancer in women living with HIV in the Dominican Republic. It compares the new method, which provides screening results and treatment on the same day, to the standard multi-visit process. The goal is to see if…

This study is testing a long-acting, injectable HIV treatment for people whose current daily pill regimen is not fully controlling the virus. About 332 participants will be randomly assigned to receive either the new monthly injections or continue their standard oral medication. …

This study is testing a new support program designed to help people in South Africa who have HIV and/or tuberculosis (TB) quit smoking. The program, called QUIT-AD, combines counseling and support to help people stop smoking and also stick to their important HIV or TB medications…

This study is testing whether a medication called bempedoic acid can help reduce heart disease risk in people living with HIV. Researchers want to see if the drug lowers cholesterol, reduces artery inflammation, and improves heart health markers. The trial involves 121 HIV-positi…

This early-stage study is testing a new long-acting injectable drug called VH4524184 for HIV treatment. Researchers are giving different doses to healthy adults to check if it's safe and how long it stays in the body. The goal is to find a dose that could eventually allow people …

This study is testing if a program that delivers healthy, doctor-approved meals and provides lifestyle coaching is better than just receiving meals alone. It aims to help adults with HIV who also have type 2 diabetes or are at high risk for it, and who struggle to afford enough h…

This is an early safety study testing new, long-acting injectable versions of HIV medications called cabotegravir and rilpivirine. Researchers are giving single injections to healthy adult volunteers to see how safe they are and to measure how long the drugs stay active in the bo…

This study is testing whether a team-based support program in the hospital helps people with HIV get connected to ongoing specialist care after they go home. It will enroll 250 adults who are hospitalized and not currently receiving proper HIV treatment. The main goal is to see i…

This study tests two different telehealth approaches to deliver a package of health services to people who inject drugs. The program offers medications to prevent HIV, cure hepatitis C if needed, and treat substance use disorders if desired. Researchers will enroll 350 participan…

This study follows people at risk of HIV who previously participated in trials for a long-acting preventive injection called cabotegravir (CAB LA). The goal is to monitor the long-term safety and continued effectiveness of the injection in preventing new HIV infections. Participa…

This study aims to prevent the spread of HIV and Hepatitis C among people who inject drugs. Researchers are testing a new support strategy for syringe service programs to help them offer routine, easy-to-get testing. The goal is to find more infections early and connect people to…

This study is testing if a text messaging program can help prevent HIV infections in young gay and bisexual men across the United States. About 5,000 participants aged 13-20 will be randomly assigned to receive either HIV prevention texts or general healthy lifestyle messages. Th…

This study is testing if taking a single dose of the antibiotic doxycycline after sex can prevent bacterial sexually transmitted infections (STIs) like syphilis, gonorrhea, and chlamydia. It involves 200 men who have sex with men, transgender women, and travestis in Rio de Janeir…

This study is testing a new community program designed to prevent HIV infections and drug overdoses among people who use drugs in Baltimore. The program uses a mobile unit to offer two main services: checking street drugs for dangerous substances and providing access to HIV preve…

This study is testing whether a personalized AI chatbot on a smartphone can help encourage more men in Malaysia to get tested for HIV. About 300 men who have sex with men will be randomly assigned to either use the AI chatbot or receive standard health messages. The main goal is …

This study tests two ways to help women living with HIV get screened for cervical cancer. One group will get HPV self-test kits only at clinics, while the other group can also get them from community health workers at home or in their community. The goal is to see which approach …

This study is developing and testing a virtual reality tool designed to help prevent HIV infection and reduce substance abuse among young people who have experienced trauma. It involves young men who have sex with men and adolescents with substance use issues, aged 15-30, from th…

This study tests a family program designed to prevent multiple health problems common in Latino immigrant families. The six-session program, led by community health workers, helps families manage stress, build resilience, and access community resources. Researchers want to see if…

This study aims to see if training people who inject drugs to become peer educators for their social networks can help increase HIV testing and the use of prevention services. The research will involve 360 participants from syringe service programs in Maryland. It will compare a …

This is an early-stage study to check the safety and body processing of a new long-acting injection, VH4011499, intended to help prevent HIV. It involves 168 healthy adults without HIV who will receive single or multiple shots. The main goal is to see how well the drug is tolerat…

This study is testing whether a 4-month supervised exercise program can help improve memory and thinking skills in older adults living with HIV. Researchers will compare high-intensity interval training to moderate continuous exercise in 110 sedentary participants. The goal is to…

This study is testing whether a 12-week exercise program can improve how the heart and blood vessels respond to physical stress in people living with HIV. Researchers will compare people with HIV who do the exercise program to those who remain inactive, and also to a group of hea…

This is a small pilot study to see if a culturally adapted talk therapy is practical and acceptable for people living with HIV who also have depression and anxiety in Pakistan. Fifty participants will be randomly assigned to either receive six sessions of this special therapy or …

This study aims to understand how the community of bacteria in the gut (the microbiome) changes over five years in older adults whose HIV is well-controlled by medication. Researchers want to see if changes in these gut bacteria are connected to signs of faster aging and increase…

This study aims to understand how the community of bacteria in the gut and vagina might influence a woman's risk of getting an HPV infection and developing cervical problems. It will follow 400 women living with HIV in China, collecting samples to analyze their bacteria and track…

This study aims to understand how HIV affects the body's cellular cleanup system called autophagy, even in patients whose virus is well-controlled with medication. Researchers will compare blood samples from 180 HIV-positive adults on different treatment paths with samples from h…

This study aims to understand why older adults living with HIV often experience more muscle fatigue and difficulty exercising than their peers without HIV. Researchers will use leg muscle scans and blood tests to compare 200 participants aged 60+ with and without HIV. The goal is…

This study looks back at the medical records of 50 people in France who were diagnosed with HIV. Researchers want to see if there were signs of infection or chances for testing in the year before their diagnosis that were missed at their general doctor's office. The goal is to un…

This study aims to understand how a hepatitis D treatment called bulevirtide affects gut bacteria and bile acids in patients. Researchers will follow 20 patients with hepatitis D and liver damage, collecting samples over 48 weeks to see how these gut factors change during treatme…

This study aims to understand how fungi from the gut might move into the bloodstream and affect lung health in people living with HIV. Researchers will enroll 100 adults with HIV to measure markers of fungal movement, gut health, and lung function over three years. The goal is to…