HIV INFECTIONS

This early-stage study aimed to see if a three-part combination treatment could help people with HIV achieve remission, meaning they could stop their daily antiviral medications and keep the virus under control. The treatment combined a therapeutic vaccine, a lab-made antibody, a…

This is an early-stage study to check the safety and immune response of three new experimental mRNA vaccines designed to prevent HIV. The study will enroll 108 healthy, HIV-negative adults to receive injections and be closely monitored for side effects. The main goal is to see if…

This is an early-stage safety study testing two experimental mRNA vaccines designed to train the immune system against HIV. The trial will enroll 53 healthy adults without HIV to check if the vaccines are safe and can trigger an immune response. This is a first-in-human study, me…

This study is testing a new way to help people with HIV get their long-acting treatment injections. It will train a friend, family member, or partner to safely give the monthly or every-other-month shots at home instead of at a clinic. The goal is to make treatment more convenien…

This study is testing the safety and correct dosing of several HIV medications in children and teenagers (from 4 weeks to under 18 years old) who already have their HIV under control with treatment. The goal is to see how the drugs work in younger bodies and to monitor for any si…

This study is testing whether a two-drug HIV treatment (dolutegravir/lamivudine) is as safe and effective as standard three-drug treatments for children aged 2-15 who already have their virus under control. About 370 children will be randomly assigned to either continue their cur…

This study tested if switching from daily HIV pills to a monthly injection of two drugs (cabotegravir and rilpivirine) keeps the virus under control just as well. It involved 618 adults whose HIV was already suppressed on their current medication. The goal was to see if the injec…

This study is testing whether having a trained peer supporter helps people with HIV get better care for mental health or substance use problems. About 405 participants at a Johns Hopkins clinic were randomly assigned to either receive this peer support or continue with their usua…

This study is testing two different ways to control HIV in adults who have never taken HIV medication before. Everyone starts with a daily pill. Once the virus is under control, participants can choose to either stay on the pills or switch to injections they receive every two mon…

This is a very small, early-stage study testing whether a new biological treatment can help control HIV. The trial involves 20 HIV-positive patients without AIDS symptoms, who receive a combination treatment through skin injections. Researchers are looking to see if this approach…

This study is testing a new support program for people in Taiwan living with HIV who struggle to take their medication consistently. The program combines digital tools, like smartphone apps, with social and behavioral support. Researchers want to see if this approach helps partic…

This large study tested if people with well-controlled HIV could switch from taking daily pills to receiving two long-acting drugs as a monthly injection. The goal was to see if the injections kept the virus suppressed just as effectively as the standard pill regimen. It involved…

This early-stage study is testing the safety and how the body processes a new antibody called VH4527079 in healthy adults and people living with HIV. Researchers are giving single doses by injection or IV to healthy volunteers, and multiple IV doses to a small group of people wit…

This study is testing a new oral medication called selgantolimod in people who have both chronic hepatitis B and HIV. The main goals are to see if the drug is safe and if it can lower the amount of hepatitis B surface antigen in the blood, which is a key marker of the infection. …

This trial provides continued access to the HIV medication etravirine for children (aged 2+) and adults who successfully completed a previous study with the drug and are still benefiting from it. The goal is to supply the medication until participants can switch to a commercially…

This early-stage study is checking if a new HIV medication called ulonivirine (MK-8507) affects heart rhythm in healthy people. Researchers are measuring how the drug changes a specific heart rhythm interval and tracking how much of the drug stays in the body over time. The study…

This study aims to understand the long-term effectiveness and safety of the HIV medication ibalizumab in real-world patients. It will compare health outcomes between 168 adults with multi-drug resistant HIV who receive ibalizumab and similar patients who do not. The goal is to se…

This study aimed to test a new, child-friendly tablet version of an existing HIV medicine (darunavir/ritonavir) for children aged 3 and older. The goal was to find the right dose, check if it was safe, and see if kids could take it easily. The trial was designed to enroll childre…

This study is testing a phone and text message wellness program designed specifically to help veterans living with HIV quit smoking. It compares this new, more comprehensive approach to the standard VA quitline and texting services. The goal is to see which method is more effecti…

This study is testing if new long-acting injections can keep HIV under control as effectively as standard daily pills. It involves adults whose HIV is already well-managed with medication. Researchers are comparing the new injection regimen, given every few months, to participant…

This early-stage study is testing the safety of new long-acting HIV drugs called capsid inhibitors in healthy volunteers. Researchers will give single injections to 85 participants and carefully monitor for side effects, particularly at the injection site. The main goal is to und…

This study tested if monthly injections of HIV medication work better than daily pills for people who have a hard time taking their medicine regularly. It involved 456 adults with HIV who had a history of poor medication adherence. The trial was so successful that an independent …

This study is testing if switching to a simpler, two-drug HIV pill works as well as a three-drug pill for keeping the virus suppressed. It involves 205 people living with HIV who are 50 or older and have had their virus under control for at least a year. The main goal is to see i…

This study is testing whether a special smartphone app and connection to a support team can help people with HIV who also struggle with substance use. The goal is to help them stay on their medication, keep their virus at undetectable levels, and make it to their doctor appointme…

This study is testing a new clinic program called CHIMES, designed to better connect HIV care with mental health services. It focuses on young Black gay and bisexual men living with HIV in Atlanta, a group that often faces barriers to getting mental health support. The goal is to…

This study is testing two different telemedicine methods to quickly start people who inject drugs on medications for HIV, Hepatitis C, and opioid addiction. It aims to see which approach is better at getting HIV under control, curing Hepatitis C, and helping people start addictio…

This study is testing three ways to help people who inject drugs in India stay on their HIV medication and achieve better health outcomes. It will compare starting treatment the same day as diagnosis versus waiting, receiving care in community centers versus government clinics, a…

This study compares two daily pill regimens for adults with HIV who are starting treatment for the first time. It tests whether a simpler two-drug combination works as well as a standard three-drug combination at keeping the virus under control. Researchers will also check for si…

This study is testing whether a group counseling program helps HIV-positive men who have sex with men in St. Petersburg, Russia, stay engaged with their medical care. 100 men who are not currently seeing a doctor regularly will be randomly assigned to receive either standard coun…

This study aims to help people with HIV who are on a common treatment that can increase weight and heart disease risk. It will test if adding the drug dapagliflozin helps with weight loss and heart health more than a placebo. It will also compare two different cholesterol-lowerin…

This study is testing whether a computer program that reads chest X-rays can help find cases of tuberculosis (TB) and COVID-19 more efficiently in communities in Africa. It will involve over 26,000 adults to see if using this artificial intelligence (AI) tool can speed up diagnos…

This study aims to find the most accurate testing method to detect early signs of cervical cancer in women living with HIV in Latin America. It involves 1002 women who will provide various samples and undergo cervical examinations to compare different screening tests. The goal is…

This early-stage study aims to understand how well healthy adults without HIV tolerate two different long-acting injection methods for HIV prevention. Researchers will give 65 participants injections in the muscle or under the skin and closely monitor any reactions at the injecti…

This study is testing whether adding special training videos and substance use counseling to standard couples HIV testing helps reduce drug use and HIV transmission risk. It involves 484 male couples where one partner has recently used drugs and engaged in higher-risk sexual beha…

This study is testing a program called TIARAS that combines two approaches to help women who inject drugs reduce their risk of getting HIV. For 3 months, participants get small rewards for taking their HIV prevention pills (PrEP) and staying off drugs, while also doing writing ex…

This large study is testing if a long-acting injection given every two months works as well as a daily pill to prevent HIV infection in women. It enrolled over 3,200 women at risk for HIV to compare the safety and effectiveness of the two methods. The goal is to offer a more conv…

This study tests whether text message reminders and simple pledges can help men who have sex with men in South Africa continue taking their daily HIV prevention pills (PrEP). Researchers want to see if this approach is practical and acceptable before running a larger trial. The s…

This study is testing a new, longer-lasting version of an injectable HIV prevention medicine. It aims to see if getting a shot every four months keeps enough medicine in the body to block HIV infection, and checks how safe and tolerable it is. The study includes 229 adolescents a…

This study is testing whether a smartphone app can help men in rural southern U.S. communities get tested for HIV and other sexually transmitted infections (STIs) and start preventive medication (PrEP). About 470 participants will use the app and be assigned to different groups t…

This study aims to see if a free mobile phone service can help prevent HIV and address related health issues like depression and alcohol use among teenagers in Uganda. Researchers will adapt an existing text and call system to include information on HIV prevention pills (PrEP) an…

This study is testing a counseling program called TENDAI4PrEP, designed to help pregnant women in Zimbabwe start and continue taking medication to prevent HIV. The program works with women, their partners, and healthcare providers to solve problems that make it hard to take the p…

This study is testing a new computer alert system for doctors. The system flags patients who might be at higher risk for getting HIV, so doctors can discuss and prescribe a daily pill to prevent it. The goal is to see if this tool helps doctors prescribe this preventive medicatio…

This study is testing a coordinated community strategy to improve access to HIV prevention and care services for men who have sex with men (MSM) at highest risk in the Southern United States. It aims to increase the number of high-risk men using healthcare facilities, boost presc…

This study is testing whether structured exercise programs can help older adults living with HIV in Côte d'Ivoire stay mobile and independent. It compares a group exercise class, a home-based program with phone support, and general health education. The goal is to see which appro…

This study asks people who participated in past HIV clinical trials for permission to use their leftover blood and tissue samples for future research. The goal is to allow scientists to study these stored samples to better understand HIV, which could include genetic testing. Part…

This study aims to understand the quality of life, depression, and sexual function in men whose HIV is well-controlled by medication, compared to healthy men. It involves 100 heterosexual men who will complete questionnaires about their wellbeing. The goal is to identify any ongo…

This study uses a special brain scan (PET/CT) to measure inflammation in the brains of four groups of people: those with HIV, those with opioid use disorder, those with both conditions, and healthy individuals. The goal is to understand how these conditions, alone or combined, af…