HIV INFECTIONS

This early-stage study tests three experimental mRNA vaccines designed to train the immune system against HIV. Researchers want to see if the vaccines are safe and whether they trigger the body to make antibodies that can neutralize the virus. The trial involves 108 healthy adult…

This early-stage study tests two experimental mRNA vaccines designed to teach the body to make powerful antibodies that can neutralize many strains of HIV. The trial involves 53 healthy adults without HIV to check safety and immune responses. If successful, this approach could le…

This study tests whether a two-medicine HIV treatment (dolutegravir and lamivudine) is as safe and effective as the standard three-medicine treatment for children aged 2 to 15 who already have the virus under control. About 386 children will take part, and researchers will monito…

This study tests a special wellness program designed to help veterans living with HIV quit smoking. The program is compared to standard services like quitlines and text support. 226 veterans who smoke at least 5 cigarettes daily are taking part. The goal is to see if the tailored…

This study compares two methods of offering HIV, hepatitis C, and addiction medications to 100 people who inject drugs. Participants are already part of syringe service programs in Miami and Tampa. The goal is to see which method helps more people achieve HIV viral suppression an…

This study looks at 168 people with multidrug-resistant HIV who have few treatment options. It compares those who receive the drug ibalizumab plus other HIV medicines to those who do not. The goal is to see how well ibalizumab controls the virus over time and how safe it is in re…

This early-stage study tests a new lab-made antibody called VH4527079 in healthy adults and people with HIV. The goal is to check if it is safe and how the body handles it when given as a shot or through an IV. About 102 participants will receive one or more doses, and researcher…

This study tests a program that combines social support and digital health tools to help people with HIV who struggle to take their medication consistently. About 210 participants in Taiwan will receive the intervention, and researchers will measure changes in viral load, CD4 cou…

This study explores whether people living with HIV can receive their long-acting injectable medication at home from a trained friend, family member, or partner instead of going to a clinic. The goal is to make treatment easier to stick with and improve viral suppression. About 1,…

This study looks at how to improve HIV treatment for people who inject drugs in India. It tests three approaches: starting HIV medicine right away, getting care at community centers instead of government clinics, and offering extra support for those whose treatment isn't working.…

This study tests whether having a peer case manager helps people with HIV who also have mental health or substance use problems get the care they need. About 405 participants will be randomly assigned to usual care or to work with a peer who supports them in finding treatment. Th…

This study tested whether people with HIV who are already well-controlled on daily pills could switch to a once-monthly injection of two long-acting drugs (cabotegravir and rilpivirine). About 618 adults with suppressed HIV took part. The goal was to see if the shots work just as…

This study looks at two different HIV treatments for people who have never taken HIV medication before. Everyone starts with a daily pill (Dolutegravir/Lamivudine) to lower the virus to undetectable levels. Once that happens, participants can choose to either stay on the daily pi…

This early-stage study tests whether adding an experimental drug (VH3810109) with or without another drug (fostemsavir) to standard HIV therapy can reduce the amount of hidden HIV in the body. The study involves 107 adults with HIV, including those new to treatment and those alre…

This study looks at how safe and effective certain HIV medicines are for children from 4 weeks to under 18 years old. The drugs are meant to keep the virus under control, not cure it. About 133 kids will take part to help find the right doses and check for side effects.

This study tests two drug combinations in 300 people with HIV who have gained weight or have high cholesterol from their HIV medications. One part compares dapagliflozin (a diabetes drug) to a placebo for weight loss. The other compares a two-statin combo to a single statin for l…

This study aimed to see if a combination of a therapeutic vaccine, a broadly neutralizing antibody (10-1074), and a drug called romidepsin could help people with HIV control the virus without needing daily antiretroviral therapy. The trial planned to enroll 56 adults with well-co…

This study tested whether adults with HIV whose virus is already suppressed can switch from taking daily pills to getting a monthly injection of two long-acting drugs (cabotegravir and rilpivirine). Over 600 participants were enrolled. The goal was to see if the shots keep the vi…

This study tests whether a program that helps HIV-positive men who have sex with men build supportive friendships and community connections can improve their medical care attendance and overall health. One hundred participants in St. Petersburg, Russia, will receive either standa…

This study tests a program called PASEO that helps teenagers living with HIV in Lima, Peru, move from pediatric to adult HIV care. The program includes a helper who checks in monthly, peer support groups, and mental health referrals. About 160 teens will be randomly assigned to r…

This study was designed to test a new, easier-to-take HIV medicine for children aged 3 years and older who weigh between 10 and 25 kg. The goal was to find the right dose and check if the drug is safe and acceptable for kids. However, the study was withdrawn before any participan…

This study tested whether a long-acting injectable HIV medication works better than daily oral pills for people who have had trouble sticking to their treatment. 456 participants with HIV and a history of poor adherence were enrolled. The goal was to see if the injectable option …

This study tests a new drug combination (VH3810109 plus cabotegravir) for adults with HIV whose virus is already well-controlled by standard medication. The goal is to see if this new approach can keep the virus suppressed as effectively as current treatments. About 185 participa…

This study gives HIV-1 patients ongoing access to the drug etravirine until they can switch to a local treatment option. It includes 180 participants aged 2 and older who previously benefited from etravirine in a parent trial. The main goal is to monitor safety by tracking any si…

This early-phase study tests a new biologic treatment in 20 HIV-positive adults without AIDS symptoms. The goal is to see if the therapy can lower the amount of virus in the blood and help the immune system better target HIV. While promising, this is a proof-of-concept trial and …

This study tests a clinic-supported mobile health program called Connections for up to 806 HIV patients who also have substance use disorders. Participants get support from their care team and peer mentors for one year to help them stay virally suppressed and attend appointments.…

This study tests whether a two-drug HIV pill (dolutegravir/lamivudine) works as well as a three-drug pill (bictegravir/emtricitabine/tenofovir alafenamide) for adults who have never taken HIV medication before. About 473 participants will take one of the two pills daily for up to…

This study aims to find the most effective screening method for detecting early signs of cervical cancer in women living with HIV in Latin America. Researchers will compare different tests (cervical swabs, self-collected vaginal swabs, urine tests, and biopsies) on 1,002 particip…

This study aims to use mobile phones to help teenagers in Uganda prevent HIV and address related issues like mental health and alcohol use. Researchers will adapt an existing text-message and voice system to include HIV prevention information and mental health screening. The stud…

This study tests a mobile app called Combine to see if it helps rural men who have sex with men get tested for HIV and STIs and start taking PrEP (a daily pill that prevents HIV). About 473 men in the rural southern U.S. will use the app and be assigned to one of four groups, som…

This study looks at whether adding communication skills training and a substance use module to standard couples HIV testing can help male couples reduce drug use and risky sexual behaviors. About 484 male couples (one partner aged 17-29, the other 17+) will be randomly assigned t…

This pilot study tests whether an electronic health record (EHR) tool can help doctors spot patients at higher risk for HIV and prescribe them preexposure prophylaxis (PrEP), a daily pill that prevents HIV. Researchers will roll out the tool in 2-3 community health centers and co…

This study tests a program called TIARAS, which combines a reward system for staying drug-free and on PrEP with expressive writing about past trauma. The goal is to see if this approach helps women who inject drugs reduce their risk of getting HIV. 219 women will take part for 12…

This study tests a new version of the HIV prevention drug cabotegravir, given as a shot every 4 months. About 229 teens and adults at risk of HIV will receive the injection to see if drug levels stay high enough to prevent infection and to check for side effects. The goal is to m…

This study tests whether text reminders, commitment pledges, and planning prompts can help men who have sex with men (MSM) in South Africa continue taking their daily HIV prevention pill (PrEP). About 106 men starting PrEP will be randomly assigned to receive either standard care…

This study tests a comprehensive approach to help high-risk men who have sex with men (MSM) in the southern US get better access to HIV prevention and treatment services. The goal is to reduce new HIV infections by increasing use of prevention pills (PrEP) for those without HIV a…

This study compares a new long-acting injectable drug (cabotegravir) to daily oral pills for preventing HIV in women who are not infected. Over 3,200 women aged 18-45 took part. The goal is to see if the shot is safer and more effective at preventing HIV than the daily pill regim…

This study tests whether a structured exercise program can improve physical function and reduce disability in HIV-positive adults over 50 in Ivory Coast. Participants are randomly assigned to a supervised group exercise, a home-based program with phone support, or health educatio…

This study looks at how healthy adults without HIV tolerate two long-acting injections used to prevent or treat HIV. Researchers are checking injection site reactions and how acceptable participants find the shots. The goal is to understand comfort and side effects, not to treat …

This study is testing a program called CHIMES to help young Black gay, bisexual, and other men who have sex with men (ages 18-29) who are living with HIV get better access to both HIV care and mental health services. The program will be offered at two clinics in Atlanta, and rese…

This study seeks permission from over 17,000 current and past HIV clinical trial participants to use their stored blood and tissue samples for future research, which may include genetic testing. The goal is to build a resource for answering scientific questions that arise later. …

This early-stage study tests the safety and how the body handles a new type of HIV drug called a capsid inhibitor. It involves 85 healthy adults who receive either the drug or a placebo as a shot under the skin or into a muscle. The goal is not to treat HIV, but to gather importa…

This study tests whether computer-assisted X-rays and other simple tests can help find more cases of tuberculosis (TB) and COVID-19 in African communities. About 26,200 adults will be screened using these tools to see if they can detect cases that are usually missed. The goal is …

This study uses a special imaging scan (PET/CT) with a radioactive tracer to measure inflammation in the brain. Researchers will compare brain inflammation patterns among 26 adults with HIV, opioid use disorder, both, or neither. The goal is to understand how these conditions aff…