MRNA HIV vaccine trial launches in healthy volunteers

NCT ID NCT05217641

Ongoing ⭐️ VACCINE ⭐️ Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-stage trial tests whether three experimental mRNA vaccines can safely teach the immune system to recognize and fight HIV. About 108 healthy, HIV-negative adults aged 18-55 will receive one of the vaccines. The main goal is to check for side effects and see if the vaccines trigger protective antibodies.

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Conditions

The condition(s) this trial relates to.

Blood-Borne Infections immune system disorder inborn error of immunity Infections infectious disease lentivirus infection RNA Virus Infections sexually transmitted disease uterine carcinosarcoma viral infectious disease viral sexually transmitted disease HIV infectious disease prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

HIV INFECTIONS

Contacts and locations

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Locations

Alabama CRS [31788]

Birmingham, Alabama, 35222, United States
Bidmc Vcrs [32077]

Boston, Massachusetts, 02115, United States
Brigham and Women's Hospital Vaccine CRS [30007]

Boston, Massachusetts, 02115, United States
Columbia P&S CRS [30329]

New York, New York, 30329, United States
New York Blood Center CRS [31801]

New York, New York, 10065, United States
Penn Prevention CRS [30310]

Philadelphia, Pennsylvania, 19104, United States
Seattle Vaccine and Prevention CRS [30331]

Seattle, Washington, 98104, United States
UCLA Vine Street Clinic CRS [31607]

Los Angeles, California, 90038, United States
University of Pittsburgh CRS [1001]

Pittsburgh, Pennsylvania, 15213, United States
University of Rochester Vaccines to Prevent HIV Infection CRS [31467]

Rochester, New York, 14642, United States

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