MRNA HIV vaccines enter human trials in south africa
NCT ID NCT06694753
First seen Jun 27, 2026 · Last updated Jul 01, 2026 · Updated 1 time
Summary
This early-stage trial tests three experimental mRNA vaccines designed to train the immune system to fight HIV. The study involves 96 healthy adults without HIV in South Africa. Researchers will check for side effects and measure whether the vaccines trigger specific immune cells that could neutralize the virus.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
mRNA vaccines encoding HIV immunogens (eOD-GT8 60mer, Core-g28v2 60mer, N332-GT5 gp151)
What this could lead to
If successful, this could point toward a safe and effective HIV vaccine, potentially preventing infection.
What could go wrong
This is an early phase 1 trial with only 96 participants, so it may not prove effective. The vaccines may cause side effects or fail to generate strong immune responses.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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CAPRISA eThekwini CRS
Durban, KwaZulu-Natal, 4001, South Africa
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Desmond Tutu Health Foundation Emavundleni CRS
Cape Town, Western Cape, 7750, South Africa
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Desmond Tutu Health Foundation- Groote Schuur Hospital/J52
Cape Town, Western Cape, 7925, South Africa
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Isipingo CRS
Isipingo, KwaZulu-Natal, 4110, South Africa
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Perinatal HIV Research Unit (PHRU)
Soweto, Gauteng, 1862, South Africa
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Setshaba Research Centre CRS
Soshanguve, Gauteng, 0152, South Africa