ANALGESIA

This study looked at whether taking ibuprofen for eight days after hip or knee replacement surgery is safe. Over 2,900 adults were randomly given either ibuprofen or a placebo. Researchers tracked serious problems like heart attack, stroke, blood clots, kidney failure, and bleedi…

This study tests whether a 15mg dose of the painkiller ketorolac works as well as a 30mg dose for relieving kidney stone pain in the emergency department. About 86 adults with severe pain will receive one of the two doses, and their pain levels will be tracked over several hours.…

This trial compares three common anesthetic blocks used during knee replacement surgery to see which one controls pain best right after the operation. It also looks at how well patients can move their knee in the first few days, and whether pain and recovery differ by age or sex.…

This trial aims to find the optimal dose of bupivacaine, a local anesthetic, for starting epidural pain relief during labor. It will enroll 100 healthy women with a single, full-term pregnancy who request an epidural for pain. The goal is to determine the dose that provides effec…

This trial compares two types of nerve blocks for pain relief after open gastric cancer surgery. The blocks are injected near the abdominal wall to numb the area, potentially reducing the need for opioid painkillers, which can cause side effects like drowsiness and constipation. …

This study tests two medications, dexmedetomidine and tramadol, given before hemorrhoid surgery to see which one better reduces anxiety and pain. Ninety adults will receive one of the drugs or a placebo before spinal anesthesia. Researchers will measure anxiety levels and pain sc…

This trial tests whether an ultrasound-guided nerve block called the mid-transverse process to pleura (MTP) block can improve pain control in children aged 5 to 15 undergoing open chest surgery. Half of the 50 participants will receive the block with bupivacaine before the incisi…

This phase 2 trial tests whether a single local dose of HTX-011, a long-acting anesthetic, can reduce pain after bunionectomy better than a placebo. About 70 adults undergoing foot surgery receive either the drug or a saline injection, and their pain is tracked over 24 hours. The…

This trial compares two ways to manage pain during hip replacement surgery: an ultrasound-guided nerve block (PENG block) versus injecting anesthetic directly into the joint. The study includes 60 adults scheduled for anterior hip replacement under general anesthesia. The main go…

This trial tests whether a newer nerve block called PENG block provides better pain relief than the standard intra-articular injection for people undergoing hip replacement surgery. Both methods use the anesthetic lidocaine. The study will measure how much morphine patients need …

This study tests if a long-acting painkiller (liposomal bupivacaine) works better than a standard one (ropivacaine) for pain after upper abdominal surgery. About 146 adults having open surgery will receive one of the two drugs injected into the belly lining before the incision is…

This study looked at whether a specific nerve block (recto-intercostal fascial plane block) can reduce pain after epigastric hernia repair. Forty adults having elective surgery received either the block or standard care. The goal was to see if the block delayed the need for extra…

This study compares three doses of a medicine called dexmedetomidine, added to the numbing drugs used for nerve blocks during arm surgery. The goal is to see if a higher dose keeps the arm numb and pain-free for longer. About 69 adults having surgery below the elbow will take par…

This study tests whether a combination of gabapentin, ketorolac, and a nerve block, along with scheduled Tylenol, can reduce the need for opioid painkillers after head and neck cancer surgery involving free flap reconstruction. Half of the 30 participants will receive the standar…

This study tests whether using a virtual reality headset during a scheduled cesarean section can help reduce pain and anxiety. Twenty women will be offered the headset at different stages of care, from admission to after birth. Researchers will measure how many accept and use it,…

This study tests whether giving magnesium during and after spinal surgery can reduce pain and the need for morphine. Adults undergoing multi-level back surgery are randomly assigned to receive either magnesium or a placebo (saline) infusion for 12 hours after surgery. Pain levels…

This study tested whether a non-opioid pain regimen, including a long-acting numbing shot (HTX-011) and standard pain relievers like ibuprofen and acetaminophen, could help people avoid opioids after hernia surgery. About 209 adults scheduled for open inguinal hernia repair took …

This study compared two types of nerve blocks for pain control after breast surgery: the serratus posterior superior intercostal plane block and the PECS II block. One hundred adults aged 21 to 70 were enrolled. Researchers measured how much morphine patients needed in the first …

This study tested whether giving the sedative dexmedetomidine during lung surgery (without a breathing tube) can reduce coughing and pain. 144 adults took part. Researchers measured cough severity and the need for other painkillers. The goal is to make recovery smoother and more …

This completed study tested whether an ultrasound-guided nerve block (TAP block) provides better pain relief after C-section than standard pain medicine. 100 women aged 20-50 who had a C-section took part. Researchers measured pain scores to see which method worked better.

This study looked at 120 boys aged 4 months to 12 years having urogenital surgery. It compared an opioid-free caudal block (using bupivacaine) with an opioid-supplemented penile nerve block (using fentanyl) to see which provides better pain control and less post-surgery delirium.…

This study tested if a local pain injection (liposomal bupivacaine) works as well as an epidural for pain relief after open gynecologic surgery. 106 adults participated. The goal was to see if the injection could provide similar pain control and recovery while being more cost-eff…

This study compared two types of nerve blocks (serratus posterior superior intercostal plane block and deep serratus anterior plane block) to see which provides better pain relief after breast surgery. Sixty-two adults having a mastectomy received one of the two blocks with bupiv…

This completed trial tested whether giving dexmedetomidine or lidocaine continuously during gallbladder surgery can control pain afterward and reduce the need for opioids. 64 adults undergoing laparoscopic cholecystectomy were randomly assigned to receive one of the two drugs. Th…

This study compared two types of nerve blocks—ISPB and ESPB—for pain relief after elective posterior cervical spine surgery. 102 adults received one of the blocks with bupivacaine, and researchers measured how much opioid painkiller they needed during and after surgery. The goal …

This study tested whether adding nalbuphine to the standard spinal anesthetic levobupivacaine helps control pain after total hip replacement. Sixty adults were split into two groups: one received levobupivacaine alone, the other received levobupivacaine plus nalbuphine. Researche…

This study compared two methods of pain relief after hip replacement surgery: a newer technique called erector spinae plane block (ESPB) and the standard epidural. 60 adults having hip replacement took part. Researchers measured pain levels, opioid use, muscle strength, and walki…

This study tested whether an ultrasound-guided belly muscle nerve block (TAP block) can reduce pain and movement during a minimally invasive heart valve replacement (TAVI). Fifty adults having elective TAVI received either the block plus sedation or sedation alone. The goal was t…

This completed study tested two versions of a cooled radiofrequency procedure to relieve chronic knee pain from osteoarthritis. Ten adults with moderate to severe pain received either the standard or a revised nerve-targeting technique. Researchers measured pain, knee function, q…

This small study tested whether taking aspirin and ketamine together by mouth can help people with treatment-resistant depression. Fifteen adults who had not gotten better with standard antidepressants received the combination alongside their usual medication. Researchers measure…

This study compared two pain relief methods for people undergoing lower back decompression surgery. One group received a nerve block (erector spinae plane block), while the other received ketamine through an IV. Researchers measured how well patients recovered using a quality-of-…

This study looked at two different nerve blocks to control pain after thigh lift surgery. 42 adults received either a quadratus lumborum block or a lumbar plexus block. Researchers measured pain levels and how long it took for patients to need extra pain medicine.

This study looked at whether adding a low-dose ketamine infusion to standard pain medication can help people who just had knee replacement surgery. One hundred adults were randomly assigned to get either standard pain relief alone or standard relief plus ketamine through a patien…

This study tested a new non-opioid pain medicine called HTX-011 in 116 people having knee replacement surgery. Everyone received the medicine as part of a pain plan that did not include opioids. The goal was to see how well it controlled pain after surgery. The study is complete,…

This study tested whether a special nerve block called the erector spinae plane (ESP) block can improve pain control after flexible ureteroscopy, a common surgery for kidney stones. 70 adults were randomly assigned to receive either the ESP block plus standard pain care or standa…

This study tested whether adding ketamine or magnesium sulfate to a standard numbing medicine (levobupivacaine) can improve pain control after breast cancer surgery. Sixty adults undergoing mastectomy received one of the two add-ons via a nerve block. The main goal was to see if …

This study tested two types of nerve blocks to manage pain after cancer surgery on the upper belly. 70 adults received either an erector spinae plane block or an external oblique intercostal plane block with the same numbing medicine. Researchers measured how much extra morphine …

This study tested three different pain-blocking methods in 75 children aged 2 to 7 having hernia surgery. The goal was to see which method works best to keep kids comfortable after the operation. Researchers measured pain levels, how much extra pain medicine was needed, and any s…

This study compared two methods of pain relief after cesarean section: injecting numbing medicine into the belly and surgical wound versus giving morphine through a spinal injection. The goal was to see which approach reduces the need for extra painkillers in the first 24 hours. …

This study looked at whether adding dexmedetomidine to standard morphine pain relief after cancer surgery could lower the chance of delirium (sudden confusion) in patients aged 65 and older. A total of 1500 participants were randomly assigned to receive either morphine alone or m…

This study tested whether a continuous infusion of nefopam, a non-opioid painkiller, can reduce the need for fentanyl (a strong opioid) in critically ill patients on mechanical ventilators. Sixty adults were randomly assigned to receive either nefopam plus standard care or standa…

This study tested whether a nerve block called an erector spinae plane block can reduce pain and the need for painkillers after robotic-assisted partial kidney removal. Forty-six adults aged 18-70 were randomly assigned to receive either the nerve block or standard care. The goal…

This study tested whether a numbing injection near the hip (femoral nerve block) works better than IV fentanyl for pain from a broken hip in the emergency room. 104 adults with hip fractures took part. The goal was to see which method provides faster and more effective pain relie…

This study tested whether adding dexmedetomidine (a sedative) to fentanyl (a painkiller) could reduce the amount of fentanyl needed for full-term newborns on breathing machines. Forty babies were given either a lower fentanyl dose plus dexmedetomidine or standard fentanyl alone. …

This study tested two different nerve block techniques to control pain after shoulder arthroscopic surgery. Fifty adults were randomly assigned to receive either a serratus posterior superior intercostal plane block or a combination of suprascapular and axillary nerve blocks. The…

This study tested three different nerve blocks to control pain after video-assisted chest surgery. Sixty adults received one of the blocks, and researchers measured how long they could go before needing morphine. The goal is to find the best way to reduce pain and the need for st…

This study tested three different numbing injections (nerve blocks) to see which one provides the best pain relief after a type of chest surgery called thoracoscopic sympathectomy. Sixty adults took part, and researchers measured how long it took before they needed morphine for p…

This study tested four different nerve blocks (erector spinae, retrolaminar, serratus anterior, and pectoral nerve block) to see which one provides the longest pain relief after breast cancer surgery. 188 women aged 18 to 65 took part. The main goal was to measure how long it too…

This study tested whether a lower dose (15 mg) of the painkiller ketorolac works as well as a higher dose (60 mg) for treating sudden muscle pain in a military emergency department. 110 adults with acute muscle pain received one injection of either dose. The results showed that t…

This study tested whether an ultrasound-guided PECS nerve block could reduce opioid use and improve pain control in 70 women undergoing breast cancer surgery. Participants received either the nerve block or standard care. The goal was to see if the block leads to less pain, less …

This study compared two types of nerve blocks—erector spinae plane (ESP) and rhomboid intercostal (RIB)—for managing pain after breast surgery. 84 patients received one of the blocks before their operation. Researchers measured how much morphine they needed afterward and their pa…

This study compared two pain-blocking techniques—epidural block and erector spinae plane block—in 71 patients undergoing open gynecologic cancer surgery. Researchers measured pain scores, opioid use, and how quickly patients could move after surgery. The goal is to find which met…

This study looked at 75 women who had planned cesarean deliveries to see if different pain relief methods affect how soon they start breastfeeding and whether they breastfeed exclusively. The researchers compared standard pain management with TAP blocks, a type of abdominal nerve…

This study looked at whether a tool called the Surgical Pleth Index (SPI), which measures stress during surgery, can predict how much pain a person will feel after waking up from a brain operation. 52 adults having craniotomy were monitored, and their pain scores and painkiller u…

This study looked at how a low dose of the sedative drug dexmedetomidine affects pain signals in the brain. Researchers used brain scans to measure changes in fluid flow. 17 healthy adults took part. The goal was to understand the drug's pain-relieving effects, not to test a new …

This study looked at how satisfied patients were with their pain control after outpatient ear, nose, and throat (ENT) procedures. Researchers compared those who received opioid pain medication to those who received non-opioid alternatives. 160 adults participated, and the main go…

This study looked at whether adding a brain wave monitor (pEEG) to standard sedation checks helps reduce delirium and time on a breathing machine in ICU patients. Researchers followed 150 adults on ventilators who needed sedation. They compared those who got both the brain monito…

This study tested a device called ANI that measures heart rate changes to assess comfort in patients who cannot speak, such as those in end-of-life care. Twenty non-communicating patients in a palliative care unit were monitored during a painful procedure. The device's readings w…

This study tested how well BD NRFit spinal needles and syringes work in real-world medical settings. A total of 161 patients receiving anesthesia or pain relief procedures were included. Researchers measured successful needle placement, syringe function, and safety issues like he…

This study looked at how much lidocaine and ropivacaine stay in the blood when both are used for pain control during major abdominal surgery. It involved 51 adults having open abdominal surgery. The goal was to understand if combining these drugs is safe and how their levels chan…