ANALGESIA

This study tested whether adding a medication called dexmedetomidine to standard pain control after cancer surgery could help older patients live longer. Researchers enrolled 1,500 patients aged 65+ who had surgery to remove a solid tumor. They wanted to see if this drug, by redu…

This study tested a simple, non-invasive heart rate monitor (called ANI) to see if it could accurately detect pain and discomfort in patients who are unable to communicate, such as those receiving end-of-life palliative care. Researchers compared the monitor's readings to pain as…

This study compared two different nerve-blocking techniques to manage pain after abdominal cancer surgery. Researchers tested which method provided better pain relief and reduced the need for strong painkillers like morphine. The trial involved 70 adults undergoing liver or kidne…

This study compared three different nerve block techniques to manage pain after shoulder surgery. Researchers tested a new nerve block method against two established techniques in 50 adults undergoing shoulder surgery. The goal was to find which approach provides the best pain re…

This study tested whether adding a low-dose ketamine infusion to standard pain medication could help patients after knee replacement surgery. 100 adults were randomly assigned to receive either the standard pain plan or the standard plan plus ketamine. Researchers measured pain l…

This study aimed to see if a smaller dose of a common pain medication (ketorolac) works as well as the standard larger dose for treating sudden muscle or joint pain. It involved 110 military-affiliated patients in an emergency room. The goal was to find the lowest effective dose …

This study tested if a targeted nerve block in the abdomen could better control pain for patients undergoing a minimally invasive heart valve replacement (TAVI). The goal was to keep patients more comfortable and still during the procedure, which may improve safety and satisfacti…

This study tested whether adding a medication called dexmedetomidine could help reduce the amount of strong pain medication (fentanyl) needed for full-term newborns on breathing machines. Researchers enrolled 40 infants aged 1-28 days who were starting mechanical ventilation. The…

This study aimed to find the most effective way to manage pain for children aged 2 to 7 after a common hernia repair surgery. Researchers compared three different methods of delivering numbing medicine: two types of nerve blocks and a simple injection at the surgery site. They me…

This study compared three different nerve-block techniques to control pain after minimally invasive sweat gland surgery. Researchers tested which method provided the longest-lasting pain relief with the fewest side effects in 60 adults undergoing the procedure. The goal was to he…

This study compared two different nerve-block techniques to see which provides better pain relief after breast cancer surgery. Researchers tested ultrasound-guided injections in the back to numb nerves before surgery. The goal was to reduce patients' need for strong pain medicati…

This study compared different methods to manage pain after cesarean section surgery. Researchers tested whether local numbing medications injected into the abdominal area could work as well as traditional spinal morphine to reduce pain. The goal was to see if these alternative me…

This study compared two different nerve-blocking techniques for pain relief after thigh lift surgery. Researchers tested whether a newer method (transmuscular quadratus lumborum block) works as well as a standard method (lumbar plexus block) for controlling pain after surgery. Th…

This study tested if a specific nerve block could help control pain after robotic surgery to remove part of a kidney. Researchers compared pain levels and painkiller use in 46 patients who either received the numbing injection or did not. The goal was to see if this common anesth…

This study compared two different nerve block techniques for pain relief after breast cancer surgery. Researchers tested which method provided better pain control and reduced the need for opioid pain medications. The trial involved 62 women undergoing mastectomy surgery to determ…

This large study tested whether taking ibuprofen for eight days after hip or knee replacement surgery is safe. Nearly 3,000 patients were randomly given either ibuprofen or a placebo pill to see which group had fewer serious complications. The goal was to find the best balance be…

This study compared two non-opioid medications (dexmedetomidine and lidocaine) given during surgery to reduce pain after gallbladder removal. Researchers tested which medication better controlled pain while minimizing the need for opioid painkillers after surgery. The trial invol…

This study tested if a specific nerve block given before a common kidney stone surgery could improve pain relief afterward. 70 patients were randomly assigned to receive either the nerve block or standard pain care. Researchers measured pain levels, opioid medication use, and sid…

This study tested a planned, non-opioid approach to managing pain after total knee replacement surgery. All 116 participants received an experimental long-acting numbing medicine (HTX-011) as part of a scheduled multi-drug plan. The main goal was to see how well this approach con…

This study tested whether adding ketamine or magnesium sulfate to a standard numbing injection (nerve block) could better control pain after breast cancer surgery. It involved 60 women undergoing surgery and measured how much morphine they needed afterward and how long their pain…

This large study tested whether adding a medication called dexmedetomidine to standard pain control could reduce the risk of delirium (sudden, severe confusion) in older adults recovering from cancer surgery. Researchers enrolled 1,500 patients aged 65 and older who were having m…

This study compared three different nerve-block techniques to manage pain after minimally invasive chest surgery. Researchers tested which method provided the longest-lasting pain relief and required the least additional pain medication in 60 adult patients. The goal was to find …

This study compared two different methods for managing pain after open surgery for gynecologic cancers. Researchers tested whether a newer nerve block (erector spinae plane block) works as well as the standard epidural block for controlling pain and reducing opioid medication use…

This study tested which method works better for quickly reducing severe pain from a broken hip in the emergency room: a targeted nerve-block injection or standard intravenous (IV) pain medication. Researchers compared an ultrasound-guided injection that numbs the leg nerve (femor…

This study tested whether a new type of nerve block injection could better control pain after surgery to repair an epigastric hernia (a bulge in the upper abdomen). Researchers compared pain levels and the need for strong painkillers like morphine in 40 adults who received either…

This study tested whether specific nerve blocks can better control pain after breast cancer surgery. Researchers enrolled 188 women to see if this technique delays the need for opioid painkillers after their operations. The goal was to find safer, more effective pain management o…

This study looked at how different methods of pain relief after a planned C-section affect a mother's ability to start and continue breastfeeding. Researchers compared three pain management techniques in 75 mothers to see which one best supported breastfeeding in the first crucia…

This study tested whether a targeted nerve block, given before surgery, could reduce pain and the need for strong opioid painkillers after breast cancer surgery. It involved 70 women having a specific type of breast cancer operation. Researchers compared the nerve block to standa…

This study tested if a non-opioid drug called nefopam, given through a continuous IV drip, could safely reduce the need for strong opioid painkillers in critically ill adults on breathing machines. Researchers compared the drug to standard pain care in 60 patients to see if it lo…

This study observed if using a brain wave monitor (pEEG) alongside standard checks helps manage sedation for adults in the ICU on breathing machines. Researchers compared outcomes like delirium, time on the ventilator, and post-ICU symptoms between patients monitored with the bra…

This study aimed to understand how a low dose of the sedative drug dexmedetomidine relieves pain by looking at brain activity. Researchers gave the drug to 17 healthy volunteers and used MRI brain scans while applying a controlled pain stimulus. The goal was to map how the drug c…

This study observed how well a new type of spinal needle and syringe system works during real-world anesthesia procedures. Researchers followed 161 patients for about 10 days after their spinal injections to see how successfully the needles were placed and to check for side effec…

This study aimed to understand the safety of using two powerful pain control methods together during major abdominal surgery. Researchers measured the levels of the drugs lidocaine (given by IV) and ropivacaine (given by epidural) in the blood of 51 patients. The goal was to see …

The aim of this study is to compare the quality of recovery of the erector spinae plane block (ESPB) versus ketamine-based multimodal analgesia regimen after spine decompressive surgery.