ANALGESIA

This study looked at whether adding dexmedetomidine to standard pain relief after cancer surgery helps elderly patients (65-90 years old) live longer. The idea is that this medicine might reduce stress, inflammation, and confusion, which could improve immune function and lower th…

This study tested three different nerve blocks to control pain after video-assisted chest surgery. Sixty adults were randomly assigned to receive one of the blocks. Researchers measured how long it took for patients to need extra pain medicine and how much they used. The goal was…

This study tested a new non-opioid pain medicine called HTX-011 in 116 people having knee replacement surgery. Everyone received the medicine as part of a planned pain control plan that did not include opioids. The goal was to see how well it controlled pain after surgery. The st…

This study compared two ultrasound-guided nerve blocks—erector spinae plane (ESP) block and rhomboid intercostal block (RIB)—for pain relief after breast surgery. 84 patients undergoing unilateral breast surgery received one of the blocks, and researchers measured morphine use an…

This study looked at two methods to help people recover from back surgery: a nerve block (ESPB) and a mix of pain medicines including ketamine. 62 adults having lumbar decompression surgery took part. The goal was to see which approach leads to a better recovery and less pain.

This study looked at whether taking ibuprofen for eight days after hip or knee replacement is safe. About 2904 adults took part. Researchers tracked serious problems like heart attack, stroke, bleeding, or kidney failure for 90 days after surgery.

This study tested whether a special nerve block (called recto-intercostal fascial plane block) can reduce pain after epigastric hernia repair. Forty adults having hernia surgery received either the nerve block or standard care. Researchers measured how long it took for patients t…

This study tested a non-invasive device called ANI that measures heart rate patterns to assess comfort in 20 non-communicating patients receiving end-of-life palliative care. The goal was to see if the ANI could reliably detect pain or stress during routine care, compared to a st…

This study looked at 71 women having open surgery for gynecologic cancer to compare two ways of controlling pain: an epidural block and a newer erector spinae plane block. The goal was to see if the newer block works just as well for pain scores, reducing the need for strong pain…

This study tested whether a special nerve block called the erector spinae plane (ESP) block can improve pain relief after flexible ureteroscopy (URS) surgery for kidney stones. Seventy adults were randomly assigned to receive either the ESP block plus standard pain care or standa…

This study looked at how different pain relief methods after a planned cesarean delivery affect a mother's ability to start and continue breastfeeding. Researchers compared a type of abdominal nerve block (TAP block) with other pain treatments in 75 women. The goal was to see if …

This study tested whether injecting local anesthetic into the belly and wound during C-section can reduce the need for strong painkillers compared to standard spinal morphine. 46 women having planned C-sections took part. The goal was to see which method provides better pain cont…

This study tested two non-opioid drugs, dexmedetomidine and lidocaine, given continuously during gallbladder surgery to control pain and reduce the need for stronger opioids. 64 adults having laparoscopic cholecystectomy took part. The goal was to see which drug provides better p…

This study tested whether a femoral nerve block (a numbing injection) works better than intravenous fentanyl (a strong painkiller) for hip fracture pain in the emergency department. 104 adults with hip fractures took part. Researchers measured pain changes and side effects. The g…

This study tested whether an ultrasound-guided PECS nerve block could reduce opioid use and improve pain control in 70 women undergoing breast cancer surgery. Participants received either the nerve block or standard care. The goal was to see if the block could lower the need for …

This study looked at different ways to manage pain after breast cancer surgery. It involved 188 women aged 18 to 65. The main goal was to see how long it took before they needed pain medicine. The results could help improve comfort after surgery.

This study tested whether an ultrasound-guided TAP block (a type of nerve block) can reduce pain and improve stability during a heart valve replacement procedure called TAVI. Fifty adults undergoing elective TAVI received either the block or standard care. The goal was to see if …

This study compared two types of nerve blocks—transmuscular quadratus lumborum block and lumbar plexus block—for pain relief after thigh lift surgery. Forty-two adults participated, and researchers measured pain levels, opioid use, and recovery milestones. The goal was to see whi…

This study tested whether adding a painkiller called nefopam to standard care could lower the amount of strong opioids needed by ICU patients on breathing machines. 60 adults were randomly assigned to receive either nefopam or a placebo alongside usual sedation. The goal was to s…

This study looked at whether a 15 mg dose of the painkiller ketorolac works as well as a 60 mg dose for treating sudden muscle pain in a military emergency department. 110 adults with acute muscle pain received one of the two doses. The main goal was to see if the lower dose was …

This study tested whether adding a continuous infusion of ketamine to standard pain management could reduce opioid use and improve pain control after knee replacement surgery. 100 adult patients were randomly assigned to receive either standard care alone or standard care plus ke…

This study tested three different nerve blocks to control pain after a type of chest surgery called thoracoscopic sympathectomy. Sixty adults were randomly assigned to receive one of the blocks. Researchers measured how long it took for patients to need extra pain medicine and ho…

This study looked at whether a specific nerve block (erector spinae plane block) can reduce pain and the need for painkillers after robotic-assisted partial kidney removal. 46 adults aged 18-70 were randomly assigned to receive either the nerve block or standard care. The main go…

This study tested whether adding dexmedetomidine to standard fentanyl treatment could reduce the amount of pain medicine needed by full-term newborns on breathing machines. 40 infants participated. Researchers measured how many extra pain doses were needed and monitored for side …

This study tested two different nerve blocks to control pain after breast surgery. One hundred adults were randomly assigned to receive either a serratus posterior superior intercostal plane (SPSIP) block or a pectoral nerve (PECS II) block. The main goal was to see which block r…

This study tested two different nerve block techniques to see which provides better pain relief after shoulder arthroscopy. Fifty adults having shoulder surgery received either a serratus posterior superior intercostal plane block or a combination of suprascapular and axillary ne…

This study tested three different pain-relief methods in 75 children aged 2 to 7 having hernia surgery. The goal was to see which approach—an ultrasound-guided back muscle block, a caudal (tailbone) block, or simple local numbing—provides the best pain control after surgery. Rese…

This study tested two types of nerve blocks to manage pain after cancer surgery on the upper belly. 70 adults received either an erector spinae plane block or an external oblique intercostal plane block. The goal was to see which one reduces the need for morphine and other pain m…

This study tested two different nerve block techniques to manage pain after breast surgery. 62 adults having a mastectomy were randomly assigned to receive one of the two blocks. Researchers measured pain scores and painkiller use over 24 hours to see which method worked better.

This study tested if adding ketamine or magnesium sulfate to a standard numbing injection (nerve block) could better control pain after breast cancer surgery. It involved 60 women and measured how much morphine they needed for pain relief in the first two days after their operati…

This study tested whether adding a medication called dexmedetomidine to standard pain control could reduce the risk of delirium (sudden, severe confusion) in elderly patients after cancer surgery. Researchers enrolled 1,500 patients aged 65 and older who were having major cancer …

This study looked at how two pain medicines, lidocaine (given through a vein) and ropivacaine (given through a tube in the back), affect each other's levels in the blood during major abdominal surgery. 51 adults having open abdominal surgery took part. The goal was to see if usin…

This study looked at how satisfied patients were with their pain control after outpatient ear, nose, and throat surgery. Researchers compared standard opioid painkillers to non-opioid options. 160 adults took part, and the goal was to see if non-opioid medicines could provide equ…

This study looked at 150 ICU patients on breathing machines to see if adding a brain activity monitor (pEEG) to standard sedation checks could reduce confusion (delirium), time on the ventilator, and long-term problems after ICU. Researchers compared patients who got both the bra…

This study used brain imaging to understand how a low dose of the sedative dexmedetomidine reduces pain. Seventeen healthy adults received the drug while researchers measured changes in brain fluid flow. The goal was to learn more about the drug's pain-relieving effects, not to t…

This study looked at how well BD NRFit spinal needles and syringes work in real medical settings. 161 patients of any age who needed a spinal procedure took part. Researchers measured how often the needle was placed correctly, how well the syringe worked, and if there were any si…