ANALGESIA

This study tests whether taking oral nifedipine, a drug usually used for high blood pressure, can reduce pain and improve wound healing after hemorrhoid removal. One hundred adults in Yemen will receive either nifedipine or a placebo twice daily for two weeks after surgery. Resea…

This trial tests whether a fentanyl nasal spray can reduce pain during eye exams for retinopathy of prematurity (ROP) in preterm infants. About 58 babies born at or before 31 weeks will receive either fentanyl or a saltwater placebo before their routine exam, along with standard …

This study tests whether a combination of two sedatives, esketamine and dexmedetomidine, can better control agitation and shorten delirium in intensive care unit (ICU) patients who are on non-invasive breathing support. The trial will enroll 388 adults with hyperactive delirium a…

This study tests whether a special ultrasound-guided nerve block can lower the amount of strong painkillers (opioids) needed after breast reduction surgery. About 80 women will be randomly assigned to receive either standard pain treatment alone or standard treatment plus the ner…

This study tests whether taking omega-3 fatty acids before and after gallbladder surgery can lower the amount of morphine needed for pain. Forty adults will receive either omega-3 supplements or a placebo, plus a small dose of morphine after surgery. Researchers will measure tota…

This study looks at two methods to control pain after hindfoot surgery: a single nerve block injection versus a small tube (catheter) that delivers numbing medicine continuously for days. The goal is to see which approach reduces pain, cuts down on opioid use, and helps people re…

This study tests a new ultrasound-guided pain block for high-risk children (ages not specified) having anal or penile surgery. The goal is to see if this block can delay or replace strong pain medicines that can cause breathing or heart problems. Sixty children will be enrolled, …

This study compares two types of nerve blocks (rectus sheath block and transversus abdominis plane block) to see which provides better pain relief after laparoscopic weight-loss surgery. About 96 adults aged 20-60 will be randomly assigned to receive one of the blocks after gener…

This study tests if using scalp nerve blocks and a drug called dexmedetomidine can reduce the need for strong opioid painkillers and prevent confusion after brain tumor surgery. About 2000 adults having brain surgery will be randomly assigned to receive one or both treatments, or…

This study tests whether adding neostigmine to a standard numbing medicine (bupivacaine) in a belly-wall nerve block can improve pain control after cesarean delivery. About 58 women having planned C-sections will receive either the combo or the standard block alone. The goal is t…

This study tests a combination of two pain-relief methods—a sedative drug called dexmedetomidine and a local anesthetic injected into the scalp—for people undergoing brain tumor surgery. The goal is to see if this approach reduces the need for strong opioid painkillers after surg…

This study tests two nasal sprays, sufentanil and ketamine, to see which works better for severe pain from injuries like broken bones in children aged 6 to 17. Both sprays are given in the emergency room along with standard care. The goal is to find a fast, needle-free way to eas…

This study looks at whether giving a scalp nerve block before a craniotomy (brain surgery) can lower pain after surgery and reduce the need for strong painkillers. Researchers will compare giving the block before the first cut versus after. The study plans to enroll 64 adults age…

This study tests whether a single injection of the numbing drug ropivacaine around nerves can reduce pain and the need for narcotic pain pills in children and teens after ACL knee surgery. About 160 participants aged 13 and older will either receive the nerve block or not during …

This study looks at whether a new, carefully designed plan for giving painkillers and sedatives to patients on ECMO (a life-support machine) is possible to use in hospitals. ECMO patients often face long-term problems like anxiety and memory issues, which may be linked to how muc…

This study will enroll 400 older adults (over 60) having heart surgery to see if genetic differences affect how well methadone and oxycodone work and their side effects. Researchers will measure pain, nausea, breathing problems, and sedation. The goal is to personalize pain treat…