ANALGESIA

This study tests whether adding ketorolac (an anti-inflammatory) to the standard numbing medicine lidocaine can reduce pain during office hysteroscopy, a procedure to look inside the uterus. About 60 women with abnormal bleeding will be randomly assigned to receive either the com…

This study compares two ways of giving morphine after a planned C-section: one injected into the spinal fluid and one into the space around the spinal cord. The goal is to see which provides better pain relief with fewer side effects like nausea or itching. About 120 women will t…

This study compares two ways of deciding when to give extra pain medicine after surgery. One method uses a standard pain scale, while the other also considers how much pain limits movement. The goal is to see if the new method reduces unnecessary painkiller use. About 76 adults h…

This study tests if a special nerve block (SPSIPB) can reduce pain and the need for strong painkillers after minimally invasive heart surgery. Sixty adults having heart bypass surgery will be split into two groups: one gets the nerve block plus standard pain care, the other gets …

This study tests three different doses of a drug called dexmedetomidine, added to the usual numbing medicine for a nerve block in the armpit area. The goal is to see if a higher dose can keep the arm numb and pain-free longer after elbow or hand surgery. About 69 adults having up…

This study tests whether a numbing injection called a TAP block can reduce pain and improve satisfaction for 100 adults undergoing heart procedures like angiography or stenting through the groin. The block targets nerves that supply the groin area. Researchers will measure pain s…

This study tests a device called NeuroCuple™ that uses no medication to manage pain after cesarean delivery. About 180 women will be randomly assigned to receive the device, a sham device, or standard care. The goal is to see if the device reduces pain and the need for opioid pai…

This study tests whether adding dexmedetomidine or dexamethasone to a standard numbing medicine (bupivacaine) provides better pain relief after thyroid surgery. Sixty adults having their thyroid removed will receive one of the two combinations via a nerve block. The goal is to se…

This study tests whether an ultrasound-guided nerve block (auricularis magnus block) can reduce pain and the need for strong painkillers after middle ear surgery. About 56 adults having elective ear surgery will receive the block or standard care. The goal is to improve recovery …

This study compares two pain-blocking injections (ESPB and PIFB) given before heart surgery to see which one reduces pain and helps patients breathe better afterward. About 80 adults having their first open-heart surgery will take part. The goal is to find the best way to manage …

This study tests whether adding an extra numbing injection (IPACK) to a standard nerve block (adductor canal block) can better control pain and reduce the need for strong painkillers after knee realignment surgery. About 100 adults aged 18-75 having specific knee procedures will …

This study looks at whether numbing the nerves in the upper and lower jaw before surgery can lower pain and the need for strong painkillers after the operation. About 60 adults having elective facial surgery will take part. Researchers will measure pain scores, heart rate, and ho…

This study tests whether adding a shoulder nerve block to a standard steroid injection works better than the steroid injection alone for people with frozen shoulder (adhesive capsulitis). About 50 adults aged 41-65 with ongoing shoulder pain and stiffness will take part. The goal…

This study tests if a long-acting painkiller (liposomal bupivacaine) works better than a standard one (ropivacaine) for pain after open upper abdominal surgery. About 146 adults having this surgery will receive one of the two drugs injected into the belly lining before the incisi…

This study tests if a long-acting painkiller called Exparel can better control pain and reduce the need for strong narcotic pain pills in children and teens after knee surgery. About 100 participants aged 13 and older will receive either Exparel plus a standard painkiller or the …

This study looks at whether a high-dose nicotine patch, placed on the skin before and after chest surgery, can help reduce pain and the need for strong painkillers in male smokers who have temporarily stopped smoking. About 80 men aged 18-75 who smoke regularly and are having lun…

This study tests whether a special nerve block (PENG block) given before hip replacement surgery can help patients have less pain, use fewer strong painkillers, and get out of bed and walk sooner. The study will include 60 adults between 40 and 85 years old who are having hip rep…

This study tests whether using virtual reality (VR) headsets during a scheduled cesarean section can help reduce pain and anxiety. Twenty women will be offered VR from admission through recovery. The goal is to see if this approach is practical and improves the birth experience.

This study tests whether giving a single dose of paracetamol or ibuprofen before nose surgery can reduce the need for stronger opioid painkillers during and after the operation. It involves 54 adults undergoing septorhinoplasty. The goal is to find a safer way to manage pain and …

This study looks at different ways to manage pain for adults with broken bones or dislocations in the emergency room. Researchers want to find which method gives the best pain relief and makes patients most satisfied. About 200 adults will take part, and their pain and satisfacti…

This study tests whether a 15mg or 30mg dose of the painkiller ketorolac provides longer pain relief for people with kidney stone pain in the emergency department. About 86 adults under 65 with moderate to severe pain will receive one of the two doses. Researchers will measure pa…

This study follows 2000 adults who are having weight-loss surgery to see how their pain and daily activities change afterward. Researchers will ask patients about their pain levels, side effects, and how much pain interferes with normal life. The goal is to find out what factors …

This study aims to find out if a person's genetic makeup influences how much pain they feel after surgery and how much pain medicine they need. Researchers will observe 5,000 adults undergoing planned operations and track their pain levels and recovery for one year. The goal is t…

This study looks at three common ways to manage pain after open heart surgery: IV pain medicine, an epidural, and a nerve block. The goal is to see which method helps prevent long-term pain that can last for months. Researchers will follow 90 adults for 3 months after surgery to …

This study tests if a device that gently stimulates nerves in the ear (tAN) relieves pain by causing the body to release its own natural painkillers (endogenous opioids). 136 healthy adults will receive either real or sham stimulation, plus an IV that either blocks opioids or is …

This study explores whether a person's genetic makeup influences how they recover from surgery. Researchers will track 20,000 adults having planned operations, looking at complications like nausea, vomiting, and pain. The goal is to identify genetic factors that could help predic…

This study aims to see if low-dose buprenorphine (a partial opioid) can provide pain relief similar to oxycodone but with less risk of abuse. Healthy volunteers will receive different doses of buprenorphine, oxycodone, or a placebo in separate sessions. Researchers will measure p…