Substance withdrawal syndrome

This study tests whether a virtual session with a peer recovery coach can help incarcerated adults with substance use disorders connect to addiction treatment and recovery resources. About 550 participants in jail will either get the coaching or just standard information. Researc…

This study examines whether adding structured high-intensity physical exercise to a 3-month residential treatment program for substance use disorder improves patients' physical health, mental health, and quality of life. Researchers measure changes in oxygen uptake, leg strength,…

This study aims to create a way for mothers with opioid use disorder to receive treatment (buprenorphine) while visiting their babies in the neonatal intensive care unit (NICU). Researchers will interview mothers and healthcare providers to understand barriers and then develop a …

This trial tests whether a helmet that delivers focused ultrasound waves can safely change brain activity in people with moderate-to-severe substance use disorder who haven't responded to medication. Participants receive two MRI-guided sessions targeting brain regions linked to a…

This early-stage trial is testing whether low-intensity focused ultrasound (LIFU) can safely help people with opioid or other substance use disorders. The device sends sound waves to specific brain areas to calm cravings. 29 adults in outpatient treatment will receive both real a…

This study compares two patient navigation models for people recently involved in the criminal legal system who have substance use disorders. One group gets standard navigation, while the other can choose from a menu of services like in-person clinics, mobile health units, or tel…

This study looks at whether having regular motivational conversations after leaving the hospital for alcohol withdrawal can help people stay sober longer. About 104 adults who want to quit drinking completely will be split into two groups: one gets standard care, the other also g…

This study tests whether a program called SBIRT (Screening, Brief Intervention, and Referral to Treatment) can help people reduce risky alcohol and drug use. About 400 adults visiting family planning clinics will either get SBIRT or usual care. Researchers will track changes in d…

This study tests whether a mobile app can help people in addiction treatment avoid relapse. 150 participants will either receive standard care or standard care plus the app, which monitors warning signs and sends alerts. The goal is to see if the app improves long-term recovery.

This pilot study tests a personalized deep brain stimulation (DBS) method for people with severe, treatment-resistant substance use disorders. Ten participants will first undergo detox, then have temporary electrodes placed in their brains to map addiction-related circuits, follo…

This study tests a new behavioral program called InTEGRA for teens aged 14-21 with alcohol or cannabis use disorder. It combines 12-step facilitation with motivational and cognitive-behavioral therapy. Researchers will compare it to standard therapy to see if it leads to more day…

This study tests a smartphone app designed to strengthen self-control in teens and young adults (ages 14-35) being treated for alcohol or cocaine use disorder. Participants will complete 12 short training sessions over about a month, plus booster sessions. The goal is to see if t…

This study tests whether prazosin, a blood pressure medicine, can help people with alcohol use disorder who also have withdrawal symptoms drink less heavily. About 150 adults will receive either prazosin or a placebo for 12 weeks, along with weekly counseling. The main goal is to…

This study tests whether trained peer recovery specialists can help Black individuals with substance use stick to their long-acting injectable HIV treatment or prevention. 186 participants will either get this peer support or standard care. The goal is to see if the peer program …

This study tests a 'rooming-in' approach where mothers and babies stay together in a quiet hospital room instead of separating the baby to the NICU. About 240 full-term infants exposed to opioids during pregnancy will take part across Alberta hospitals. The goal is to reduce NICU…

This study tests whether a 'practice coaching' program can help opioid treatment clinics offer more HIV and hepatitis C testing to their patients. Clinics are randomly assigned to receive either coaching focused on HIV testing, coaching that adds hepatitis C testing, or just info…

This pilot trial tests a counseling program called CHOICES-PLEAS for women in a jail-based substance use treatment program. The goal is to reduce the risk of substance-exposed pregnancies by helping women change their substance use and risky sexual behaviors. Participants receive…

This study tests whether adding a trained family advocate to a proven parenting program can help prevent substance use and reduce childhood trauma. About 360 families from 36 high-risk communities in New Jersey will take part. The goal is to see if extra support makes the program…

This study tests a wearable device worn on the ear that stimulates nearby nerves to change brain signals. The goal is to see if it can reduce chronic pain and ease symptoms of opioid withdrawal. Adults aged 18 to 65 with chronic pain who are tapering off opioid medication will re…

This study tests a new medication called PP-01 to help adults with cannabis use disorder manage withdrawal symptoms when they stop using cannabis. About 420 participants will receive PP-01, an existing drug (nabilone), or a placebo daily for 34 days, with a one-week hospital stay…

This study tests a web-based platform called KulaMind-Recovery designed to help loved ones of people recovering from substance use disorders. The platform offers skill-building modules, one-on-one video sessions, text-based coaching, and a community forum. Researchers will see if…

This study tests suzetrigine, a new FDA-approved non-opioid pain medication, in 210 adults undergoing total hip replacement. Participants receive either suzetrigine or a placebo for seven days, starting before surgery. The goal is to see if suzetrigine reduces the amount of opioi…

This Phase 2 trial tests whether adding buspirone (an anxiety medication) to lofexidine (a withdrawal drug) can reduce opioid withdrawal symptoms and cravings during detox. About 100 adults with opioid use disorder will stay in a residential setting for 10–12 days, undergo a step…

This study tests whether music therapy can help newborns who are withdrawing from opioids they were exposed to before birth. Researchers will try six different music-based approaches, including parent-sung lullabies and rhythmic sounds, to see if they calm the babies and improve …

This study is testing a wearable device called Sparrow Link that sends gentle electrical pulses to nerves in the ear to help reduce opioid withdrawal symptoms. About 50 hospitalized adults with opioid use disorder will receive either the active device or a sham version, along wit…

This study tests a wearable earpiece that gently stimulates nerves to help people going through alcohol withdrawal. Twenty adults with alcohol use disorder will wear the device or a sham version for 5 days during detox. Researchers will measure withdrawal severity, cravings, and …

This pilot study tests whether probenecid, a drug currently used for gout, can reduce withdrawal symptoms in people with chronic pain who are voluntarily lowering their opioid dose. Researchers will enroll 40 adults and randomly assign them to take probenecid or a placebo for 12 …

This study is testing whether music therapy can help people with substance use disorder. 600 participants across Europe will be randomly assigned to either active music-making, music listening, or standard treatment. The goal is to see if music therapy improves addiction severity…

This pilot study tests whether adding ear acupressure (small seeds taped to ear points) to standard nicotine patches or gum can reduce cravings, withdrawal symptoms, and anxiety in psychiatric inpatients who must stop smoking during their hospital stay. Sixty participants will be…

This study tests whether a non-invasive device that stimulates the vagus nerve in the neck can reduce withdrawal symptoms in people with opioid use disorder. About 103 participants will stay in the hospital for a week, receive either active or sham stimulation, and have brain sca…

This study tests whether adding pregabalin to the standard withdrawal drug lofexidine helps people with opioid use disorder feel less sick while quitting. About 150 adults who want to start long-acting naltrexone will take either the combination or a placebo for 8 days. The goal …

This study tests a multi-sensory therapy called Heal, which uses calming sounds, gentle vibrations, and soft lighting to help detained youth (ages 12-18) manage their emotions before counseling sessions. The goal is to see if this brief, non-verbal intervention improves emotional…

This study tests whether peer support workers—people with lived experience of substance use—can help people who use drugs feel safer and stay in the emergency department until their care is complete. The study will compare what happens when peer workers are on shift versus when t…

This study is testing three treatments one after another for people with chronic pain who are already taking long-term opioids. First, participants try a low-dose buprenorphine patch (a safer opioid) without going through withdrawal. Then, they receive a brief cognitive behaviora…

This study tests whether a buprenorphine patch can reduce withdrawal symptoms when pregnant women with opioid use disorder start sublingual buprenorphine treatment. Forty participants will receive either a real patch or a sham bandage during the initial withdrawal period. Researc…

This study tests whether a ketone supplement drink can reduce alcohol withdrawal symptoms in 30 adults with moderate to severe alcohol use disorder. Participants will receive either the ketone drink or a placebo for 4 days during inpatient detox. The main goal is to see if the ke…

This study tests whether a special team of doctors, nurses, and peer supporters can help people with substance use disorders get the follow-up care they need after a hospital stay. The team meets patients in the hospital and provides support and treatment after they leave, helpin…

This study follows 700 people with substance use disorders over two years to see how addiction symptoms, especially craving, are connected and whether those connections change as addiction severity shifts. Participants complete annual diagnostic assessments and two-week periods o…

This study investigates what happens when exclusive e-cigarette users stop vaping, focusing on withdrawal symptoms like cravings, mood changes, and sleep disruption. Researchers will give participants either a nicotine patch or a placebo patch to see how nicotine affects these sy…

This study tests a bundle of smartphone-based tools, including a mobile health app and other online resources, to see if they are practical and helpful for people who use drugs. The goal is to lower overdose risk by improving access to prevention services. Forty participants will…

This study will follow 40 adults aged 18-70 who currently take tirzepatide, a medication for blood sugar and appetite control. Researchers will temporarily stop the drug for 3-4 weeks and then restart it for 6-8 weeks, using brain scans, questionnaires, and stool samples to track…

This study looks at whether brain activity related to learning can predict how well teens respond to a program aimed at reducing cannabis use. Teens aged 14-17 get a brain scan, then attend 10 weekly virtual sessions where they report use and take drug tests. They can earn prizes…

This study is testing whether a smartwatch can pick up on body changes—like skin temperature—that happen during opioid withdrawal and cravings. Twenty people with opioid use disorder will wear the device for 14 days while their symptoms are tracked. The goal is to see if the watc…

This study looks at how stopping smoking for six weeks affects the body's chemistry and gut bacteria in people being treated for substance use disorders. Researchers will compare 100 participants who quit smoking with 50 healthy controls, using blood and stool samples along with …

This study aims to see if a digital version of the WHO's mental health guide for substance use disorders can be used effectively in primary care settings in Pakistan. Researchers will train 300 primary care doctors in three major cities using this digital tool. The goal is to und…

This study is building a Canada-wide registry of people who come to emergency departments with opioid poisoning. Researchers will track treatments and outcomes for up to 7,200 patients. The goal is to learn what works best and create a tool to predict who is at highest risk of dy…

This study looks at whether using a special counseling style called Motivational Interviewing during the first visit can help people stay in addiction treatment. Researchers will compare this approach to the usual intake process. About 150 adults seeking outpatient addiction trea…

This study looks at medical records of about 800 full-term newborns with Neonatal Opioid Withdrawal Syndrome (NOWS) to compare two standard treatments: buprenorphine and morphine. Researchers want to find out which medicine helps babies recover and become ready for discharge soon…

This study looks at whether a tool called MyPath helps women with substance use disorder make better decisions about birth control after having a baby. About 400 women will use the tool during pregnancy or right after delivery. The goal is to see if it helps them pick a method th…

This study looks at tiny molecules called microRNAs in the saliva of newborns exposed to opioids before birth. Researchers want to see if these molecules can predict how severe withdrawal symptoms will be and guide treatment. The goal is to move away from one-size-fits-all care a…

This study is looking at 120 people who are already in treatment for abusing opioids and/or benzodiazepines (anti-anxiety drugs). Researchers want to understand why people use these drugs together, which greatly raises the risk of overdose and death. Participants will complete in…

This study aims to develop and test a supervision strategy for clinical supervisors in substance use disorder treatment programs. The goal is to reduce counselor burnout and turnover, and improve their well-being and performance. About 43 supervisors and counselors from residenti…

This study is testing a cooking and nutrition program for 50 people in Texas who are recovering from opioid use and living in recovery homes while on medication therapy. The program aims to improve their eating habits and confidence in cooking skills. Participants will fill out q…

This study is following 10,000 people who are seeking help for substance or behavioral addictions. Researchers will track their medical, brain, social, and psychological health over several years using interviews, questionnaires, and cognitive tests. The goal is to better underst…

This study looks at whether having a specially trained peer recovery specialist in the emergency department helps people with substance use disorders connect to treatment and support services. Researchers will follow 400 adults who visit the ER for substance-related issues, compa…

This study looks at how opioid withdrawal symptoms vary from person to person. Sixty adults with opioid use disorder will go through a medically supervised taper using hydromorphone and lofexidine. Researchers will measure withdrawal severity during the taper and after a naloxone…