Substance withdrawal syndrome
MONDO:0005567A substance-specific organic brain syndrome that follows the discontinuation of administration or use, or reduction in intake of a substance (including alcohol, prescribed medications and recreational drugs). Syndrome manifests with diverse, often painful physical and psychological symptoms, which include but not limited to intense drug craving, anxiety, depression, insomnia, nausea, perspiration, body aches, tremors, hallucinations, and convulsions.
Also known as: drug withdrawal, drug withdrawal syndrome, substance withdrawal, substance withdrawal disorder, substance withdrawal syndrome, withdrawal syndrome, withdrawal disorder
145 clinical trials for this condition and its sub-types.
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Broader categories
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New approach aims to boost HIV prevention in LGBTQ+ individuals struggling with addiction
Prevention TerminatedThis study tested a program to help HIV-negative transgender women and men who have sex with men who also have a substance use disorder stick with PrEP, a daily pill or shot that prevents HIV. Participants received counseling and text support, with extra help for those who strugg…
Phase: NA • Sponsor: Friends Research Institute, Inc. • Aim: Prevention
Last updated Jun 27, 2026 09:04 UTC
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Ear stimulation device may tame alcohol withdrawal symptoms
Symptom relief TerminatedThis study tests whether a wearable device that sends tiny electrical pulses to the ear — a method called transcutaneous auricular neurostimulation (tAN) — can help people going through alcohol withdrawal. The device targets the vagus and trigeminal nerves, which may influence wi…
Phase: NA • Sponsor: Erin Takemoto • Aim: Symptom relief
Last updated Aug 07, 2026 00:00 UTC
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Methadone tested to shorten time on breathing machines in ICU
Symptom relief TerminatedThis study tested whether giving methadone to ICU patients on breathing machines could help them get off the ventilator faster. Patients who needed strong painkillers were given either methadone or a placebo. The trial was stopped early and only included 9 people, so no firm conc…
Phase: PHASE4 • Sponsor: Henry Ford Health System • Aim: Symptom relief
Last updated Jun 27, 2026 08:02 UTC
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Can a restless legs drug ease opioid withdrawal?
Symptom relief TerminatedThis study tested whether pramipexole (Mirapex), a drug for restless legs syndrome, could also reduce symptoms of opioid withdrawal in people with opioid use disorder. The trial planned to enroll 75 adults but was terminated early. Researchers measured changes in restless legs se…
Phase: PHASE2, PHASE3 • Sponsor: Massachusetts General Hospital • Aim: Symptom relief
Last updated Jun 27, 2026 07:51 UTC