Osteoarthritis

This trial is testing a new type of knee replacement for younger patients with severe knee osteoarthritis. Instead of the standard metal and plastic implant, surgeons will use a graft made of donor bone, cartilage, and meniscus to replace the damaged parts of the knee. The goal i…

This study tests a community-based exercise program for people aged 50 and older who have at least two chronic conditions, such as heart disease, diabetes, arthritis, or obesity. The program is designed to improve muscle strength, heart and lung fitness, and overall well-being. R…

This trial tests whether a single oral dose of ondansetron, a drug that curbs vomiting, can help children with cholera keep down oral rehydration solution (ORS). About 120 children aged 6 months to 17 years with suspected or confirmed cholera and active vomiting will receive eith…

This trial tests whether two oral antibiotic combinations—doxycycline with levofloxacin or moxifloxacin—can treat brucellosis as effectively as the standard doxycycline-rifampicin regimen. Brucellosis is a bacterial infection from animals that can cause fever and joint pain, and …

This study is following people who receive a Tornier Perform™ Reversed MonoPost shoulder replacement to see how well it works and how safe it is. The implant is designed for patients with severe shoulder damage, such as from arthritis, fractures, or failed previous surgeries. Res…

This study tests an experimental injection called TG-C for people with early hip osteoarthritis. The injection contains cells that release a growth factor to help repair damaged cartilage. 255 adults will receive either TG-C or a placebo, and researchers will track pain and hip f…

This trial compares two surgical techniques for total knee replacement—the subvastus approach and the medial parapatellar approach—to see which one leads to better recovery and function. The study will enroll 84 people with severe knee osteoarthritis who need a knee replacement. …

This clinical trial tests whether injecting a person's own purified blood cells into the knee can reduce pain and improve movement in people with knee osteoarthritis. The study compares two doses of these cells against a standard steroid injection. Participants are adults aged 40…

This study is testing a new shoulder implant that doesn't use a stem, designed for people with arthritis or shoulder damage. About 136 adults will receive the implant and be followed for 2 years to see if it improves shoulder function and pain. The goal is to confirm the implant …

This trial tests whether taking the anti-bleeding medication tranexamic acid (TXA) for three days after hip or knee replacement surgery helps people recover faster and with less pain. Adults with osteoarthritis who are having a first-time joint replacement receive either TXA or a…

This study tests two procedures done before ACL surgery: draining excess knee joint fluid (arthrocentesis) or injecting platelet-rich plasma (PRP) from the patient's own blood. The goal is to see if either reduces inflammatory chemicals linked to cartilage damage. About 99 adults…

This study is for adults aged 40 and older who have two or more chronic conditions like high blood pressure, diabetes, or depression. Researchers are testing a program that includes a digital decision-support system for doctors, telemedicine for specialist advice, and a mobile ap…

This study tests a stem cell product called XytriX, made from donated umbilical cord cells, for treating knee osteoarthritis. About 75 adults with mild to severe knee arthritis will receive an injection into the knee joint. The goal is to see if it safely reduces pain and improve…

This study looks at whether two common diabetes drugs, GLP-1 analogs and SGLT2 inhibitors, can reduce osteoarthritis symptoms like joint pain and stiffness in people with type 2 diabetes. Researchers will follow 390 adults over 50 who have been on one of these drugs for at least …

This study compares a new scaffold implant (MaioRegen Prime) to standard surgical cleaning (debridement) for treating deep cartilage lesions in the knee. About 400 patients aged 18-60 with knee lesions will be randomly assigned to one of the two procedures. The main goal is to se…

This study compares two surgical techniques to realign the knee in people with early arthritis and bowleg deformity. Twenty-eight adults will be randomly assigned to receive either a plate and screws or an external fixator to stabilize the bone after it is cut and repositioned. R…

This Phase 3 trial tests whether a single injection of MAG200 stem cells can improve pain and daily function in adults with knee osteoarthritis. About 573 participants will receive either a low dose, a high dose, or a placebo injection. The study aims to confirm if this approach …

This study investigates whether triphasic bone scans combined with SPECT/CT can accurately diagnose osteoarthritis in the foot and ankle, using MRI as the gold standard. Researchers will compare the imaging results from 40 adults with chronic foot or ankle pain to see how well th…

This study will test whether adding a T2 mapping sequence to a standard MRI can improve detection of early knee osteoarthritis. Researchers will compare MRI scans from 28 healthy volunteers and 28 patients with early OA. The goal is to see if this extra scan can measure cartilage…

This study will test whether artificial intelligence can accurately tell the difference between inflammatory arthritis (like rheumatoid arthritis) and degenerative arthritis (like osteoarthritis) in people aged 60 and older. Researchers will compare the AI's analysis of X-rays, M…

Researchers are testing whether a single injection of an experimental gene therapy called GNSC-001 can reduce knee osteoarthritis pain and improve joint function in adults. The trial enrolls about 240 people with moderate knee arthritis confirmed by X-ray. Participants receive on…

Researchers are testing whether tranexamic acid, a drug that helps prevent bleeding, reduces blood loss and wound complications during high tibial osteotomy. This surgery realigns bow-legged knees to ease osteoarthritis pain and slow joint damage. The trial enrolls 200 adults wit…

This study looks at ways to reduce pain during knee steroid injections for osteoarthritis. Researchers will test if using a thinner needle or a numbing spray (ethyl chloride) makes the injection hurt less. 88 adults with knee osteoarthritis will rate their pain right after the sh…

This trial tests whether a home-based strength training program combined with self-management education can reduce symptoms and improve quality of life for people with knee osteoarthritis. Participants aged 45 and older are randomly assigned to either the exercise and education p…

This trial tests whether two different collagen supplements can reduce pain, stiffness, and disability in adults with knee osteoarthritis. Adults aged 35 to 65 with moderate knee osteoarthritis will take either a 10-gram hydrolyzed collagen, a 5-gram bioactive collagen peptide, o…

This pilot study tests whether photobiomodulation therapy—using a special laser device—can reduce pain in people who go home the same day as their total knee replacement surgery. Participants receive the light therapy as part of their post-operative pain plan, and their pain leve…

This study tests whether applying bee venom gel to the knee during ultrasound therapy can reduce pain and improve movement in people with knee osteoarthritis. Thirty adults aged 40-75 will either get the bee venom treatment or a placebo gel. Researchers will measure pain, walking…

This pilot trial tests whether a web-based conversational assistant can help people recovering from total knee replacement. About 60 adults who have had knee replacement surgery will either receive standard care alone or standard care plus access to the online assistant for 6 wee…

This study tests whether taking the drug tranexamic acid for up to 7 days after total knee replacement can improve pain, function, and knee movement. About 351 adults having knee surgery will be randomly assigned to take the drug for 3 days, 7 days, or a placebo. Researchers will…

This study tests whether a long-acting painkiller (bupivacaine-meloxicam) can reduce pain and the need for opioid medications after robot-assisted knee replacement. 150 adults with knee osteoarthritis will receive either the new painkiller or a standard injection. Researchers wil…

This study tests whether adding a simple numbing injection (SSSI) to standard pain blocks can better control pain after knee replacement surgery. About 90 adults aged 45-90 will be randomly assigned to receive either the extra injection or a sham (fake) one. The main goal is to s…

This study will compare two probiotic drinks—Bacillus clausii and a mix of four bacterial strains—in 138 children aged 1 to 5 with acute watery diarrhea. All children will also receive standard care like rehydration and zinc. The goal is to see which probiotic reduces diarrhea du…

This study tests whether walking backwards on a treadmill (called retro walking) can help reduce pain and improve how people with knee osteoarthritis walk. Participants will do retro walking sessions, starting with 10 minutes and gradually increasing up to 30 minutes if pain stay…

This pilot study tests whether a topical CBD oil can reduce pain in people with knee osteoarthritis. Thirty participants will apply either CBD in castor oil or plain castor oil to their knees twice daily for 30 days, then switch treatments. Researchers will track pain scores and …

This study compares two ways to align the knee during total knee replacement in 80 obese adults (BMI 35+). One method uses robotic or computer assistance, the other uses traditional manual tools. The goal is to see which leads to better knee motion and recovery after surgery.

This study will test whether Egoscue postural exercises, alone or combined with a hands-on technique called Mobilization with Movement (MWM), can reduce pain, improve balance, and boost quality of life in people with knee osteoarthritis. Researchers plan to enroll 56 adults aged …

This study tests whether a gel called Conjuran can reduce pain in people with knee osteoarthritis better than the current standard treatment, Hyruan. About 180 adults with mild to moderate knee arthritis will receive two cycles of injections, each cycle consisting of five weekly …

This study will test Mobithron Xtra, an oral supplement containing hyaluronic acid, collagen, and Boswellia extract, in 100 adults with knee osteoarthritis. Participants will take it once daily for 3 months while researchers track changes in pain, stiffness, and daily function us…

This study will test whether taking prednisone for 5 days after knee or hip replacement surgery helps reduce pain, swelling, and the need for opioids compared to the standard steroid given only during surgery. About 104 adults will participate, and their blood sugar will be track…

This study looks at two different methods to control pain after total knee replacement. One method combines two nerve blocks given by an anesthesiologist, while the other uses a nerve block plus a local painkiller injection by the surgeon. Researchers will review the medical reco…

This study looks at whether adding kinesiotaping (a special elastic tape) to standard physical therapy can improve pain, movement, and fear of activity in people with knee osteoarthritis. Sixty adults aged 40-65 with mild knee arthritis will be randomly assigned to receive either…

This study will test whether high-intensity laser therapy, added to standard physiotherapy, can increase knee cartilage thickness and reduce pain in people with knee osteoarthritis. About 58 adults aged 40-60 with moderate knee OA will receive either laser plus physiotherapy or p…

This study looks at whether a well-formulated ketogenic diet can reduce pain and improve thinking in adults with osteoarthritis and mild cognitive impairment. Ten participants will follow a supervised low-carb, high-fat diet for a period, with before-and-after tests for pain, phy…

This study tests a 2-hour online class called Empowered Relief for 100 adults with advanced knee or hip osteoarthritis who cannot have joint replacement surgery. The class teaches simple pain management skills based on cognitive behavioral therapy and mindfulness. Researchers wil…

This study looks at whether injecting platelet-rich plasma (PRP) into the sacroiliac joint after hip replacement surgery can help people recover faster and have less pain. About 60 adults with hip arthritis who are scheduled for a hip replacement will take part. Half will get the…

This study tests whether tecar therapy, a type of targeted radiofrequency treatment, can reduce pain and improve physical function in people with chronic knee osteoarthritis. About 60 adults aged 40 to 75 with moderate knee arthritis will receive the therapy or a sham treatment. …

This study tests a special brace designed to gently distract (separate) the knee joint, aiming to reduce pain and improve function in people with medial knee osteoarthritis. Researchers will enroll 150 adults aged 30-70 with a BMI under 35. Participants will wear the brace and be…

This pilot study tests whether getting extra sleep (sleep banking) before knee or hip replacement surgery can help reduce chronic pain and the need for painkillers after the operation. Researchers will enroll 22 adults aged 18-74 scheduled for joint replacement at a Navy medical …

This study tests whether a powder made from Rosa roxburghii (a type of rose fruit) can help people recover after total knee replacement surgery for osteoarthritis. 184 participants will take either the supplement or a placebo daily for 30 days after surgery. Researchers will meas…

This study tests whether applying metformin gel through the skin with a mild electric current (iontophoresis) plus physical therapy can reduce pain and improve function in postmenopausal women with knee osteoarthritis. Sixty-eight women aged 50-70 will receive either the active g…

This study compares general anesthesia (being fully asleep) with spinal anesthesia (numbing the lower body) in 600 adults having knee or hip replacement as outpatient surgery. The goal is to see which method leads to successful same-day discharge without readmission. Researchers …

This early-phase trial tests whether giving a drug called palmitoylethanolamide before total knee replacement surgery can lower pain afterward. One adult aged 40–80 will receive either the drug or a placebo pill. Pain will be measured using a standard scale at 6, 12, and 24 hours…

This study tests a gel called Sensovisc, made of sodium hyaluronate, injected into the hip joint to relieve pain from osteoarthritis. The gel aims to restore the joint's natural fluid, reducing pain and improving movement. Researchers will track 25 adults with moderate hip arthri…

This study tests whether a new tablet called Laybon is as good as an existing drug (Layla) at reducing knee pain from osteoarthritis. About 172 adults aged 40-80 with knee osteoarthritis will take either Laybon or Layla twice daily for 8 weeks. The main goal is to see if knee pai…

This early-phase trial tests whether injecting a fluid made from stem cells (called secretome) mixed with growth factors from the patient's own blood can safely reduce knee pain and improve function in people with mild knee osteoarthritis. The study will enroll 25 adults aged 30-…

Researchers at the University of Reading are studying how sleep and pain relate in adults with hip or knee osteoarthritis. Participants wear a wrist sleep monitor for seven days and nights while answering daily questions about sleep, pain, and mood. The team compares reported sle…

This study will use DEXA bone scans to see how the CoreHip hip replacement stem affects bone density around the implant over two years. Forty adults with hip arthritis or other hip conditions will be enrolled. The goal is to understand if the implant's design helps maintain healt…

This study looks at whether levels of a protein called 15-PGDH in the blood and joint fluid are linked to the severity of osteoarthritis and ankylosing spondylitis. Researchers will measure 15-PGDH in about 51 adults with these conditions and compare it with ultrasound images and…

This study will test whether common orthopedic materials, like titanium alloy and polylactic acid (PLA), are safe for use in knee surgery. Researchers will expose human tissue samples from 50 knee replacement patients to these materials in the lab. They will check for cell damage…

This study tracks 30 people receiving a CATALYSTEM cementless hip implant to measure how much the stem moves (subsides) in the thigh bone over two years. Using specialized CT scans, researchers aim to see if the implant stays firmly in place, which is key for long-term success. P…

This study looks at whether a routine blood test can predict which patients with knee osteoarthritis will get good pain relief from platelet-rich plasma (PRP) injections. Researchers will enroll 120 people aged 40-60 with moderate knee arthritis. Each person will receive three PR…

This study looks at 80 people having hip or knee replacement surgery to compare two ways of giving a drug called tranexamic acid, which helps reduce bleeding. Half will get the drug through a standard IV, and the other half will get it injected into the bone. Researchers will mea…

This study will track sleep patterns in 20 people before and after reverse shoulder replacement surgery. Participants will wear a MotionWatch 8 sleep tracker for a week before surgery and again 6 months after. The goal is to see if better sleep is linked to better recovery and sh…

This observational study in Mexico will follow 30 adults already taking tirzepatide for conditions like diabetes or obesity. Researchers will use MRI scans of the knees, CT scans of the heart, and body composition tests to see how the drug affects cartilage, heart fat, and overal…

This study looks at two different ways to perform reverse total shoulder replacement in 130 people aged 60-85 with severe shoulder arthritis and torn rotator cuffs. The goal is to see which technique leads to better muscle activity and arm movement. Participants will have their s…

This study will check how many people with knee osteoarthritis also have sarcopenia—a condition of low muscle mass and strength. Researchers in Upper Egypt will study 224 adults aged 40 and older to measure muscle health, nutrition, and quality of life. The goal is to better unde…

This study looks at how starting a gradual running program affects knee joint health in people who are new to running, including those with knee osteoarthritis. Researchers will use MRI scans to measure changes in knee cartilage over six months. The goal is to understand whether …

This study follows 60 adults with hand or upper limb injuries to see if improvements in the first weeks of rehab can predict function months later. A digital tool created by a therapist tracks progress and patient feedback. The goal is to help clinicians make better, data-driven …

This study investigates the connection between temporomandibular joint (TMJ) disorders and tinnitus (ringing in the ears). Researchers will use 3D jaw imaging and hearing tests in 50 adults to see if jaw bone shape and arthritis are linked to tinnitus. The goal is to better under…

This pilot study will test whether a smartwatch can measure pain levels in 15 people with knee osteoarthritis. Participants will wear an Embrace Plus smartwatch that tracks electrodermal activity (skin signals) while reporting their pain during standard physical tests. The goal i…

This study tests a new digital health tool designed to help adults aged 40 and older who have two or more long-term health conditions, like high blood pressure, diabetes, or depression. The tool includes an electronic system to guide doctors, telemedicine for specialist visits, a…

This study will look at tissue and bacteria samples from 20 people having surgery for severe temporomandibular joint (TMJ) problems like ankylosis or osteoarthritis. Researchers want to find out what causes these severe conditions and whether bacteria in the joint affect recovery…

This study will test if a digital education app helps patients prepare for hip or knee replacement surgery. About 160 adults scheduled for a first-time joint replacement will either use the app or receive standard preparation. The goal is to see if the app improves knowledge, con…

This study looks at how having a structured, values-based conversation affects people's decisions about diagnostic imaging tests for common musculoskeletal conditions like arthritis, carpal tunnel syndrome, and tendon problems. About 220 adults from a specialty clinic will read a…