Musculoskeletal system disorder

This study is a follow-up to an earlier trial, testing the long-term safety and effects of a drug called AOC 1001 in adults with myotonic dystrophy type 1 (DM1), a genetic muscle disease. 37 participants who completed the first study received multiple doses of AOC 1001 by IV infu…

This trial asks whether a telerehabilitation program—guided exercises done at home—can reduce shoulder pain and disability as effectively as traditional in-person physiotherapy. Adults aged 18 to 60 with persistent shoulder pain lasting at least three months are randomly assigned…

This study tested whether a personalized talk with a pharmacist could help people take opioid painkillers for a shorter time. 100 adults with non-cancer pain in a hospital rheumatology ward took part. The goal was to see if the pharmacist's advice could keep opioid use closer to …

This study tested a community-based care model that adds physiotherapy to standard antenatal care for pregnant women with chronic diseases like diabetes or high blood pressure. 200 women were split into two groups: one received the extra physiotherapy (including exercises for str…

This study tested a daily oral drug called infigratinib in 114 children aged 3 to 18 with achondroplasia, the most common form of dwarfism. The goal was to see if it could safely increase their growth rate compared to a placebo. The trial is now complete, and results will show wh…

This study tested a drug called ataluren in 360 boys with Duchenne muscular dystrophy caused by a specific genetic mistake (nonsense mutation). The main goal was to see if ataluren could help them walk farther over 72 weeks compared to a placebo. All participants were also taking…

This early-stage trial tested a single dose of the drug PGN-EDODM1 in 24 adults with myotonic dystrophy type 1, a genetic muscle disorder. The main goal was to check safety and how the body handles the drug. The study is complete, but results are not yet available.

This study compared two common surgeries for fixing a broken kneecap: tension band wiring and locking plate fixation. Researchers randomly assigned 122 adults to one of the two procedures and tracked their recovery using a knee function score. The goal was to see which method lea…

This study tested the long-term safety and effectiveness of a drug called KZR-616 in 18 adults with active polymyositis or dermatomyositis, rare diseases that cause muscle inflammation and weakness. Participants who completed an earlier study received weekly injections of KZR-616…

This Phase 2 trial tested a drug called KZR-616 (zetomipzomib) in 25 adults with active polymyositis or dermatomyositis, two rare diseases that cause muscle inflammation and weakness. Participants received either the drug or a placebo for 16 weeks, then switched to the other trea…

This early-stage study tested a new cell therapy called MuSK-CAART in 7 people with a rare, severe form of myasthenia gravis (MuSK MG). The treatment uses a patient's own immune cells, modified to attack the harmful antibodies causing the disease. The main goal was to check safet…

This study tested an oral drug called infigratinib in 84 children aged 3 to 11 with achondroplasia, the most common form of dwarfism. The goal was to see if it could safely increase their growth rate. Children took the drug daily, and researchers measured height changes and side …

This study tested an oral drug called upadacitinib (RINVOQ) against a placebo and an injected drug (adalimumab/Humira) in 1705 people with active psoriatic arthritis who had not responded well to standard non-biologic treatments. The goal was to see if upadacitinib reduces joint …

This phase 3 study tested upadacitinib, an oral anti-inflammatory drug, in 642 adults with active psoriatic arthritis who had not responded well to at least one biologic treatment. Participants received either 15 mg or 30 mg of upadacitinib daily or a placebo. The main goal was t…

This study tested whether a radiation-free ultrasound system can accurately screen for scoliosis in 442 Hong Kong schoolgirls aged around 10, who are at high risk for curve progression. The goal was to see if ultrasound could identify which girls truly need an X-ray, reducing unn…

This study tested an artificial intelligence (AI) program called Carebot AI Bones to see how well it finds fractures on X-rays. Researchers compared the AI's performance to that of experienced radiologists using 600 X-rays from both children and adults. The goal was to see if the…

This study tested a Turkish version of the Johns Hopkins In-Room Independence Scale, which measures a patient's ability to move, use the toilet, and think clearly while in their hospital room. Researchers worked with 100 adults who had conditions like stroke, Parkinson's, or ampu…

This study tests whether brief, daily exercise breaks at work can prevent muscle and joint problems in workers. 150 participants will do either strength exercises with elastic bands or standard stretching for 5 minutes each day for 8 weeks. Researchers will measure physical funct…

This study tested whether a workplace program called GLAD can be used to prevent muscle and joint pain in blue-collar workers. 70 workers and safety professionals took part in an 8-week program with education, ergonomic changes, and exercises. The main goal was to see if workers …

This study tested whether a single dose of zoledronic acid, a drug already used for osteoporosis, can prevent the rapid bone loss that often follows a spinal cord injury. Researchers enrolled 60 adults who had recently lost the ability to walk due to injury. They measured changes…

This study tests whether an 8-week program combining exercise and health education can reduce muscle pain and improve well-being in textile workers. Thirty-eight volunteers from a Spanish textile factory will attend weekly workshops and do two online exercise sessions per week vi…

Boys with hemophilia often miss out on games and activities because of concerns about bleeding and joint damage. Researchers developed a 12-week muscle-strengthening exercise programme with input from children, parents, and physiotherapists. The DOLPHIN-II trial compares this pro…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study tests whether a device called Compex SP8.0, which sends mild electrical pulses through the skin to stimulate sensory nerves, can reduce musculoskeletal pain. Adults with pain rated 4 or higher on a 0-10 scale will use the device's pain management programs at home for u…

This study tests whether a wearable exoskeleton—a supportive device worn around the torso—can reduce physical effort and pain for nursing home staff who regularly lift, turn, and bathe residents in bed. Over 11 weeks, 35 care workers across five French nursing homes will wear the…

This study tests whether a combination of special stretches and movement retraining can reduce shoulder pain and improve motion in fast bowlers with a condition called GIRD (limited internal rotation). 42 male cricketers aged 18-45 will be split into two groups: one gets the new …

This study tests a simple ergonomics program for university employees who use computers at least 3 hours daily. Participants get a self-assessment checklist and personalized advice on desk setup and posture. Over 4 weeks, researchers will check if this reduces muscle and joint pa…

This study tested whether adding high-intensity laser therapy to exercise can reduce pain and improve muscle strength in people with knee osteoarthritis. 31 adults aged 45-77 with knee pain received either real laser or a sham laser alongside a standard exercise program for four …

This study looked at whether adding core exercises to regular football practice helps teenage players resist fatigue, improve balance, and perform better. Forty male players aged 14-18 from a football club took part. Half did an 8-week core training program plus their usual train…

This phase 2 study tested whether JBT-101 (lenabasum) can reduce joint pain in people with systemic lupus erythematosus (SLE). 109 adults with active arthritis and at least moderate pain took either the drug or a placebo for 84 days. The main goal was to see if pain scores improv…

This pilot study tested whether a 5-day sailing therapy program followed by 3 months of home-based telerehabilitation is safe and feasible for young people aged 12–30 with rare skeletal disorders. 24 participants were randomly assigned to either the sailing-plus-rehab group or a …

This study tested whether a single injection of amniotic suspension allograft (ASA) can reduce pain and improve function in adults with knee osteoarthritis who haven't found relief from other treatments. About 594 participants received either ASA or a placebo, and their pain and …

This study looked at whether teaching bank employees about ergonomics and giving them breathing exercises could reduce their muscle and joint pain, improve their posture, and increase their awareness of how they sit and breathe. 62 office workers who sit at computers for at least…

This study looked at whether high-intensity laser therapy can reduce shoulder pain and improve movement in people who have had a stroke. Forty participants aged 50-85 with lasting shoulder pain after a stroke received the laser treatment. The goal was to see if it helps with pain…

This pilot study tested a web-based mind-body program (Web-TIRELESS) in 5 adults with painful upper-limb conditions and risky substance use. Participants completed 4 video sessions at their own pace. The goal was to see if the program was feasible, acceptable, and helpful for bui…

This completed study tested two different rehabilitation approaches for chronic neck pain: manual therapy (hands-on mobilization) and instrument-assisted soft tissue mobilization (using tools). Twenty-four adults with neck pain lasting at least 12 weeks received treatment three t…

This study tested whether dry needling—a technique where thin needles are inserted into muscle knots—combined with neck exercises can reduce pain and improve movement in people with chronic mechanical neck pain. Forty adults aged 25 to 65 were split into two groups: one received …

This study looked at how common muscle and posture problems are in physiotherapy students and whether a special physiotherapy program could help. 44 students with back pain and muscle tightness received treatments like trigger point release, stretching, and joint mobilization. Th…

This study looked at whether a single session of percussion massage can quickly improve neck movement and reduce pain in people with nonspecific neck pain. Thirty adults with moderate neck pain were randomly assigned to get either the real massage or a sham (fake) treatment. Rese…

This study looked at whether letting patients control their own sedation during arm surgery under regional anesthesia leads to higher satisfaction compared to having an anesthesiologist control it. 70 adults having upper limb orthopedic surgery were randomly assigned to either pa…

This Phase 2 trial tested a drug called LEVI-04 in 518 adults with knee osteoarthritis. The drug is designed to block pain signals. Researchers measured pain changes using a standard knee pain scale. The goal is to see if LEVI-04 can safely reduce pain and improve daily function.

This pilot study tested whether an 8-week program of neck exercises could reduce pain and improve brain function in women with chronic temporomandibular disorders (TMD), a common cause of jaw and face pain. 113 women were randomly assigned to either the exercise program or a plac…

This study tested whether an injection made from donated human amniotic tissue and cells (called ASA) can reduce pain and improve function in people with knee osteoarthritis. Over 500 adults with moderate to severe knee OA received either ASA or a placebo (salt water) injection. …

This study looks at whether people with lipedema, a condition that causes painful swelling in the legs, also have sarcopenia, which is age-related loss of muscle mass and strength. Researchers will measure muscle thickness, grip strength, and walking speed in 102 adults with lipe…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study looks at people with musculoskeletal conditions (like back or joint problems) who take part in a work-specific rehabilitation program called RehaJET. The goal is to see whether a 3-week or a 4-week program leads to better work ability and job outcomes. Researchers will…

This study translated the Generic Functional Index, a questionnaire that measures how well people can do daily activities, into Turkish. Researchers tested it with 200 adults who have muscle or joint problems to see if it is accurate and reliable. The goal is to give Turkish-spea…

This study watched 12 chiropractors in Quebec to see how they decide on treatments for aging patients. Researchers measured the force used during adjustments and asked chiropractors about their choices. The goal was to understand what influences care, not to test a new treatment.…

This completed study with 30 volunteer doctors compared how well they could locate knee, elbow, ankle, and wrist joints by physical exam versus ultrasound. The goal was to measure the gap between clinical touch and imaging truth. Results may help improve training in musculoskelet…

This study aims to create a better way to help older adults with muscle, bone, or nerve problems who are at risk of falling. Researchers will first study patients' health profiles and balance, then test a simple exercise program called OTAGO to see if it prevents falls. The goal …

This study looked at how a mix of step-aerobic and resistance training affects the knee joint in postmenopausal women with mild knee osteoarthritis. 103 women were split into two groups: one did the special exercise program, and the other followed standard home exercises. Researc…

This study looked at how work stress and burnout are connected to muscle and bone pain in university teachers and researchers. About 99 academic staff from Yalova University filled out surveys about their pain, stress, burnout, and work-life balance. The goal was to understand th…

This study looked at how healthy adults' bodies handle calcium from drinking water. 41 participants drank low-calcium water first, then high-calcium water, and researchers measured changes in blood and urine calcium and parathyroid hormone levels after 2.5 hours. The goal was to …

This study looked at how dental students hold their bodies while doing root canal work. Ten students were recorded on video for 5 minutes, and their posture and muscle fatigue were analyzed. The goal was to understand how their working positions might lead to pain or injury. This…

This study looked at whether a 6-month strength training program could improve bone health, sleep patterns, and quality of life in healthy adults aged 30 and older. 56 participants did specific exercises using equipment, and researchers measured changes in muscle mass, bone marke…

This study tested whether a low-dose standing CT scanner can detect early signs of arthritis in people who had an ankle fracture. Researchers followed 97 adults for up to 5 years, measuring joint space changes and pain. The goal was to see if this imaging method could predict ost…

This study looked at 110 medical secretaries to see how their office setup, posture, and work organization relate to muscle and joint pain. Participants filled out questionnaires about their work environment and any discomfort. The goal is to find patterns that could lead to bett…

This study followed 271 children with achondroplasia, ages 2.5 to 17, to understand their growth, medical issues, and quality of life over time. No medication or treatment was given. The goal was to gather natural history data to help design future clinical trials.

This study tested whether specially trained physiotherapists can safely diagnose and treat non-urgent muscle and joint pain in the emergency room, compared to standard care from doctors. 102 patients with back, neck, or shoulder pain were randomly assigned to either a physiothera…

This study tested a surgical navigation system called NextAR TKA that helps surgeons balance soft tissues during knee replacement. Forty adults scheduled for knee replacement with a specific implant were enrolled. The goal was to see if the system improves patient-reported outcom…

This study measured hip and upper back movement in 60 adults with chronic low back pain to see if they are related. Participants had their hip range of motion and thoracic spine flexibility tested. The goal was to understand how these body areas might influence each other in peop…

This completed study reviewed medical records of 1,788 elderly patients (65+) treated at four Korean medicine hospitals after traffic accidents. Researchers wanted to see if integrative Korean medicine—combining acupuncture, herbal medicine, and manual therapy—is safe and effecti…

This study followed 225 people who had ACL reconstruction surgery to see how their knees were doing 10 years later. Researchers looked at X-rays and pain scores to find out which factors increase the risk of developing osteoarthritis. The goal is to better understand long-term ou…

This study measured muscle activity in surgeons performing hysterectomies with robotic assistance versus conventional laparoscopy. The goal was to see which method causes less physical strain, potentially reducing work-related injuries. Four trained surgeons participated, and the…

This pilot study tested whether a very low carbohydrate ketogenic diet or a Mediterranean diet affects bone health and muscle function in older adults. Twelve postmenopausal adults followed each diet for six weeks. The goal was to see if these diets are safe and worth studying fu…

This study looked at whether follow-up visits after sports medicine surgery can be done by phone instead of in person. 90 patients were randomly assigned to virtual phone visits or in-person visits at 6 weeks, 12 weeks, and 6 months after surgery. Researchers measured patient sat…

This completed study compared how well people with complex regional pain syndrome (CRPS), people with other muscle or bone pain, and healthy individuals can imagine movements. Researchers used a questionnaire called the MIQ-RS to measure motor imagery skills. The goal was to see …

This study measured the quadriceps angle (Q angle) in 130 healthy adults aged 18-25 to understand how it changes in different positions—lying down, standing, and during walking. Researchers used photos and video recordings to compare static and dynamic measurements. The goal was …

This study looked at whether special imaging techniques can predict how knee osteoarthritis will get worse over time. Researchers followed 167 people with knee osteoarthritis for 3 years, using MRI, X-rays, and bone texture analysis. The goal was to find patterns that could help …

This study measured static and dynamic balance in 41 adults with hemophilia and 40 healthy volunteers using a special platform. Researchers also looked at how joint health, physical activity, and fear of movement affect balance. The goal is to understand why balance may be worse …

This study surveyed 116 adults with chronic pain at a rehabilitation clinic to understand how their pain beliefs, spiritual well-being, and attitudes toward complementary and alternative medicine are related. Participants filled out several questionnaires about their pain, mood, …

This study looked at how common joint pain and swelling are in 100 nursing home residents aged 65 and older, both with and without dementia. Researchers performed a physical exam and used simple pain questions or a special checklist for those with severe dementia. The goal was to…

This study followed 310 people who had elbow surgery with specific implants to see how their arm function improved over two years. Researchers measured disability using a standard questionnaire and tracked any complications or need for additional surgeries. The goal was to gather…

This study tested a mixed reality system called HOLOBLUEPRINT that helps surgeons see 3D plans during shoulder replacement surgery. 44 adults having shoulder surgery used the tool. Researchers checked if the implant was placed accurately by comparing CT scans before and after sur…

This completed study looked at the safety of pharmacopuncture—herbal extracts injected into acupuncture points—in 1,000 hospitalized adults with spine or joint problems. Researchers tracked infections and other side effects to see how often problems occur. The goal was to gather …