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Lipedema and muscle loss: is there a hidden link?

NCT ID NCT05739279

Knowledge-focused Sponsor: Dokuz Eylul University Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 02, 2026 · Last updated Sep 03, 2026 · Updated 1 time

Summary

This study looks at whether people with lipedema, a condition that causes painful swelling in the legs, also have sarcopenia, which is age-related loss of muscle mass and strength. Researchers will measure muscle thickness, grip strength, and walking speed in 102 adults with lipedema and compare them to healthy volunteers. The goal is to see if muscle weakness is part of lipedema itself or a result of being less active, and to find out if sarcopenia is more common in these patients.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Diagnostic tests: ultrasound muscle measurement, hand grip strength, chair stand test, and walking speed test
What this could lead to
If this study finds a link, it could lead to earlier detection of muscle loss in lipedema patients and better exercise recommendations.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The results may not apply to all people with lipedema.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

102 people

The number who actually took part.

Started

Jan 2023

Finished

Aug 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

Descriptive, cross-sectional, case-control

Ages

18 to 85 years

Sex

Female participants only

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * between the ages of 18-85 * with a diagnosis of lipoedema * who agreed to participate in the study * having a sociocultural level suitable for participation in the study * healthy volunteers in a similar age group for the control group Exclusion Criteria: * with chronic venous insufficiency and/or lymphedema * with Parkinson's disease, previous stroke, cerebellar diseases, multiple sclerosis, major depression, neuromuscular diseases, history of major orthopedic surgery, severe hip/knee osteoarthritis, rheumatological diseases, malignancies, advanced heart/liver/renal failure, visual impairment, and vestibular diseases, and those who use any assistive device to walk * who are illiterate and have cognitive impairment that will prevent them from giving written consent will not be included in the study

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Conditions

The condition(s) this trial relates to.

Lipedema musculoskeletal system disorder Sarcopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Lipedema Musculoskeletal diseases Sarcopenia

Contacts and locations

Locations

  • Department of Physical Medicine and Rehabilitation, Medical Faculty of Dokuz Eylül University, İzmir, Turkey

    Izmir, Turkey (Türkiye)

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