Fasciitis

This large real-world study is testing whether platelet-rich plasma (PRP) injections can reduce pain and improve function in people with chronic tendinopathies, including patellar, Achilles, elbow, and plantar fasciitis. Researchers will follow 2000 participants for 12 months, tr…

This study tests a special wound dressing made from pig tissue (Cytal Wound Matrix and MicroMatrix) to see if it helps heal wounds from necrotizing fasciitis (a severe flesh-eating infection) faster than standard dressings. Fifty adults with large wounds (at least 30 cm²) will be…

This early-stage study tests a new imaging agent called 18F-4FN for PET scans to safely detect inflammation in the body. It involves 55 adults with cancer who are on immunotherapy or have suspected inflammation. The goal is to see if this agent can highlight areas of inflammation…

This study tests two simple physical exam techniques to see if they can accurately diagnose chronic plantar fasciopathy, a common cause of heel pain. Researchers will compare these tests in 45 adults—some with the condition and some without—to measure how well they work. If prove…

This study tests whether a safe, FDA-approved dye called indocyanine green (ICG) can help doctors quickly tell the difference between a life-threatening flesh-eating infection (necrotizing fasciitis) and a less dangerous skin infection. About 420 adults with suspected infections …

This study looks at how well the shingles vaccine works in people with weakened immune systems, such as those with cancer or autoimmune diseases. Researchers will measure immune responses and track side effects in 300 adults. The goal is to see if the vaccine can effectively prev…

This study compares two manual therapy techniques—myofascial release and instrument-assisted soft tissue mobilization—for treating plantar fasciitis in pregnant women. Forty-four women in their second or third trimester will receive one of the two treatments over four weeks, alon…

This study tests if watching a video of exercises is as good as getting live instruction from a doctor for treating plantar fasciitis, a common cause of heel pain. About 300 adults with heel pain for at least 3 months will be randomly assigned to either a video or an in-person se…

This study looks at whether walking barefoot can ease heel pain (plantar fasciopathy) better than standard stretching and strengthening exercises. Adults aged 18 to 70 with heel pain will be randomly assigned to either a 12-week barefoot walking program or a stretching program. T…

This study tests two taping techniques—Low-Dye and calcaneal taping—to see which better reduces pain and improves foot function in people with plantar fasciitis. Forty adults with heel pain for over three months will receive one of the taping methods plus physical therapy for two…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study compares two types of massage—deep friction massage by hand and a tool-assisted technique—for treating plantar fasciitis, a common cause of heel pain. Fifty-two adults with moderate pain will receive 12 sessions over six weeks. Researchers will measure changes in pain,…

This study tests whether cognitive training (brain exercises) can reduce pain and improve balance in people with plantar fasciitis, a common cause of heel pain. Eighty adults will be split into two groups: one doing cognitive training plus stretching, the other doing only stretch…

This study tests whether a new calf stretching device works better than standard night splints for easing plantar fasciitis pain. One hundred adults with this condition will use one of the two devices for 6 weeks and report their pain levels. The goal is to see which approach pro…

This study is testing whether a lower dose of radiation can relieve pain from heel spurs just as well as the standard dose. About 366 adults with chronic heel pain that hasn't improved with other treatments will receive one of three radiation schedules. The goal is to find a gent…

This study compares two exercise programs for people with long-term pain in the Achilles, patellar tendon, or plantar fascia. One group does standard strength training, while the other adds early jumping (plyometric) exercises. Researchers will measure jump function after 12 week…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study looks at whether treating an extra nerve in the foot can improve pain relief for people with long-term heel pain. About 48 adults will receive a standard nerve treatment, with half also getting treatment on a second nerve. Researchers will measure pain and foot functio…

This early study tests a minimally invasive procedure for chronic heel pain from plantar fasciitis. Doctors use a small tube to inject a temporary blocking agent into foot blood vessels. Ten adults aged 25-80 who haven't found relief from other treatments will be followed for a y…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study tests if a needle-based treatment called percutaneous electrolysis can reduce pain and improve function in people with chronic plantar fasciitis (long-term heel pain). Half of the 50 participants will get the treatment on the heel only, while the other half will get it…

This early-phase trial tests whether shockwave therapy, collagen peptide injections, or a combination of both can reduce pain and improve foot function in people with plantar fasciitis. Eighty-four adults with heel pain are randomly assigned to one of three groups. Researchers wi…

This study tests a new treatment for heel pain caused by plantar fasciitis. Tiny, dissolvable beads are injected to block blood flow to the painful area. The goal is to see if this procedure safely reduces pain better than standard care. About 45 adults with chronic heel pain wil…

This study tests two types of injections—bone marrow or platelet-rich fibrin—to treat chronic plantar fasciitis (long-term heel pain). About 72 adults with heel pain lasting over 6 months will receive one of the treatments under ultrasound guidance. The goal is to see which works…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study tests whether using ultrasound to guide a steroid injection into the heel works better than the usual method of injecting based on touch alone. About 62 adults with plantar fasciitis will receive one of the two injection types. Researchers will measure pain and foot fu…

This study looks at whether the brain and nervous system (central sensitization) play a role in the pain of plantar fasciitis, a common cause of heel pain. Researchers will measure pain sensitivity, ultrasound images of the foot, and psychological factors in 128 adults with the c…

This study follows 4,000 people with interstitial lung disease (including conditions like pulmonary fibrosis and sarcoidosis) to understand how the disease naturally changes over time. Researchers will collect medical data and blood samples, and compare them to a healthy control …

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This pilot study is measuring prednisolone levels in 120 people with inflammatory diseases like thyroid eye disease, vasculitis, COPD, asthma, and others. Participants take high-dose prednisolone as part of their routine care, and researchers take timed blood samples to see how t…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study is observing up to 20 children diagnosed with juvenile eosinophilic fasciitis, a rare connective tissue disease. Researchers will track symptoms, lab results, and treatments over time to better understand the condition and improve future care. No new drugs or procedure…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study looks at 320 adults who are about to start strong immune-suppressing therapy and have already had at least two COVID-19 shots. Researchers want to find out if giving a COVID-19 booster right before starting therapy or waiting six months provides better protection. Part…

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study looks at 300 adults hospitalized with rare but life-threatening flesh-eating infections (necrotizing soft tissue infections). Researchers want to find out which early signs and routine lab tests can predict who is most likely to die during their hospital stay. The goal…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study will examine chest CT scans from 500 adults with rheumatoid arthritis, connective tissue diseases, or idiopathic pulmonary fibrosis to better understand lung disease patterns. Researchers want to see which scan features are most common in rheumatoid arthritis-related i…