Fasciitis

This study will test whether adding hyperbaric oxygen therapy to standard care helps people with necrotizing fasciitis, a severe flesh-eating infection. Researchers will compare death rates and complications in 160 adults who receive the treatment versus historical controls. The …

This study looks at whether a blood gas measurement (the difference in carbon dioxide between central venous and arterial blood) can accurately diagnose low cardiac output in patients with septic shock from severe skin infections. About 74 adults will be monitored during hyperbar…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study compares a 6-week non-surgical treatment (manual therapy plus nerve stimulation) with surgery for people who have had heel pain for over 6 months and haven't gotten better with standard care. 120 adults aged 30-65 will choose their preferred treatment and be followed f…

This study will compare two types of nerve mobilization added to standard physical therapy for chronic plantar fasciitis. Sixty adults with heel pain for at least six weeks will be randomly assigned to receive either posterior tibial nerve mobilization or saphenous nerve mobiliza…

This study looks at whether having more sessions of shock wave therapy (ESWT) helps people with long-term heel pain (plantar fasciitis) feel better and move easier. About 57 adults with pain lasting at least 3 months will be split into groups getting different numbers of ESWT ses…

This study tests if a specific acupuncture point on the hand can safely reduce heel pain and improve walking. Researchers will treat 150 adults aged 40-70 who have had heel pain for less than two months. The main goal is to see if at least half of participants get significant pai…

This study tests whether extracorporeal shockwave therapy (ESWT) can reduce pain and improve daily function in people with peripheral neuropathy who also have plantar fasciitis (heel pain). About 114 adults will receive either real or sham shockwave treatment. The goal is to see …

This study tests two non-invasive treatments for plantar fasciitis, a common cause of heel pain. 28 adults will receive either high-intensity laser therapy or focused shock wave therapy, plus exercises. Researchers will measure pain and foot function over 12 weeks to see which wo…

This study tests whether applying a nitroglycerin gel (glyceryl trinitrate) to the heel using ultrasound (phonophoresis) can reduce pain and thickening of the plantar fascia. Eighty adults with chronic plantar fasciitis will receive either the gel plus exercises or exercises alon…

This study tests which injection therapy—platelet-rich plasma (PRP) or prolotherapy—works better for people with plantar fasciitis that hasn't improved with usual treatments like rest or stretching. About 68 adults will receive one type of injection, and researchers will measure …

This study tests whether focused shockwave therapy (fESWT) plus exercise reduces pain and improves walking in people with chronic plantar fasciitis (heel pain lasting over 6 months). About 20 adults will be randomly assigned to either fESWT plus exercise or exercise alone. Resear…

This study looks at a surgery called calcaneal osteotomy for adults with severe plantar fasciosis that hasn't improved with other treatments. The surgery aims to reduce tension on the plantar fascia without cutting it. Researchers will measure pain and foot function in 11 partici…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study compares two minimally invasive treatments for chronic plantar fasciitis (heel pain): pulsed radiofrequency ablation and steroid injections. It will enroll 122 adults aged 18-65 with chronic plantar fasciitis. The goal is to see which method provides better pain relief…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study compares two treatments for plantar fasciitis, a common cause of heel pain. One treatment, prolotherapy, involves injecting a sugar solution to help the tissue heal. The other, extracorporeal shock wave therapy (ESWT), uses sound waves to stimulate healing. The study w…

This study tests whether taking N-acetylcysteine (NAC), a common supplement, before and after hand or foot surgery can reduce pain and the need for opioid painkillers. About 80 adults will be randomly assigned to take NAC or a placebo for 14 days. Researchers will track pain, fun…

This study compares two taping techniques for plantar fasciitis, a common cause of heel pain. One method supports the arch, while the other stretches the plantar fascia. Researchers will measure pain, ankle movement, and foot function in 36 adults aged 25-65 with acute or subacut…

This study tests whether specific foot exercises—like toe yoga and arch doming—can improve big toe movement and walking patterns in people with chronic plantar fasciitis. Researchers will measure pain, foot function, and gait in 34 adults aged 25-45. The goal is to see if these s…

This pilot study will test whether nerve gliding exercises (neural mobilization) can reduce pain and improve foot function in people with plantar fasciitis. Twelve adults aged 19 to 40 will be randomly assigned to either nerve gliding or standard physiotherapy for three weeks. Re…

This study tests whether adding fascial therapy (a type of hands-on tissue manipulation) to standard electrotherapy can improve pain, movement, and joint awareness in people with frozen shoulder. Thirty-six adults aged 35-60 will be split into two groups: one gets only electrothe…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study follows 1,000 patients with rare, life-threatening skin and soft tissue infections who are treated through a special care network in the greater Paris area. Researchers will track survival rates, long-term complications, and quality of life to understand what factors a…

This study will collect blood samples from 30,000 adults in the UK with various health conditions, including blood clots, infections, heart disease, diabetes, and more. The samples will be used to develop and fine-tune new diagnostic tests for the cobas® lumira device, which allo…

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study will measure harmful molecules called AGEs in 300 people with various rheumatic diseases (like rheumatoid arthritis and ankylosing spondylitis) and compare them to healthy volunteers. AGEs build up over time and can cause inflammation. Researchers will use a non-invasi…