Can pressurized oxygen beat Flesh-Eating bacteria?

NCT ID NCT07170020

Not yet recruiting Disease control Sponsor: Corewell Health West Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 26, 2026 · Updated 2 times

Summary

This study will test whether adding hyperbaric oxygen therapy to standard care helps people with necrotizing fasciitis, a severe flesh-eating infection. Researchers will compare death rates and complications in 160 adults who receive the treatment versus historical controls. The goal is to see if the oxygen treatment improves survival and reduces the need for repeated surgeries.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Hyperbaric oxygen therapy (breathing pure oxygen in a pressurized chamber)
What this could lead to: If it works, this could provide a proven way to lower death and complication rates from severe flesh-eating infections.
What could go wrong: This trial hasn't started yet and is relatively small. Prior evidence is from case studies, so the benefit is uncertain. Hyperbaric oxygen can cause ear or sinus pain and, rarely, lung injury.

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Conditions

The condition(s) this trial relates to.

fasciitis necrotizing fasciitis necrotizing soft tissue infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NECROTIZING FASCITIS

Contacts and locations

Locations

Corewell Health

Grand Rapids, Michigan, 49503, United States

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