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Can a 12-Week exercise programme build strength safely in boys with hemophilia?

NCT ID NCT05895032

Symptom relief Sponsor: East Kent Hospitals University NHS Foundation Trust Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 10, 2026 · Last updated Sep 11, 2026 · Updated 1 time

Summary

Boys with hemophilia often miss out on games and activities because of concerns about bleeding and joint damage. Researchers developed a 12-week muscle-strengthening exercise programme with input from children, parents, and physiotherapists. The DOLPHIN-II trial compares this programme with usual care in 132 boys aged 6 to 12 who have moderate or severe hemophilia A or B. The study measures changes in leg muscle strength and tracks bleeding episodes and factor usage to see whether the exercise is safe and helpful.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
a 12-week muscle-strengthening exercise programme
What this could lead to
If the exercise programme helps, it could give families and physiotherapists a clear, evidence-based way to build muscle strength in children with hemophilia and support their joint health.
What could go wrong
This is a single trial in a small group of children, so the results may not apply to everyone. Exercise carries a small risk of bleeding or injury, especially in children with a bleeding disorder, and the trial monitors this closely.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

132 people

The number who actually took part.

Started

May 2021

Finished

Jun 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

6 to 12 years

Sex

Male participants only

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: • Children aged 6-12 years, with severe or moderate haemophilia A or B Exclusion Criteria: * von Willebrand disease * past history of fracture or trauma to the lower limb * orthopaedic surgery * acquired brain injury or any other disturbance of the central nervous system; joint or muscle bleed in the lower limb in the past 6 weeks * presence of lower limb pain or unable to fully comply with verbal instructions.

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Conditions

The condition(s) this trial relates to.

CHILD syndrome hemophilia hemophilia A hemophilia B Motor Activity musculoskeletal system disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Child, only Hemophilia Musculoskeletal diseases or conditions

Contacts and locations

Locations

  • Haemophilia Centre

    Canterbury, Kent, CT1 3NG, United Kingdom

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