Metabolic syndrome X

This study tests whether spermidine, a natural substance found in foods like soy and aged cheese, can improve heart and muscle health in elderly people with coronary artery disease. 180 participants aged 65 and older will receive either spermidine capsules or a placebo for a peri…

This study explores whether combining a high-protein Mediterranean diet with resistance exercise can help people with heart disease build muscle and lower their risk of future heart problems. The trial enrolls adults who have completed cardiac rehab and may have low muscle mass w…

This completed pilot study tested whether transferring gut bacteria from lean donors or from people who had gastric bypass surgery could improve metabolism in 29 obese adults with prediabetes or diabetes. Participants received fecal transplants, and researchers measured changes i…

This study tested whether bars made with polyunsaturated fatty acids could improve cholesterol and fat levels in people with metabolic syndrome. 60 adults aged 40-65 with high BMI and abnormal cholesterol took part. The goal was to see if these bars could help control dyslipidemi…

This study looked at whether eating only within a 10-hour window each day helps overweight adults aged 50 to 75 with prediabetes lose fat and improve their metabolism. 57 participants either followed the 10-hour eating plan or their usual 13-hour eating pattern, while tracking th…

This pilot study tested whether adding krill oil to standard metformin therapy improves metabolic health in women with PCOS and obesity. Fifty-four women were split into three groups: metformin alone, krill oil alone, or both together for 8 weeks. Researchers measured changes in …

This study looked at whether a 16-week strength training program can prevent or reduce late effects like muscle loss, heart disease, and diabetes in adults who had a bone marrow transplant as children. 28 survivors and a matched control group participated. The goal was to see if …

This phase 2 trial tested a drug called orticumab in 77 adults with moderate-to-severe psoriasis who also had cardiometabolic risks (like obesity and high cholesterol). The goal was to see if orticumab could safely reduce skin plaques and inflammation linked to heart disease. Par…

This study tested whether eating a fermented pea-and-legume product for three weeks could improve gut health and reduce inflammation in people with metabolic syndrome. 56 adults with a large waist and at least one other risk factor (like high blood sugar or cholesterol) took part…

This study looked at whether eating only during a 10-hour window each day and doing high-intensity interval training three times a week can improve health in people with metabolic syndrome. Two hundred adults took part for 16 weeks. Researchers measured changes in metabolic syndr…

This study tested whether taking phytosterols (plant-based supplements) for 3 months can improve liver health, cholesterol, and insulin levels in people with nonalcoholic fatty liver disease (NAFLD). 27 participants took either phytosterol pills or a placebo. Researchers measured…

This study explored whether using a mobile app and a Fitbit Inspire 3 tracker can help adults with metabolic syndrome become more physically active. One hundred participants were split into two groups: one used the digital tools plus usual care, the other received usual care alon…

This study looked at 60 men with metabolic syndrome who also had erectile dysfunction and early signs of heart stiffness. Researchers compared three treatments: tadalafil (a common ED drug), an SGLT2 inhibitor (a diabetes drug), and a combination of both, given for three months. …

This study looked at 781 adults with moderate-to-severe plaque psoriasis and metabolic syndrome (a cluster of conditions like high blood pressure and obesity). Researchers wanted to see if adding a lifestyle intervention (diet and exercise) to the drug Secukinumab (Cosentyx) impr…

This study looked at whether a program of physical exercise combined with a daily supplement of leucine and arginine could help obese adults with metabolic syndrome lose body fat and improve their health. About 79 participants took part. The goal was to see if this approach could…

This study tested whether a probiotic supplement (Pediococcus acidilactici) could reduce metabolic problems like high cholesterol and blood sugar caused by antipsychotic drugs. 36 adults with first-episode psychosis or schizophrenia took the probiotic or a placebo alongside their…

This study looked at whether omega-3 supplements from plants can improve blood vessel function in people with high blood pressure and metabolic syndrome. About 95 adults with treated hypertension and at least two signs of metabolic syndrome took part. Researchers measured artery …

This study tested a 'digi-physical' approach for families with children or teens living with obesity. Participants either received standard in-person care or a mix of digital tools (an app for tracking health and chatting with caregivers) plus fewer in-person visits. The goal was…

This study looked at whether eating fermented plant-based foods (like certain vegetables and grains) can improve health in people with metabolic syndrome—a condition that raises risk for heart disease and diabetes. About 89 adults with signs of metabolic syndrome ate either ferme…

This study looked at 192 women with PCOS to see which treatment works best for improving insulin resistance and other symptoms. Participants were randomly assigned to take metformin, inositol, follow a calorie-restricted diet, or combine all three for 12 weeks. The goal was to fi…

This study tested whether the drug vericiguat can improve the function of small blood vessels in the heart for people with metabolic syndrome (a cluster of conditions like high blood pressure and belly fat). 45 adults took either vericiguat or a placebo for 6 weeks. Researchers u…

This study tested whether a very low-carbohydrate ketogenic diet could improve brain network stability and thinking skills in people with schizophrenia or bipolar disorder. The diet is high in fat and low in carbs, which makes the body produce ketones that may provide extra energ…

This study tested whether a special fiber supplement, combined with a healthy Mediterranean diet and lifestyle changes, could improve gut bacteria and metabolic health in children with obesity. 36 children aged 8-14 took part for 8 months. The goal was to see if this approach cou…

This study tested three different diets—a traditional Mediterranean diet, a low-carb Mediterranean diet, and a high-protein diet—in 45 adults who are overweight or have obesity. Over 12 weeks, researchers measured changes in weight, body fat, muscle, and blood markers like choles…

This study tested whether a structured, intensive lifestyle program could help overweight or obese people with metabolic syndrome achieve remission. 68 participants followed a program aiming for 15% weight loss. The goal was to see if this approach could reduce the number of meta…

This study tested a black seed extract (Nisatol®) in 50 perimenopausal women with metabolic syndrome, a cluster of conditions like high blood sugar and blood pressure. Over 4 months, researchers measured changes in blood sugar, cholesterol, blood pressure, and menopausal symptoms…

This study looked at whether drinking hydrogen-rich water every day for 12 weeks can improve body composition and metabolic health in adults with metabolic syndrome. 40 adults participated, and researchers measured changes in waist size, body fat, blood sugar, and cholesterol. Th…

This study tested whether a home exercise program using electrical stimulation to move the legs, combined with a personalized diet, could improve body composition and metabolism in adults with spinal cord injury. Twenty-six participants were assigned to either exercise plus diet …

This study tested whether taking green tea extract for one month could improve gut health and reduce inflammation in people with metabolic syndrome and in healthy adults. Participants took either the extract or a placebo for a month, then switched. The study measured markers of i…

This study tested two different chemotherapy drugs (Treosulfan and Busulfan) given before a stem cell transplant in 106 children with serious non-cancer diseases like immune disorders, metabolic diseases, blood disorders, and bone marrow failure. The goal was to see which drug le…

This study tested whether providing medically tailored meals, with or without weekly group support sessions, helps Black adults with high blood pressure, type 2 diabetes, obesity, or metabolic syndrome improve their health. 75 participants received either meals alone, meals plus …

This study looked at whether eating only during a set window each day (time-restricted eating) combined with supervised exercise can reduce fat in the liver and improve heart health in adults with obesity. 187 people took part. The goal was to see if the combination works better …

This study looked at whether a natural part of milk fat called milk fat globule membrane (MFGM) can lower harmful gut bacteria products in the blood and improve health markers in adults with metabolic syndrome. Thirty people with metabolic syndrome followed a controlled diet with…

This study tested a 3-month lifestyle program, delivered by Pasifika community health workers, to help Native Hawaiians and Pacific Islanders with conditions like diabetes, high blood pressure, and obesity. The program included healthy eating and activity tips plus support for so…

This pilot study tested whether metformin, a common diabetes drug, can reduce blood vessel damage in the brain of people living with HIV who also have metabolic syndrome (a cluster of conditions like high blood pressure and cholesterol). The study enrolled 30 adults in South Afri…

This study compares a newer weight-loss surgery called SADI-S to an older, more complex one called BPD-DS in 62 adults with severe obesity. The goal is to see if SADI-S is safer and just as effective for long-term weight loss and managing related health problems like diabetes. Re…

This study tested whether taking moringa leaf powder capsules for 8 weeks could improve metabolic syndrome in Mexican adults. 36 participants were randomly assigned to receive either moringa or a placebo. Researchers measured changes in weight, blood pressure, waist size, and blo…

This completed study tested whether eplerenone, a drug that blocks a hormone called aldosterone, improves blood flow and reduces scarring in the heart more than another drug, chlorthalidone, in 79 people with obesity and high blood pressure. Participants took one of the two drugs…

This study looked at whether combining exercise with the diabetes drug metformin improves blood vessel function in adults with metabolic syndrome. 91 participants were assigned to different exercise intensities with or without metformin for 16 weeks. The goal was to see if the co…

This study followed 1,581 adults with metabolic syndrome who had bariatric surgery (gastric bypass or sleeve gastrectomy). Researchers tracked weight, blood pressure, blood sugar, and cholesterol for up to 10 years to see if surgery provides lasting health benefits. The goal is t…

This study looked at whether eating canola oil every day for 12 weeks can improve cholesterol, blood vessel function, and other risk factors in people with metabolic syndrome. Eighty adults with the condition were randomly assigned to consume either canola oil or a typical Wester…

This completed study tested whether a Mediterranean diet could improve metabolic syndrome markers in 30 hospitalized adults with psychiatric conditions. Participants followed either a Mediterranean diet or a standard hospital diet for 8 weeks, then switched. Researchers measured …

This study looked at whether drinking a strawberry beverage every day for four weeks could improve cholesterol, blood sugar, and other heart health markers in overweight or obese adults. Forty-eight participants with borderline-high cholesterol and normal to slightly elevated blo…

This study tested a new blood test called LLIFT to see if it can accurately diagnose fatty liver disease and its severe form, NASH, without needing a liver biopsy. Researchers enrolled 158 people at high risk for metabolic syndrome. The LLIFT test combines patient information lik…

This study tested a new method called global metabolomic profiling to diagnose inborn errors of metabolism, a group of rare genetic disorders. Researchers compared this approach to traditional testing in 240 participants. The goal was to see if the new method could more accuratel…

This study tested a 12-week diet and lifestyle program called the SWW Method in 85 women aged 35-75. The program included intermittent fasting, a high-protein diet, and other healthy habits. Researchers measured changes in blood sugar, weight, and other markers to see if it could…

This study tested whether taking 1,000 mg of glycine daily for six months could improve memory and thinking in older adults. Fifty-nine participants took the supplement, and researchers measured changes in a brain health marker and cognitive test scores. The goal was to see if th…

This study looked at whether taking Korean ginseng extract daily for eight weeks could reduce fatigue and improve exercise performance in healthy adults aged 20 to 50. Sixty participants were randomly assigned to receive either the ginseng extract or a placebo. The researchers me…

This completed study tested whether semaglutide, a drug used for type 2 diabetes and weight loss, could improve sleep apnea in 15 people with diabetes or obesity. Researchers measured breathing pauses during sleep (AHI) after 1 and 4 weeks of treatment. The goal was to see if the…

This study tested whether a special turmeric supplement (MERIVA®) could improve memory and thinking in older adults with metabolic syndrome. 85 people took either the supplement or a placebo for 6 months. Researchers measured changes in cognitive tests to see if turmeric helped p…

This small study tested whether gummy candies made with maqui berry could help overweight adults control their blood sugar after eating a carb-rich meal. Ten participants ate white bread alone, or with maqui berry gummies, and had their blood sugar and antioxidant levels measured…

This study tested whether drinking VitalPLANT and Helichrysum italicum teas for one week could improve signs of metabolic syndrome in 30 overweight adults. Participants had at least two components of metabolic syndrome and were not taking any related medications. Researchers meas…

This study tested two types of time-restricted eating in 103 overweight adults with metabolic syndrome. One group ate all their food within an early 8-hour window, the other within a late 8-hour window. Researchers measured changes in body weight and belly fat to see which timing…

This study tested whether a phone-based cognitive behavioral therapy program could help people with severe or morbid obesity reduce their food addiction. 154 participants received either 12 therapy sessions over 18 weeks or their usual care. The goal was to see if the therapy cou…

This study created a registry of medical records from women with inborn errors of metabolism—rare conditions that affect how the body turns food into energy. Researchers collected data from past or current pregnancies and followed babies for one year after birth. The goal was to …

This completed study looked at how the social networks of caregivers affect their stress and health when caring for someone with an inherited disease. Researchers surveyed over 680 participants, including family members and formal caregivers, to understand caregiving burden and s…

This study looked at health records from over 5,000 adults to see if having an H. pylori stomach infection is linked to metabolic syndrome—a cluster of conditions like high blood sugar, high blood pressure, and excess belly fat. Researchers compared people with and without the in…

This study followed 53 adults with overweight or obesity who were already receiving standard lifestyle-based weight loss care at a clinic. Researchers measured changes in body weight, fat mass, blood sugar, cholesterol, and other health markers before and after weight loss. The g…

This study looked at 315 HIV-positive adults to build models that predict fatty liver disease and liver scarring. Researchers used ultrasound and FibroScan tests to track liver changes over time. The goal was to better understand and identify liver problems early in people living…

This study looked at 88 women newly diagnosed with primary hypothyroidism (underactive thyroid) to see if taking levothyroxine to normalize thyroid hormones also improves metabolic health. Researchers measured special proteins called adipokines, which are linked to fat tissue and…

This study checks if a program called COPE helps Navajo people with diabetes and related health problems. The program uses community health workers to support patients and connect them with doctors. Researchers compared nearly 29,000 people who took part in COPE with those who di…

This completed pilot study in Yomitan Village, Okinawa tested three simple, low-cost approaches to reduce stress and encourage healthy habits in 45 adults with overweight or pre-metabolic syndrome. Participants were randomly assigned to receive health leaflets, wear functional cl…

This study looked at 90 children and teens (ages 7-18) taking antipsychotic medication to see how it affects their hormones, growth, and metabolism. Researchers measured prolactin levels and checked for links to sex hormones, metabolic health, and puberty development. The goal wa…

This study followed 201 adults with diabetes who were hospitalized for COVID-19 in Algeria. Researchers tracked their blood sugar, weight, and kidney function for up to a year after leaving the hospital. The goal was to learn how COVID-19 affects long-term diabetes control and to…

This study looked at two easy methods to measure hidden belly fat in 110 adults with type 2 diabetes. Researchers compared a simple waist measurement to a device that sends a mild electrical signal through the body. The goal was to see which method better relates to heart disease…

This small pilot study looked at whether combining walking with mindful attention is a practical and acceptable way to help people with metabolic syndrome become more active. 34 participants were assigned to a walking program, a mindfulness program, both, or neither. The goal was…

This study looked at whether a special drink called ketone ester can improve brain energy use and thinking skills in healthy adults aged 55 and older who have metabolic syndrome. Participants took the drink or a placebo for 28 days and had brain scans and memory tests. The goal w…

This study looked at 470 adults aged 18-75 with type 2 diabetes and metabolic syndrome to identify their Traditional Chinese Medicine (TCM) patterns. Researchers used a standard questionnaire and four TCM diagnostic methods to classify each person's syndrome. The goal was to bett…

This study looked at how two different nutritionally balanced diets affect insulin levels and other markers of metabolic health in 52 adults who are overweight or at risk for diabetes. Participants followed each diet while maintaining their weight, and researchers measured change…

This study tested whether a genetic score could predict how well adults with metabolic syndrome respond to a calorie-cutting diet. 115 Mexican adults followed a reduced-calorie diet for a period, and researchers measured changes in waist size, blood sugar, cholesterol, and blood …

This study followed 42 adults with spinal cord injury for one year after leaving rehab. Researchers tracked what they ate, how active they were, and their mood to understand why weight gain happens. The goal is to use this information to design better programs that help people wi…

This completed study examined 292 people with non-alcoholic fatty liver disease (NAFLD) to see if liver scarring is linked to heart disease risk. Researchers used non-invasive tests like the coronary calcium score and liver elastography. The goal was to better understand how to s…

This study looked at whether a 12-month lifestyle program could lower body fat and change certain gene markers in 26 adults with metabolic syndrome. Participants tracked their food and activity using a mobile app, and had blood tests and body scans at the start and end. The goal …

This study looked at whether a new test (CDMT) helps primary care doctors make better decisions for patients with cardiometabolic syndrome. 247 board-certified physicians participated, with some using the test and others not. Researchers measured the quality of care and expected …

This study looked at whether high-intensity interval training (HIIT) or weight-loss surgery can reduce the risk of nerve damage (peripheral neuropathy) in people with obesity. About 140 adults who were candidates for bariatric surgery took part. Researchers measured nerve health …

This study tested whether taking gum arabic, a natural dietary fiber, can improve markers of metabolic syndrome in 100 postmenopausal women. The researchers looked at changes in inflammation, blood sugar, and cholesterol levels. The goal was to understand how gum arabic might wor…

This study looked at how daily rhythms—like sleep and meal timing—affect fat cell genes and insulin response in 28 women with obesity scheduled for bariatric surgery. Researchers used timed lights and meals to align or disrupt the body's internal clock, then measured changes in f…

This study examined the relationship between metabolic syndrome and vitamin D levels in 549 older adults (65+). Researchers collected health questionnaires and blood samples to understand how these factors are connected. The goal was to gather knowledge, not to test a treatment.

This study looked at 320 people with HIV in Chile to understand why they often develop health problems like heart disease and diabetes, even when their HIV is controlled with medication. Researchers collected blood samples and used advanced techniques to measure inflammation and …

This completed observational study looked at how gut length and gut bacteria relate to how well healthy people absorb energy from food. Researchers measured gut length via MRI, tracked food intake, and analyzed energy in feces and urine. The goal was to better understand the link…

This study looked at whether taking short walks at different frequencies during long periods of sitting can improve blood sugar and fat levels. Twenty-five healthy but sedentary adults participated. Researchers measured changes in blood markers after different patterns of sitting…

This completed study looked at 60 obese patients who had bariatric surgery (like gastric bypass or sleeve gastrectomy). Researchers checked their gut bacteria and hormone levels before and 6-12 months after surgery. The goal was to see how the microbiome changes and if those chan…

This study followed 215 people newly diagnosed with HIV in Hong Kong to see how often they developed non-AIDS conditions like high blood pressure, diabetes, bone thinning, and kidney problems. Participants were on different anti-retroviral regimens, and researchers compared the r…

This study used advanced MRI scans to look for organ damage in 693 adults who had recovered from COVID-19. Researchers focused on the heart, kidneys, and liver to see how often and how severely these organs were affected. The goal was to better understand the long-term health imp…

This study looked at 514 people with stable coronary artery disease to see if how their body processes fat after a meal (triglyceride tolerance) is linked to future heart attacks or death. Researchers also checked blood sugar tolerance. The goal was to find a better way to identi…

This study examined whether having metabolic syndrome (a cluster of conditions like high blood pressure and diabetes) changes how well a steroid injection works for people with chronic back pain from a herniated disc. Researchers treated 51 adults who had not improved with other …

This completed study looked at 332 adults with obesity to see if simple body measurements and blood tests could predict metabolic syndrome, a cluster of conditions that raise heart disease and diabetes risk. Participants were grouped by obesity severity, and researchers calculate…

This study looked at whether a blood marker called PTX3 can predict how well people do after gastric bypass surgery. Researchers followed 23 patients for 6 months after surgery, measuring weight loss, insulin resistance, and inflammation. The goal was to see if PTX3 levels before…

This study examined blood samples and physical measurements from 158 adults aged 55-69 to see if certain immune system patterns are linked to insulin resistance, a condition that can lead to diabetes. Researchers measured various immune cells and markers to find a profile that co…

This study looked at how many girls and young women aged 11 to 20 with chronic diseases (like diabetes or immune conditions) got the HPV vaccine, compared to those without chronic illness. Researchers reviewed records of 223 participants from a hospital in France. The goal was to…

This small pilot study looked at whether people with major depression who eat a lot of ultra-processed foods could cut back on them. Twenty adults tried a personalized plan to reduce these foods. The goal was to see if it was possible and acceptable, not to measure mood changes. …

This study examined 170 men from couples struggling with infertility to see if metabolic syndrome—a cluster of conditions like high blood pressure, high blood sugar, and abnormal cholesterol—is linked to poor sperm quality. Researchers measured sperm count and other sperm feature…

This study looked at how drinking orange juice compared to a sugar-sweetened beverage affects risk factors for heart disease and type 2 diabetes. Fifty-six adults drank either orange juice or a sugary drink for four weeks. Researchers measured changes in cholesterol, blood sugar,…

This study tested whether a personalized lifestyle program could be run in a family medicine clinic for people with insulin resistance and related conditions like obesity, diabetes, and high blood pressure. Forty participants were randomly assigned to start with either nutrition …

This completed study followed 1,100 adults with shoulder pain for up to five years to see how metabolic syndrome (a cluster of conditions like high blood pressure and diabetes) affects recovery. Participants received standard treatments like physiotherapy, injections, or surgery.…

This completed study looked at 357 healthy adults aged 35-65 to understand how excess belly fat relates to the buildup of fatty plaque in arteries, a key cause of heart attacks. Using MRI and CT scans, researchers measured abdominal fat and artery wall thickness. The goal was to …

This study looks at whether the body's ability to switch between burning fat and sugar (called metabolic flexibility) is linked to changes in metabolic health over 16 years. Researchers will re-examine 18 people who had their metabolic flexibility measured in 2008-2009. They will…

This completed study in Cameroon followed 406 adults with and without type 2 diabetes for one year. Researchers tested blood and stool samples at four time points to see if diabetes increases the risk of malaria and other parasitic infections. The goal is to understand how non-co…