Human papilloma virus infection

This trial tests whether a single dose of the 9-valent HPV vaccine triggers the same immune response as two doses in healthy adults aged 18 to 45. Researchers will measure antibody and B cell responses in blood, lymph nodes, and bone marrow. The goal is to understand how the vacc…

This study tests whether a combination of a culturally tailored video message from an HPV cancer survivor and a reminder phone call can increase the number of adolescents aged 10-12 who get the HPV vaccine. The intervention is delivered through a patient portal and direct outreac…

This study is testing how well the 9-valent HPV vaccine (Gardasil9) triggers an immune response in people born male who have used estrogen or androgen blockers, including those living with HIV. Participants receive three doses of the vaccine over six months, and their immune resp…

This phase 1 trial tests a DNA vaccine designed to target HPV16, a virus that can cause high-grade cervical lesions (CIN2/3). The vaccine is given by injection into the muscle followed by a mild electrical pulse to help cells take up the DNA. The study includes both HIV-negative …

This trial is testing whether three different batches of a 9-valent HPV vaccine produce similar immune responses in 720 women aged 18-30 in China. Participants will receive three doses over six months, and researchers will measure antibody levels one month after the final dose. T…

This study tests a bivalent HPV vaccine in healthy infants (9 months), toddlers (15 months), children (2-5 years), and unmarried young women (15-20 years) in Ghana. Researchers want to see if the vaccine is safe and triggers a strong immune response, especially when given alongsi…

This phase 2 trial tests a DNA vaccine called PVX4 in 138 women with HPV16-related high-grade cervical dysplasia (CIN2/3). The vaccine is given as a shot with a small electrical pulse to help it enter cells. The goal is to see if it can clear the virus and make abnormal cervical …

This study looks at whether giving two doses of the HPV vaccine instead of three can protect women living with HIV just as well. Researchers will compare immune responses in 275 Canadian women aged 18-45 who have not been vaccinated before. If two doses work, it could make HPV va…

This Phase 3 trial is testing an 11-valent HPV vaccine in 13,500 Chinese women aged 18-45. The vaccine targets 11 types of HPV linked to cervical cancer and genital warts. Participants receive three shots over six months and are monitored for several years to see if the vaccine p…

This early-phase trial tests a new vaccine called PANHPVAX in 45 healthy adults aged 18-45. The vaccine targets a part of the HPV virus (L2 antigen) to potentially protect against multiple HPV types. The main goal is to check safety and how well the body's immune system responds …

This study tests a new 15-valent HPV vaccine to see if it is safe and triggers a strong immune response. It involves 330 healthy Chinese volunteers aged 9 to 45. Participants will receive three doses of the vaccine or a placebo, and researchers will monitor side effects and measu…

This study tests whether active health education methods can increase HPV vaccination rates among 5,000 students aged 9-14 in 196 Brazilian schools. Schools are randomly assigned to different education approaches, and researchers track how many students get vaccinated. The goal i…

This study is for people with HPV-related throat cancer who have surgery to remove the tumor. Normally, some patients also get radiation afterward to lower the risk of cancer coming back. This trial tests whether it's safe to skip that radiation if a blood test two weeks after su…

This phase 2 trial tests whether applying a special gel (Geniwa gel) after laser removal can better treat recurrent genital warts and prevent them from returning. Adults who have had at least three laser treatments and still experience recurrences are eligible. Participants recei…

This Phase 3 trial tests YCANTH, a topical solution containing cantharidin (a substance from blister beetles), against a placebo for treating common warts. About 300 people aged 2 and older with at least one wart on their body (excluding certain areas) will receive either the act…

This study in El Salvador tests a new thermal ablation device (IRIS™) to treat cervical precancer and an AI algorithm to help decide who needs treatment. About 5,000 HPV-positive women aged 30-49 will receive the treatment and be followed for one year to see if the precancer is c…

This trial tests whether 2LPAPI, an immune regulator used for over 20 years, can help clear high-risk genital HPV infections faster than a placebo. Researchers will enroll 284 women aged 25 to 45 with a current high-risk HPV diagnosis. Participants receive either 2LPAPI or a plac…

This study tests whether DARE-HPV, a vaginal capsule containing HIV drugs lopinavir and ritonavir, can clear persistent high-risk HPV infections in women aged 22-50. Participants will receive one of two doses for 14 or 21 days, or a placebo. The main goal is to see if the infecti…

This phase III trial compares a new, shorter radiation approach to the standard 7-week chemoradiation for patients with HPV-positive oropharynx cancer. The experimental treatment uses a precise, high-dose radiation boost to the tumor followed by a reduced-dose chemoradiation cour…

This trial tests an experimental drug called STAR0602, which is designed to help the immune system attack cancer cells. It is being studied in people with advanced solid tumors that have not responded to standard treatments. The drug is given alone or combined with chemotherapy, …

This early-stage trial tests whether a mushroom-based vaginal gel (Papilocare) can help clear HPV and reverse mild to moderate cervical dysplasia (CIN1/CIN2). Seventy women aged 30-50 will either use the gel for 6 months or follow the standard 'watch and wait' approach. The study…

This trial studies people with HPV-positive oropharynx cancer whose tumors can be surgically removed. After surgery, patients are grouped by risk: low-risk patients get no further treatment, intermediate-risk get a lower dose of radiation, and high-risk get lower-dose radiation p…

This study tests whether an experimental biologic called NWRD09 can clear persistent cervical HPV16 infection in women aged 45 to 65. Participants receive either NWRD09 or a placebo by injection, and researchers check if the virus is gone after 16 weeks. The trial also monitors f…

This early-stage trial tests an experimental therapy called NWRD09 in 10 adults aged 18 to 60 who have had a persistent HPV16 infection in the anal area for at least a year. The therapy is given as an injection and is designed to help the body clear the virus. The study primarily…

This trial tests a vaccine called BVAC-E6E7 in people with head and neck cancer linked to HPV types 16 or 18 that cannot be removed by surgery or has spread. The vaccine is designed to teach the immune system to attack cancer cells. The study first checks safety and the best dose…

This study tests a supplement called Papillex® to see if it can help reverse abnormal cervical cells caused by HPV. Researchers will compare Papillex® to a placebo in 60 women with mild to moderate cervical changes (CIN 1 or 2). Participants take the supplement daily for 180 days…

This early-phase study tests two cancer drugs—lenvatinib (a daily pill) and pembrolizumab (an IV infusion)—in 20 adults with HPV-related recurrent respiratory papillomatosis (RRP) that has spread to the lungs. The goal is to see if the combination can shrink papillomas and reduce…

This phase 2 trial tests a DNA vaccine called pBI-11 in 48 women with persistent HPV16 or HPV18 cervical infection. The vaccine is designed to boost the immune system to clear the virus. Participants receive the vaccine or a placebo via injection with a special device. The study …

This study tests whether a non-invasive physical plasma treatment can clear HPV infections from the cervix. About 50 adults with HPV will receive the treatment, and researchers will check if the virus is gone afterward. The goal is to find a new way to prevent cervical cancer cau…

This study tests whether a vaginal suppository called Dysplasix can help women clear high-risk human papillomavirus (HPV) and reverse low-grade cervical abnormalities. About 45 women with HPV and mild cervical changes will use the suppository or a placebo for 19 days. Researchers…

This early-stage trial is testing whether injecting the local anesthetic lidocaine into HPV-related throat tumors before robotic surgery is safe and might help destroy more cancer cells. About 30 adults with HPV-positive oropharyngeal cancer will receive the injection during a ro…

This study follows people who already took part in earlier YCANTH wart studies. It tests whether up to 4 more treatments, applied every 21 days, can safely clear common warts. About 600 adults and children will be monitored for a year. The goal is to see if the medicine continues…

This study is testing whether a much lower dose of radiation (30 Gy) combined with standard chemotherapy can control HPV-positive throat cancer as well as the usual high dose (70 Gy). The goal is to reduce side effects from radiation while still keeping the cancer from coming bac…

This study tests giving chemotherapy and immunotherapy before standard surgery for head and neck cancer. The goal is to shrink tumors enough so that surgeons can perform less extensive, function-preserving operations, reducing damage to swallowing, speech, and vision. The trial e…

This study is testing whether people with early-stage HPV-positive throat cancer can be treated with radiation alone at a lower dose, instead of the usual full-dose radiation plus chemotherapy. The goal is to see if this gentler approach can keep the cancer from coming back while…

This study is testing whether a blood test that detects HPV DNA can help doctors decide who needs radiation after surgery for HPV-related oropharynx cancer. In one group, patients with no detectable HPV DNA after surgery will be watched closely and only get radiation if the test …

This study is testing whether the Gardasil 9 vaccine can reduce the infectivity of HPV16 virus in women who already have the infection. About 50 women aged 18-45 will receive two doses of the vaccine, and researchers will use urine samples to measure virus activity and immune res…

This study is testing whether a liquid called Paiteling, applied directly to the cervix, can clear persistent high-risk HPV infections. The trial will enroll 115 women aged 25 to 65 who have had the same high-risk HPV type for at least two years. Researchers will check if the vir…

This study tests a new drug called volrustomig combined with standard chemotherapy (paclitaxel and carboplatin) in people with advanced head and neck cancer that is not caused by HPV. The goal is to see if this combination shrinks tumors before further treatment is tailored based…

This study looks at whether giving the 9vHPV (Gardasil-9) vaccine to women who already have HPV16 or 18 can reduce the virus's ability to infect others. Researchers will measure viral activity in cervical, anal, and oral samples before and after vaccination. The goal is to see if…

This study tests whether a same-day HPV screening and treatment approach can help prevent cervical cancer in women living with HIV in the Dominican Republic. 600 women will be randomly assigned to either the new same-day method or standard care. The goal is to see if more women c…

This study tests a gel called YCANTH on common warts caused by HPV. About 300 people aged 2 and older with at least one wart will apply the gel or a fake version. The goal is to see if the gel can clear all warts by day 84.

This study tests a gene therapy called Zopapogene imadenovec (Zopa) in 30 adults with recurrent respiratory papillomatosis (RRP), a condition causing non-cancerous throat tumors that often require repeated surgeries. One group will check how the virus used in the therapy leaves t…

This phase II trial tests whether artesunate, a drug originally used for malaria, can reverse cervical pre-cancer (CIN2/3) when given as a vaginal insert. About 78 women with high-grade cervical lesions will receive either artesunate or a placebo for three 5-day cycles. The main …

This study explores whether women can accurately collect their own samples for HPV testing, which could make cervical cancer screening easier and more accessible. The research focuses on minority women who are often under-screened, using community health workers to help with the …

This trial evaluates whether a new self-collection device, Mia by XytoTest, can be used effectively by people to collect their own vaginal samples for cervical cancer screening. The study compares the accuracy of these self-collected samples against clinician-collected samples fo…

This study is testing whether self-collected vaginal samples for HPV testing work as well as samples collected by a doctor during a pelvic exam. The goal is to make cervical cancer screening more accessible and comfortable. About 500 people referred for colposcopy or cervical pro…

This study looks at whether giving women at-home kits to test for HPV (a virus that can cause cervical cancer) makes it easier for them to get screened. About 100 women who are overdue for screening will receive a kit and be asked to return a sample by mail. Researchers will comp…

This study is testing whether a special menstrual pad, called the Q-Pad, can accurately detect high-risk HPV from menstrual blood collected at home. About 450 people who need a colposcopy after an abnormal Pap or HPV test will use the pad during their period and mail it to a lab.…

This study compares two ways to offer cervical cancer screening to women living with HIV: standard clinic-based screening versus adding community outreach where health workers provide HPV self-collection kits at home or in community settings. About 7,600 women across multiple cli…

This study is testing a new point-of-care diagnostic test for HPV, called the Rice HPV test, to see if it works as well as standard tests. Researchers at MD Anderson Cancer Center will enroll 600 people with a cervix aged 21 or older. The goal is to develop a test that requires l…

This study tests whether offering a self-sampling kit for HPV in the emergency department can increase the number of people who get screened for cervical cancer. About 200 eligible individuals (ages 30-65 with a cervix) will be offered the kit while in the ED. The goal is to see …

This study evaluates a same-day cervical cancer screening approach for women in Cameroon. Participants first collect their own sample for HPV testing, and if positive, they receive a digital cytology exam on the same day to determine if further treatment is needed. The goal is to…

This study is testing whether giving women a simple self-sampling kit to use at home can increase the number of women who get screened for cervical cancer. The trial will enroll 15,000 women in Czech Republic, especially those who haven't had a Pap smear in over 3 years. Particip…

This study aims to make cervical cancer screening more convenient by offering HPV self-collection kits that women can use at home or in the clinic. Researchers will enroll 1,000 women aged 25-65 who are overdue for screening. The goal is to see how many women complete the test an…

This study is testing a new, low-cost screening tool for cervical cancer that uses artificial intelligence to analyze digital images of the cervix. It does not require a lab and can be used at the point of care. The goal is to see if this AI tool can accurately detect precancerou…

This study is testing a small, AI-powered camera called the Pocket colposcope to see if it can accurately detect early signs of cervical cancer in women who have tested positive for HPV. About 1,054 women in Kenya will use the device during a routine exam. The goal is to find a s…

Women treated for vulvar high-grade squamous intraepithelial lesion (vHSIL), a precancerous condition linked to HPV, often see it return. This trial tests whether giving the Gardasil 9 HPV vaccine alongside standard treatment (surgery, laser, or imiquimod) can lower that recurren…

This study compares the immune response from 2 doses versus the standard 3 doses of the HPV vaccine in women aged 27-45. About 618 participants will be randomly assigned to receive either 2 or 3 doses, and their antibody levels will be checked over 12 months. If 2 doses prove non…

This study in Tanzania tests whether giving boys a single dose of the HPV vaccine (Gardasil) can lower HPV infections in the community. Over 10,000 participants in 26 communities will be split: some communities vaccinate only girls (as usual), while others also vaccinate boys age…

This study tests a community-based approach to make cervical cancer screening easier for women who haven't had a Pap test in over 3.5 years. It involves 920 women in low-resource areas of Texas. The goal is to see if this strategy is safe and works well.

This study tests a program called SAKHI HPV for women in India who have both HPV and HIV. The program provides support from community health workers, group sessions, and nutrition education to help women stay healthy and reduce their risk of cervical cancer. Researchers will comp…

This study tests whether at-home HPV self-sampling (using urine or a vaginal swab) can help more people get screened for cervical cancer compared to the traditional in-clinic Pap smear. About 735 Latinx individuals aged 30-65 who haven't had a Pap test in at least three years wil…

This study aims to make cervical cancer prevention easier for women who often miss out on routine care, such as those experiencing homelessness, substance use, or incarceration. Researchers will offer the HPV vaccine (Gardasil-9) and a self-swab test during regular sexual health …

This study tests whether giving nurses and doctors special training and allowing nurses to give the HPV vaccine without a doctor's order can increase vaccination rates. About 16,000 teens aged 9-17 from 40 medical practices will take part. The goal is to prevent HPV-related cance…

This study compares two strategies to help clinics increase HPV vaccination rates among children aged 9-17. One strategy provides online communication training for providers; the other adds a learning collaborative with performance feedback. The goal is to see which approach work…

This pilot study tests whether a health-themed video game can encourage HPV vaccination among underserved youth aged 11-14 who have not yet received the vaccine. About 180 parent-child pairs will play the game and report their vaccination intentions and actual shots. The goal is …

This study tests whether training and supporting healthcare providers can increase HPV vaccination rates among Latino adolescents. Researchers will work with nine health centers to implement strategies like provider education and clinical plans. The goal is to see if these effort…

This study checks how well the HPV vaccine prevents cervical HPV infection in women in Sikkim, India, about 7 years after the vaccine was introduced. Researchers will collect cervical samples from 5,500 married women aged 18-22 and compare infection rates to those before vaccinat…

This study tests whether people living with HIV can accurately collect their own swab samples to screen for HPV, a virus that can lead to anal cancer. Researchers will compare self-swabs to those taken by a doctor and ask participants which method they prefer. If self-screening w…

This study tests a new school-based program to encourage HPV vaccination among 11-17 year olds in France. HPV is a common virus that can cause cancer, but vaccination rates are low. The program will be used in middle and high schools, and researchers will check if more teens get …

This study is testing whether an educational video and toolkit can help more people from underserved groups start and finish the HPV vaccine series. The vaccine protects against HPV, a virus that can cause certain cancers. The trial will enroll 1,000 patients and parents at Denve…

This pilot study is testing whether a daily supplement containing green tea extract (EGCG), folic acid, and vitamin B12 can help women clear a persistent high-risk HPV infection in the cervix. About 100 women with a positive HPV test but no serious cell changes will take the supp…

This study in Honduras tests a new way to prevent cervical cancer using a self-collected HPV test that gives results in under an hour, combined with AI-powered imaging. 5,000 women will participate to see if this same-day screening-and-treatment approach is accurate, feasible, an…

This study tests whether a short video can encourage college students aged 18-26 to get the HPV vaccine, which helps prevent certain cancers. About 123 students who have never received the vaccine will watch the video and report their intentions and attitudes. The goal is to find…

This study tests different strategies to increase HPV vaccination among 9- to 12-year-olds in rural North Central Florida. Clinics will be randomly assigned to offer clinician training alone, training plus parent reminders, or all three including help accessing healthcare. Resear…

This study looks at people who have had unusually severe or long-lasting viral infections, like serious cases of herpes, HPV, or the flu. Researchers want to find out if these people have hidden immune system or genetic problems that make them more vulnerable. Up to 600 participa…

This study aims to learn more about oropharyngeal carcinoma, a type of throat cancer that can be linked to HPV. Researchers will collect blood samples from 1,000 patients before treatment and at six follow-up visits, and also gather tumor tissue when available. The goal is to bet…

This study is testing a mobile app called mSaada that helps community health workers educate women, track screening, and send reminders for cervical cancer screening. The trial involves 6,000 women and health workers across 12 health facilities in western Kenya. The goal is to se…

This study tests whether short educational videos can help young adults who survived childhood cancer learn about and get the HPV vaccine. The researchers will enroll 55 survivors aged 18-26 who haven't finished the vaccine series. Participants will watch the videos on Facebook a…

This study looks at how people with endometrial cancer find medical information and how satisfied they are with it. Researchers will also ask patients if they'd be interested in using an AI-powered educational tool. The goal is to understand current needs and see if AI could help…

This study looks at whether digital tools like chatbots, games, and videos can help parents in Nigeria decide to vaccinate their daughters against HPV, a virus that can cause cervical cancer. About 3,340 parents of unvaccinated girls aged 9-14 will be randomly assigned to try one…

This study is for people aged 3 and older who have severe, recurring HPV-related warts or lesions that don't respond to standard treatments. Researchers want to learn why some people get sicker from HPV than others by studying their genes and immune systems. Participants will pro…

This study looks at anal cancer risk in men who have sex with men (MSM) who take PrEP to prevent HIV. Researchers want to find out how common high-grade anal lesions are, how well anal swabs detect them, and how these lesions affect quality of life. About 296 participants will an…

This study looks at how different menstrual products—tampons, cups, and pads—affect the bacteria and immune cells in the vagina. Researchers will collect samples from 300 women aged 18-49 to compare these groups. The goal is to understand if internal products like tampons and cup…

This study tests whether a structured, stage-based educational program can improve HPV knowledge, health beliefs, and vaccination intentions among first-year nursing students. 88 participants will be randomly assigned to receive the program or no education. The goal is to see if …

This study looks at whether testing for HPV DNA from a cervical swab or a blood sample can help find cervical cancer that has come back after radiotherapy. Researchers will follow 120 patients for two years after treatment, collecting samples at regular visits. The goal is to see…

This study looks at whether it's practical to surgically remove a type of eye surface tumor (OSSN) in people living with HIV in Sub-Saharan Africa. About 84 participants will have the tumor cut out and be followed for a year to see if the procedure is safe and if patients return …

This study is testing a blood test that looks for tiny pieces of cancer DNA in the bloodstream of people with throat cancer. The goal is to see if this test can track how well treatment is working and spot if the cancer comes back earlier than current methods. Researchers will co…

This study follows 300 women aged 18–40 with severe cervical precancer (CIN 2 or 3) to see how often these lesions regress on their own or after surgery. Researchers will track HPV and Pap test results to identify factors that predict healing. The goal is to create a model that h…

This study aims to find out how many healthy adults over 40 carry high-risk HPV in their mouth, which can lead to oropharyngeal cancer. Researchers will test 20,000 volunteers in the Czech Republic to develop a better screening method. The goal is to identify people at risk earli…

This study is testing two blood tests that look for HPV DNA and RNA to see if they can track how well cervical cancer responds to surgery, radiation, and chemotherapy. Researchers will enroll 55 adults with HPV-related cervical cancer and compare the test results with standard im…

This study is testing whether liquid biopsies (blood tests that look for bits of HPV and tumor DNA) can help doctors monitor treatment and spot early signs of cancer returning in people with HPV-related cervical and oropharyngeal cancers. Researchers will follow 480 participants …

This study will test 10,000 people in Cambodia for 57 different infectious diseases, including dengue, flu, and malaria. Researchers want to understand how these diseases spread and who is at risk. The goal is to give local health authorities the information they need to create b…

This study explores whether a simple at-home HPV test can help women in war-torn Ukraine get screened for cervical cancer. About 1,000 women aged 30-60 who haven't had a recent negative HPV test will receive a self-sampling kit. The goal is to see if this approach is practical an…

This study looks at 400 women living with HIV to understand how the bacteria in their gut and vagina might influence HPV infection and cervical changes. Researchers will collect samples to see if an imbalance in vaginal bacteria makes these women more likely to get HPV and develo…

This study looks at whether people living with HIV can collect their own anal swab to test for HPV (a virus that can cause anal cancer) as accurately as a doctor can. About 400 adults aged 30 and older in Reunion Island will try both methods and share which they prefer. The goal …

This study examines whether an HPV education program called e-Bug, used in one middle school in France, is linked to higher parental consent and vaccination rates. Researchers compared anonymized vaccination data from that school with regional averages. No students were directly …

This study follows up with 100 men who took part in the ANRS IPERGAY HIV prevention trial to see how many have developed high-grade anal lesions or anal cancer a decade later. Researchers will use a special test to look for HPV mutations and viral DNA integration in the body. The…

This study looks at whether a single dose of the 9vHPV vaccine, given to 9-11 year olds in 2019-2020, still provides protection six years later. About 300 teens (150 girls and 150 boys) will give a small blood sample to measure HPV antibodies. The goal is to understand how long o…

This study aims to find out how often men with inflammatory bowel disease (IBD) have HPV infection in their mouth and anal area. Researchers will collect swab samples from 384 men with Crohn's disease or ulcerative colitis and test for HPV and abnormal cell changes. The goal is t…