Dental caries

This study investigates how bacteria that cause tooth decay and gum disease spread among family members. Researchers will treat either the child alone, the child and parents, or all family members with professional dental cleaning. They will track bacterial transmission using DNA…

This study tests whether one or two applications of 38% silver fluoride can stop cavities in the baby teeth of children aged 4 to 6 years. Researchers compare a single treatment against two treatments given three months apart, and also measure how the children's oral health affec…

This study compares 3D-printed resin crowns to standard stainless steel crowns for children's back teeth that have had pulp treatment. Twenty-six children aged 4 to 8 will receive one type of crown and be followed for a year. The goal is to see if the 3D-printed crowns lead to he…

This study compares two types of computer-designed and milled inlays—hard hybrid ceramic and resin composite—for repairing large cavities in vital back teeth. Fifty healthy adults aged 16 to 50 with a single molar needing a large filling will receive one of the two inlays. Resear…

This study compares two treatments for severely damaged lower molars: a tooth-saving surgery called hemisection (removing the damaged root) versus replacing the whole tooth with a dental implant. Researchers will track 28 participants over 12 months to see which option leads to b…

This study tests whether applying a thin, clear surface sealant over tooth-colored fillings helps prevent discoloration and improves how long the filling lasts. Twenty-five adults with cavities in their back teeth will receive either a sealant or standard polishing. Researchers w…

This study looks at three types of dental cement used to attach zirconia crowns to young children's front teeth. About 120 healthy kids aged 2 to 7 with decayed or injured teeth will get crowns and be checked for up to 3 years. The goal is to see which cement holds the crown best…

This study compares two treatments for severely damaged upper molars: root amputation (removing only the damaged root and keeping the rest of the tooth) versus replacing the whole tooth with a dental implant. Researchers will track pain, bone healing, and implant stability over 1…

This study tests if a new bioactive varnish can fix white spot lesions on teeth better than standard fluoride varnish. About 60 people aged 16-35 with at least four white spots will get one of the two varnishes. Researchers will check how well the spots heal and if tooth color im…

This study tests whether a robot can place dental implants more accurately than a computer-guided navigation system in the front upper jaw. Twenty-four adults needing an implant will be randomly assigned to one of the two methods. The main goal is to see which approach achieves b…

This study compares two types of dental fillings for cavities in the back teeth. Researchers will test a bulk-fill flowable resin against a submicron hybrid resin in 25 patients over 18 months. The goal is to see which filling performs better in terms of shape, comfort, and appea…

This study compares two dental filling materials for cavities that form near the gum line (cervical lesions). One is a self-hardening composite, the other a flowable composite. Fifty adults will receive one of the two fillings and be checked over 18 months to see which stays in p…

This study tests a new type of tooth filling that sticks to the tooth without needing a separate bonding step. Researchers will compare it to the standard filling method in 75 adults with small to moderate cavities near the gum line. The fillings will be checked over 18 months fo…

This study compares three types of dental fillings—bioactive, nanohybrid, and bulk-fill—for treating cavities between teeth. Sixty adults with at least three cavities will receive each type of filling and be monitored for up to four years. The goal is to see which material holds …

This study will test a new injectable tooth filling material against a standard one for fixing cavities between baby molars in children aged 3 to 8. Fifty kids will get one of the two fillings, and dentists will check how well they hold up over a year. The goal is to see which fi…

This study will compare two treatments for cavities in children's back baby teeth. One uses a new injectable bioactive filling material, and the other uses the Hall Technique (placing a metal crown without drilling). About 50 children aged 3-8 with moderate cavities will be follo…

This study tests whether using plaque-disclosing dyes (like erythrosine) with a special light can kill more cavity-causing bacteria in children aged 3 to 7 years. Seventy-two kids at high risk for cavities will get either standard dental cleaning or cleaning plus the dye-and-ligh…

This study compares two types of tooth-colored fillings—injectable and packable—for cavities in children's back baby teeth. Researchers will check how well each filling holds up over time using dental exams and X-rays. The goal is to see if the injectable type, which may be easie…

This study will compare Bioflx crowns (a newer, tooth-colored material) with standard stainless steel crowns for children aged 6 to 9 who have had pulp treatment on their back baby teeth. The goal is to see how each crown affects bite force and the space between teeth, and how sa…

This study will test four different dental filling materials in 92 children aged 4-8 who have cavities in their baby molars. The fillings include newer materials like Cention N and Stela, as well as standard options like Beautifil II and resin-modified glass ionomer. Researchers …

This study tests a new material made from treated dentin and calcium silicate for treating deep cavities that have reached the tooth's nerve. The goal is to see if it can keep the nerve healthy better than the current standard material. Fifty-six people aged 14 to 35 with deep ca…

This study will test whether 3D-printed fillings work as well as standard bulk-filled resin ones for large cavities in back teeth. About 50 adults aged 22 to 45 with deep decay in a molar will receive one of the two filling types. Researchers will check the fillings' strength, fi…

This study tests different sequences of minimally invasive dental treatments—like silver diamine fluoride, sealants, and fluoride varnish—plus a hygiene program, to see which works best for children aged 5 to 13 in schools. The goal is to reduce the number of kids who don't respo…

This study tests a new material called NeoPutty MTA against a standard chemical, formocresol, for treating deep cavities in children's back baby teeth. About 68 kids aged 4 to 9 will get one of the two treatments to save the tooth and prevent pain or infection. Researchers will c…

This study looks at how well a new type of dental filling (bioactive restorative system) works in people with controlled diabetes compared to those without diabetes. Fifty adults needing a filling in a back tooth will be followed for 18 months. Researchers will check for discolor…

This study tests two cavity-stopping liquids in 60 children aged 3-5 with active tooth decay. One is a well-known treatment that turns cavities black; the other is a newer version that may avoid staining. Researchers will check which works better over 12 months, and ask parents a…

This study compares toothpaste tablets to a standard toothpaste (Colgate Cavity Protection) for cleaning teeth and gums. Fifty adults will use one of the two products for six weeks. Researchers will measure plaque, gum inflammation, and cavities before and after the trial to see …

This study tests whether a mouthwash made from moringa leaves can reduce dental plaque, bacteria, and early cavities as well as the standard chlorhexidine rinse. Researchers will enroll 90 adults with mild gum inflammation and moderate-to-high cavity risk. Participants will use e…

This study tests whether silver diamine fluoride or silver fluoride, sometimes with a special LED light, can stop early cavities in the back teeth of young adults. About 366 high-risk dental students will receive one of these treatments. The goal is to see which approach works be…

This study compares two types of dental glue used to attach braces to teeth. One is a traditional three-step system, the other a simpler two-step system. The goal is to see which causes less damage (white spots) to tooth enamel. Thirty-four teenagers will have each type of glue u…

This study tests whether a new bioactive filling material helps teeth repair themselves after deep cavities are removed. 66 adults with deep decay will get either the bioactive filling or a standard one. Researchers will check for new tooth layer formation and pain over 2 years.

This study compares the natural chewing stick Miswak to standard fluoride toothpaste for managing tooth sensitivity and preventing cavities in children aged 6-12 with a condition called Molar-Incisor Hypomineralization (MIH). MIH causes weak, discolored enamel that is prone to pa…

This study compares a new, easier-to-use tooth-colored filling material to a standard one for cavities between back teeth. Fifty adults aged 18-64 with cavities will receive one of the two fillings and be checked after 12 months for how well they hold up, look, and feel. The goal…

This study looks at whether applying cold (cryotherapy) during a pulpotomy—a procedure that removes infected nerve tissue from a tooth—improves the chance of saving the tooth. Researchers will compare treatment success in 140 healthy adults with deep cavities. Success means no pa…

This study compares two dental treatments for teeth with deep cavities and reversible pulpitis (early nerve inflammation). One treatment caps the exposed nerve directly, while the other removes a small part of the nerve before capping. The study will include 138 people aged 15-40…

This study will test whether a liquid called silver diamine fluoride works as well as gentle fillings (atraumatic restorative treatment) for stopping cavities in children aged 2 to 5. About 156 kids from kindergartens will get one of the two treatments, and researchers will check…

This study compares two dental procedures for treating deep cavities in baby molars of children aged 6-8. One group gets a partial nerve treatment (pulpotomy) using a special cement, while the other gets a full root canal (pulpectomy) with a medicated paste. Researchers will trac…

This study will compare two dental filling materials—alkasite-based resin and nanohybrid composite resin—for treating cavities in the chewing surfaces of children's baby molars. About 50 children aged 4-6 will receive one of the two fillings and be checked at 3, 6, and 12 months …

This study tests a new root canal filling made from zinc oxide and ozonated olive oil against a standard material called Metapex in children aged 3-5 with cavities in their front teeth. Over 12 months, researchers will check for pain, swelling, and healing on X-rays. The goal is …

This study will test a gentler way to fix cavities in children's permanent molars using the Hall Technique, which places a stainless steel crown without drilling or numbing shots. Ten children will get either the Hall Technique or the standard method (with drilling and anesthesia…

This study looks at how different 3D-printed materials affect gum health and restoration success in teeth with deep cavities that need margin elevation. Researchers will treat 48 patients and check their teeth at 6 and 12 months using dental and gum health scores. The goal is to …

This study compares two cavity removal methods in 144 adults with deep cavities and reversible pulpitis (tooth nerve inflammation that can heal). One method removes all decay, the other leaves some near the nerve. Researchers will check pain, tooth vitality, and X-rays over 12 mo…

This study tests how mouth rinses made with monk fruit or Splenda affect saliva acidity and levels of cavity-causing bacteria. 90 healthy young adults (ages 20-24) with no active cavities will rinse with one of the sweetener solutions. Saliva samples will be checked before rinsin…

This study tests whether a special silver liquid (silver diamine fluoride) can stop tooth decay in elderly people living in nursing homes. Sixty participants will either get the silver treatment or a placebo, and their teeth will be checked after 6 and 12 months. The goal is to i…

This study tests whether different fluoride treatments—like varnishes, solutions, and mousse—can stop root cavities from getting worse in adults over 44. About 136 participants in Switzerland will use these products at home or get them applied by a dentist twice a year. The goal …

This study compares a new material made from eggshells (calcium hydroxyapatite) to a standard one (calcium hydroxide) for protecting the nerve in deep cavities. Fifty-four adults with reversible pulpitis will receive one of the two materials after cavity cleaning. Researchers wil…

This study will test two types of dental cement—bioactive and resin—to see which one works better for putting zirconia crowns on children's front teeth. Sixty kids with cavities in at least two baby teeth will get crowns, and researchers will check how well the crowns stay on, if…

This study compares artificial intelligence analysis of dental photographs to standard clinical exams for detecting white spot lesions—early signs of tooth decay. Researchers will train AI models (YOLO and Mask-RCNN) on 329 labeled images from adult patients at Cairo University D…

This study will check if smartphone photos, 3D dental scans, and a special fluorescent light can accurately detect early cavities in people who have finished braces. Thirty participants aged 11 to 46 with early white spots on their teeth will be followed for three months. Researc…

This study tests a handheld scanner that uses safe near-infrared light to find early cavities without radiation. Fifty adults scheduled for a tooth extraction will get an extra 5-minute scan before their procedure. The scanner's results will be compared to standard X-rays and vis…

This study tests if using a diode laser before applying a tooth-colored sealant helps it stick longer and prevent cavities better. About 111 young adults aged 17-22 will get sealants on their back teeth, with or without laser pre-treatment. Researchers will check sealant retentio…

This study tests whether motivational interviewing — a supportive, patient-centered conversation style — can help mothers adopt better oral care habits for their infants, preventing early childhood caries. Researchers will enroll 228 mother-infant pairs in Malaysia, with half rec…

This study tests whether a new medicine called Fexuprazan (Fexuclue) can prevent stomach ulcers caused by NSAID painkillers like ibuprofen. About 360 adults with joint or muscle pain who need daily NSAIDs will take either Fexuprazan or an older drug (Lansoprazole) for 24 weeks. T…

This study will test a new self-sticking dental material against a standard sealant to see which better prevents cavities in children's permanent molars. About 88 healthy kids aged 6-8 with high cavity risk will take part. The goal is to find out which material stays on teeth lon…

This study compares two ways to remove cavities in children's baby molars: a special gel that softens decay, versus scraping by hand. The goal is to see which method causes less pain and is more acceptable to kids. Twenty-eight healthy children aged 5 to 9 will take part, and the…

This study tests a gel called Cariclast that softens tooth decay, allowing dentists to remove cavities without a drill. It will involve 24 children aged 4-7 with cavities in their back baby teeth. The goal is to see if this method causes less pain and is more accepted by kids tha…

This study compares different numbing methods to reduce pain during dental cavity treatment. About 204 adults with tooth decay will receive either a light-based device, a numbing gel, or a placebo before local anesthesia. Researchers will measure pain during and after the procedu…

This early-phase trial will test four orthobiologic treatments—PRP, bone marrow concentrate, hyaluronic acid, and nanofat—in 300 adults with various muscle, joint, tendon, or bone conditions. The goal is to see if these natural substances can reduce pain and improve joint functio…

This study looks at whether a mobile app can help people with common pains (neck, shoulder, back, or knee) do their prescribed home exercises more regularly. About 30 adults will be split into two groups: one using the app and one doing traditional exercises. The goal is to see i…

This study tests a new gel that dissolves tooth decay without drilling, aiming to reduce patient anxiety. Eighty adults with cavities in lower molars will be randomly assigned to either the gel or a standard drill. The main goal is to see which method causes less pain and discomf…

This study compares two methods for fixing cavities in children's back teeth: the Hall Technique (a less invasive approach) and traditional stainless-steel crowns. Researchers will measure bite force, jaw changes, and child comfort in 22 kids aged 6-9. The goal is to see if the g…

This study compares a single-shade flowable composite resin to a multi-shade composite for filling cavities in back teeth. Thirty adults with at least four cavities will receive both types of fillings and be followed for five years. Researchers will check how well the fillings ma…

This study will compare two treatments—low-level laser therapy and hyaluronic acid gel—to see which helps children's gums heal better after removing a badly decayed first permanent molar. Thirty-six children aged 6 to 10 will receive one of the treatments right after extraction. …

This study tests whether applying Gluma desensitizer before a filling can reduce tooth sensitivity afterward. Sixty adults with cavities in their back teeth will be randomly assigned to get either the desensitizer plus a standard filling or just the standard filling. Their pain r…

This study compares a computer-controlled injection device (Starpen) to a standard syringe for numbing and extracting upper baby molars in 38 children aged 6-8. The goal is to see if the new device causes less pain during the injection. Children will rate their pain using a faces…

This study looks at how well 3D-printed resin fillings hold up in back teeth with large cavities. Researchers will compare two different ways of shaping the tooth before placing the filling. Fifty adults will be followed for 18 months to see which design leads to fewer cracks or …

This study tests whether artificial intelligence (AI) can improve how dental students and experienced dentists detect cavities on X-rays. About 60 participants will view dental X-rays, some enhanced by AI and some not, and answer questions about what they see. The goal is to see …

This study tests how well three different toothpastes repair early tooth damage (enamel lesions) in 30 healthy adults aged 18-70. Participants wear a removable mouth device with human enamel pieces for 14 days per toothpaste, with breaks in between. Researchers measure mineral ga…

This study aims to translate and adapt a widely used questionnaire for musculoskeletal problems into Urdu. Researchers will enroll 110 Urdu-speaking adults, including patients with muscle or joint issues and healthy volunteers. The goal is to create a validated tool to measure sy…

This study looks at how patients feel when reading their own medical notes. Some will read the original doctor's note, others will read a simpler version written by artificial intelligence. Researchers want to see if the AI summary changes how much patients trust their doctor or …

This study asks 200 practicing midwives in Germany about their role in oral health for pregnant women and young children. Through an anonymous online survey, researchers will learn how confident midwives feel giving dental advice, what barriers they face, and what training they n…

This study follows 400 obese adults in Norway to see how weight loss from lifestyle changes, medication, or surgery affects their oral health. Researchers will measure gum disease, cavities, and tooth erosion before and after weight loss. The goal is to understand the link betwee…

This study looks at how stainless steel crowns placed on weak permanent molars (due to a condition called MIH) affect a child's bite and jaw function. Forty-six children will have their teeth scanned before, right after, and up to 3 months after crown placement. The goal is to un…

This study will test five different types of tooth-colored fillings (bulk-fill composites) in 70 adults who need a cavity filled. The fillings use different technologies, like heating or sound waves, to see which one works best. Dentists will check the fillings right after placem…

This study looks at the teeth, mouth, and face health of 25 people with Mowat-Wilson syndrome, a rare genetic condition. Researchers will check for cavities, gum disease, and facial features, and ask about quality of life. No treatment is given—the goal is to gather information t…

This observational study looks at whether eating lots of ultra-processed foods (like chips, soda, and packaged snacks) is linked to cavities and gum disease. Researchers will track the diets and oral health of 200 adults aged 18 to 65. No treatments or changes are given—just care…

This study looks at how two types of dental cement used to attach stainless steel crowns affect gum health in 45 children aged 6-10. Researchers measured gum inflammation and certain immune markers before and one week after placing the crowns. The goal is to see if one cement cau…

This study looks at 1,200 preschool children to understand why some get severe tooth decay. Instead of just looking at teeth, researchers will also study family stress, parenting burnout, children's sleep, and diet. The goal is to create a tool that predicts which kids are most a…

This study looks at how well a special type of dental filling called Giomer works in people with and without diabetes. Researchers will place fillings in cavities on the tooth neck and check them over 18 months to see if they stay in place and prevent new decay. The goal is to un…

This study uses interviews with parents of young children who have severe early childhood cavities treated under general anesthesia. The goal is to understand the real-life obstacles that make it hard for families to change sugary eating habits and prevent cavities from returning…

This study looks at whether sending short dental health videos through WhatsApp can improve how much 10-12 year old children in Cairo know about taking care of their teeth, and whether it changes their brushing and eating habits. About 150 children will take part, with one group …

This study tests a decision support system called SmaRTWork to help people on sick leave due to muscle or back pain return to work. About 298 adults in Norway will either use the system or receive usual care. The main goal is to see if the tool helps them return to work sustainab…

This study looks at 58 children with deep cavities in their baby molars. Dentists will perform a pulpotomy (removing the infected nerve and sealing the tooth) and measure levels of cytokines—substances that signal inflammation—in the pulp. The goal is to see if these levels can p…