Tooth hard tissue disease

This study tests whether curing (hardening) the bonding agent before placing dental sealants helps them stay on children's molars longer. Sealants are a standard way to prevent cavities, but they can wear off over time. Researchers will compare sealants placed with cured bond ver…

This trial compares two treatments for white spot lesions—early cavities that appear as milky-white marks on front teeth after braces. One treatment uses a special paste (MI Paste Plus) combined with etching, while the other uses a resin infiltration technique (Icon). The study i…

This study tests whether ozone therapy, followed by a remineralizing gel, can reverse the earliest stage of cavities in children aged 6-14. Half of the 80 participants will get ozone plus gel, the other half just gel. Researchers will check the teeth over 8 weeks using special li…

This study compares a new flexible white dental crown (BioFLX) to the standard stainless steel crown for treating cavities in baby molars. Researchers want to see if the white crown works just as well as the metal one in terms of gum health, plaque buildup, wear, and staying in p…

This study tests whether a self-assembling peptide called P11-4 can help remineralize white spot lesions—early signs of tooth decay—on smooth tooth surfaces. Seventy-five participants aged 10 to 17 will be split into three groups: one gets a single peptide application, another ge…

This study compares two methods for treating cavities in children's back molars: the Hall Technique, which places a crown over the tooth without drilling or numbing, and the conventional method, which requires drilling and anesthesia. Researchers will track 200 children aged 5-8 …

This study looks at whether the position of a deep cavity (on the chewing surface or between teeth) affects how well a tooth-saving procedure called direct pulp capping works. Researchers will treat 154 people aged 15-40 with reversible pulpitis, a condition where tooth pain goes…

This study looks at two types of tooth-colored filling materials (ormocer and methacrylate-based bulk-fill) and different polishing methods for cavities near the gum line (class V). About 25 adults with these cavities will receive fillings and be followed for 2 years to see which…

This study tests a new cleaning method (air-polishing with erythritol) against standard cleaning (ultrasound) to prevent white spots on teeth and gum inflammation in 60 teens aged 12-16 who are getting braces. Participants will be followed for 2 years to see which method works be…

This study tests a new type of dental filling called a bioactive bulk-fill composite for treating cavities in back teeth. Researchers will compare it to a standard filling in 34 adults, each receiving both types in similar cavities. The goal is to see if the new material improves…

This study compares two materials used to repair large cavities in back teeth: a hybrid resin composite and a hybrid ceramic onlay. Sixty-four adults with decayed molars will receive one of the two onlays and be followed for 18 months. Researchers will check how well each restora…

This study compares two types of dental crowns: one made with a 3D printer and one made with a standard CAD-CAM machine. Twelve people with two damaged teeth will get one of each crown to see which performs better in terms of look, function, and gum health over two years. The goa…

This study tests two methods for cleaning deep cavities in permanent teeth: removing all decayed tissue (total removal) or leaving a thin layer near the nerve (selective removal). Researchers want to see which approach better keeps the tooth alive and causes less pain after treat…

This study tests whether a daily cream called MI Paste Plus can reduce cavity-causing bacteria and prevent white spots on teeth in people with braces. Two hundred participants will apply the cream nightly for three months. Researchers will measure bacteria levels and check for ne…

This study compares two methods of hardening a tooth-colored filling material in children's baby molars. One method uses a fast 5-second light, the other a standard longer light. Researchers want to see if the fast method works just as well and is as safe over 12 months. About 70…

This study compares three materials used to treat deep cavities in permanent teeth: Egyptian MTA, Biodentine, and calcium hydroxide. About 35 adults aged 22-45 with deep decay will receive one of these materials under a filling. Researchers will check if the tooth stays healthy a…

This study tests a new type of dental filling that hardens on its own, compared to a standard filling that requires a special light. The goal is to see if the new filling is easier to place and works just as well for cavities between back teeth. About 50 adults aged 18-47 with ne…

This early study compares a mouthwash containing tropolone to the standard chlorhexidine 0.2% mouthwash for reducing bacteria that cause cavities. Thirty healthy adults aged 18–45 will stop their usual oral hygiene for a few days, then use one of the mouthwashes. Researchers will…

This study tests whether a new material called PILP is safe to use when treating cavities in adults. Thirty participants will have PILP or a placebo applied to their tooth before getting a filling. They will be monitored for six months to check for tooth health, pain, and gum inf…

This study tests two kinds of toothpaste that contain hydroxyapatite, a mineral that helps rebuild tooth enamel. Forty children and teens with early signs of enamel damage will brush with one of the pastes twice a day for six months. Researchers will measure if the enamel gets st…

This study tests a surgical technique called free mucogingival graft (FMG) to cover exposed tooth roots and improve gum conditions in the lower front teeth. Researchers will enroll 24 healthy adults with gum recession and unfavorable gum tissue. The goal is to see if this approac…

This study looks at two new ways to treat deep cavities in children's second molars. It compares a bioceramic putty to a standard material for the nerve treatment (pulpotomy), and 3D-printed resin crowns to standard metal crowns. Sixty children aged 5 to 7 will be followed for a …

This study compares two ways of applying dental glue for filling cavities in front teeth. 120 healthy adults will receive fillings and be checked over 18 months. The goal is to see which method keeps fillings in good shape.

This study tests a special dressing made from chitosan (a substance from shrimp shells) for treating damaged immature permanent teeth. The goal is to preserve the tooth's nerve and allow the root to finish growing. 26 children and teens with tooth decay or injury will be randomly…

This study compares eggshell powder to Biodentine for treating tooth pulp exposure in children's baby molars. Thirty kids with deep cavities but no infection will get a pulpotomy, where the damaged pulp is removed and the material is placed. Researchers will check for pain, swell…

This study compares two ways to treat deep cavities in young permanent teeth without exposing the nerve. In selective excavation, the dentist removes only the outer decay and seals the tooth. In stepwise excavation, they place a temporary filling first and remove more decay a few…

This early study tests a new type of dental implant that uses the leftover ligament tissue from a pulled tooth to help the implant bond with the jawbone. Six adults needing a single tooth extraction will get the implant right away and be followed for 48 weeks. Researchers will ch…

This study compares two dental treatments—pulpotomy and pulpectomy—for deep cavities in baby teeth that cause pain. About 40 children aged 4 to 6 will receive one of the treatments. Researchers will check x-rays and symptoms to see which approach works better and is more comforta…

This study compares two dental materials, MTA and Biodentine, used to treat deep cavities in baby teeth. Researchers want to see which one works better and causes less tooth discoloration. The study involves 646 children aged 2 to 12 who need treatment on at least two baby molars…

This study compares two treatments for extremely deep cavities that reach the tooth's nerve: a full pulpotomy (removing only the top part of the nerve) versus a standard root canal. About 93 people aged 12 and older with a deep cavity in a permanent tooth will be randomly assigne…

This study tests whether a silver liquid (silver diamine fluoride) is better than standard fluoride varnish at reducing cavity-causing bacteria in children aged 3 to 8. Each child will get both treatments on different sides of their mouth. The goal is to see which one works bette…

This study follows 480 older adults (average age 74) from low-income housing to see which treatment better stops tooth decay over 3 to 6 years. One group gets a simple painted-on silver solution (SDF) twice a year; the other gets a standard filling plus fluoride varnish. Research…

This study compares three different tooth-colored onlay materials used to repair back teeth with deep cavities that extend below the gum line. Each of the 18 adult participants will receive three onlays made from different materials. Researchers will check the onlays at 2 weeks, …

This study tests whether computer analysis of 3D dental scans can accurately detect gum disease, gingivitis, and cavities, compared to traditional manual exams. About 30 adults with at least one gum recession will participate. If successful, this approach could make dental diagno…

This study is testing how well different digital tools—like special cameras, X-rays, and AI analysis—can find cavities compared to a standard dental exam. About 100 adults with cavities will be checked using these methods. The goal is to see which tools are most accurate so denti…

This study is testing whether a special intraoral scanner can accurately detect dental plaque and cavities, compared to standard methods like dye and X-rays. Researchers will scan the teeth of 50 adults aged 18 to 70 and compare the results to traditional plaque-disclosing agents…

This study looks at 212 children aged 4-9 with cavities in their baby teeth. After a simple filling procedure, dentists will use three different methods to check for any leftover decay: a special light (FACE), a dye, and a visual-tactile exam. The goal is to see which method is m…

This study looks at whether digital tools like intraoral scanners and cone-beam CT can help dentists spot cavities, plaque, and gum disease more accurately than a standard exam. About 350 adults will get both a regular check-up and digital imaging, and researchers will compare th…

This study looks at two methods for finding cavities between baby molars in children aged 4 to 10: standard X-rays and a newer light-based technique. Researchers want to see which method is more accurate and which children prefer. About 174 children will participate, and their co…

This study will give thousands of elementary school students refillable water bottles and install hydration stations in their schools, along with lessons about healthy hydration. Researchers will track whether this simple change reduces tooth decay and helps maintain healthy body…

This study tests whether a probiotic spray containing good bacteria can help prevent and treat cavities in children. 130 kids aged 7-10 will use the spray or a placebo twice daily for 3 months. Researchers will check if it reduces harmful mouth bacteria and slows cavity growth.

This study will place dental sealants on 420 back teeth in children and teens aged 7 to 18. Half of the teeth are healthy, and half have very early cavities. Researchers will check how well the sealants stay on over 12 months to see if early decay affects retention. The goal is t…

This study will test whether applying fluoride varnish and placing special sealants can prevent and control cavities in 2,500 children aged 6 to 12. The treatments are minimally invasive and designed for use in public health settings. Children will be checked every three months f…

This study tests whether providing health education and helping mothers form supportive social networks can prevent dental cavities and unhealthy weight gain in their young children. About 460 Bangladeshi mothers and their children (ages 1-4) will take part. One group gets educat…

This study compares a toothpaste made with 2% calcium hypophosphite to a standard fluoride toothpaste (1450 ppm F) to see if it can prevent cavities in adults. Over 18 months, 164 healthy adults will brush twice daily with one of the two toothpastes. The goal is to prove the new …

This study tests whether a special iodine gel applied to teeth can prevent new cavities in children aged 2 to 6 who have severe early childhood cavities. After dental surgery, children will receive either the iodine gel plus fluoride varnish or a placebo plus fluoride varnish eve…

This study looks at whether a toothpaste or mouthwash containing hydroxyapatite can prevent white spot lesions (early cavities) that often appear during orthodontic treatment with braces. 75 people getting braces will be split into three groups: one using hydroxyapatite toothpast…

This study tests three cavity-prevention methods in 204 Mexican schoolchildren aged 6-8. One group gets fluoride varnish alone, another gets a glass ionomer sealant plus fluoride varnish, and the third gets a Giomer® sealant. All children also receive dental health education. Res…

This study looks at how well temporary crowns and bridges made from special plastic materials work and if they are safe. About 120 adults who need a temporary tooth replacement will be split into four groups based on the material used. They will be checked over 6 months to see ho…

This study tests two different fluoride varnishes to see which one better reduces tooth sensitivity in young adults. Participants receive a single application of either varnish, and researchers measure pain relief and quality of life improvements. The goal is to find a more effec…

This study looks at whether doing breathing exercises before orthopedic surgery (like knee, hip, or fracture repair) can help your lungs work better after the operation. It involves 36 adults who have used tobacco and are at risk for breathing problems after surgery. Participants…

This study looks at whether putting thin covers (veneers) on the front teeth can improve the daily life of children aged 11-14 who have a rare genetic condition that makes tooth enamel weak and discolored. Researchers will measure changes in oral health, self-esteem, and social c…

This study tests if making small holes in the jawbone (micro-osteoperforations) helps move front teeth more safely and effectively in people with a deep bite. 18 participants aged 15-25 will receive standard braces with or without the extra procedure. The goal is to see if it red…

This study tests whether a special toothpaste and mousse can reduce tooth sensitivity and enamel damage in adults with celiac disease. Forty participants will either use the toothpaste alone or add a nightly mousse for six months. Researchers will measure changes in sensitivity, …

This study compares two numbing techniques for dental work in children aged 6 to 12: a computer-controlled injection into the jawbone (digital intraosseous) and a manual injection into the ligament around the tooth. Researchers will measure pain, heart rate, and how well the numb…

This study tests whether 3D-printed custom nightguards whiten teeth better and more comfortably than traditional ones. Forty adults with stained teeth will use a standard whitening gel at home. Researchers will measure color change, tooth sensitivity, and gum irritation to find t…

This study looks at whether a toothpaste with a special ingredient (calcium sodium phosphosilicate) can improve daily life for people with sensitive teeth. About 500 adults aged 18 to 65 with self-reported tooth sensitivity will use the toothpaste for 24 weeks. Researchers will m…

This study tests whether a program of exercise and ergonomics training can reduce muscle and joint pain in teachers. About 80 teachers who have had pain for at least three months will be randomly assigned to receive the training or not. Researchers will measure changes in pain, d…

This study tests a web-based app called IAMABLE that provides evidence-based rehabilitation strategies for people with chronic conditions like heart disease, arthritis, or neurological disorders. Fifty adults aged 45 to 75 will use the app for 4 months to set goals and learn abou…

This study looks at whether different types of tooth-colored filling materials can reduce pain or sensitivity after a cavity is filled. Researchers will compare two modern composite materials in 120 healthy adults who need a filling in a back tooth. Participants will be followed …

This study compares AI-generated, child-friendly explanations and stories to traditional behavior management techniques for reducing anxiety in children aged 6-12 during dental local anesthesia. Researchers will measure pulse, oxygen levels, and anxiety scores in 60 healthy child…

This study will compare two types of crowns—stainless steel and zirconia—placed on children's back baby teeth after pulp treatment. Ten healthy children aged 4 to 5 will receive both types of crowns, and researchers will check gum health, plaque buildup, tooth wear, and how satis…

This study tests a new adhesive for braces that doesn't require acid etching, which can weaken enamel and cause white spots. Twenty people getting braces will have one side of their mouth bonded with the new glue and the other side with the standard method. Researchers will track…

This study tests whether extra support for case managers helps veterans leaving the military better manage pain and reduce risky substance use. About 1800 veterans will take part. The program focuses on non-drug pain treatments and counseling.

This study looks at whether using a tooth-whitening gel in one long session or several short sessions changes how much tooth pain people feel and how white their teeth get. About 60 adults with darker teeth will receive one of two common whitening gels. Researchers will measure p…

This study tests two treatments for white spot lesions—early signs of decay that often appear after braces. One is a peptide gel that helps rebuild enamel, and the other is a calcium paste that remineralizes teeth. Eighteen people aged 15 to 25 will get both treatments on differe…

This study aims to learn more about rare skeletal disorders by collecting medical records, blood samples, and genetic data from 100 participants. People with known or suspected bone conditions, as well as their healthy family members, can join either remotely or in person. The go…

This study looks at whether a common yeast infection in babies' mouths, called oral thrush, is linked to severe cavities in early childhood. Researchers will follow 70 children, half with a history of thrush and half without, for two years. They will regularly check teeth and tak…

This study looks at tooth decay and oral hygiene in children aged 7-12 with specific learning disabilities (SLD) and compares them to healthy children. Researchers will check teeth and gums, and ask about brushing and eating habits. The goal is to see if children with SLD have di…

This study translates and tests several health questionnaires—covering pain, arm and leg function, mood, and daily activities—for use with Albanian-speaking people. Researchers will check if the translated versions are reliable and accurate by giving them to about 300 participant…

This study tests a new tool called the PRISM Dashboard, which gives physiotherapists feedback on how their decisions compare to their peers. The goal is to see if this feedback helps reduce differences in care for people with muscle and joint pain. About 60 physiotherapists and t…

This study looks at certain substances in the saliva of children aged 6-8 with and without cavities. Researchers will apply a fluoride varnish or a combination of fluoride and chlorhexidine (a germ-killing rinse) to see how these treatments change the saliva markers over one mont…

This study looks at children's baby teeth that were previously treated for cavities with either silver diamine fluoride (SDF) plus a filling or just a filling alone. After the teeth are naturally lost or extracted, researchers will examine them under a microscope to see how the i…

This study looks at how two types of dental crowns—stainless steel and bioflex—affect oral hygiene and bacteria levels in children aged 4 to 8. Each child will get one crown of each type on opposite sides of the mouth. Researchers will measure plaque bacteria and gum health to se…

This study looks at two different orthodontic techniques to bring a displaced upper canine tooth into its correct position. Researchers will use 3D X-rays to measure changes in the bone and tooth roots before and after treatment. The goal is to see which method causes less damage…

This study tests a 6-month program called PROTECT for caregivers of young children who need dental surgery. The program provides parenting tools and support from community health workers to improve tooth brushing and reduce added sugar intake. The goal is to prevent future caviti…

This study looks at tooth wear and tooth sensitivity in 2,500 adults across five U.S. locations. Researchers will use dental scans and questionnaires to find out how common these problems are and what factors—like diet or brushing habits—might cause them. Participants must be 18 …

This study follows 375 adults who recently started experiencing tooth sensitivity and have begun using products to treat it. Over 12 months, researchers will measure changes in oral-health-related quality of life using a questionnaire. The goal is to understand how sensitivity af…

This study looks at how a patient's symptoms before treatment and how deep the cavity is affect the success of partial decay removal in adult teeth. One hundred adults with deep cavities will be treated and followed for 12-24 months. The goal is to see if these factors influence …

This study surveys 100 dental professionals to find the best methods for cleaning teeth after braces are removed, aiming to reduce enamel damage and tooth sensitivity. It compares different tools and techniques used in clinics. The goal is to identify the safest, most effective a…

This study follows 252 adults with muscle, bone, or joint problems (like arthritis, back pain, or after surgery) to see how well they do their prescribed home exercises. Researchers will track who sticks with the program and why, looking at factors like pain, mood, and support. T…

This study looks at adults having dental procedures under general anesthesia to see if undiagnosed sleep apnea raises the risk of breathing problems after surgery. Researchers will use two common screening tools (STOP-BANG and ASA criteria) to identify high-risk patients and refe…

This study tests whether using a virtual reality (VR) headset during shoulder exercises helps patients feel more engaged and motivated. Fifty adults with shoulder problems will do rehab exercises in a VR environment and then answer questionnaires about how easy and immersive the …

This study looks at whether archaea, a type of microbe, are involved in tooth decay. Researchers will collect saliva and cavity tissue samples from 200 adults to check for the presence and amount of archaea. The goal is to better understand what causes cavities and possibly find …

This study looks at whether children with a condition called molar incisor hypomineralization (MIH), which causes weak enamel on molars and front teeth, experience more stress during dental checkups. Researchers will measure stress by testing saliva for cortisol and checking hear…

This study aims to create a secure national database for muscle and joint (musculoskeletal) conditions by collecting routine data from community clinics and GP practices. About 22,000 adults will have their information anonymously gathered to help develop a dashboard that tracks …

This study watches 2000 people having hip or knee replacement surgery to see how long spinal anaesthesia lasts. The goal is to learn how the amount of anaesthetic affects timing, helping doctors decide if patients can safely go home the same day. No new treatments are tested—just…

This study looks at children who had dental treatment under general anesthesia for severe early childhood cavities between 2015 and 2020. Researchers will measure their current risk for new cavities using a special tool that considers diet, oral hygiene, and other factors. The go…

This study tests whether using an intraoral camera to show parents real-time images of their child's teeth and gums leads to better brushing and less plaque than standard verbal instructions. Forty children aged 5-7 and their parents will be split into two groups: one gets camera…

This study looks at how changing the heel cushion on an ankle-foot brace (AFO) affects walking in people who use one daily. Forty adults with leg injuries or nerve problems will try four different heel wedges—tall or short, soft or firm—while walking at controlled speeds. Researc…

This study looks at how 3D computer simulation and printing can help surgeons better plan and perform bone correction surgeries. Researchers will compare the planned corrections to the actual results in 100 children and young adults with rare bone deformities. The goal is to make…

This study follows 4,000 children who receive orthopedic implants (like rods or screws) during standard care for bone fractures, deformities, or hip problems. Researchers will track how long the implants last, any complications, and how well they work over time. The goal is to ga…

This study looks at how placing a special type of crown (Hall crown) on decayed baby molars changes the way children's teeth fit together. Researchers will measure tooth movements and bite contact areas in 60 children over one month using digital scans. The goal is to understand …

This study is building a registry of people with rare bone diseases (skeletal dysplasias) in Italy. Researchers will collect medical history, genetic data, and treatment details over time to better understand how these conditions progress. No experimental treatments are given; th…

This study follows 144 adults with muscle or bone problems who are already scheduled to receive treatment with Chattanooga Intelect devices (like TENS or ultrasound). Researchers will measure pain, muscle strength, and movement range to confirm the devices are safe and work as ex…

This study looks at whether training medical staff and using electronic health records can encourage older adults (55+) on Medicaid to visit the dentist more often. About 929 participants from 12 primary care clinics will be split into two groups: one where doctors get extra trai…

This study looks at a dental procedure called deep margin elevation (DME) for fixing cavities that go below the gum line. Researchers want to see if placing the filling slightly deeper than usual is safe for the gums and tooth nerve. They will treat 81 adults with deep cavities a…

This study tests a dental procedure called Deep Marginal Elevation (DME) in 36 adults with deep cavities. DME uses a special cement to raise the cavity margin, making it easier to clean and restore. Researchers will check gum fluid and X-rays to see if the procedure affects gum i…