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Fluoride-Free toothpaste could be just as good at stopping cavities

NCT ID NCT07068204

Recruiting now Prevention Sponsor: Dr. Joachim Enax Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compares a toothpaste made with 2% calcium hypophosphite to a standard fluoride toothpaste (1450 ppm F) to see if it can prevent cavities in adults. Over 18 months, 164 healthy adults will brush twice daily with one of the two toothpastes. The goal is to prove the new toothpaste is not worse than fluoride at keeping teeth cavity-free.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
2% calcium hypophosphite toothpaste
What this could lead to
If it works, this could offer an alternative cavity-preventing toothpaste for people who cannot or prefer not to use fluoride.
What could go wrong
This is a non-inferiority trial, meaning it only aims to show the new toothpaste is not worse than fluoride—not that it is better. The study is relatively small (164 adults) and results may not apply to everyone, such as those with existing cavities.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dental caries prevention target

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CALCIUM HYPOPHOSPHITE CARIES,DENTAL FLUORIDATION

Contacts and locations

Study contacts

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

  • Contact

    Phone: •••-•••-•••• Email: •••••@•••••

Locations

  • Department of Integrated Dentistry Medical University of Białystok

    NOT_YET_RECRUITING

    Bialystok, Poland, 15-276, Poland

    Contact Phone: •••-•••-•••• Email: •••••@•••••

  • Poznan University of Medical Sciences, Department of Integrated Dentistry

    RECRUITING

    Poznan, Poland, 60-812, Poland

    Contact Phone: •••-•••-•••• Email: •••••@•••••

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