Could a peptide gel make early cavities disappear?
NCT ID NCT07664046
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests whether a self-assembling peptide called P11-4 can help remineralize white spot lesions—early signs of tooth decay—on smooth tooth surfaces. Seventy-five participants aged 10 to 17 will be split into three groups: one gets a single peptide application, another gets two applications three months apart, and a third gets standard fluoride varnish every three months. The main goal is to see if the peptide reduces the size and severity of the lesions over 12 months using a special fluorescence camera.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
self-assembling peptide P11-4
What this could lead to
If it works, this could offer a new, non-invasive way to reverse early tooth decay without drilling or fillings.
What could go wrong
This is a small, early-stage trial with only 75 participants. The peptide may not work better than standard fluoride varnish, and results may not apply to all ages or tooth types.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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University Clinical Center of the Medical University of Warsaw, Department of Pediatric Dentistry
RECRUITINGWarsaw, Masovian Voivodeship, 02-097, Poland
Contact
Contact
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••