PAIN, POSTOPERATIVE

This study tested whether adding acupuncture to standard anti-nausea medication could better prevent nausea and vomiting after gallbladder removal surgery. 270 adults scheduled for laparoscopic cholecystectomy received either standard drugs alone or drugs plus acupuncture at spec…

This study tested whether a dressing soaked with heparin, a common blood thinner, could prevent thick, raised scars and reduce pain at the site where skin is taken for a graft. 400 patients each had two donor sites—one treated with standard care and one with heparin. The results …

This study tested whether a mix of non-opioid pain medicines (multimodal anesthesia) helps patients recover better after major surgery compared to using only opioids. 240 adults having long surgeries took part. The goal was to see if the multimodal approach improves patient satis…

This study tested two different nerve-block methods to manage pain after video-assisted lung surgery (VATS). 176 adults received either a long-acting liposomal bupivacaine intercostal block or a standard bupivacaine paravertebral block. The main goal was to see which method reduc…

This study looked at 159 people who had nose surgery (rhinoplasty) to see if a combination of acetaminophen and ibuprofen controls pain as well as acetaminophen with hydrocodone, a stronger opioid. Participants rated their pain on a scale of 0 to 100 over 5 days. The goal was to …

This study tested whether ketamine or lidocaine works better for pain after gallbladder removal. 76 adults were split into two groups and received one of the drugs during surgery. Pain levels were checked at several times over 24 hours to see which provided better relief.

This study tested whether injecting a numbing medicine (ropivacaine) into the belly and around certain nerves before fibroid removal surgery could lower pain after the operation. 207 women having laparoscopic myomectomy took part. The goal was to see if this approach reduces pain…

This study looked at 670 women who had a hysterectomy to see if spinal morphine works better than IV morphine for pain control. The goal was to reduce pain and the need for opioids after surgery. Researchers measured pain scores and side effects in the first 48 hours.

This study tested different ways to control pain after laparoscopic gallbladder removal in 160 adults. Some patients received a nerve block (TAP block), others got local anesthetic, both, or no extra pain treatment. The TAP block group reported less pain and fewer wound problems …

This study compared two nerve block techniques—paravertebral block and erector spinae plane (ESP) block—for controlling pain after video-assisted thoracic surgery (VATS). 80 adults undergoing VATS were randomly assigned to receive one of the blocks either before or after surgery.…

This study tested two different methods of pain control during back surgery: a nerve block (erector spinae plane block) and a large injection of numbing medicine into the surgical area. 29 adults having 1-2 level lower back fusion surgery took part. The goal was to see which meth…

This study tested two ways to numb the shoulder for pain relief after arthroscopic surgery. The standard method can sometimes weaken the diaphragm, making breathing harder. The new method combines two different nerve blocks to try to avoid that problem. 50 adults having shoulder …

This study looked at finding a safe dose of ketamine given through an IV to help with pain and depression after a cesarean delivery. Twelve women who had a C-section took part. The goal was to find a dose that caused few side effects, like changes in blood pressure or heart rate.…

This study tested whether injecting a long-lasting numbing medicine (liposomal bupivacaine) into the breastbone before making the surgical cut reduces pain and the need for strong painkillers after heart surgery. 70 adults having heart surgery through the breastbone took part. Th…

This study tested whether freezing small nerves between the ribs (cryoablation) can reduce pain and the need for strong painkillers after minimally invasive mitral valve surgery. Thirty adults were randomly assigned to receive either the nerve freezing or standard care. The goal …

This study tested whether giving ketamine and dexamethasone during back surgery helps control pain and reduces the need for morphine afterward. 128 adults having lumbar fusion surgery took part. Researchers measured how much morphine patients used and checked pain levels for thre…

This study tested different anesthesia methods to improve pain control after outpatient surgery while reducing the need for opioid painkillers. Over 900 adults having same-day or short-stay surgery took part. The goal was to lower opioid use, side effects, and the risk of addicti…

This study tested whether a virtual reality program that uses biofeedback (like heart rate monitoring) could help children and teenagers aged 12-18 manage pain after surgery. 93 participants used the program before and after their operation. The goal was to see if the approach wa…

This study tested whether a long-acting numbing medicine (liposomal bupivacaine) can better control pain and reduce the need for opioid painkillers after skin graft surgery. 74 burn patients with small injuries took part. Researchers compared pain scores and opioid use between th…

This study tested whether combining non-opioid pain medicines could reduce pain and the need for opioids after lower back surgery. 75 adults having lumbar disc surgery were given different pain treatments to see which worked best. The goal was to find safer ways to manage pain an…

This study looked at whether injecting numbing medicine around the nerve bundle (instead of directly into it) could lower the chance of severe rebound pain after shoulder surgery. Rebound pain is a short but intense pain that can happen as the numbing medicine wears off. The stud…

This study tested whether adding a long-acting painkiller called Exparel to standard numbing injections can improve pain control and reduce the need for opioid pain pills after foot or ankle surgery. 248 adults having elective foot or ankle surgery took part. Researchers measured…

This study tested two simple techniques—breathing yoga and progressive muscle relaxation—in 125 liver transplant recipients to see which better reduces pain, breathing complications, and fear of movement. Both methods are drug-free and can be done at home. The goal is to help pat…

This study tested whether a fixed-dose combination of dipyrone and codeine provides better pain relief than either drug alone after open pelvic-abdominal surgery. About 491 adults with moderate to severe pain after surgery took part. The main goal was to see if more people got at…

This study tested two methods of pain control after hip replacement surgery in 60 adults. One group received a continuous nerve block near the spine (erector spinae plane block), while the other received standard epidural pain relief. Researchers measured pain levels, opioid use,…

This study looked at whether listening to local music can lower pain and boost comfort in patients who had laparoscopic abdominal surgery. 120 adults from Turkey and Iran took part. The goal was to see if a simple, drug-free method like music could help people feel better after s…

This study compared two standard numbing medicines, lidocaine and bupivacaine, in 60 patients aged 15-35 having jaw surgery. The goal was to see which one provides better pain relief and affects numbness and touch sensation after surgery. Results will help doctors choose the best…

This study tested whether a special numbing injection (serratus posterior superior intercostal plane block) can reduce pain in adults getting a pacemaker or similar heart device. Sixty participants received either the numbing medicine or a placebo. Researchers measured pain level…

This study looked at two different nerve block methods to control pain and help people walk sooner after total knee replacement surgery. 90 adults having knee replacement under spinal anesthesia received either a fascia iliaca block or a combination of adductor canal and IPACK bl…

This study tested two methods to control pain after gallbladder removal: a nerve block (external oblique intercostal block) versus injecting pain medicine into the surgical cuts (port-site infiltration). Sixty adults took part to see which approach lowered pain and the need for s…

This study tested whether adding sufentanil to ropivacaine in a nerve block reduces pain after video-assisted lung surgery better than ropivacaine alone. 90 adults scheduled for surgery took part. The main goal was to see if the combination lowered morphine use in the first 48 ho…

This study tested whether applying cryotherapy (cold therapy) during pulpotomy or root canal treatment reduces pain and improves quality of life for people with deep cavities. 144 adults with deep decay in a molar were randomly assigned to receive either standard treatment or tre…

This study looked at whether duloxetine, a medication usually used for depression, can help reduce pain and the need for strong painkillers after knee replacement surgery. 241 adults having knee replacement took part. The goal was to see if adding duloxetine to standard pain trea…

This study tested two different pain relief methods after liver surgery: continuous wound infiltration with local anesthetics and spinal analgesia. The goal was to see which method reduces the need for morphine and lowers the chance of long-term pain. A total of 186 adults having…

This study looked at whether special nerve blocks (PECS II, parasternal, and serratus plane blocks) can reduce pain after minimally invasive heart bypass surgery (MIDCAB). Researchers reviewed records of 88 adults who had this surgery, comparing those who got the blocks to those …

This study tested whether placing small seeds on specific points of the ear (auricular acupressure) can help reduce pain after a cesarean section. Seventy women who had a C-section were randomly assigned to receive either real acupressure seeds or fake (sham) patches on both ears…

This study tested whether teaching patients about pain before surgery (called pain neuroscience education) could lower their anxiety, stress, and pain after a total abdominal hysterectomy. 62 adults having this surgery took part. The goal was to see if this simple education sessi…

This study tested four ways of conditioning the gas used during laparoscopic womb surgery to see if it could prevent a drop in body temperature and reduce pain after surgery. 248 women took part, and the gas was either dry or moistened with salt water or a numbing medicine. The g…

This study tested whether vibration therapy, alone or with cold, could reduce pain and anxiety when chest tubes are removed after heart bypass surgery. 93 adults were randomly assigned to vibration, vibration plus cold, or standard care. Results showed both vibration methods lowe…

This study looked at 75 women who had a planned cesarean section to compare two pain relief techniques: a TAP block (injection into the abdominal wall) and wound infiltration (injection into the incision area). The goal was to see which method leads to better recovery quality, le…

This study tested whether a PECS nerve block, given before surgery, could lower the amount of opioids needed and improve pain control in women undergoing breast cancer surgery. Seventy women took part, and the approach aimed to reduce pain and increase satisfaction. The results h…

This study tested whether adding hyaluronidase to a standard numbing medicine (bupivacaine) in a TAP block (a type of pain injection) could extend pain relief after cesarean section. 114 women scheduled for C-section participated. The main goal was to see how long pain relief las…

This study tested two different nerve block approaches to control pain after hip fracture surgery. 96 adults with hip fractures received either a PENG block plus lateral femoral cutaneous nerve block or a supra-inguinal fascia iliaca compartment block. The goal was to see which m…

This study tested an eye drop called OCS 01 in 153 adults who had cataract surgery. The goal was to see if it could reduce eye inflammation and pain better than a placebo. Participants used the drops once or twice a day for a few weeks. The results help determine the best dose fo…

This study tested whether injecting a local anesthetic (ropivacaine) during breast cancer surgery could prevent chronic pain that sometimes lingers for months. Researchers compared pain levels three months after surgery in 260 women who either received the injection or a placebo.…

This study tested two pain relief methods after total hip replacement: a nerve block (erector spinae plane block) versus a small dose of morphine injected into the spinal fluid. The goal was to see which method helps patients walk sooner after surgery. 70 adults aged 18-60 partic…

This study looked at whether watching comedy videos (comedy therapy) can help reduce pain and anxiety in adults after uretero-renoscopy (URS) surgery for kidney stones. 110 patients took part. The goal was to see if laughter could be a simple, drug-free way to improve recovery.

This study looked at whether watching clips from classic Turkish comedy movies could help reduce pain and increase comfort in people who just had a liver transplant. 120 adult liver transplant recipients took part. Researchers measured their pain and comfort levels after watching…

This study tested three different numbing techniques to see which one works best for pain after chest surgery. 155 adults having video-assisted lung surgery received either one block, another block, or both blocks before their operation. The goal was to find the most effective wa…

This study looked at different ways to clean a tooth's root canal to see which one causes the least pain afterward. Eighty adults with a dead front tooth received one of several disinfection methods. Their pain was checked at 6, 24, 48, and 72 hours, and again after a week. The g…

This study looked at 174 adults who had knee replacement surgery to see which pain relief method works better: a combination of nerve blocks and an injection around the knee, or the injection alone. The goal was to find out which approach reduces pain and the need for opioid pain…

This study looked at whether adding morphine to the standard spinal anesthetic could provide longer pain relief for people having hernia repair surgery. Fifty adults were split into two groups: one received morphine plus bupivacaine, the other bupivacaine alone. Researchers measu…

This study tested whether avoiding opioids during gallbladder surgery helps patients recover better. Fifty adults having planned laparoscopic gallbladder removal were randomly assigned to receive either opioid-free or standard opioid-based pain medicines. The main goal was to mea…

This study looked at whether a TAP block (a type of nerve block) can reduce pain after laparoscopic gallbladder removal. Sixty adults having this surgery were split into two groups: one got the TAP block with numbing medicine, the other did not. Researchers measured pain scores a…

This study tested whether taking melatonin for three nights before wisdom tooth removal can lower pain and the need for painkillers after surgery. Sixty adults aged 18-35 took either melatonin or a placebo before their procedure. Researchers measured how many pain pills participa…

This study tested whether giving a single dose of pregabalin (a nerve pain medication) about an hour before kidney stone surgery could reduce pain and the need for opioid painkillers afterward. 118 adults having ureteroscopy with a ureteral stent were randomly assigned to receive…

This study tested whether leaving surgical wounds uncovered after gastrointestinal cancer surgery is as safe as changing dressings every two days. Over 1,100 patients were randomly assigned to either no dressing changes or routine care. The goal was to see if skipping dressings c…

This study looked at 60 adults having knee replacement surgery to compare two types of nerve blocks for pain relief. One group got a BiFeS block plus an adductor canal block, and the other got an IPACK block plus an adductor canal block. Researchers measured how much pain medicin…

This study looked at whether cognitive behavioral therapy (CBT) can help people who had surgery for a broken bone feel less pain over the next year. Over 1,000 adults took part, some getting CBT and others usual care. The goal was to see if CBT lowers the chance of developing lon…

This study tested whether using the Headspace meditation app before surgery could help reduce pain after a minimally invasive hysterectomy. 72 women participated and reported their pain levels the day after surgery. The goal was to see if mindfulness training could improve recove…

This study tested whether wearing green or blue glasses after kidney donation surgery can help reduce pain and nausea without medication. 48 kidney donors were randomly assigned to wear green, blue, or clear glasses, or no glasses at all. Their pain and nausea levels were checked…

This study tested two types of nerve blocks to reduce pain in children after hip surgery. 80 children aged 1-7 years received either a caudal block or a pericapsular nerve group (PENG) block. The goal was to see which block provides better pain control and reduces the need for st…

This study looked at two ways to manage pain after arthroscopic shoulder surgery. The standard nerve block can sometimes cause temporary diaphragm paralysis, making breathing harder. The new block targets different nerves and may avoid that problem. Researchers tested it in 60 ad…

This study tested whether a special nerve block (RIB block) could reduce pain and the need for strong painkillers after laparoscopic sleeve gastrectomy, a common weight-loss surgery. Fifty-six adults with severe obesity were randomly assigned to receive either the nerve block plu…

This study tested a nerve-freezing technique (cryoanalgesia) during robot-assisted lung surgery to see if it reduces pain afterward. 33 adults having lung surgery were randomly assigned to receive the nerve block or not. Researchers measured pain scores and pain medication use fo…

This study looked at 36 people having breast cancer surgery to see how well different numbing techniques block pain. Researchers mapped the numb areas on the skin to understand which method covers the surgical cut best. The goal is to help doctors choose the right pain relief for…

This study aimed to find out what factors can predict pain after oral surgery, like a tooth extraction. Researchers measured pain levels in 148 adults for five days after surgery and used simple questionnaires and tests done before the procedure. The goal was to create a model th…

This study looked at 120 adults having gallbladder surgery to see if a nerve block (ESP block) given before or after the operation changes the heart's electrical signals. The goal was to understand if the timing of the block affects heart safety. Participants were split into thre…

This study followed 2,500 adults before and after major surgery to find out who develops persistent pain. Researchers collected information on medical history, physical and emotional health, and daily symptoms via smartphone surveys. The goal was to identify factors that can pred…

This study looked at whether a genetic marker called COMT can predict how well a person responds to hypnosis for pain relief after surgery. Researchers tested a new, fast DNA test on 80 people who had already been in hypnosis trials. The goal was to see if this genetic test could…

This study tested whether a device that measures pupil changes (automated pupillometry) can help detect pain in intensive care patients who are confused after surgery. Pain is hard to assess in these patients because they cannot communicate clearly. The study included 49 adults a…

This study examined whether a person's body mass index (BMI) influences how well a nerve block controls pain after surgery for a slipped disc in the lower back. Researchers measured pain levels in 75 adults at different times after surgery. The goal was to see if higher BMI leads…

This study looked at whether very small doses of fentanyl can help predict who will feel more pain after surgery. Researchers tested 48 healthy men, some who had surgery before and some who hadn't, by measuring their pain threshold after receiving ultra-low fentanyl doses. The go…

This study looked at 128 children aged 2-18 who had ear, nose, or throat surgery. Researchers compared two routine anesthesia methods—one with opioids and one without—to see which led to less agitation and delirium after surgery. The goal was to find out if avoiding opioids could…

This study looked at 120 adults having open heart surgery to see if an AI program could accurately judge whether nerve blocks were placed correctly. A computer and a doctor each rated ultrasound images of the blocks. The goal was to see if better block placement leads to less pai…

This study looked at whether specific brain wave signals during surgery can predict how much pain a person will feel afterward. Researchers monitored 57 adults having laparoscopic abdominal surgery. The goal is to find better ways to manage pain after operations.