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Nerve freezing cuts opioid use after heart surgery?

NCT ID NCT06443931

Symptom relief Sponsor: Meshalkin Research Institute of Pathology of Circulation Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether freezing certain nerves in the chest (cryoablation) can reduce pain and the need for strong painkillers after minimally invasive mitral valve surgery. Thirty adults took part, and researchers measured pain levels and opioid use. The goal was to gather early data for a larger trial.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

30 people

The number who actually took part.

Started

Mar 2024

Finished

Oct 2025

Lead sponsor

A research network

The lead sponsor is a research network or cooperative group.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

Children (under 18), adults (18 to 64) and older adults (65 and over)

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion criteria: * Written informed consent; * Minimally invasive mitral valve surgery. Non-inclusion criteria: * patient refusal; * pregnancy; * treatment with antidepressants or epileptic drugs; * depression, which can significantly affect the perception of pain; * chronic use of analgesics; * participation in competing randomized clinical trials. Exclusion criteria: \- Extended mechanical ventilation, more than 12 hours.

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Conditions

The condition(s) this trial relates to.

mitral valve insufficiency Pain Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Mitral regurgitation Pain, postoperative

Contacts and locations

Locations

  • Meshalkin Research Institute of Pathology of Circulation

    Novosibirsk, 630055, Russia

More trials for these conditions

Other studies related to the condition(s) this trial covers.