MITRAL REGURGITATION

This study looks at the best way to use blood thinners after a minimally invasive heart valve repair (TEER) in people with mitral regurgitation. About 1,032 participants who do not need long-term blood thinners will be randomly assigned to different anti-clotting strategies. The …

This study tests a new device called the Cephea Mitral Valve System for people with a leaky or narrowed mitral heart valve. The device is placed using a thin tube through a blood vessel, avoiding open-heart surgery. The study will include about 50 people and will check if the dev…

This early study tests a new device called the CardioMech Mitral Valve Repair System in 25 people with moderate-to-severe mitral regurgitation (a leaky heart valve). Participants are at intermediate or high risk for open-heart surgery. The goal is to see if the device is safe and…

This study follows 550 people who receive Abbott annuloplasty rings or bands during surgery to fix leaky mitral or tricuspid heart valves. Researchers will track survival, need for repeat surgery, and symptom improvement for five years after the implant. The goal is to confirm th…

This study tests a new device called the Medtronic Intrepid™, which replaces the mitral valve without open-heart surgery. It is for people with severe mitral regurgitation (a leaky heart valve) who cannot have standard treatments. About 400 participants will be followed for at le…

This study is testing a new device called the HighLife 28mm mitral valve for people with moderate-severe or severe mitral regurgitation (a leaky heart valve) who are at high risk for open-heart surgery. The valve is placed using a thin tube through a vein, avoiding major surgery.…

This early study tests a new device called the ReValve System to replace the mitral valve in people with significant mitral regurgitation (a leaky heart valve). About 20 participants who are eligible for mitral valve surgery will receive the device. The main goal is to see if the…

This study tests a less invasive way to replace the mitral valve in people with severe calcium buildup and valve problems who are too high-risk for open-heart surgery. About 210 participants will either get the new valve or continue with medical care alone. The goal is to see if …

This study tests a minimally invasive procedure to repair a leaky heart valve in people with severe cardiogenic shock (when the heart can't pump enough blood). Participants will either get the valve repair plus standard medical care, or medical care alone. The goal is to see if t…

This study tests a new device called GeminiOne that repairs a leaky mitral valve in the heart using a thin tube inserted through a vein, avoiding open-heart surgery. It is for people with severe symptoms who are not good candidates for surgery. The goal is to see if the device is…

This study tests a new device called the SAPIEN M3 System to replace the mitral valve in people with severe mitral regurgitation (leaky valve) who cannot have standard surgery or other treatments. The goal is to see if the device is safe and effective at reducing death and hospit…

This study tests a new device called the Tioga TMVR System to treat a leaky heart valve (mitral regurgitation) without open-heart surgery. It will include 30 adults with moderate to severe symptoms who are not good candidates for surgery. The goal is to see if the device is safe …

This study looks at the best way to use blood thinners after a minimally invasive heart valve repair (TEER) in people with mitral regurgitation who also need long-term blood thinners for conditions like atrial fibrillation. About 880 participants will be randomly assigned to diff…

This study is testing a new device called the Cephea Mitral Valve System for people with leaky or narrowed heart valves. The goal is to see if it is safe and works well as an alternative to open-heart surgery. About 20 participants will receive the device through a tube inserted …

This study tests a hospital-wide treatment plan for people with heart failure and a leaky mitral valve (secondary mitral regurgitation). The goal is to see if the plan helps doctors identify who will benefit most from a minimally invasive valve repair procedure called MitraClip. …

This study collects information from 1,000 people with symptomatic mitral valve disease who may be candidates for a less invasive valve replacement procedure. The goal is to better understand how correcting the valve problem affects patient outcomes and to help guide future produ…

This study is a registry that collects information from 1000 people with a leaky mitral valve (mitral regurgitation) who are being considered for a catheter-based valve replacement. The goal is to see how well different treatments work in real-world settings, including valve repl…

This study aims to identify biological differences between men and women with heart valve disease (aortic regurgitation, mitral regurgitation, or aortic stenosis) using advanced MRI techniques. Researchers will enroll 200 adults with moderate to severe valve disease to develop se…

This study looks at 90 people with a heart condition called mitral valve prolapse who need surgery to fix a leaky valve. Researchers want to see if the surgery reduces dangerous heart rhythms and changes scarring in the heart muscle. Participants will have heart scans and wear a …