Mitral regurgitation

Researchers compare two timings for giving the blood thinner heparin during minimally invasive heart procedures that require a puncture through the wall between the heart's upper chambers. Adults scheduled for mitral valve repair or left atrial appendage closure join the trial. O…

This study is testing a new device called the Cephea Mitral Valve System for people with mitral valve disease (leaky or narrowed heart valves) who cannot have open-heart surgery. The goal is to see if the device is safe and works well. About 20 people will take part.

This trial is testing a new device called the HARPOON system, which is designed to repair a leaky mitral valve in the heart while it is still beating, avoiding the need for open-heart surgery. The study will include people with severe degenerative mitral regurgitation, a conditio…

This study is testing a device called PASCAL, which is used to repair a leaky mitral valve in the heart without open-heart surgery. The procedure involves guiding a small clip through a blood vessel to the heart to help the valve close properly. Researchers are following about 1,…

This study tests if adding a tiny shunt (a small passage) between the upper chambers of the heart can lower pressure after a standard valve repair procedure called MitraClip. Ten people with heart failure and a leaky mitral valve will receive the shunt right after their MitraClip…

This study tests a new device called Tendyne, which is a replacement heart valve placed through a tube in the blood vessels, avoiding open-heart surgery. It is for people with a leaky mitral valve (mitral regurgitation) who are too high-risk for traditional surgery. The trial com…

This trial tests a new device called the Edwards SAPIEN M3 System for people with severe mitral regurgitation, a condition where a heart valve leaks blood backward. The device is placed using a thin tube threaded through blood vessels, avoiding open-heart surgery. The study inclu…

This study compares two devices—the Edwards PASCAL and the Abbott MitraClip—that repair leaky mitral heart valves without open-heart surgery. About 1,200 people with severe mitral regurgitation who are too high-risk for surgery are being randomly assigned to one device. The goal …

This study is testing a device called the Tendyne mitral valve system in 200 people with mitral regurgitation, a condition where the heart's mitral valve doesn't close properly, causing blood to leak backward. The valve is implanted through a tube in an artery, avoiding open-hear…

This study planned to test a new device called the Cardiovalve, which is threaded through a leg vein to replace a leaky mitral valve in people too sick for open-heart surgery. The trial was withdrawn before any participants were enrolled, so no results are available. The approach…

This study tests whether using a specific set of measurements (an algorithm) to decide between repairing or replacing a leaky mitral valve leads to better outcomes than letting the surgeon choose. About 110 patients with severe ischemic mitral regurgitation will be randomly assig…

This study tests a new device called the Cardiovalve, which is threaded through a blood vessel in the leg to fix a leaky mitral valve without open-heart surgery. It includes 30 people with severe mitral regurgitation who are too high-risk for traditional surgery. The goal is to s…

This early study is testing a new device called the Cardiovalve system in 10 people with severe mitral regurgitation (a leaky heart valve) who are at high risk for open-heart surgery. The valve is delivered through a vein in the leg, avoiding a large chest incision. The main goal…

This study tests whether a device called MitraClip, which repairs the mitral valve through a small tube inserted in a blood vessel, works as well as traditional open-heart surgery for people with severe mitral regurgitation who are at high risk for surgery. About 330 participants…

This study tests whether the pressure gradient across an intentionally created atrial septal defect, measured right after a minimally invasive mitral valve repair called M-TEER, can indicate how much mitral regurgitation remains. Researchers will compare this gradient with echoca…

This study looks at whether using a cardiac MRI (CMR) instead of the usual ultrasound helps doctors make better decisions about heart valve surgery for people with severe mitral regurgitation (a leaky heart valve). About 260 adults with no symptoms but severe leakage will be foll…

This study tests whether artificial intelligence can help doctors see heart valve structures more clearly during a minimally invasive repair procedure called TEER. Researchers will use data from 1,500 patients who have already had the procedure to train and test the AI. The goal …

This study looks at whether a special MRI scan can detect early scarring in the heart muscle of people with leaky heart valves. The goal is to find a way to predict when the heart might start to fail, so doctors can decide on surgery sooner. About 316 adults with moderate to seve…