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Which nerve block eases knee replacement pain better?

NCT ID NCT07231692

Symptom relief Sponsor: Karabuk University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looked at 60 adults who had knee replacement surgery to see which of two nerve block combinations worked better for pain. One group got a biceps femoris short head block plus an adductor canal block, and the other got an IPACK block plus an adductor canal block. Researchers measured how much opioid pain medicine patients used and their pain scores in the first 24 hours after surgery.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
nerve block (biceps femoris short head block or IPACK block combined with adductor canal block)
What this could lead to
If one block combination works better, it could help reduce opioid use and improve recovery after knee replacement surgery.
What could go wrong
This is a small observational study (60 people) that only looks at existing practices, not a controlled experiment. Results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

60 people

The number who actually took part.

Started

Oct 2025

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will include adult patients aged 18-80 years undergoing elective unilateral total knee arthroplasty (TKA) under spinal anesthesia at Karabük Training and Research Hospital. Eligible participants will have ASA physical status I-III and be capable of using patient-controlled analgesia (PCA). Patients will be prospectively observed as part of routine multimodal analgesia including either BiFeS + ACB or IPACK + ACB block combinations for postoperative pain management.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Adults aged 18-80 years scheduled for elective unilateral total knee arthroplasty (TKA) under spinal anesthesia * ASA physical status I-III * Eligible for and capable of using patient-controlled analgesia (PCA) * Provided written informed consent Exclusion Criteria: * Chronic opioid use for more than four weeks before surgery * Presence of chronic pain conditions (e.g., migraine, fibromyalgia) * History of alcohol or drug abuse * Known allergy or hypersensitivity to local anesthetics or opioids * Severe organ dysfunction (e.g., significant hepatic or renal disease) * Revision or bilateral knee arthroplasty * Contraindications to regional anesthesia * Preexisting neuropathy or prior femoral vascular surgery on the operated side. * Infection near the injection site (e.g., osteomyelitis, septic joint). * Contraindication to spinal anesthesia (e.g., refusal, coagulopathy, use of anticoagulants or antiplatelet agents) or inability to understand NRS. * Severe psychiatric or cognitive disorders (e.g., psychosis, dementia) that prevent cooperation or pain assessment * Pregnant or breastfeeding women

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Conditions

The condition(s) this trial relates to.

osteoarthritis, knee Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Arthroplasty, replacement, knee Pain after total knee arthroplasty Pain, postoperative

Contacts and locations

Locations

  • Karabuk Training and Research Hospital, Department of Anesthesiology and Reanimation

    Karabük, Karabük Province, 78200, Turkey (Türkiye)

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