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New anesthesia cocktail aims to cut opioids and boost recovery after surgery

NCT ID NCT06985069

Symptom relief Sponsor: Insel Gruppe AG, University Hospital Bern Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This completed trial tested whether a combination of four non-opioid drugs (magnesium, dexmedetomidine, ketamine, and lidocaine) given during major surgery could improve patient recovery compared to standard opioid-only anesthesia. 240 adults undergoing planned major surgery were randomly assigned to one of the two approaches. The main goal was to measure patient satisfaction and recovery quality using a standard questionnaire.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Multimodal anesthesia (magnesium, dexmedetomidine, ketamine, lidocaine)
What this could lead to
If it works, this approach could reduce opioid use and improve patient satisfaction after major surgery.
What could go wrong
This is a single-center study with 240 participants, so results may not apply to all hospitals or surgeries. The combination of drugs may also cause side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

240 people

The number who actually took part.

Started

Jun 2025

Finished

Sep 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Existing informed consent * German, Italian or French speaking * Age 18 or more * Planned duration of surgery 60min or more * Inpatients and postoperative transfer to PACU or 24h ICU Exclusion Criteria: * Palliative or emergency procedures * Reoperation (e.g. 2nd look) * Bariatric surgery patients * Pregnancy / breastfeeding * Adults legally protected * Known allergy or contraindication to interventional medication

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Conditions

The condition(s) this trial relates to.

opioid abuse Pain, Postoperative Postoperative Complications Postoperative Nausea and Vomiting

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Opioid use Pain, postoperative Postoperative complications Postoperative nausea

Contacts and locations

Locations

  • Department of Anaesthesiology and Pain Medicine, Inselspital, Bern University Hospital

    Bern, 3010, Switzerland

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