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Jaw surgery pain study: which numbing drug works best?

NCT ID NCT06450028

Symptom relief Sponsor: Boston Children's Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Aug 05, 2026 · Updated 6 times

Summary

This study compared two common numbing drugs, lidocaine and bupivacaine, in 60 people aged 15–35 having jaw surgery. Researchers measured pain, numbness, and touch sensation after surgery. The goal is to find which drug gives patients a better recovery experience.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
lidocaine and bupivacaine (local anesthetics)
What this could lead to
If this study shows one drug works better, surgeons may use it to reduce pain and numbness after jaw surgery.
What could go wrong
This is a small, completed Phase 4 trial with only 60 participants. Results may not apply to everyone, and both drugs are already standard care, so no major breakthrough is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

64 people

The number who actually took part.

Started

Oct 2024

Finished

Nov 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

15 to 35 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Undergoing an orthognathic procedure at Boston Children's Hospital * Between the ages of 15 and 35 years old Exclusion Criteria: * Any patient undergoing any other procedures in addition to their orthognathic procedure during the same sedation period (extraction, bone graft, etc.). * Any patient with a history of chronic pain. * Any patient with a history of an allergic reaction to bupivacaine or lidocaine. * Any patient with known neurologic changes to the lip or chin. * Any patient not enrolled in an Enhanced Recovery After Surgery (ERAS) Protocol. * Any patient known to be pregnant or with a positive pregnancy test prior to the procedure.

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Conditions

The condition(s) this trial relates to.

Hypesthesia Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Numbness Pain, postoperative Perception of touch Temperature sensation

Contacts and locations

Locations

  • Boston Children's Hospital

    Boston, Massachusetts, 02115, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.