Pain, postoperative

This phase 3 trial tests whether taking tranexamic acid (TXA) by mouth for an extended period after total knee replacement can improve recovery. TXA is already used during surgery to reduce bleeding, but its benefits when continued afterward are unclear. The study will compare di…

This study tests whether a jaw muscle nerve block (Twin block) and a smart pill dispenser (iPill) can reduce opioid use after wisdom tooth removal. About 133 adults will be enrolled. The nerve block aims to ease pain right after surgery, while the dispenser only releases opioids …

This study tests whether a new nano-based paste (chitosan-coated silver nanoparticles) works better than a standard antibiotic paste for treating infected baby molars in children aged 4-8. The goal is to reduce pain, swelling, and infection, and to see which paste kills bacteria …

This trial tests whether an automated video analysis algorithm can detect pain in post-surgical patients by analyzing their facial expressions and body movements. Participants will be videotaped with a smartphone before and after surgery or pain procedures, and their reported pai…

This trial tests whether burst spinal cord stimulation, a type of implanted device that delivers high-frequency electrical pulses, can reduce chronic leg pain that persists after lumbar spine surgery. Participants, who have had pain for at least six months despite other treatment…

This trial tests whether using virtual reality (VR) relaxation before and after gynecologic surgery can reduce anxiety and pain. About 220 women undergoing day or inpatient gynecologic procedures will either use a VR headset with calming scenes or receive standard care. Researche…

This study looks at whether a 12-week virtual dance program can improve quality of life and reduce pain, fatigue, and body image issues in breast cancer survivors who have ongoing pain after surgery. Thirty participants who had a lumpectomy or mastectomy and still have moderate t…

This study compares two types of nerve blocks for pain after kidney transplant surgery. One uses a single injection of long-lasting pain medicine, and the other uses a continuous drip through a small tube. The goal is to see which method reduces the need for opioid painkillers an…

This study tests whether injecting bupivacaine, a common numbing medication, into the surgical site after skin surgery can improve pain control. About 100 adults having skin surgery will receive either bupivacaine or a saline placebo injection. Participants will track their pain …

This study tests whether a saphenous nerve block can safely reduce pain after surgery for a tibial plateau fracture. Typically, nerve blocks are avoided in these fractures because numbness might mask compartment syndrome, a serious complication. The saphenous nerve block targets …

This pilot study tests whether giving dexmedetomidine and lidocaine during major non-cardiac surgery can help patients recover faster and with less pain. About 100 adults having elective surgery will be randomly assigned to receive one of these drugs or standard care. The main go…

This study tests whether a quadratus lumborum (QL) nerve block can reduce pain and the need for opioid painkillers after hip replacement surgery. 80 adults having a first-time hip replacement will receive the block, and their pain scores and opioid use will be tracked for 48 hour…

This study tests whether giving a single dose of dexamethasone (a steroid) before spinal anesthesia for planned C-sections can prevent common side effects like low blood pressure, nausea, and vomiting, and also improve pain relief after surgery. About 176 pregnant women will rece…

This study tests whether a nerve block called erector spinae plane block can reduce the amount of morphine needed for pain after spinal fracture surgery. About 86 adults having minimally invasive spine surgery will be randomly assigned to receive either the nerve block or a place…

This trial tests whether a Pain and Coordination Plan (PAC-plan) can reduce opioid use and improve quality of life in adults who have had surgery after an accidental injury. Participants receive the plan at hospital discharge, which includes an opioid management plan, a follow-up…

This study compares two types of nerve blocks (serratus plane block and rhomboid intercostal plane block) to see which provides better pain relief after breast reduction surgery. About 90 women will receive one of the blocks before surgery, and their pain and opioid use will be t…

This study compares three pain management techniques for teenagers undergoing minimally invasive repair of pectus excavatum (a sunken chest). The methods are: patient-controlled analgesia (PCA, where the patient pushes a button for pain medicine), erector spinae block (a nerve bl…

This study looks at whether giving magnesium through an IV during hip surgery can lower pain and the need for strong painkillers after the operation. About 50 adults having a specific type of hip surgery are taking part. Researchers will measure pain levels and medication use to …

This study tests a new pain medicine called NTM-001 for people with moderate to severe pain after bunionectomy (foot surgery). About 341 adults will receive either NTM-001, morphine, or a placebo to see how well it works and if it is safe. The study is currently on hold.

This study tests whether repeated magnetic pulses (rTMS) aimed at the brain's motor area can safely reduce chronic nerve pain that hasn't responded to other treatments. About 32 adults with conditions like post-stroke pain, trigeminal neuralgia, or spinal cord injury will receive…

This study planned to test whether giving ear acupuncture during wrist fracture surgery could lower the amount of opioid painkillers patients need afterward. It was designed for adults aged 18–64 having a specific type of wrist repair. However, the trial was withdrawn before enro…

This study planned to test whether adding ear acupuncture to standard pain management could reduce opioid use after surgery for lower leg fractures. It was designed for adults aged 18–64 undergoing ankle or foot fracture repair. However, the trial was withdrawn before enrolling a…

This study tests whether a nerve block given before heart surgery can reduce pain and the need for opioid painkillers afterward. About 150 adults having heart surgery will receive either a long-acting or standard form of the numbing drug bupivacaine via ultrasound-guided injectio…

This study looks at whether playing music before or during hernia repair surgery can help lower pain after the operation. About 308 adults having surgery at Bethesda Surgery Center will take part. Researchers will measure pain scores and how much narcotic pain medicine is needed …

This study tests a technique called intercostal nerve cryotherapy, where doctors freeze nerves between the ribs during minimally invasive lung surgery to control pain afterward. About 110 adults having lung nodule removal will be randomly assigned to receive either the freezing t…

This study planned to test whether a 6-day course of oral methylprednisolone after total knee replacement could improve pain, sleep, and knee movement. Participants would also receive a steroid injection during surgery. The study was withdrawn before enrolling anyone, so no concl…

This study looks at whether prescribing fewer opioid painkillers after laparoscopic hysterectomy still keeps patients comfortable. About 120 adults having the surgery for non-cancer reasons will be randomly assigned to get a smaller or standard opioid prescription. The goal is to…

This study compares a standard painkiller (bupivacaine) to a slow-release version (Exparel) for pain after eye removal surgery. 88 adults having their eye removed at Mayo Clinic will receive one of the two injections during surgery. The goal is to see if the slow-release drug pro…

This study tests whether adding transcutaneous electrical acupoint stimulation (TEAS) to standard pain relief can reduce pain and inflammation after lung cancer surgery. 90 people scheduled for thoracic surgery will receive either standard care alone or standard care plus TEAS. T…

This pilot study tests whether daily meditation can improve recovery for children and adults having surgery for kidney stones. Participants will be randomly assigned to either a meditation group or a control group. Those in the meditation group will practice a daily 20-minute gui…

This study aimed to see if a nerve block called a parasternal subpectoral plane block could reduce pain and the need for opioids after heart surgery. It planned to compare a numbing medicine (bupivacaine) to a saltwater placebo in about 100 adults having elective heart surgery. H…

This study uses surveys to understand how caregivers, surgeons, and anesthesiologists feel about using methadone for pain in children having outpatient surgery. Researchers want to see if factors like neighborhood, language, or race affect these views. The goal is to gather infor…

This study looks at whether a quick pain sensitivity test, called mechanical temporal summation, can help predict which women will have severe pain after a cesarean delivery. Researchers will also examine other factors like anxiety and pain catastrophizing. The goal is to better …

This study looks at whether heavy smartphone use affects how much pain people feel after nose surgery and how much pain medicine they need. Researchers will follow 100 adults having rhinoplasty and measure their pain scores and painkiller use. The goal is to understand if phone h…

This study planned to compare two types of nerve blocks (erector spinae block and quadratus lumborum block) for pain control after hip surgery in young people aged 15-30. The goal was to see if one block reduced opioid use or pain scores more than the other. However, the study wa…