PAIN, POSTOPERATIVE

This study compares two ways to prevent seroma (fluid buildup) after breast removal surgery. Normally, two drains are placed under the arm and chest. Here, doctors use special quilting stitches to attach skin to muscle, and test if one drain works as well as two. 60 women having …

This study tests whether giving the numbing drug lidocaine through a vein during breast cancer surgery can prevent persistent pain that often lasts for months after the operation. About 1,600 adults having a lumpectomy or mastectomy will be randomly assigned to receive either lid…

This study tests a new device that only gives out opioid pain pills at set times after spine surgery. Half of the 30 participants will use the device, while the other half use a standard pill bottle. The goal is to see if the device helps people take fewer pills and feel safer, w…

This study tests whether a continuous drip of pain medicine into the belly after minimally invasive hysterectomy can lower pain and reduce the need for narcotics. About 120 women having surgery for non-cancer reasons will be randomly assigned to receive either the pain medicine o…

This study compares two numbing medicines for leg surgery: a mix of lidocaine and bupivacaine versus bupivacaine alone. Researchers want to see if the combo works faster and provides better pain control. About 60 adults having elective lower leg surgery will take part.

This study compares two methods of delivering pain relief through a nerve block after surgery: a continuous slow drip versus scheduled larger doses. Researchers want to see which approach better controls pain and reduces the need for opioid painkillers. The study involves 240 adu…

This study tests whether a special nerve block (QL block) can reduce pain and the need for strong painkillers after hip replacement surgery. About 80 adults having a planned hip replacement will take part. The study will measure pain levels and how quickly patients can stand up a…

This study tests whether adding either dexamethasone or dexmedetomidine to a standard numbing medicine (bupivacaine) in a nerve block can provide longer pain relief after abdominal surgery. About 96 adults aged 25-65 undergoing laparotomy will be enrolled. The goal is to see whic…

This study tests whether patients recovering from shoulder surgery can safely and effectively give themselves liquid acetaminophen (Tylenol) instead of receiving pills from a nurse. About 24 adults will be enrolled to see if this approach is practical and acceptable. The goal is …

This study tests whether a specific nerve block (called PIFB) can help people recover better after open-heart surgery. About 123 adults having planned heart surgery will receive either this block or another standard block. The goal is to see which method reduces pain and improves…

This study tests a mobile app called L-WebTIPS, designed to help Latinx children ages 2-7 and their families prepare for and recover from outpatient surgery. The app provides coping skills and information in a culturally adapted format. Researchers will measure whether it reduces…

This study tests whether a nerve block can help people who have neck surgery use fewer opioid painkillers and feel less pain. About 60 adults having posterior cervical spine surgery will be randomly assigned to receive either the nerve block plus standard pain medication or stand…

This study compares a pain management plan that avoids opioids to one that includes them, for people having joint replacement or other orthopedic surgeries. About 80 adults will be randomly assigned to one of two groups and report their pain levels for 14 days after surgery. The …

This study looks at whether non-narcotic pain medications work as well as opioids for pain after knee arthroscopy. About 148 adults having knee surgery will receive either opioids or non-opioids and report their pain levels and medication use. The goal is to find effective pain r…

This study tests a device called VibraCool that uses cooling and vibration to reduce pain after ACL reconstruction. Researchers want to see if it helps people use fewer opioid painkillers. About 130 adults who had ACL surgery will use the device and report their pain levels and o…

This study tests whether a numbing injection (bupivacaine) into a nerve cluster in the face can reduce pain after minimally invasive pituitary tumor surgery. About 108 adults will receive either the nerve block, a placebo, or no extra injection during surgery. Researchers will tr…

This study tests a new, less invasive way to place screws in the neck spine (cervical spine) to treat spine disease and reduce post-surgery pain. About 76 adults will be randomly assigned to either the new minimally invasive method or the standard open surgery. The main goal is t…

This study compares a new local numbing technique (PENG block) to standard spinal anesthesia for adults having hip replacement surgery. Researchers want to see if the new method controls pain just as well while allowing patients to move their leg sooner. About 100 participants wi…

This study looks at two different types of nerve blocks to see which one works better for pain after lower back surgery. About 80 adults having elective back surgery will get one of the two blocks. The main goal is to see which block reduces the need for strong painkillers in the…

This study tests whether brief mindfulness breathing, heart rate biofeedback, or pain education before shoulder surgery can reduce pain, improve shoulder function, sleep, and mood afterward. About 120 adults with chronic shoulder pain scheduled for surgery will be randomly assign…

This study compares two ways to manage pain after abdominal surgery: a standard numbing medicine (bupivacaine) alone versus the same medicine plus a sedative (dexmedetomidine). About 80 adults having elective belly surgery will receive one of these two options via a nerve block. …

This study tests a non-invasive device placed on the ear that gently stimulates nerves to help manage pain after lumbar spine surgery. The goal is to see if it can lower pain scores and reduce the need for opioid painkillers. About 20 adults having back surgery will participate, …

This study tests whether a special nerve block (PECS) given before surgery can lower the amount of strong pain medicine (opioids) children need after getting a heart device like a pacemaker. About 48 kids aged 3-18 will be randomly assigned to get either the nerve block or standa…

This study looks at three ways to manage pain in young children after dental surgery done under general anesthesia. The three options are ibuprofen alone, ibuprofen and acetaminophen given at different times, or both given together. The goal is to find which method works best to …

This study compares a single dose of methadone (a long-acting opioid) to standard short-acting opioids like fentanyl for pain control after tonsillectomy in children aged 3 to 17. The goal is to see if methadone reduces the need for extra pain medicine after surgery. About 440 ch…

This study tests whether a single spinal injection of morphine before lung surgery can reduce the amount of pain medication patients need afterward. About 90 adults having video-assisted or robotic lung surgery will receive either the morphine injection or a placebo. The goal is …

This study tests whether avoiding opioids during breast cancer surgery can reduce side effects like nausea and breathing problems, while still controlling pain. About 200 adults having a lumpectomy or mastectomy will be randomly assigned to receive either opioid-free or standard …

This study tests whether a targeted numbing injection (erector spinae plane block) reduces pain and opioid use after lumbar spinal fusion better than standard numbing under the skin. About 66 adults having one- or two-level lumbar fusion will be randomly assigned to one of the tw…

This study compares two pain management methods for hip fracture surgery: standard multimodal analgesia versus a pericapsular nerve group (PENG) block. Researchers will measure pain scores, opioid use, how soon patients can walk, and hospital stay length. The goal is to see if th…

This study tests a new nerve block method (BiFeS) against a standard one (iPACK) for pain after knee replacement. About 88 adults having knee surgery will be randomly assigned to one of the two blocks. Researchers will measure pain scores, painkiller use, and how quickly patients…

This study tests two different numbing injections to see which one controls pain better after hypospadias repair in boys aged 1 to 5 years. One injection targets a nerve area near the tailbone, the other targets a different spot in the lower back. Researchers will measure pain le…

This study compares two common pain medicine combinations after low-risk surgeries like gallbladder removal, hernia repair, or breast lump removal. About 900 adults will be randomly assigned to receive either NSAIDs (like ibuprofen) plus acetaminophen (Tylenol) or low-dose opioid…

This study tests if a long-lasting painkiller called Exparel can better control pain and reduce the need for strong narcotic pain pills in children and teens after knee surgery. About 100 participants aged 13 and older will receive either Exparel plus a standard painkiller or the…

This study tests a device called the NOL monitor, which tracks pain signals during surgery. Doctors use it to decide how much pain medicine to give. The goal is to see if this approach reduces pain medicine use, shortens hospital stays, and improves recovery. The trial involves 6…

This study tests whether helping people sleep better for 4 weeks before knee or hip replacement surgery can reduce pain and speed recovery afterward. About 100 adults with insomnia and osteoarthritis will receive either a brief sleep therapy (CBT-I) or sleep education before thei…

This study tests whether a device that creates a pulsed magnetic field (PEMF) can reduce pain and the need for painkillers after shoulder or knee surgery. About 76 adults having these surgeries will use the device or a placebo for 10 days after their operation. Researchers will m…

This study tests three different doses of a long-lasting painkiller (liposomal bupivacaine) injected near the knee nerve to see which works best after total knee replacement. About 177 adults having robotic knee surgery will take part. The goal is to find the dose that reduces pa…

This study looks at whether a 12-week online dance program can improve quality of life, reduce pain, and ease fatigue in breast cancer survivors who still have pain months after surgery. About 30 adults who had a lumpectomy or mastectomy and have moderate to severe pain will take…

This study looks at whether giving gabapentin before and after chest surgery can reduce the amount of strong painkillers (opioids) that children need. About 60 children under 18 having heart or lung surgery will take part. The goal is to manage pain with fewer opioids, which can …

This study tests if placing a steroid directly on the spine during back surgery helps reduce pain and the need for opioid painkillers afterward. About 150 adults having a 1-2 level lumbar laminectomy will be randomly assigned to receive the steroid or not. Researchers will track …

This study compares two types of nerve blocks—Quadratus Lumborum and Transversalis Fascia—to see which provides better pain relief after inguinal hernia surgery. Sixty adults aged 18-65 will be enrolled, and researchers will measure how long it takes before patients need addition…

This study compares two types of anesthesia—spinal and epidural—for people having liver surgery. The goal is to see if spinal anesthesia leads to better blood pressure control, less need for IV fluids, and similar pain relief, helping patients recover faster. About 128 adults und…

This study tests whether giving methadone as a pill before heart surgery works better than giving it through an IV during surgery to control pain afterward. About 100 adults having planned heart surgery will take part. Researchers will measure how much additional pain medicine pa…

This study tests whether a 7-day buprenorphine skin patch can safely control pain after ankle fracture surgery and reduce the need for addictive opioids. About 100 adults who have never taken opioids before will receive either the patch or a placebo, along with standard pain care…

This study compares aloe vera gel dressings to traditional paraffin-based dressings for pain at the skin graft donor site. About 72 adults aged 18-60 will receive one of the two dressings after surgery. Pain is measured on day 7 using a standard scale, and extra pain medication u…

This study compares two types of nerve blocks (PENG block and L-ESP block) to see which one provides better pain relief after total hip replacement surgery. About 52 adults having hip replacement under spinal anesthesia will take part. Researchers will track pain scores, painkill…

This study tests two different numbing injections for pain after kidney transplant surgery. One group gets a single long-lasting shot, and the other gets a shot plus a small tube that delivers numbing medicine for a longer time. The goal is to see which method reduces the need fo…

This study tests whether taking 600 mg of gabapentin two hours before wisdom tooth extraction can lower pain and reduce the need for opioid painkillers afterward. About 98 adults will be randomly assigned to receive either gabapentin or a placebo. Researchers will track opioid us…

This study tests whether giving the sleep medication zolpidem before and after lumbar spine fusion surgery helps reduce pain and improve function. About 140 adults with degenerative lumbar disease will be randomly assigned to receive zolpidem or a placebo. The goal is to see if b…

This study tests if freezing certain nerves during surgery for broken ribs can reduce pain and the need for strong painkillers afterward. About 80 adults with multiple broken ribs will either get standard surgery or surgery plus nerve freezing. The goal is to see if the freezing …

This study tests whether avoiding opioids during and after obesity surgery can improve recovery and reduce side effects. About 220 adults having laparoscopic obesity surgery will be randomly assigned to opioid-free care (with or without personalized support) or standard opioid-ba…

This study looks at how pain pathways in the brain and nerve regrowth in the eye change after corneal crosslinking (CXL) for keratoconus. Researchers will use brain scans (fMRI) and special eye imaging to measure these changes in 60 participants aged 8-35. The goal is to better u…

This study watches 60 people who are having their bladder removed with robot-assisted surgery. The goal is to see how much blood they lose, how much pain they have, and how many need blood transfusions. No new treatment is being tested — the researchers are just collecting inform…