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New painkiller injection could cut opioid use after chest surgery

NCT ID NCT03737292

Symptom relief Sponsor: Milton S. Hershey Medical Center Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether a long-acting form of the numbing drug bupivacaine (liposomal bupivacaine) provides better pain relief than the standard version after minimally invasive chest surgery. Forty adults undergoing thoracoscopic procedures will receive one of the two drugs injected between their ribs. Researchers will measure drug levels in the blood and track pain, opioid use, and recovery for up to 3 months. The goal is to see if the liposomal version can safely reduce pain and opioid-related complications.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
liposomal bupivacaine (Exparel) and plain bupivacaine
What this could lead to
If successful, this could lead to better pain management after chest surgery, reducing the need for opioids and their side effects.
What could go wrong
This is a small, early-phase study with only 40 participants, so results may not apply to everyone. The long-term benefits and safety are still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 4

Runs after approval, following long-term safety and how well the treatment works in everyday use.

Participants

About 40 people

The number the study aims to enrol. It can still change while the study runs.

Started

Apr 2019

Expected to finish

Dec 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1\. Male or female patients over age 18 undergoing minimally invasive thoracic surgeries including but not limited to: 1. VATS wedge resection /segmentectomy 2. VATS lobectomy. 3. Robot assisted thoracoscopic wedge resection/segmentectomy. 4. Robot assisted thoracoscopic lobectomy procedures. Exclusion Criteria: 1. Patients under18 years of age 2. Patients weighing less than 48 kg 3. Pregnant and lactating females will be excluded from the trial 4. Patients preoperatively taking narcotics for chronic pain in proximity to surgical site 5. Patients with previous ipsilateral thoracic surgery 6. Patients undergoing pleurectomy/mechanical pleurodesis. 7. Patients with high likelihood of conversion from thoracoscopic procedure to open thoracotomy as determined by an operating surgeon 8. Patients with pre-existing painful conditions (CRIPS, fibromyalgia, neuropathy) 9. Patients unable to reliably communicate pain scores such as patients with dementia, alterations in mental status 10. Patients with hypersensitivity to local anesthetics and pain medications used in the study 11. Patients with previous thoracic spine surgeries 12. Patients with increased creatinine (over 1.5mg/dl) 13. Patients with liver dysfunction 14. Non-English speaking patients

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain, postoperative Pharmacokinetics

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Milton S. Hershey Medical Center

    RECRUITING

    Hershey, Pennsylvania, 17033, United States

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