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Freezing nerves to fight pain after lung surgery: a new hope?

NCT ID NCT05348447

Symptom relief Sponsor: Allegheny Singer Research Institute (also known as Allegheny Health Network Research Institute) Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing This study
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a technique called intercostal nerve cryotherapy, where doctors freeze nerves between the ribs during minimally invasive lung surgery to control pain afterward. About 110 adults having lung nodule removal will be randomly assigned to receive either the freezing treatment or standard pain control. The main goals are to see if cryotherapy reduces the amount of morphine needed and lowers pain scores.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Intercostal nerve cryotherapy (freezing nerves between ribs using a device)
What this could lead to
If it works, this could offer a new way to manage post-surgical pain with less need for strong painkillers like morphine.
What could go wrong
This is a small, early-stage trial (110 people) testing a procedure, not a drug. The freezing may not reduce pain enough to change standard care, and there could be side effects like nerve damage or prolonged numbness.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

110 people

The number who actually took part.

Started

Apr 2022

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Patients 18 year and older. 2. Undergoing elective minimally invasive (VATS or robotic) lung resection for nodules (wedge resection, segmentectomy, lobectomy). 3. Performance status of 1 or 2. Exclusion Criteria: 1. Patients with ejection fraction less than 40% 2. Patients with creatinine greater than 1.5. 3. Patients with Child's B or C cirrhosis 4. Patients on chronic narcotics for other reasons 5. Patients diagnosed with fibromyalgia 6. Patients who had previous thoracic surgery on the same side. 7. Patients who cannot communicate in English. 8. Patients unable to provide informed consent for the study.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Cryotherapy effect Pain, postoperative

Contacts and locations

Locations

  • AHN Allegheny General Hospital

    Pittsburgh, Pennsylvania, 15212, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.