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New approach aims to slash opioid use after wisdom tooth surgery

NCT ID NCT04414917

Disease control Sponsor: Rutgers, The State University of New Jersey Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused This study
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study tests whether a jaw muscle nerve block (Twin block) and a smart pill dispenser (iPill) can reduce opioid use after wisdom tooth removal. About 133 adults will be enrolled. The nerve block aims to ease pain right after surgery, while the dispenser only releases opioids when pain is severe, based on a phone app. The goal is to lower opioid consumption and misuse.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Twin block (dental local anesthetic) and iPill dispenser (active pill dispenser)
What this could lead to
If successful, this approach could reduce opioid prescriptions and misuse after wisdom tooth extractions, especially in young people.
What could go wrong
This is a small Phase 2 trial that is currently suspended, so results are uncertain. The nerve block and pill dispenser may not significantly cut opioid use in practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

About 133 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Nov 2026

An estimate. Start dates often move.

Expected to finish

Apr 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Adults (\> 18) 2. American Society of Anesthesiologists Classification I 3. No h/o temporomandibular disorder (TMD) symptoms 4. No h/o trauma to jaws/teeth 5. No h/o surgery in maxillofacial region 6. Presenting for extraction of at least 1 mandibular partially bony/ full bony impacted 'wisdom' or third molar/s under intravenous sedation 7. iPhone or Android smart phone (compatible with iPill® App) 8. Informed consent 9. No cognitive/intellectual disability 10. Not from vulnerable population Exclusion Criteria: 1. Acute infection or pain in relation to the impacted molars on day of procedure 2. h/o opioid prescription for acute/chronic pain 3. h/o of allergy or contraindication to amide-type local anesthetics, epinephrine or opioids 4. Chronic use of non-steroidal anti-inflammatory drugs (NSAIDs)/muscle relaxants/other prescriptions to manage pain/inflammation 5. Refusal/inability to use iPill® App or dispenser 6. h/o eczema

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Pain, postoperative

How to take part

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  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    The full official record for this study. This one lists no contact details, but it is the first place any would appear.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Rutgers Health University Dental Associates

    New Brunswick, New Jersey, 08901, United States

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