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New study tests better pain relief after back surgery

NCT ID NCT06199999

Symptom relief Sponsor: Rashmi Mueller Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study compared two methods of pain control for people having back fusion surgery: a nerve block given before surgery versus numbing medicine injected at the end. Researchers measured pain, inflammation, confusion after surgery, and overall recovery in 29 adults. The goal is to find which approach leads to better recovery and less opioid use.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
erector spinae plane block and local anesthetic infiltration
What this could lead to
If one method works better, it could improve pain control and reduce confusion after back surgery.
What could go wrong
This is a small, early-phase study with only 29 participants, so results may not apply to everyone. Both methods are already used, so no major breakthrough is expected.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Phase 2

Tests whether the treatment actually works, and watches for side effects, in a larger group.

Participants

29 people

The number who actually took part.

Started

May 2024

Finished

Apr 2025

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria for all groups: 1. Age: Greater than 18 years but less than 80 2. Surgical procedure: 1 to 2 level thoraco-lumbar fusion between T8 and S2; non-emergent surgery 3. Opioid naive (less than 6 oxycodone/day or 30 mg oxycodone equivalent) 4. No contraindication to local anesthetics or regional procedures. Exclusion Criteria for all groups: 1. Emergency surgery 2. Allergy to study medications 3. BMI less than 20 or greater than 50 4. Major liver or kidney dysfunction or other pre-existing major organ dysfunction 5. Revision surgery 6. Opioid tolerant (60 mg morphine equivalents/day for 1 week) or narcotic dependence (opioid intake morphine equivalent greater than10 mg/day for more than 3 months) 7. Other sources of chronic pain (e.g. fibromyalgia) 8. Patients with associated significant central nervous system (CNS) or respiratory disease (home oxygen use) 9. Pre-operative neurological deficits 10. Co-existing hematological disorders or deranged coagulation parameters 11. Significant psychiatric illnesses that impedes the subject's ability to provide informed consent 12. Language barrier 13. Vulnerable population (e.g. prisoners) 14. Pregnant females 15. History of recent myocardial infarction 16. History of recent cardiac stent procedure (within 3 months) 17. Cardiac ejection fraction \< 30%

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Conditions

The condition(s) this trial relates to.

Emergence Delirium intervertebral disk degenerative disorder lumbar disk degenerative disorder Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Degenerative disc disease Pain, postoperative Postoperative delirium

Contacts and locations

Locations

  • University of Iowa Health Care Medical Center

    Iowa City, Iowa, 52242, United States

More trials for these conditions

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