DEGENERATIVE DISC DISEASE

This study is comparing two different bone graft materials used during spinal fusion surgery. The surgery aims to permanently join vertebrae together to relieve chronic back or leg pain. Researchers will track 100 patients for a year to see which material helps the spine fuse tog…

This study is testing a new spinal implant designed to match a patient's bone density scan. It aims to help bones fuse together more reliably after surgery for painful neck disc disease. Researchers will track 80 patients for a year to see how well the implant works at reducing p…

This study is testing a new artificial disc implant designed to reduce chronic low back pain while preserving natural spine movement. The implant replaces damaged cushioning in the spine as an alternative to traditional fusion surgery, which limits motion. Researchers will track …

This study aims to compare two different, already FDA-approved, artificial discs used to replace a damaged disc in the neck. The goal is to see which design—one with more constrained movement versus one with less—leads to better outcomes for patients with neck pain and nerve prob…

This study monitors the safety and performance of the Ennovate® Cervical implant system in real-world use. Researchers will track 200 patients with various spine conditions including fractures, degenerative disc disease, and spinal instability. The study collects data on pain lev…

This study is testing two medical devices used in spine surgery: special cages that hold vertebrae apart and a bone graft material that helps bones heal together. Researchers want to see how well these devices work for people with degenerative disc disease or herniated discs in t…

This study is testing a new, moldable bone graft material called OssiMend for use in spinal fusion surgery. It aims to see how well it helps bones fuse together in the lower back over 12 months. The study will enroll 120 adults with degenerative disc disease who haven't improved …

This study aims to see if a newer titanium implant helps bones heal better after neck surgery compared to the standard bone graft material. Researchers will look at past and future patients who had surgery for worn-out neck discs to compare how well the bones fuse together and ho…

This study is testing an investigational injectable cell therapy (IDCT) to see if it can safely reduce pain and improve function in people with chronic lower back pain caused by a single worn-out spinal disc. About 162 adults who haven't gotten better with standard treatments wil…

This study is testing the safety and effectiveness of a new bone graft material called LDGraft for spinal fusion surgery. It will be compared to standard human donor bone in 40 adults with severe, painful degenerative disc disease in their lower back who haven't improved with oth…

This study compares two different bone graft materials used during spinal fusion surgery for patients with degenerative disc disease and back pain. Surgeons will use a synthetic bone putty on one side of the spine and a standard bone graft mixture on the other side in the same pa…

This study is testing whether a single injection of donor disc tissue can safely reduce chronic low back pain caused by worn-out spinal discs. About 500 adults with long-term pain that hasn't improved with standard care will receive either the real injection or a sham (fake) proc…

This study is testing if a single injection of a stem cell-based treatment (rexlemestrocel-L) can provide long-term relief for people with chronic low back pain caused by a worn-out spinal disc. It will compare the injection to a control treatment in 300 adults who have had signi…

This study is testing whether a specific nerve block injection given before minimally invasive back surgery can help manage pain afterward. The goal is to see if this reduces the need for strong opioid pain medications and their side effects. Researchers will compare the injectio…

This study is testing a new oral medication called EC5026 to see if it is safe and tolerable for people with chronic nerve pain caused by a spinal cord injury. Researchers will enroll 36 adults who have had this pain for over a year and have not gotten enough relief from other st…

This study is testing whether an experimental injection called CELZ-201-DDT can safely reduce pain and improve movement in people with long-term lower back pain caused by worn spinal discs. Researchers will give 45 participants either the real injection or a placebo shot in their…

This study is a registry that collects information on how well commercially available bone grafts work in real-world spinal fusion surgeries. It will follow about 450 patients who have already been scheduled for spine fusion surgery and whose surgeon has chosen to use an OssDsign…