DEGENERATIVE DISC DISEASE

This study tests a new device called PerQdisc, which is surgically placed in the spine after removing a damaged disc. It aims to reduce pain and improve function in people with degenerative disc disease. The trial will enroll 72 adults aged 22-70 who have not gotten relief from a…

This study tests whether a single injection of Rexlemestrocel-L (a type of stem cell therapy) combined with hyaluronic acid can reduce pain in people with moderate to severe chronic low back pain caused by degenerative disc disease. About 300 adults who have had back pain for at …

This study follows 200 adults who receive the Ennovate Cervical implant for spine fractures, disc disease, instability, tumors, or myelopathy. Researchers track pain and quality of life over time to see if the device performs safely. It is not a cure—patients may need ongoing car…

This study compares two FDA-approved artificial disc implants (Mobi-C and Simplify) used in neck surgery for conditions like herniated discs or pinched nerves. About 20 adults aged 18-60 who haven't improved with non-surgical care will be randomly assigned to receive one of the i…

This study compares two bone graft materials used during spinal fusion surgery to treat back and leg pain caused by degenerative disc disease. One is a synthetic material (MagnetOs Flex Matrix) and the other is a donated human tissue graft (Trinity Elite). About 100 adults needin…

This study is testing a new spinal implant designed to help bones in the neck fuse together better after surgery. The implant is customized based on a patient's bone density scan. Researchers will follow 80 people for one year to see if the implant improves fusion rates and reduc…

This study tests a synthetic bone graft putty called MagnetOs Easypack Putty for spinal fusion surgery. The goal is to see if it works as well as or better than current bone graft materials when used alone. About 60 adults with back pain or spine instability from disc disease or …

This study tests a new material called Novosis Putty used during spinal fusion surgery for people with degenerative disc disease in the lower back. The putty is meant to help the bones fuse together more successfully. About 316 adults who have not improved with other treatments w…

This study tests a one-time injection called VIA Disc NP for people with long-term low-back pain caused by degenerative disc disease. The injection adds tissue to worn discs to help reduce pain. About 496 adults will receive either the real injection or a sham procedure, and rese…

This study tests a new bone graft material called LDGraft for spinal fusion surgery in people with degenerative disc disease. The goal is to see if it helps bones fuse better and reduces pain compared to a standard bone graft. About 40 adults aged 22 to 80 will take part.

This study tests a new material called OssiMend Bioactive Moldable for spinal fusion surgery in 120 adults with degenerative disc disease. The goal is to see if it helps the spine bones fuse together successfully after 12 months. Participants will have their pain and function mea…

This study tests an experimental cell treatment (IDCT) for people with mild to moderate lower back pain caused by a worn disc. About 162 adults will receive either the cell injection or a sham procedure. The goal is to see if the treatment safely reduces pain and improves daily f…

This study tests two devices used together in spine surgery: conduit cages (to support the spine) and Fibergraft (a material that helps bone heal). Researchers will follow 100 adults with degenerative disc disease or herniated discs for two years after surgery. The goal is to see…

This early-stage trial tests a new drug called EC5026 for nerve pain caused by spinal cord injury. About 36 adults with this type of pain will take either the drug or a placebo daily for 14 days. The main goal is to check if the drug is safe and tolerable, while also seeing if it…

This study tests an experimental drug called CELZ-201-DDT, given as a shot into the back muscles, for people with long-term lower back pain due to worn-out spinal discs. The goal is to see if it is safe and can reduce pain and improve movement. About 45 adults aged 18 to 80 who h…

This study tests whether a specific nerve block (erector spinae plane block) can reduce the need for opioid painkillers after minimally invasive lumbar spine surgery. About 125 adults undergoing certain types of back surgery will receive either the nerve block or a placebo. The g…

This study looks at how well the bones in the neck fuse together after surgery using two different materials: a new titanium device (Tritanium C) or a bone graft from a donor. Researchers will track 60 adults aged 18-80 with degenerative disc disease who need surgery on one or tw…

This study is a registry that will follow 450 adults getting spine fusion surgery with a specific bone graft material (OssDsign). The goal is to see how well the bones fuse together and how patients' quality of life changes over time. It is an observational study, meaning no new …